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The map label for this gene is serA [H]

Identifier: 114800302

GI number: 114800302

Start: 3305657

End: 3307252

Strand: Reverse

Name: serA [H]

Synonym: HNE_3126

Alternate gene names: 114800302

Gene position: 3307252-3305657 (Counterclockwise)

Preceding gene: 114798225

Following gene: 114800229

Centisome position: 89.26

GC content: 61.09

Gene sequence:

>1596_bases
ATGCCTAAAGTCCTTATCGGAGATACGCTCTCCCCCGCCGCCGTCGAGATTTTCAAGGCGCGCGGTATCGAAACCGACAT
CAAGGTCGGTCTGTCCAAGGAAGATCTGATCAAGATCATTCCGGACTATGACGGCCTCGCTGTGCGCTCGGCCTGCAAGC
CGGACGCAGACGTCATCGCCGCTGCGACCAACCTGAAAGTCATCGGCCGGGCCGGTATCGGCGTCGACAATATCGACATC
AAAGCGGCAACCGCCAAGGGTGTCGTGGTCATGAACACGCCGTTCGGAAACGCCATCACCACGGCAGAACACGCCATCGC
CATGTTGTTTGCCGCCGCCCGCCAGATCCCCGCCGCCAATGCGGATACGCAGGCGGGCAAATGGCCCAAATCCGGCTATA
TGGGCGTCGAGCTTTCCTACAAGACGCTCGGCCTCATCGGTTGCGGCAATATCGGCAGCCGCGTGGCCGAGCGCGCCATC
GGCCTCAAGATGAAGGTTGTGGCCTATGACCCCTTCCTGACCGAGGAGCGCGCCATTGAGTTGGGCGTTGAAAAGGTTGA
TCTCGACACGCTTCTGGCCCGCGCGGACTTCATCACACTGCACGTTCCGCTTACGGATCAGACCAAGAATGTCCTCTCTC
GCGAAGCGCTGGAGAAAACCAAGAAGGGCCTCATCCTCGTCAACTGCGCGCGGGGCGGCCTTGTCGATGAAGAAGCCGTG
CGCGATCTGCTCGAAAGTGGCCATCTGGCCGGCGCGGCGTTTGACGTGTTTGCTGTCGAGCCCGCGAAAGAAAACGTCCT
GTTCGGCGCGAAGAATTTCGTTGCCACCCCCCACCTTGGCGCGGCAACCGCCGAGGCGCAGGAAAATGTCGCCTTGCAGG
TGGCCGAGCAGATGGCGGACTATATCCTCACCGGCGCGGTCACCAACGCCCTCAACATGCCGTCTGTCACCGCCGAGGAA
GCTCCGCGCCTGAAACCCTTTGCGACACTCGCTGAGAAACTCGGCAGCTTTGCGGGCCAGATCTCCGACTATGGCTATGA
AGAAGTCGTCATCGAATATGAAGGCGAAGTTTCGGAGCTCAACCGCAAGCCGATCACGGCAGCGCTTCTGGCTGGCCTCC
TGCGCGCCTCGCGCGGTGACGTGAATATGGTATCGGCGCCTGCCATCTTGGCCGATAGCGGCGTGAAACTGACCGAGACC
AAAACTGAGACCAGCCCCGTCTATGACAGCCTGATCCGCATCAAGGTGAAGACCAAGGCGACGAAGAATTCGCCCGAAGG
CGGCTGGCGCACCCTTGCCGGGGCTCTCATTGCCGGCAAGCCGCGGATCGTTGAAGTGAAGGGCATGGCGCTGGAAGGCG
ATTTCTCGCCGGTGACGCTCTATGTGAATAACATCGACAAGCCGGGCTTCATCGGCGCGCTTGGCCAGATGCTGGGCGAG
GCAAAGGTCAACATTGCGACCTTCCACCTTGGCCGCCAGGAAGCCGGCGGAGAGGCGATTGCACTGATCGGGATCGACTC
GACCCCGCCCGCCTCGCTCGTCGAGAAGCTCGATGCGCTGCCGCAGGTGCGCTACGTCAAGGTGTTGTCTTTCTGA

Upstream 100 bases:

>100_bases
GAATCCCTGGGGTTTGAACTTCTCGGGCCGCGCCGTTTCGGCCCTGATGCTTCCCTTGTCTATCAACTCACACGCGCCGC
CTGGCGCTCTGGAGCCACCC

Downstream 100 bases:

>100_bases
CCGCTCAGGGAAGGGGGCCGGGCAAACCTGTCTGGCCTCCCTTGACTATCCGAGGCGACTGGCGCGAAGATTCGCAATCG
TAATAGTTGTGAAAGTCTGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MPKVLIGDTLSPAAVEIFKARGIETDIKVGLSKEDLIKIIPDYDGLAVRSACKPDADVIAAATNLKVIGRAGIGVDNIDI
KAATAKGVVVMNTPFGNAITTAEHAIAMLFAAARQIPAANADTQAGKWPKSGYMGVELSYKTLGLIGCGNIGSRVAERAI
GLKMKVVAYDPFLTEERAIELGVEKVDLDTLLARADFITLHVPLTDQTKNVLSREALEKTKKGLILVNCARGGLVDEEAV
RDLLESGHLAGAAFDVFAVEPAKENVLFGAKNFVATPHLGAATAEAQENVALQVAEQMADYILTGAVTNALNMPSVTAEE
APRLKPFATLAEKLGSFAGQISDYGYEEVVIEYEGEVSELNRKPITAALLAGLLRASRGDVNMVSAPAILADSGVKLTET
KTETSPVYDSLIRIKVKTKATKNSPEGGWRTLAGALIAGKPRIVEVKGMALEGDFSPVTLYVNNIDKPGFIGALGQMLGE
AKVNIATFHLGRQEAGGEAIALIGIDSTPPASLVEKLDALPQVRYVKVLSF

Sequences:

>Translated_531_residues
MPKVLIGDTLSPAAVEIFKARGIETDIKVGLSKEDLIKIIPDYDGLAVRSACKPDADVIAAATNLKVIGRAGIGVDNIDI
KAATAKGVVVMNTPFGNAITTAEHAIAMLFAAARQIPAANADTQAGKWPKSGYMGVELSYKTLGLIGCGNIGSRVAERAI
GLKMKVVAYDPFLTEERAIELGVEKVDLDTLLARADFITLHVPLTDQTKNVLSREALEKTKKGLILVNCARGGLVDEEAV
RDLLESGHLAGAAFDVFAVEPAKENVLFGAKNFVATPHLGAATAEAQENVALQVAEQMADYILTGAVTNALNMPSVTAEE
APRLKPFATLAEKLGSFAGQISDYGYEEVVIEYEGEVSELNRKPITAALLAGLLRASRGDVNMVSAPAILADSGVKLTET
KTETSPVYDSLIRIKVKTKATKNSPEGGWRTLAGALIAGKPRIVEVKGMALEGDFSPVTLYVNNIDKPGFIGALGQMLGE
AKVNIATFHLGRQEAGGEAIALIGIDSTPPASLVEKLDALPQVRYVKVLSF
>Mature_530_residues
PKVLIGDTLSPAAVEIFKARGIETDIKVGLSKEDLIKIIPDYDGLAVRSACKPDADVIAAATNLKVIGRAGIGVDNIDIK
AATAKGVVVMNTPFGNAITTAEHAIAMLFAAARQIPAANADTQAGKWPKSGYMGVELSYKTLGLIGCGNIGSRVAERAIG
LKMKVVAYDPFLTEERAIELGVEKVDLDTLLARADFITLHVPLTDQTKNVLSREALEKTKKGLILVNCARGGLVDEEAVR
DLLESGHLAGAAFDVFAVEPAKENVLFGAKNFVATPHLGAATAEAQENVALQVAEQMADYILTGAVTNALNMPSVTAEEA
PRLKPFATLAEKLGSFAGQISDYGYEEVVIEYEGEVSELNRKPITAALLAGLLRASRGDVNMVSAPAILADSGVKLTETK
TETSPVYDSLIRIKVKTKATKNSPEGGWRTLAGALIAGKPRIVEVKGMALEGDFSPVTLYVNNIDKPGFIGALGQMLGEA
KVNIATFHLGRQEAGGEAIALIGIDSTPPASLVEKLDALPQVRYVKVLSF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=406, Percent_Identity=40.1477832512315, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI145580578, Length=260, Percent_Identity=34.6153846153846, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4557499, Length=260, Percent_Identity=34.6153846153846, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=34.6153846153846, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=33.587786259542, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=33.587786259542, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=31.3253012048193, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=37.2307692307692, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=32.4110671936759, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=31.6, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI87081824, Length=282, Percent_Identity=25.531914893617, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=28.4644194756554, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=300, Percent_Identity=43.3333333333333, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=28.6764705882353, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=328, Percent_Identity=32.9268292682927, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=32.2188449848024, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324055, Length=287, Percent_Identity=28.9198606271777, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=28.0898876404494, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=27.5510204081633, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=122, Percent_Identity=33.6065573770492, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=151, Percent_Identity=30.4635761589404, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=46, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24585516, Length=308, Percent_Identity=27.9220779220779, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574286, Length=238, Percent_Identity=30.672268907563, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=244, Percent_Identity=32.3770491803279, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=32.3770491803279, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=32.3770491803279, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=32.3770491803279, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=32.3770491803279, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574284, Length=270, Percent_Identity=28.5185185185185, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551003, Length=270, Percent_Identity=28.5185185185185, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585514, Length=270, Percent_Identity=28.5185185185185, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574282, Length=270, Percent_Identity=28.5185185185185, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI45552429, Length=238, Percent_Identity=29.8319327731092, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=30.9433962264151, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56069; Mature: 55938

