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The map label for this gene is iscS [H]

Identifier: 116515301

GI number: 116515301

Start: 410114

End: 411322

Strand: Direct

Name: iscS [H]

Synonym: BCc_391

Alternate gene names: 116515301

Gene position: 410114-411322 (Clockwise)

Preceding gene: 116515295

Following gene: 116515302

Centisome position: 98.5

GC content: 23.82

Gene sequence:

>1209_bases
ATGAAATTTCCTATTTATTTAGATTATGCAGCTACAACACCTATGGATTCTAAAGTAAAAAAAAAAATGAATCAATATTA
TTTAATTAATGATATTTTTGGAAATTCAGCATCTAGATCTCATCAATTTGGCTGGGAAGCAGAAGAAGCAGTAGATATTT
CTAGAAATGAAATTGCTAAGTTAATTAATGCAGATTCTAGAGAAATTATTTTTACTTCAGGAGCTACTGAATCTAACAAT
TTAGCTATTAAAGGAATTTATGAATTTCATAAAAAAAAAAACACACATATTATCACTAGTACTATAGAACATAAATCAGT
ACTAGATTGTTACCGATATTTAGAATATAAAGGATGTAATGTAACATATTTATCACCTAATAAATATGGAATTATTAAAA
TTAAACAAATAAAAAAAAACATTAATAAAAATACACTTTTAATTTCAATTATGCATGTTAATAATGAAATCGGATCTATT
CAAAATATTAAAAAAATAGGAAAATTTTGTAGAAAAAAAAGAATTTTTTTTCATGTAGACGCTACTCAAAGTATTGGAAA
AATCAAAATTAATATGCAAAAACTAAAAATTGATTTATTATCTTTTTCTGCTCATAAAATATATGGACCTAAAGGAATTG
GAGCTTTATACATTAGTAAAAAACCTCGTATTAGATTATCACCTCAAATCCATGGAGGAGGACAAGAAAGAGGATTTCGT
TCAGGAACTTTACCAGTACATCAAATTGTTGGATTTGGTGAAGCATGTAGAATTTTAAGAAAAAATATGCATCATGATAT
AAAACATATGAAAAATTTACAAAAAATATTATGGAATGGACTAAAAAATATTGAAGAAATATATTTAAATAGTAATTTTA
ATTATTGTGTTTATAATATTATTAATATAAGTTTTAATTATATAGAAGGTGAATCATTACTAATGGCTTTAAAAAACTTA
GCTGTTTCTTCAGGTTCAGCATGTACTTCACAAAGTTTAGAACCATCTTATGTATTAAAATCTATAGGAGTAAAAGATGA
ATTAGCTCATAGCTCAATTAGATTTTCTTTAGGAAGATTTACAACTTATCAAGAAATTGAATATGCTATAATAGAAATAA
AAAAAGCAGTATTAAAATTAAGAAAATTATCTCCACTTTGGGAAATGTTTAAAGCAGGTATTAATATTGATTCTATTAAT
TGGAATTAA

Upstream 100 bases:

>100_bases
TTAAAAAATTTCTAAATTAAATAAATATAATTATTATTATTATAATATAATATAAATTATATTATTTAAAATAAATATAA
TACATTTAAAGGTTATAAAA

Downstream 100 bases:

>100_bases
TTATTTATATAGGAAAAAAAATATGTCATATAGTAAAAAAGTAATTGATCATTATGAAAATCCAAGAAATGTAGGATCTT
TTCCTGAAAAAGAAAATAAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKFPIYLDYAATTPMDSKVKKKMNQYYLINDIFGNSASRSHQFGWEAEEAVDISRNEIAKLINADSREIIFTSGATESNN
LAIKGIYEFHKKKNTHIITSTIEHKSVLDCYRYLEYKGCNVTYLSPNKYGIIKIKQIKKNINKNTLLISIMHVNNEIGSI
QNIKKIGKFCRKKRIFFHVDATQSIGKIKINMQKLKIDLLSFSAHKIYGPKGIGALYISKKPRIRLSPQIHGGGQERGFR
SGTLPVHQIVGFGEACRILRKNMHHDIKHMKNLQKILWNGLKNIEEIYLNSNFNYCVYNIINISFNYIEGESLLMALKNL
AVSSGSACTSQSLEPSYVLKSIGVKDELAHSSIRFSLGRFTTYQEIEYAIIEIKKAVLKLRKLSPLWEMFKAGINIDSIN
WN

Sequences:

