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The map label for this gene is lysS

Identifier: 116328407

GI number: 116328407

Start: 2034917

End: 2036404

Strand: Direct

Name: lysS

Synonym: LBL_1747

Alternate gene names: 116328407

Gene position: 2034917-2036404 (Clockwise)

Preceding gene: 116328406

Following gene: 116328411

Centisome position: 56.3

GC content: 42.54

Gene sequence:

>1488_bases
ATGTTAGACTCAAACGAACTCATCCAACAAAGAATTCAAAAGATCGAAGACTTAAAAAACCAGGGAATCAATCCGTACCC
GGTTCGTTTTTTTCCGGACTCAAAATCGAAAGACATCGTTGAGAAGTTCGAAAAAGATCCTACCGGACCGGAAACCAAAT
TCAAATTAGGCGGAAGATTACATTCTAAAAGAGTGATGGGAAAAGCGAGTTTCGCCCATCTCAAAGACAGCACAGGAATC
ATTCAACTTTATGCAACCCGCGACGATTTAGGGGAAATTTCCTACTCAATTTTTAAATCTCTCGACCTGGGAGATATCAT
CGGACTGGAAGGTTATCTTTTTAAAACCCAAAAAGGAGAAGTCACATTACACGTCACATCTGTGGAACTTCTCGCCAAAT
GTATTCGCCCTCTTCCCGTGGTAAAAGAGAAAGACGGAGTAATATACGACGCATTTGCCGACGTAGAACAGAGATATAGA
ATGCGGTACGTGGATCTTGTGGTAAACGATCATGTCAGAGATACGTTCATCACGAGAAGCCGGATCGTTTCTGAAATCAG
AAATTTCCTCACCAACGAAGGTTTTTTAGAGGTGGAAACTCCGATGATGCAACCGATCGCAGGAGGTGCTGCGGCAAGAC
CTTTCGTAACCCATCATAACACACTGGACATGCAGTTGTTTTTAAGAATCGCTCCCGAACTTTATCTTAAACGTTTGATC
GTGGGAGGTATGGATCGAGTTTTCGAACTCAATCGAAATTTTAGAAACGAAGGAATCTCGACAAAACATAACCCTGAATT
TACGATGATGGAAGCATACATCGCATTCGCGGACATGAATACGATGCTTGACCTTACCGAAAGACTTATCACACACTTAG
CGCAAAAAATCCACGGAGCATTAAAAATTCAATACGGCAAAGATCTGATCGATCTTTCTCCTCCTTGGAGAAAAATAACT
TATACGGATATCATCAAAGAATATAGCGGAATCGATTTCAGTCTGATCACTTCTTTGGAAGAAGCGAAGAAAAAAGCCTC
CGAATTGAATGTGGACGTTTCCAAATGTAATACAATCTGGAAAGTGGCGGATGAGGTCTTTTCCGAAAAAGCGGAACCGA
ATCTAATCCAGCCCGTTTTTATCATCGATTATCCGAAAGAACTCTCTCCTCTCGCAAAATCCAATCCGGATAAGCCGGGT
TATGTGGAACGATTTGAACCTTACGTAGCCGGAAGGGAAATCGGAAACGCATTCACGGAGTTAAACGATCCTTTCGATCA
GAAAGAAAGATTCGAAGATCAGGTTCAACAAAGAGAAGCTGGAGACGATGAGGCATTTATGATGGATGAGGATTATATCC
GCGCGCTGGAATACGGAATGCCTCCTACGGGAGGACTCGGAATCGGAATAGACCGTTTGGTAATGCTTTTGACCGATTCC
CATTCTATTCGGGATACCATTCTGTTTCCATTGATGAGACCGGAATAA

Upstream 100 bases:

>100_bases
GACTTGGAAATTGGTTCTTAAGCGAAGAAGGATTCGAAATTGTCTTTTTAAATATAGCCAGAATGTTTTATCAAATACTC
TTAGGAAAATAAAATCTAAA

Downstream 100 bases:

>100_bases
CTCCGGTCACGAAAAAACTGTCCGTTTGAATCATCAAGATTTCGTAGCTCATTCTAAGATGCGCGAAACCGGATCAGGAA
ATTTGCAACCGATTCACTCC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLDSNELIQQRIQKIEDLKNQGINPYPVRFFPDSKSKDIVEKFEKDPTGPETKFKLGGRLHSKRVMGKASFAHLKDSTGI
IQLYATRDDLGEISYSIFKSLDLGDIIGLEGYLFKTQKGEVTLHVTSVELLAKCIRPLPVVKEKDGVIYDAFADVEQRYR
MRYVDLVVNDHVRDTFITRSRIVSEIRNFLTNEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYIAFADMNTMLDLTERLITHLAQKIHGALKIQYGKDLIDLSPPWRKIT
YTDIIKEYSGIDFSLITSLEEAKKKASELNVDVSKCNTIWKVADEVFSEKAEPNLIQPVFIIDYPKELSPLAKSNPDKPG
YVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVQQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTDS
HSIRDTILFPLMRPE

Sequences:

>Translated_495_residues
MLDSNELIQQRIQKIEDLKNQGINPYPVRFFPDSKSKDIVEKFEKDPTGPETKFKLGGRLHSKRVMGKASFAHLKDSTGI
IQLYATRDDLGEISYSIFKSLDLGDIIGLEGYLFKTQKGEVTLHVTSVELLAKCIRPLPVVKEKDGVIYDAFADVEQRYR
MRYVDLVVNDHVRDTFITRSRIVSEIRNFLTNEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYIAFADMNTMLDLTERLITHLAQKIHGALKIQYGKDLIDLSPPWRKIT
YTDIIKEYSGIDFSLITSLEEAKKKASELNVDVSKCNTIWKVADEVFSEKAEPNLIQPVFIIDYPKELSPLAKSNPDKPG
YVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVQQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTDS
HSIRDTILFPLMRPE
>Mature_495_residues
MLDSNELIQQRIQKIEDLKNQGINPYPVRFFPDSKSKDIVEKFEKDPTGPETKFKLGGRLHSKRVMGKASFAHLKDSTGI
IQLYATRDDLGEISYSIFKSLDLGDIIGLEGYLFKTQKGEVTLHVTSVELLAKCIRPLPVVKEKDGVIYDAFADVEQRYR
MRYVDLVVNDHVRDTFITRSRIVSEIRNFLTNEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYIAFADMNTMLDLTERLITHLAQKIHGALKIQYGKDLIDLSPPWRKIT
YTDIIKEYSGIDFSLITSLEEAKKKASELNVDVSKCNTIWKVADEVFSEKAEPNLIQPVFIIDYPKELSPLAKSNPDKPG
YVERFEPYVAGREIGNAFTELNDPFDQKERFEDQVQQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTDS
HSIRDTILFPLMRPE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=513, Percent_Identity=41.9103313840156, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI194272210, Length=513, Percent_Identity=41.9103313840156, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI45439306, Length=459, Percent_Identity=23.3115468409586, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI226491502, Length=460, Percent_Identity=23.4782608695652, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI40789249, Length=289, Percent_Identity=24.2214532871972, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790571, Length=500, Percent_Identity=51.2, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1789256, Length=500, Percent_Identity=51, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI87082379, Length=330, Percent_Identity=32.1212121212121, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788173, Length=290, Percent_Identity=23.7931034482759, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535925, Length=513, Percent_Identity=42.1052631578947, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535927, Length=513, Percent_Identity=42.1052631578947, Blast_Score=393, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71994340, Length=505, Percent_Identity=42.3762376237624, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI32566633, Length=292, Percent_Identity=25.6849315068493, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=521, Percent_Identity=42.9942418426104, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6324256, Length=502, Percent_Identity=31.0756972111554, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6323011, Length=469, Percent_Identity=24.5202558635394, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325153, Length=249, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24640849, Length=515, Percent_Identity=41.5533980582524, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24640851, Length=515, Percent_Identity=41.5533980582524, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24584738, Length=271, Percent_Identity=26.9372693726937, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136276, Length=457, Percent_Identity=21.4442013129103, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_LEPBJ (Q04SM4)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800854.1
- ProteinModelPortal:   Q04SM4
- SMR:   Q04SM4
- STRING:   Q04SM4
- GeneID:   4411737
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1523
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- PhylomeDB:   Q04SM4
- ProtClustDB:   PRK00484
- BioCyc:   LBOR355277:LBJ_1523-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 56622; Mature: 56622

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSNELIQQRIQKIEDLKNQGINPYPVRFFPDSKSKDIVEKFEKDPTGPETKFKLGGRL
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCEEEECCCH
HSKRVMGKASFAHLKDSTGIIQLYATRDDLGEISYSIFKSLDLGDIIGLEGYLFKTQKGE
HHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEECCCCEEEEECCCC
VTLHVTSVELLAKCIRPLPVVKEKDGVIYDAFADVEQRYRMRYVDLVVNDHVRDTFITRS
EEEEEEHHHHHHHHHCCCCCEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RIVSEIRNFLTNEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
HHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYIAFADMNTMLDLTERLITHLAQKIHGA
HCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKIQYGKDLIDLSPPWRKITYTDIIKEYSGIDFSLITSLEEAKKKASELNVDVSKCNTIW
EEEEECCCEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KVADEVFSEKAEPNLIQPVFIIDYPKELSPLAKSNPDKPGYVERFEPYVAGREIGNAFTE
HHHHHHHHCCCCCCCCCEEEEEECCHHHCHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHH
LNDPFDQKERFEDQVQQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTDS
CCCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
HSIRDTILFPLMRPE
CCHHHHHCCCCCCCC
>Mature Secondary Structure
MLDSNELIQQRIQKIEDLKNQGINPYPVRFFPDSKSKDIVEKFEKDPTGPETKFKLGGRL
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCEEEECCCH
HSKRVMGKASFAHLKDSTGIIQLYATRDDLGEISYSIFKSLDLGDIIGLEGYLFKTQKGE
HHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEECCCCEEEEECCCC
VTLHVTSVELLAKCIRPLPVVKEKDGVIYDAFADVEQRYRMRYVDLVVNDHVRDTFITRS
EEEEEEHHHHHHHHHCCCCCEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RIVSEIRNFLTNEGFLEVETPMMQPIAGGAAARPFVTHHNTLDMQLFLRIAPELYLKRLI
HHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHH
VGGMDRVFELNRNFRNEGISTKHNPEFTMMEAYIAFADMNTMLDLTERLITHLAQKIHGA
HCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKIQYGKDLIDLSPPWRKITYTDIIKEYSGIDFSLITSLEEAKKKASELNVDVSKCNTIW
EEEEECCCEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KVADEVFSEKAEPNLIQPVFIIDYPKELSPLAKSNPDKPGYVERFEPYVAGREIGNAFTE
HHHHHHHHCCCCCCCCCEEEEEECCHHHCHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHH
LNDPFDQKERFEDQVQQREAGDDEAFMMDEDYIRALEYGMPPTGGLGIGIDRLVMLLTDS
CCCCHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCC
HSIRDTILFPLMRPE
CCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA