Click here to switch to the map view.

The map label for this gene is ivd [H]

Identifier: 116327465

GI number: 116327465

Start: 762724

End: 763884

Strand: Direct

Name: ivd [H]

Synonym: LBL_0682

Alternate gene names: 116327465

Gene position: 762724-763884 (Clockwise)

Preceding gene: 116327458

Following gene: 116327466

Centisome position: 21.1

GC content: 46.51

Gene sequence:

>1161_bases
ATGAGAGCTGTGCTTGAAAAACCGAATGATTTATTCAACCCGACAGAGAACCATCTCGCGCTTCGGGAAACCATCGTAAA
ATTTGCAAAAGAGAATATGGATACCCAGGTGAAGGAGCACGACGACCGCGAAACCTTCAACCTTGCGTTATTTCGAAGAA
TCGGTTCCGAACTCGGACTTTTCGGAATAACCGTTCCGGAAGAAGACGGCGGGATGGGAATGGACGCGGTTGCTGCGGTT
ATCATTCACGAGGAAATGTCCGCATACGATCCGGGTTTTATGCTTTCGTATCTGGCGCACGAAGTATTATTCGTAAATAA
TTTTTATCATAGTTCCAGTCCGGCCCAAAGAGAGAAGTATCTTTCGAAAGTGATTTCGGGAGAATGGGTTGGTGGAATGG
GAATGACCGAACCCGGAGCGGGAACGGACGTTCTCGGTATGAGAACGATCACCGTAAAGAAGGGCGACAAATACGTGTTA
AACGGTTCCAAACAGTACATTACAAACGGAAATATAGGAAGTGTGTTTTTGGTGTATGCAAAAATGAGTAAGGATTCCAA
GAGGACCACTTCCTTCATCGTGGAAAGTTCCTTCCCCGGTTTTAGCGTAGGCAAGAAAGAAGAAAAAATGGGAATGCGTT
CCTCTCCTACCACTCAACTTATATTCGAAGATTGTGAAGTTCCTGCGGAGAATTTAGTCGGTCAGGAAGACGGGGCTCTC
GTTCACATGATGAGGAATTTGGAAATCGAAAGGGTTACCCTTGCCGCTCAATCTCTGGGAATCGCAAAACGTTGTGTGGA
CATCATGGCCGATTATACGATTCGTCATAGAGAGGCGTTCGGTAAAAAACTTTCGGAGTTTGGACAAATCCAAAGACTTC
TCGCGGAATCGTATGCGGATTATCAAGTTGCGAGTGGGATCAACCCGGACAGCCGGAATTCTCTTGGAGCCGCTTCCGCA
AAATTAGTCGCGACTCAAATGGCGGAAAGAGTGTCTCGAAACGCAATACAAGCGTTAGGCGGCTATGGATATTGCAGAGA
ATATCCCGTGGAAAGACTTCATAGGGATTCCATTCTTCTATCCATCGGAGGAGGGACGAACGAAGCGATGCAAAAGAACA
TCGTAGCCGACTTGAAAAAGATCTACGAAGGGGTTTCTTGA

Upstream 100 bases:

>100_bases
CAAAATCAGAGCGTAGATCATAAGATAGTTTTTGGAAAATAAAGATTCTCTGTCGAGCTGTTTTAGTCTTGGGGTAGAGG
ATATTAAGAAAGAGGGCAAT

Downstream 100 bases:

>100_bases
GTAGAAAGAACATACAGCTCACGGAAAAACTGGAAGAGTATATCTTGCGGAATTCCGTAAGGGAGCCGGACTCTTTTCGA
AGATTACGGGAAGAGAGACC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRAVLEKPNDLFNPTENHLALRETIVKFAKENMDTQVKEHDDRETFNLALFRRIGSELGLFGITVPEEDGGMGMDAVAAV
IIHEEMSAYDPGFMLSYLAHEVLFVNNFYHSSSPAQREKYLSKVISGEWVGGMGMTEPGAGTDVLGMRTITVKKGDKYVL
NGSKQYITNGNIGSVFLVYAKMSKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
VHMMRNLEIERVTLAAQSLGIAKRCVDIMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQVASGINPDSRNSLGAASA
KLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGVS

Sequences:

>Translated_386_residues
MRAVLEKPNDLFNPTENHLALRETIVKFAKENMDTQVKEHDDRETFNLALFRRIGSELGLFGITVPEEDGGMGMDAVAAV
IIHEEMSAYDPGFMLSYLAHEVLFVNNFYHSSSPAQREKYLSKVISGEWVGGMGMTEPGAGTDVLGMRTITVKKGDKYVL
NGSKQYITNGNIGSVFLVYAKMSKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
VHMMRNLEIERVTLAAQSLGIAKRCVDIMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQVASGINPDSRNSLGAASA
KLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGVS
>Mature_386_residues
MRAVLEKPNDLFNPTENHLALRETIVKFAKENMDTQVKEHDDRETFNLALFRRIGSELGLFGITVPEEDGGMGMDAVAAV
IIHEEMSAYDPGFMLSYLAHEVLFVNNFYHSSSPAQREKYLSKVISGEWVGGMGMTEPGAGTDVLGMRTITVKKGDKYVL
NGSKQYITNGNIGSVFLVYAKMSKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
VHMMRNLEIERVTLAAQSLGIAKRCVDIMADYTIRHREAFGKKLSEFGQIQRLLAESYADYQVASGINPDSRNSLGAASA
KLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILLSIGGGTNEAMQKNIVADLKKIYEGVS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=367, Percent_Identity=38.9645776566758, Blast_Score=253, Evalue=1e-67,
Organism=Homo sapiens, GI226958414, Length=331, Percent_Identity=39.5770392749245, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=33.245382585752, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=34.3915343915344, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=34.3915343915344, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI21361497, Length=339, Percent_Identity=35.3982300884956, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=28.9817232375979, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=30.6451612903226, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI76496475, Length=334, Percent_Identity=33.2335329341317, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4557235, Length=334, Percent_Identity=33.2335329341317, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI7656849, Length=368, Percent_Identity=29.3478260869565, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI7669494, Length=350, Percent_Identity=27.1428571428571, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4503943, Length=350, Percent_Identity=27.1428571428571, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI48976061, Length=285, Percent_Identity=25.9649122807018, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI211971008, Length=285, Percent_Identity=25.9649122807018, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081958, Length=332, Percent_Identity=31.6265060240964, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786223, Length=351, Percent_Identity=26.7806267806268, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=37.5647668393782, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=33.0687830687831, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=32.8947368421053, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=385, Percent_Identity=31.4285714285714, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=32.0855614973262, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=30.5039787798408, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71985184, Length=335, Percent_Identity=34.6268656716418, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=31.3672922252011, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=373, Percent_Identity=30.2949061662198, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=28.8770053475936, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71990804, Length=304, Percent_Identity=33.5526315789474, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=251, Percent_Identity=35.8565737051793, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=351, Percent_Identity=28.4900284900285, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=29.4545454545455, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=234, Percent_Identity=26.0683760683761, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=276, Percent_Identity=25, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355753, Length=390, Percent_Identity=38.2051282051282, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=34.2105263157895, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=32.987012987013, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=30.9090909090909, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=32.8042328042328, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI281363737, Length=384, Percent_Identity=32.2916666666667, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI19920834, Length=290, Percent_Identity=30.3448275862069, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42629; Mature: 42629

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVLEKPNDLFNPTENHLALRETIVKFAKENMDTQVKEHDDRETFNLALFRRIGSELGL
CCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCE
FGITVPEEDGGMGMDAVAAVIIHEEMSAYDPGFMLSYLAHEVLFVNNFYHSSSPAQREKY
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LSKVISGEWVGGMGMTEPGAGTDVLGMRTITVKKGDKYVLNGSKQYITNGNIGSVFLVYA
HHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEECCCEEEEECCCCCEEEEEEE
KMSKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
ECCCCCHHHHHEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHCCCCCCCHH
VHMMRNLEIERVTLAAQSLGIAKRCVDIMADYTIRHREAFGKKLSEFGQIQRLLAESYAD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YQVASGINPDSRNSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHCCCCEEE
SIGGGTNEAMQKNIVADLKKIYEGVS
EECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRAVLEKPNDLFNPTENHLALRETIVKFAKENMDTQVKEHDDRETFNLALFRRIGSELGL
CCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHCCE
FGITVPEEDGGMGMDAVAAVIIHEEMSAYDPGFMLSYLAHEVLFVNNFYHSSSPAQREKY
EEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LSKVISGEWVGGMGMTEPGAGTDVLGMRTITVKKGDKYVLNGSKQYITNGNIGSVFLVYA
HHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEECCCEEEEECCCCCEEEEEEE
KMSKDSKRTTSFIVESSFPGFSVGKKEEKMGMRSSPTTQLIFEDCEVPAENLVGQEDGAL
ECCCCCHHHHHEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHCCCCCCCHH
VHMMRNLEIERVTLAAQSLGIAKRCVDIMADYTIRHREAFGKKLSEFGQIQRLLAESYAD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YQVASGINPDSRNSLGAASAKLVATQMAERVSRNAIQALGGYGYCREYPVERLHRDSILL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHCCCCEEE
SIGGGTNEAMQKNIVADLKKIYEGVS
EECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]