>Translated_402_residues
MKFPIYLDYAATTPMDSKVKKKMNQYYLINDIFGNSASRSHQFGWEAEEAVDISRNEIAKLINADSREIIFTSGATESNN
LAIKGIYEFHKKKNTHIITSTIEHKSVLDCYRYLEYKGCNVTYLSPNKYGIIKIKQIKKNINKNTLLISIMHVNNEIGSI
QNIKKIGKFCRKKRIFFHVDATQSIGKIKINMQKLKIDLLSFSAHKIYGPKGIGALYISKKPRIRLSPQIHGGGQERGFR
SGTLPVHQIVGFGEACRILRKNMHHDIKHMKNLQKILWNGLKNIEEIYLNSNFNYCVYNIINISFNYIEGESLLMALKNL
AVSSGSACTSQSLEPSYVLKSIGVKDELAHSSIRFSLGRFTTYQEIEYAIIEIKKAVLKLRKLSPLWEMFKAGINIDSIN
WN
>Mature_402_residues
MKFPIYLDYAATTPMDSKVKKKMNQYYLINDIFGNSASRSHQFGWEAEEAVDISRNEIAKLINADSREIIFTSGATESNN
LAIKGIYEFHKKKNTHIITSTIEHKSVLDCYRYLEYKGCNVTYLSPNKYGIIKIKQIKKNINKNTLLISIMHVNNEIGSI
QNIKKIGKFCRKKRIFFHVDATQSIGKIKINMQKLKIDLLSFSAHKIYGPKGIGALYISKKPRIRLSPQIHGGGQERGFR
SGTLPVHQIVGFGEACRILRKNMHHDIKHMKNLQKILWNGLKNIEEIYLNSNFNYCVYNIINISFNYIEGESLLMALKNL
AVSSGSACTSQSLEPSYVLKSIGVKDELAHSSIRFSLGRFTTYQEIEYAIIEIKKAVLKLRKLSPLWEMFKAGINIDSIN
WN

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=50.75, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI156713448, Length=417, Percent_Identity=32.6139088729017, Blast_Score=200, Evalue=2e-51,
Organism=Escherichia coli, GI48994898, Length=401, Percent_Identity=62.0947630922693, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1789175, Length=236, Percent_Identity=27.9661016949153, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787970, Length=391, Percent_Identity=22.7621483375959, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=401, Percent_Identity=53.8653366583541, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=33.6391437308869, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319831, Length=399, Percent_Identity=51.8796992481203, Blast_Score=443, Evalue=1e-125,
Organism=Drosophila melanogaster, GI20129463, Length=400, Percent_Identity=50.25, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45970; Mature: 45970

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFPIYLDYAATTPMDSKVKKKMNQYYLINDIFGNSASRSHQFGWEAEEAVDISRNEIAK
CCCEEEEEECCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHH
LINADSREIIFTSGATESNNLAIKGIYEFHKKKNTHIITSTIEHKSVLDCYRYLEYKGCN
HHCCCCCEEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCE
VTYLSPNKYGIIKIKQIKKNINKNTLLISIMHVNNEIGSIQNIKKIGKFCRKKRIFFHVD
EEEECCCCEEEEEEHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEE
ATQSIGKIKINMQKLKIDLLSFSAHKIYGPKGIGALYISKKPRIRLSPQIHGGGQERGFR
CCCCCCEEEEEEEHEEEEEEECCCCEEECCCCCEEEEECCCCCEEECCEECCCCCCCCCC
SGTLPVHQIVGFGEACRILRKNMHHDIKHMKNLQKILWNGLKNIEEIYLNSNFNYCVYNI
CCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEE
INISFNYIEGESLLMALKNLAVSSGSACTSQSLEPSYVLKSIGVKDELAHSSIRFSLGRF
EEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
TTYQEIEYAIIEIKKAVLKLRKLSPLWEMFKAGINIDSINWN
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCC
>Mature Secondary Structure
MKFPIYLDYAATTPMDSKVKKKMNQYYLINDIFGNSASRSHQFGWEAEEAVDISRNEIAK
CCCEEEEEECCCCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHHH
LINADSREIIFTSGATESNNLAIKGIYEFHKKKNTHIITSTIEHKSVLDCYRYLEYKGCN
HHCCCCCEEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCE
VTYLSPNKYGIIKIKQIKKNINKNTLLISIMHVNNEIGSIQNIKKIGKFCRKKRIFFHVD
EEEECCCCEEEEEEHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEE
ATQSIGKIKINMQKLKIDLLSFSAHKIYGPKGIGALYISKKPRIRLSPQIHGGGQERGFR
CCCCCCEEEEEEEHEEEEEEECCCCEEECCCCCEEEEECCCCCEEECCEECCCCCCCCCC
SGTLPVHQIVGFGEACRILRKNMHHDIKHMKNLQKILWNGLKNIEEIYLNSNFNYCVYNI
CCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEE
INISFNYIEGESLLMALKNLAVSSGSACTSQSLEPSYVLKSIGVKDELAHSSIRFSLGRF
EEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
TTYQEIEYAIIEIKKAVLKLRKLSPLWEMFKAGINIDSINWN
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA