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The map label for this gene is iorA [H]

Identifier: 114800410

GI number: 114800410

Start: 2296179

End: 2296637

Strand: Direct

Name: iorA [H]

Synonym: HNE_2200

Alternate gene names: 114800410

Gene position: 2296179-2296637 (Clockwise)

Preceding gene: 114798483

Following gene: 114797647

Centisome position: 61.97

GC content: 59.69

Gene sequence:

>459_bases
ATGCCCTATTCCCTGTCGGTCAATGGCCAGGTCCATCTCGTCGAGGATGAGGCTCAGACGCCCCTTCTTTGGGTGCTGCG
CGATACATTAAAGATGACCGGCACAAAATACGGCTGCGGCGTCGGCCAGTGTGGCGCATGTACAGTACATGTTGACGGAC
AGCCGACGCGGTCGTGTTCCCTGCCGCTGATCGCCGTGGCCGAGTCAGAGATTACCACGATCGAAGGCATGTCCGGGGCG
GAAACCAGAGCGGTTCAGGATGCATGGGTCAGACATGACGTCCCCCAATGCGGCTTCTGCCAGTCAGGTCAAATCATGAG
CGCGGTTGCACTGCTGCGTGCGAACCCGGCCCCGGACGATCGCGATATCGATACATCGATGAGCGGCAATATCTGCCGGT
GCGGTACATATAATCGCATTCGCGCAGCCATCCGCGATGCGGCGCAGTCCCTGCCTTAG

Upstream 100 bases:

>100_bases
CCGCCCCGCAGGATCAGGCAGATTCTTTGGAGGATCGTGCCTTCGCGCCCGAACCGCTGATCAGTACACTGAGGCATAGA
TATTTTCCGGGACACCCTCC

Downstream 100 bases:

>100_bases
GTATTCGTTTGTTATGGCCTGGCTCTCGCTCCCTGCTTTTGGACGCCGCGTCCGGTCTCACTGGCGCGCCCTCCTGACGT
GTATCGTCTTCGTCTCGATC

Product: putative isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MPYSLSVNGQVHLVEDEAQTPLLWVLRDTLKMTGTKYGCGVGQCGACTVHVDGQPTRSCSLPLIAVAESEITTIEGMSGA
ETRAVQDAWVRHDVPQCGFCQSGQIMSAVALLRANPAPDDRDIDTSMSGNICRCGTYNRIRAAIRDAAQSLP

Sequences:

>Translated_152_residues
MPYSLSVNGQVHLVEDEAQTPLLWVLRDTLKMTGTKYGCGVGQCGACTVHVDGQPTRSCSLPLIAVAESEITTIEGMSGA
ETRAVQDAWVRHDVPQCGFCQSGQIMSAVALLRANPAPDDRDIDTSMSGNICRCGTYNRIRAAIRDAAQSLP
>Mature_151_residues
PYSLSVNGQVHLVEDEAQTPLLWVLRDTLKMTGTKYGCGVGQCGACTVHVDGQPTRSCSLPLIAVAESEITTIEGMSGAE
TRAVQDAWVRHDVPQCGFCQSGQIMSAVALLRANPAPDDRDIDTSMSGNICRCGTYNRIRAAIRDAAQSLP

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=157, Percent_Identity=36.9426751592357, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI71773480, Length=100, Percent_Identity=33, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786480, Length=164, Percent_Identity=43.2926829268293, Blast_Score=125, Evalue=1e-30,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=38.6666666666667, Blast_Score=84, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=151, Percent_Identity=41.0596026490066, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=35.0649350649351, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566215, Length=159, Percent_Identity=34.5911949685535, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737937, Length=149, Percent_Identity=37.5838926174497, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647201, Length=158, Percent_Identity=32.2784810126582, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24647199, Length=158, Percent_Identity=32.2784810126582, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647193, Length=160, Percent_Identity=29.375, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16268; Mature: 16136

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYSLSVNGQVHLVEDEAQTPLLWVLRDTLKMTGTKYGCGVGQCGACTVHVDGQPTRSCS
CCEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCC
LPLIAVAESEITTIEGMSGAETRAVQDAWVRHDVPQCGFCQSGQIMSAVALLRANPAPDD
CCEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
RDIDTSMSGNICRCGTYNRIRAAIRDAAQSLP
CCCCCCCCCCEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PYSLSVNGQVHLVEDEAQTPLLWVLRDTLKMTGTKYGCGVGQCGACTVHVDGQPTRSCS
CEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCC
LPLIAVAESEITTIEGMSGAETRAVQDAWVRHDVPQCGFCQSGQIMSAVALLRANPAPDD
CCEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
RDIDTSMSGNICRCGTYNRIRAAIRDAAQSLP
CCCCCCCCCCEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]