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The map label for this gene is serA [H]

Identifier: 116327921

GI number: 116327921

Start: 1422293

End: 1423291

Strand: Direct

Name: serA [H]

Synonym: LBL_1207

Alternate gene names: 116327921

Gene position: 1422293-1423291 (Clockwise)

Preceding gene: 116327920

Following gene: 116327922

Centisome position: 39.35

GC content: 36.44

Gene sequence:

>999_bases
ATGAAATCAAAAAAAATATTTATTTCTACATACCCATTCGGTTTTTATAATTCTGAACCTTTGGAAATTCTCCAGGAAAC
CGGCTGGGAAATTTTTACCAATCCTTTAAAACGGAAGTTGACTCCTATTGAAGTTTCTGAGTTTGCAAAAGATGTGGATG
GTATCATCGCAGGGACAGAAGATTTGACTCCTTTGATTTATAAGAACGAAAATTTAAAGATTATTTCTCGAGTTGGAATT
GGTTTGGATTCTGTTCCATTAAAGTTATGCAGAGAGCGAGGAATTGCAGTCGCTTACACTCCAGATGCGGTCACTATGGC
GGTCGTAGAATTGACGATTGGCTTAATGGTTTCCCTCACAAGAAAAGTCCTTTCGGCACATCAGGAATTGAAAGTTGGAG
GGTGGTCTAGATTTACTGGAAAACGATTGGGCGAGTCTACGATTGGAATTATTGGCGCTGGCAGAGTCGGACTGAACGTA
ATTCGTATCTTATCAGAATTCAAGCCTAAAATAATTTTGATCAATGACCTGAAAGCAAAAGAAAAAGAAATTTTAGAAAT
GTTAAAAGGTAAAAACGTTAATTTTAAACTCGTCAATAAAGAAGAGATCTACGCGACTTCTGATATTGTTTCTTTGCATG
TTCCTTTGACAAATAAAACTAGAAATCTGATTGGAGAAAAAGAATTCAGCACCTTTTCTAAAGATACTTTTTTGATCAAC
ACTGCTAGAGGGGGGATTGTCAACGAAAGTGATCTATACAATGCATTAAAGTTTAATCGGATTGCAGGGGCTGCAATTGA
CGTTTTTGAACAGGAGCCATATAAGGGAAATTTAATTGAGTTAGATAATATTATACTTACGGAACATATGGGATCTTGTT
CGTATGATTGTAGGCTTTTAATGGAAAAAGGTTCAGCGGAAGAGGTGGTTCGTTTTTTTCAAGGTCAGAGTCTACTTAAT
CCGGTGCCAGAAGAAGAATATCAGAATCAAATTGTCTAA

Upstream 100 bases:

>100_bases
TTAAAAAATACCAATTAAGTTCACACATTTGGGTTTTTGCTAAAAAATAATTTTAATTTATTCTAAAACATTATTAAGTT
TTAATTTTATTAGATCGTTT

Downstream 100 bases:

>100_bases
CCGAGGCTCAAATCAAAATTCTATCTTAGTCTGGGATCATTCAAGGGATCTACCTGATTTTTCTGGTAGTATCTATCTTT
GGAGAGATTATTCAGAAGAT

Product: dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKSKKIFISTYPFGFYNSEPLEILQETGWEIFTNPLKRKLTPIEVSEFAKDVDGIIAGTEDLTPLIYKNENLKIISRVGI
GLDSVPLKLCRERGIAVAYTPDAVTMAVVELTIGLMVSLTRKVLSAHQELKVGGWSRFTGKRLGESTIGIIGAGRVGLNV
IRILSEFKPKIILINDLKAKEKEILEMLKGKNVNFKLVNKEEIYATSDIVSLHVPLTNKTRNLIGEKEFSTFSKDTFLIN
TARGGIVNESDLYNALKFNRIAGAAIDVFEQEPYKGNLIELDNIILTEHMGSCSYDCRLLMEKGSAEEVVRFFQGQSLLN
PVPEEEYQNQIV

Sequences:

>Translated_332_residues
MKSKKIFISTYPFGFYNSEPLEILQETGWEIFTNPLKRKLTPIEVSEFAKDVDGIIAGTEDLTPLIYKNENLKIISRVGI
GLDSVPLKLCRERGIAVAYTPDAVTMAVVELTIGLMVSLTRKVLSAHQELKVGGWSRFTGKRLGESTIGIIGAGRVGLNV
IRILSEFKPKIILINDLKAKEKEILEMLKGKNVNFKLVNKEEIYATSDIVSLHVPLTNKTRNLIGEKEFSTFSKDTFLIN
TARGGIVNESDLYNALKFNRIAGAAIDVFEQEPYKGNLIELDNIILTEHMGSCSYDCRLLMEKGSAEEVVRFFQGQSLLN
PVPEEEYQNQIV
>Mature_332_residues
MKSKKIFISTYPFGFYNSEPLEILQETGWEIFTNPLKRKLTPIEVSEFAKDVDGIIAGTEDLTPLIYKNENLKIISRVGI
GLDSVPLKLCRERGIAVAYTPDAVTMAVVELTIGLMVSLTRKVLSAHQELKVGGWSRFTGKRLGESTIGIIGAGRVGLNV
IRILSEFKPKIILINDLKAKEKEILEMLKGKNVNFKLVNKEEIYATSDIVSLHVPLTNKTRNLIGEKEFSTFSKDTFLIN
TARGGIVNESDLYNALKFNRIAGAAIDVFEQEPYKGNLIELDNIILTEHMGSCSYDCRLLMEKGSAEEVVRFFQGQSLLN
PVPEEEYQNQIV

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=30.4635761589404, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI6912396, Length=297, Percent_Identity=31.3131313131313, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=30.8270676691729, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=30.8270676691729, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580578, Length=278, Percent_Identity=32.0143884892086, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=278, Percent_Identity=32.0143884892086, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=31.5789473684211, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=26.4797507788162, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789279, Length=277, Percent_Identity=32.129963898917, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=28.5024154589372, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=32.6797385620915, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=238, Percent_Identity=30.672268907563, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=300, Percent_Identity=30, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=300, Percent_Identity=30, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=271, Percent_Identity=27.6752767527675, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=28.4644194756554, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=139, Percent_Identity=31.6546762589928, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551003, Length=289, Percent_Identity=31.8339100346021, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585514, Length=289, Percent_Identity=31.1418685121107, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574282, Length=289, Percent_Identity=31.1418685121107, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574284, Length=289, Percent_Identity=31.1418685121107, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552429, Length=289, Percent_Identity=31.1418685121107, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=29.4303797468354, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28571528, Length=294, Percent_Identity=30.6122448979592, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=27.2425249169435, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24585516, Length=258, Percent_Identity=27.906976744186, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646446, Length=276, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646448, Length=276, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646452, Length=276, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646450, Length=276, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=30.3249097472924, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37151; Mature: 37151

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKIFISTYPFGFYNSEPLEILQETGWEIFTNPLKRKLTPIEVSEFAKDVDGIIAGTE
CCCCEEEEEECCCCCCCCCHHHHHHHCCHHHHHCHHHHCCCCCCHHHHHHHHHHEEECCC
DLTPLIYKNENLKIISRVGIGLDSVPLKLCRERGIAVAYTPDAVTMAVVELTIGLMVSLT
CCCEEEEECCCEEEEEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
RKVLSAHQELKVGGWSRFTGKRLGESTIGIIGAGRVGLNVIRILSEFKPKIILINDLKAK
HHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHH
EKEILEMLKGKNVNFKLVNKEEIYATSDIVSLHVPLTNKTRNLIGEKEFSTFSKDTFLIN
HHHHHHHHCCCCCCEEEECHHHEEEECCEEEEEECCCCCHHHHCCCHHHCCCCCCEEEEE
TARGGIVNESDLYNALKFNRIAGAAIDVFEQEPYKGNLIELDNIILTEHMGSCSYDCRLL
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCEEEECCCCCCCCCEEEE
MEKGSAEEVVRFFQGQSLLNPVPEEEYQNQIV
ECCCCHHHHHHHHCCCHHCCCCCCHHHHCCCC
>Mature Secondary Structure
MKSKKIFISTYPFGFYNSEPLEILQETGWEIFTNPLKRKLTPIEVSEFAKDVDGIIAGTE
CCCCEEEEEECCCCCCCCCHHHHHHHCCHHHHHCHHHHCCCCCCHHHHHHHHHHEEECCC
DLTPLIYKNENLKIISRVGIGLDSVPLKLCRERGIAVAYTPDAVTMAVVELTIGLMVSLT
CCCEEEEECCCEEEEEEECCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
RKVLSAHQELKVGGWSRFTGKRLGESTIGIIGAGRVGLNVIRILSEFKPKIILINDLKAK
HHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHH
EKEILEMLKGKNVNFKLVNKEEIYATSDIVSLHVPLTNKTRNLIGEKEFSTFSKDTFLIN
HHHHHHHHCCCCCCEEEECHHHEEEECCEEEEEECCCCCHHHHCCCHHHCCCCCCEEEEE
TARGGIVNESDLYNALKFNRIAGAAIDVFEQEPYKGNLIELDNIILTEHMGSCSYDCRLL
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEECCEEEECCCCCCCCCEEEE
MEKGSAEEVVRFFQGQSLLNPVPEEEYQNQIV
ECCCCHHHHHHHHCCCHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]