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The map label for this gene is napA [H]

Identifier: 116492049

GI number: 116492049

Start: 289755

End: 290915

Strand: Direct

Name: napA [H]

Synonym: PEPE_0245

Alternate gene names: 116492049

Gene position: 289755-290915 (Clockwise)

Preceding gene: 116492048

Following gene: 116492050

Centisome position: 15.81

GC content: 40.14

Gene sequence:

>1161_bases
ATGGAGTTCGTGGGCGTACTTGTACTAATTTTAGTACTGACCCTTTTAGCTGGTCATTTTGCTCAACGAATGGGATTTCC
TGCAGTTGTAGGACAATTATTGGTCGGAATTATTTTAGGGCCTGGAATTTTAGGGATTATTCATTCAGACGAATTGATAT
CAGTGTTTTCAGAAATCGGGGTAATTATCCTGATGTTTCTAGCAGGACTAGAAAGTGATCTGAAAATGTTGAAAAAATAC
ATCAAGCCGGCGCTGGTAGTTGCGATATTAGGGGTAGTTTTACCCATTGTATTAGTCGGTGGCGCGAGCCTTCTTTTTGG
AGTCCATCCGATGGAAGCACTATTCATCGGGGTCATCTTTTCAGCTACTTCAGTTAGTATTTCTGTGGAAGTCTTAAAGG
AATATCACACCCTAAATACTAAAGAGGGGGCCACCATTTTGGGGGCGGCTGTAGCCGATGATATTATTGGAGTTTTATTA
CTAGGTGTTATGATTGCGTTGACTAGTTCTAAATCGGGATCCAATTCAAACGTGGGGATGGCCATCTTTTATCAAGTGTT
ATTCTTCATTGGAGTATATGTGATCGGAAAATGGGTGGTTCCGATGCTTATGCGCCTTTCAGACCAACTGTTTATTACGG
CTTCGCGCCCAGTGATGTCGATTATTATTTGTTTAGGTTTAGCGTGGCTGGCTGATGTAGCCGGTTTGAGCGGAGCGATC
GGCGCATTTTTTGCGGGAGTAGCCGTTTCGTTAACCGATGAAGATGATGAAATCAATGAGAGCATTGAACCAATTGGTTA
TGCTATCTTTATTCCAGTTTTCTTCGTTAGTGTTGGTTTATCAATGAATTTTGATGGACTTCAAACTGTACTGGGACTAA
TTGTGGTATTAACTATTTTAGCCACTATTACCAAATTATTTGGTTGTGGATTAGGAGCTCGAATGTCGGGATTTGATTTA
ACTAGTAGTGGGGTAATTGGAGCTGGAATGATTTCCCGTGGCGAGATGGCGCTAATTACTTTACAAATTGGTTATGGTGA
ACATTTAATGAGTGAAACTTATTATTCAGCAATTGTATTAGTGATTGTTTTGGTTACCCTCATTGCACCGTTTATTTTGA
AGGATGCTATTAAGAAAAATAAAGCAGCTACTCATGCTTAA

Upstream 100 bases:

>100_bases
TCTTAGCTTATCCTACGGAAGCCAGTGATTTAGGCTATATGTAGTATACTTAATTAGTGATTGTTATAATTTAGCTTTAT
TTTGAAAGGAACGTGGTTTA

Downstream 100 bases:

>100_bases
AAACTAAACTTAGAATTTTCATCAAATTCTAAGTTTAGTTTTTTTATTTAGCAAATTACACAACAAGACCCGTTTAATTT
GATACAATGAACATTAAATA

Product: Kef-type K+ transport system, membrane component

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MEFVGVLVLILVLTLLAGHFAQRMGFPAVVGQLLVGIILGPGILGIIHSDELISVFSEIGVIILMFLAGLESDLKMLKKY
IKPALVVAILGVVLPIVLVGGASLLFGVHPMEALFIGVIFSATSVSISVEVLKEYHTLNTKEGATILGAAVADDIIGVLL
LGVMIALTSSKSGSNSNVGMAIFYQVLFFIGVYVIGKWVVPMLMRLSDQLFITASRPVMSIIICLGLAWLADVAGLSGAI
GAFFAGVAVSLTDEDDEINESIEPIGYAIFIPVFFVSVGLSMNFDGLQTVLGLIVVLTILATITKLFGCGLGARMSGFDL
TSSGVIGAGMISRGEMALITLQIGYGEHLMSETYYSAIVLVIVLVTLIAPFILKDAIKKNKAATHA

