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The map label for this gene is ilvC [H]

Identifier: 116515299

GI number: 116515299

Start: 406239

End: 407711

Strand: Reverse

Name: ilvC [H]

Synonym: BCc_388

Alternate gene names: 116515299

Gene position: 407711-406239 (Counterclockwise)

Preceding gene: 116515300

Following gene: 116515298

Centisome position: 97.92

GC content: 24.37

Gene sequence:

>1473_bases
ATGAAAAATTTTTTTAATAAACTTTCTTTTAGAGAAAAATTAATAGAATTAAATACTGGTTTTTTAATGAATTCAAATGA
ATTTCTACATTCAAAAAAGAAATTAAAAAACAAAAAAATTGTTATAATAGGATGTGGAGCTCAAGGATTAAATCAAGGAT
TGAATTTAAGAGATTCTGGATTTAATGTTACTTATGCTTTACGAAAAAAATCAATAGAAAATAAATCTATTTCTTGGAAA
AATGCTATTAGAGAAAAATTTTTTGTAGATACATATGAAAATTTAGTTCCTAGTGCAGATTTAGTAATTAATTTAACTCC
TGACAAACAACATTCTGTTGTAGTAAAAAAATTACAAAAATTAATGAAAAAAAATTCTGTTTTAGGATATTCACATGGTT
TTAATATTGTAGAAATAGGAGAAGAAATTCGATCTGATATTACTGTTATCATGGTAGCACCTAAATGTCCGGGTACTGAA
GTTAGAAAAGAATTTTTAAAAGGTTTCGGTGTTCCAACATTAATTGCTGTACATAAAAAAAATGATCCTAAAAAAATAGG
ATTAGATATTGCTAAAGCCTGGGCTACAGGATTAGGATCACATAAAGCAGGAATATTAAAATCTTCTTTTATTGCGGAAG
TTAAATCTGATTTAATGGGTGAACAAACTATTTTATGTGGTATGTTACAAGCTTGTTCTTTAGTTTGTTTTAATCATTTA
ATTGAAAAAGGATATAGTTCTGATTTTTCAGCGACTTTGTTACAGTTTGGTTGGGAAAAATTAGCTGAATGTATGAAAGA
AGGTGGAATAACACTTTTATTTAATAGATTATCAATTTCATCTAAAATTCGTGCATATAAATTATCTATAGTATTAAAAT
CTTTATTAAGACCTTTATTTTGTTTACATATGGATAATATTATTTCTGGTGATTTTTCCAAAAATATGATAGCTGATTGG
AATAATTCTGATATTCAGTTATATAACTGGAGAAAGAAATTAAAGAAATCTCATTTTGAAAATTCTAATTTATATTCTAA
TAGAAAAATTTTAGATCATGAATATTTTGAAAAATGTACATTAATGGCTGCTATGTTAAAAGATTTGAAACTATGTATTA
ATACTGGAATTACTTCTGCTTCAGCATATTATGAATCTTTACATGAACTTCCTTTAATTGCAAATACTATTTCTAGAAAA
AGATTATATGAAATGAATCTTGTTATATCTGATACTGCAGAATATGGAAGTCATTTATTTTCTGAAAGAGCAATTTCAAT
TTTAAATAAATTTTTAAAATCTATTAATAGTGATGATTTAGGTGAAACAATTCGAGATACAAATATTACTAATTCAGAAT
TATTATATGTAAATGATATGATAGAAAATCATCATATTGAAAGAATTGGAAAAAAATTGCGTTTATATATGACTAATATG
AAACGTACAGCATTGCATGATTGTAAAAACTAA

Upstream 100 bases:

>100_bases
CAACTAGTGCAGATAAGGGTGCAGTAAGAAATATACATAAAATAAATTTTTAATATTTTAAATATATAAATTTTTCTACA
TTATCAAAAGGACAAATTAT

Downstream 100 bases:

>100_bases
TTACATATAATTATTTATATTATTTTTAATAAAAATTAATTTTATTATAAATTTTTTTTATTTTTTATGTTTTTTATATT
TTAATTTTAAAAAATTATTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MKNFFNKLSFREKLIELNTGFLMNSNEFLHSKKKLKNKKIVIIGCGAQGLNQGLNLRDSGFNVTYALRKKSIENKSISWK
NAIREKFFVDTYENLVPSADLVINLTPDKQHSVVVKKLQKLMKKNSVLGYSHGFNIVEIGEEIRSDITVIMVAPKCPGTE
VRKEFLKGFGVPTLIAVHKKNDPKKIGLDIAKAWATGLGSHKAGILKSSFIAEVKSDLMGEQTILCGMLQACSLVCFNHL
IEKGYSSDFSATLLQFGWEKLAECMKEGGITLLFNRLSISSKIRAYKLSIVLKSLLRPLFCLHMDNIISGDFSKNMIADW
NNSDIQLYNWRKKLKKSHFENSNLYSNRKILDHEYFEKCTLMAAMLKDLKLCINTGITSASAYYESLHELPLIANTISRK
RLYEMNLVISDTAEYGSHLFSERAISILNKFLKSINSDDLGETIRDTNITNSELLYVNDMIENHHIERIGKKLRLYMTNM
KRTALHDCKN

