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The map label for this gene is aqpM [H]

Identifier: 116492103

GI number: 116492103

Start: 343903

End: 344553

Strand: Direct

Name: aqpM [H]

Synonym: PEPE_0299

Alternate gene names: 116492103

Gene position: 343903-344553 (Clockwise)

Preceding gene: 116492100

Following gene: 116492105

Centisome position: 18.77

GC content: 38.4

Gene sequence:

>651_bases
ATGAAGAAATATGTTTCAGAAATTATTGGTACGTTCGTACTTGTTTTTGTTGGTACTGCCGCTGTTACAATTGGTAAAGC
CGACGTTTTAGGAATTGGATTAGCTTTTGGTTTGGCTGTTACGATTATGGCTTACTCTGTTGGTGCAATTTCAGGAGGAC
ACTTTAACCCAGCTGTTACATTAGGTATGTGGATTAATAAGCGAATCAGTGGAGCAGATGCTATTTATTATGTTATTTCA
CAATTTATTGGTGCTGTCCTGGCTTCAGGAATGGTTAAGTATTTCCTAAGTGCTATGGGAGCTTCAACTAGCAATCTTGG
ACAAACTGATTTTGCAAAAATCTCAGCATTTCCAGCACTCGTAACTGAAACTTTGGTAACATTCCTATTTGTGCTTGTTA
TCTTGCTAGTTACAAGTAAAAAGTATGGTAATGCTAACTTTGCTGGTTTAATTATTGGATTAACGCTAGCATTCATGATT
ATTGCATCATTGAACTTAACTGGCGGTTCATTGAACCCTGCTCGTAGTTTTGGTCCTGCAATCTTAGTTGGTGGTTCAGC
TTTATCTCACTACTGGGTTTACGTTGTGGCTCCATTATTAGGTGCTGCAATTGCTGCTTTTGTTGCTAAGGCAATGGGTA
GCGAAGAATAA

Upstream 100 bases:

>100_bases
AAAAGATACGCTCAAGATTAATACATTTTATTTGAGAAAATGGTTAAAGTGGTATACAATTTTCGTACGGGTTTTTGCCT
GTGGATAGGAGAGATTATTG

Downstream 100 bases:

>100_bases
TAGCTAATCTAAAAAAATAAGGATTAACGCTGGGCGAATAATTTCGTCTCAAAACGTTAATCCTTATTTTTTTCGCGTAT
TTTTACGTCGTTCTAGATTG

Product: glycerol uptake facilitator related permease (major Intrinsic protein family)

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKKYVSEIIGTFVLVFVGTAAVTIGKADVLGIGLAFGLAVTIMAYSVGAISGGHFNPAVTLGMWINKRISGADAIYYVIS
QFIGAVLASGMVKYFLSAMGASTSNLGQTDFAKISAFPALVTETLVTFLFVLVILLVTSKKYGNANFAGLIIGLTLAFMI
IASLNLTGGSLNPARSFGPAILVGGSALSHYWVYVVAPLLGAAIAAFVAKAMGSEE

Sequences:

>Translated_216_residues
MKKYVSEIIGTFVLVFVGTAAVTIGKADVLGIGLAFGLAVTIMAYSVGAISGGHFNPAVTLGMWINKRISGADAIYYVIS
QFIGAVLASGMVKYFLSAMGASTSNLGQTDFAKISAFPALVTETLVTFLFVLVILLVTSKKYGNANFAGLIIGLTLAFMI
IASLNLTGGSLNPARSFGPAILVGGSALSHYWVYVVAPLLGAAIAAFVAKAMGSEE
>Mature_216_residues
MKKYVSEIIGTFVLVFVGTAAVTIGKADVLGIGLAFGLAVTIMAYSVGAISGGHFNPAVTLGMWINKRISGADAIYYVIS
QFIGAVLASGMVKYFLSAMGASTSNLGQTDFAKISAFPALVTETLVTFLFVLVILLVTSKKYGNANFAGLIIGLTLAFMI
IASLNLTGGSLNPARSFGPAILVGGSALSHYWVYVVAPLLGAAIAAFVAKAMGSEE

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=219, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4755125, Length=180, Percent_Identity=36.1111111111111, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4502181, Length=180, Percent_Identity=36.1111111111111, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4502183, Length=210, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI6912506, Length=207, Percent_Identity=32.8502415458937, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI4502179, Length=202, Percent_Identity=32.1782178217822, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI45446752, Length=202, Percent_Identity=28.7128712871287, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI86792455, Length=212, Percent_Identity=33.0188679245283, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI157266307, Length=241, Percent_Identity=29.4605809128631, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4826645, Length=244, Percent_Identity=30.7377049180328, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI22538420, Length=239, Percent_Identity=30.5439330543933, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=39.9038461538462, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1790362, Length=248, Percent_Identity=26.2096774193548, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=226, Percent_Identity=34.070796460177, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17558372, Length=224, Percent_Identity=32.5892857142857, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994009, Length=239, Percent_Identity=30.9623430962343, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=239, Percent_Identity=25.9414225941423, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24652747, Length=213, Percent_Identity=36.150234741784, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45551084, Length=213, Percent_Identity=36.150234741784, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24762342, Length=230, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24652751, Length=209, Percent_Identity=33.9712918660287, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19922038, Length=209, Percent_Identity=33.9712918660287, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24762344, Length=226, Percent_Identity=33.1858407079646, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24762346, Length=226, Percent_Identity=33.1858407079646, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24762348, Length=226, Percent_Identity=33.1858407079646, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130305, Length=226, Percent_Identity=33.1858407079646, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550503, Length=225, Percent_Identity=28, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136672, Length=217, Percent_Identity=28.110599078341, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22289; Mature: 22289

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYVSEIIGTFVLVFVGTAAVTIGKADVLGIGLAFGLAVTIMAYSVGAISGGHFNPAVT
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LGMWINKRISGADAIYYVISQFIGAVLASGMVKYFLSAMGASTSNLGQTDFAKISAFPAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
VTETLVTFLFVLVILLVTSKKYGNANFAGLIIGLTLAFMIIASLNLTGGSLNPARSFGPA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCE
ILVGGSALSHYWVYVVAPLLGAAIAAFVAKAMGSEE
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKYVSEIIGTFVLVFVGTAAVTIGKADVLGIGLAFGLAVTIMAYSVGAISGGHFNPAVT
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LGMWINKRISGADAIYYVISQFIGAVLASGMVKYFLSAMGASTSNLGQTDFAKISAFPAL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
VTETLVTFLFVLVILLVTSKKYGNANFAGLIIGLTLAFMIIASLNLTGGSLNPARSFGPA
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCE
ILVGGSALSHYWVYVVAPLLGAAIAAFVAKAMGSEE
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]