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The map label for this gene is melR [H]

Identifier: 116248927

GI number: 116248927

Start: 268950

End: 269816

Strand: Direct

Name: melR [H]

Synonym: pRL120257

Alternate gene names: 116248927

Gene position: 268950-269816 (Clockwise)

Preceding gene: 116248917

Following gene: 116248930

Centisome position: 30.91

GC content: 55.71

Gene sequence:

>867_bases
ATGAAACATACCCAAAGCCGTGGCGAATGGATTGGATCCCGAGGGGCGTTTTTGGTCGAGCGTCACATCGCTGATGCGAT
GGCCGCACCGCATTGGCACGACCACGTTGAATTAAACCTGCTCATGGAAGGCCGGATGACCTACCTTTTTAATGGACGGC
AGGAGCAGGTGGAGGCCGGCCGTCTGGTTTTATTCTGGGCTGCAATTCCGCATCAGACGATTGCTGTTGCCGAAAACGCG
CCGCTCGTATGCCTCTATGTTCCCCTTGTCGATTTTCTGAGTCTGCCGGTGGACAGAAAGGCCAGGCAGTCGATCATGCA
GGGGAGGTTTCTGGCGCAGGGAAATCAGGAAACGATGGATGCGTTGACACTCCCACGATGGGAAAAGGAATGGCAATTCG
GCAGTGCGGCAAGACGGAAATTGGTCGTGGAGGAGGCACGACTGCGAATACGGCGTCTGATCCTGGACAATGCTGAAATC
GACAATTCGCCAACCCATGTCTCTCCGACATCGTTGGCTGGCCATGCAGTGCGCCACGTCGAGCTGTTGATCGACCTCAT
CAATTCCCGCTACGCAGATCCGATTAGCGTAGCCGATCTCGCAAAGCTTGCGGGCATGCATCCAAGCACCGCCAACAGCG
CTTTCCGAAAGATTTTGGGAATATCAGTCAACGAATACCTGACCCGACATCGGATTGCCCGGGCGATGCAGCTGCTGACG
GACACGGACGATCCGGTCCTCCAGATCGGTTTTGACTGCGGGTTTGGTTCCAGCAGTCGCTTCTACGAGATTTTCAAGGA
GCGAACGGGTACGACTCCCCGTCATTTCCGGGAAGCGGTGAACTCCAAGACCACTCCAGCGCAATGA

Upstream 100 bases:

>100_bases
TTGCAATCTCCCCATGGGTTGTGATTGCTTGTTGCTCCTTCTAGATCAGAATTTCCTCCTGGCATCGGCCTATTAATTCC
GGGATTCGAGTCTTCTGCAA

Downstream 100 bases:

>100_bases
TGAGATTCCAACAGACAAGGTCGTGAAGGCTCTGGGTGCTCACCTATTTCGGCGCATTACTTGAGCAGCTGCGTGCCGCT
TGCGCTTCGGCCTCACGCGG

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKHTQSRGEWIGSRGAFLVERHIADAMAAPHWHDHVELNLLMEGRMTYLFNGRQEQVEAGRLVLFWAAIPHQTIAVAENA
PLVCLYVPLVDFLSLPVDRKARQSIMQGRFLAQGNQETMDALTLPRWEKEWQFGSAARRKLVVEEARLRIRRLILDNAEI
DNSPTHVSPTSLAGHAVRHVELLIDLINSRYADPISVADLAKLAGMHPSTANSAFRKILGISVNEYLTRHRIARAMQLLT
DTDDPVLQIGFDCGFGSSSRFYEIFKERTGTTPRHFREAVNSKTTPAQ

Sequences:

>Translated_288_residues
MKHTQSRGEWIGSRGAFLVERHIADAMAAPHWHDHVELNLLMEGRMTYLFNGRQEQVEAGRLVLFWAAIPHQTIAVAENA
PLVCLYVPLVDFLSLPVDRKARQSIMQGRFLAQGNQETMDALTLPRWEKEWQFGSAARRKLVVEEARLRIRRLILDNAEI
DNSPTHVSPTSLAGHAVRHVELLIDLINSRYADPISVADLAKLAGMHPSTANSAFRKILGISVNEYLTRHRIARAMQLLT
DTDDPVLQIGFDCGFGSSSRFYEIFKERTGTTPRHFREAVNSKTTPAQ
>Mature_288_residues
MKHTQSRGEWIGSRGAFLVERHIADAMAAPHWHDHVELNLLMEGRMTYLFNGRQEQVEAGRLVLFWAAIPHQTIAVAENA
PLVCLYVPLVDFLSLPVDRKARQSIMQGRFLAQGNQETMDALTLPRWEKEWQFGSAARRKLVVEEARLRIRRLILDNAEI
DNSPTHVSPTSLAGHAVRHVELLIDLINSRYADPISVADLAKLAGMHPSTANSAFRKILGISVNEYLTRHRIARAMQLLT
DTDDPVLQIGFDCGFGSSSRFYEIFKERTGTTPRHFREAVNSKTTPAQ

Specific function: Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790559, Length=254, Percent_Identity=27.5590551181102, Blast_Score=140, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008917
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 32529; Mature: 32529

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTQSRGEWIGSRGAFLVERHIADAMAAPHWHDHVELNLLMEGRMTYLFNGRQEQVEAG
CCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEECCCHHHHCCC
RLVLFWAAIPHQTIAVAENAPLVCLYVPLVDFLSLPVDRKARQSIMQGRFLAQGNQETMD
CEEEEEEECCCCEEEEECCCCEEEEHHHHHHHHCCCCCHHHHHHHHHCHHHCCCCHHHHH
ALTLPRWEKEWQFGSAARRKLVVEEARLRIRRLILDNAEIDNSPTHVSPTSLAGHAVRHV
HHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ELLIDLINSRYADPISVADLAKLAGMHPSTANSAFRKILGISVNEYLTRHRIARAMQLLT
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DTDDPVLQIGFDCGFGSSSRFYEIFKERTGTTPRHFREAVNSKTTPAQ
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKHTQSRGEWIGSRGAFLVERHIADAMAAPHWHDHVELNLLMEGRMTYLFNGRQEQVEAG
CCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEECCCHHHHCCC
RLVLFWAAIPHQTIAVAENAPLVCLYVPLVDFLSLPVDRKARQSIMQGRFLAQGNQETMD
CEEEEEEECCCCEEEEECCCCEEEEHHHHHHHHCCCCCHHHHHHHHHCHHHCCCCHHHHH
ALTLPRWEKEWQFGSAARRKLVVEEARLRIRRLILDNAEIDNSPTHVSPTSLAGHAVRHV
HHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ELLIDLINSRYADPISVADLAKLAGMHPSTANSAFRKILGISVNEYLTRHRIARAMQLLT
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DTDDPVLQIGFDCGFGSSSRFYEIFKERTGTTPRHFREAVNSKTTPAQ
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]