Sequences:

>Translated_386_residues
MEFVGVLVLILVLTLLAGHFAQRMGFPAVVGQLLVGIILGPGILGIIHSDELISVFSEIGVIILMFLAGLESDLKMLKKY
IKPALVVAILGVVLPIVLVGGASLLFGVHPMEALFIGVIFSATSVSISVEVLKEYHTLNTKEGATILGAAVADDIIGVLL
LGVMIALTSSKSGSNSNVGMAIFYQVLFFIGVYVIGKWVVPMLMRLSDQLFITASRPVMSIIICLGLAWLADVAGLSGAI
GAFFAGVAVSLTDEDDEINESIEPIGYAIFIPVFFVSVGLSMNFDGLQTVLGLIVVLTILATITKLFGCGLGARMSGFDL
TSSGVIGAGMISRGEMALITLQIGYGEHLMSETYYSAIVLVIVLVTLIAPFILKDAIKKNKAATHA
>Mature_386_residues
MEFVGVLVLILVLTLLAGHFAQRMGFPAVVGQLLVGIILGPGILGIIHSDELISVFSEIGVIILMFLAGLESDLKMLKKY
IKPALVVAILGVVLPIVLVGGASLLFGVHPMEALFIGVIFSATSVSISVEVLKEYHTLNTKEGATILGAAVADDIIGVLL
LGVMIALTSSKSGSNSNVGMAIFYQVLFFIGVYVIGKWVVPMLMRLSDQLFITASRPVMSIIICLGLAWLADVAGLSGAI
GAFFAGVAVSLTDEDDEINESIEPIGYAIFIPVFFVSVGLSMNFDGLQTVLGLIVVLTILATITKLFGCGLGARMSGFDL
TSSGVIGAGMISRGEMALITLQIGYGEHLMSETYYSAIVLVIVLVTLIAPFILKDAIKKNKAATHA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1789749, Length=375, Percent_Identity=28.2666666666667, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786232, Length=270, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786685, Length=377, Percent_Identity=28.1167108753316, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322367, Length=427, Percent_Identity=25.0585480093677, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 40621; Mature: 40621

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFVGVLVLILVLTLLAGHFAQRMGFPAVVGQLLVGIILGPGILGIIHSDELISVFSEIG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHH
VIILMFLAGLESDLKMLKKYIKPALVVAILGVVLPIVLVGGASLLFGVHPMEALFIGVIF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
SATSVSISVEVLKEYHTLNTKEGATILGAAVADDIIGVLLLGVMIALTSSKSGSNSNVGM
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AIFYQVLFFIGVYVIGKWVVPMLMRLSDQLFITASRPVMSIIICLGLAWLADVAGLSGAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHH
GAFFAGVAVSLTDEDDEINESIEPIGYAIFIPVFFVSVGLSMNFDGLQTVLGLIVVLTIL
HHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ATITKLFGCGLGARMSGFDLTSSGVIGAGMISRGEMALITLQIGYGEHLMSETYYSAIVL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
VIVLVTLIAPFILKDAIKKNKAATHA
HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFVGVLVLILVLTLLAGHFAQRMGFPAVVGQLLVGIILGPGILGIIHSDELISVFSEIG
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHH
VIILMFLAGLESDLKMLKKYIKPALVVAILGVVLPIVLVGGASLLFGVHPMEALFIGVIF
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHH
SATSVSISVEVLKEYHTLNTKEGATILGAAVADDIIGVLLLGVMIALTSSKSGSNSNVGM
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
AIFYQVLFFIGVYVIGKWVVPMLMRLSDQLFITASRPVMSIIICLGLAWLADVAGLSGAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHH
GAFFAGVAVSLTDEDDEINESIEPIGYAIFIPVFFVSVGLSMNFDGLQTVLGLIVVLTIL
HHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ATITKLFGCGLGARMSGFDLTSSGVIGAGMISRGEMALITLQIGYGEHLMSETYYSAIVL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
VIVLVTLIAPFILKDAIKKNKAATHA
HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]