Sequences:

>Translated_490_residues
MKNFFNKLSFREKLIELNTGFLMNSNEFLHSKKKLKNKKIVIIGCGAQGLNQGLNLRDSGFNVTYALRKKSIENKSISWK
NAIREKFFVDTYENLVPSADLVINLTPDKQHSVVVKKLQKLMKKNSVLGYSHGFNIVEIGEEIRSDITVIMVAPKCPGTE
VRKEFLKGFGVPTLIAVHKKNDPKKIGLDIAKAWATGLGSHKAGILKSSFIAEVKSDLMGEQTILCGMLQACSLVCFNHL
IEKGYSSDFSATLLQFGWEKLAECMKEGGITLLFNRLSISSKIRAYKLSIVLKSLLRPLFCLHMDNIISGDFSKNMIADW
NNSDIQLYNWRKKLKKSHFENSNLYSNRKILDHEYFEKCTLMAAMLKDLKLCINTGITSASAYYESLHELPLIANTISRK
RLYEMNLVISDTAEYGSHLFSERAISILNKFLKSINSDDLGETIRDTNITNSELLYVNDMIENHHIERIGKKLRLYMTNM
KRTALHDCKN
>Mature_490_residues
MKNFFNKLSFREKLIELNTGFLMNSNEFLHSKKKLKNKKIVIIGCGAQGLNQGLNLRDSGFNVTYALRKKSIENKSISWK
NAIREKFFVDTYENLVPSADLVINLTPDKQHSVVVKKLQKLMKKNSVLGYSHGFNIVEIGEEIRSDITVIMVAPKCPGTE
VRKEFLKGFGVPTLIAVHKKNDPKKIGLDIAKAWATGLGSHKAGILKSSFIAEVKSDLMGEQTILCGMLQACSLVCFNHL
IEKGYSSDFSATLLQFGWEKLAECMKEGGITLLFNRLSISSKIRAYKLSIVLKSLLRPLFCLHMDNIISGDFSKNMIADW
NNSDIQLYNWRKKLKKSHFENSNLYSNRKILDHEYFEKCTLMAAMLKDLKLCINTGITSASAYYESLHELPLIANTISRK
RLYEMNLVISDTAEYGSHLFSERAISILNKFLKSINSDDLGETIRDTNITNSELLYVNDMIENHHIERIGKKLRLYMTNM
KRTALHDCKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=490, Percent_Identity=57.7551020408163, Blast_Score=593, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6323387, Length=275, Percent_Identity=31.6363636363636, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 55733; Mature: 55733

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFFNKLSFREKLIELNTGFLMNSNEFLHSKKKLKNKKIVIIGCGAQGLNQGLNLRDSG
CCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCC
FNVTYALRKKSIENKSISWKNAIREKFFVDTYENLVPSADLVINLTPDKQHSVVVKKLQK
CCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKKNSVLGYSHGFNIVEIGEEIRSDITVIMVAPKCPGTEVRKEFLKGFGVPTLIAVHKK
HHHHCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECC
NDPKKIGLDIAKAWATGLGSHKAGILKSSFIAEVKSDLMGEQTILCGMLQACSLVCFNHL
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IEKGYSSDFSATLLQFGWEKLAECMKEGGITLLFNRLSISSKIRAYKLSIVLKSLLRPLF
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
CLHMDNIISGDFSKNMIADWNNSDIQLYNWRKKLKKSHFENSNLYSNRKILDHEYFEKCT
HHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LMAAMLKDLKLCINTGITSASAYYESLHELPLIANTISRKRLYEMNLVISDTAEYGSHLF
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECHHHHHHHHH
SERAISILNKFLKSINSDDLGETIRDTNITNSELLYVNDMIENHHIERIGKKLRLYMTNM
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
KRTALHDCKN
HHHHHHHCCC
>Mature Secondary Structure
MKNFFNKLSFREKLIELNTGFLMNSNEFLHSKKKLKNKKIVIIGCGAQGLNQGLNLRDSG
CCHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCC
FNVTYALRKKSIENKSISWKNAIREKFFVDTYENLVPSADLVINLTPDKQHSVVVKKLQK
CCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKKNSVLGYSHGFNIVEIGEEIRSDITVIMVAPKCPGTEVRKEFLKGFGVPTLIAVHKK
HHHHCCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECC
NDPKKIGLDIAKAWATGLGSHKAGILKSSFIAEVKSDLMGEQTILCGMLQACSLVCFNHL
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IEKGYSSDFSATLLQFGWEKLAECMKEGGITLLFNRLSISSKIRAYKLSIVLKSLLRPLF
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
CLHMDNIISGDFSKNMIADWNNSDIQLYNWRKKLKKSHFENSNLYSNRKILDHEYFEKCT
HHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LMAAMLKDLKLCINTGITSASAYYESLHELPLIANTISRKRLYEMNLVISDTAEYGSHLF
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECHHHHHHHHH
SERAISILNKFLKSINSDDLGETIRDTNITNSELLYVNDMIENHHIERIGKKLRLYMTNM
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
KRTALHDCKN
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10555290 [H]