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLIGDTLSPAAVEIFKARGIETDIKVGLSKEDLIKIIPDYDGLAVRSACKPDADVIA
CCCEEECCCCCHHHHHHHHHCCCCCHHEECCCHHHHEEECCCCCCCEECCCCCCCCCEEE
AATNLKVIGRAGIGVDNIDIKAATAKGVVVMNTPFGNAITTAEHAIAMLFAAARQIPAAN
EECCEEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
ADTQAGKWPKSGYMGVELSYKTLGLIGCGNIGSRVAERAIGLKMKVVAYDPFLTEERAIE
CCCCCCCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCCCHHHH
LGVEKVDLDTLLARADFITLHVPLTDQTKNVLSREALEKTKKGLILVNCARGGLVDEEAV
HCCCCCCHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHH
RDLLESGHLAGAAFDVFAVEPAKENVLFGAKNFVATPHLGAATAEAQENVALQVAEQMAD
HHHHHCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YILTGAVTNALNMPSVTAEEAPRLKPFATLAEKLGSFAGQISDYGYEEVVIEYEGEVSEL
HHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHC
NRKPITAALLAGLLRASRGDVNMVSAPAILADSGVKLTETKTETSPVYDSLIRIKVKTKA
CCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCEEEECCCCCCHHHEEEEEEEEEECC
TKNSPEGGWRTLAGALIAGKPRIVEVKGMALEGDFSPVTLYVNNIDKPGFIGALGQMLGE
CCCCCCCCHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCC
AKVNIATFHLGRQEAGGEAIALIGIDSTPPASLVEKLDALPQVRYVKVLSF
CCEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure 
PKVLIGDTLSPAAVEIFKARGIETDIKVGLSKEDLIKIIPDYDGLAVRSACKPDADVIA
CCEEECCCCCHHHHHHHHHCCCCCHHEECCCHHHHEEECCCCCCCEECCCCCCCCCEEE
AATNLKVIGRAGIGVDNIDIKAATAKGVVVMNTPFGNAITTAEHAIAMLFAAARQIPAAN
EECCEEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
ADTQAGKWPKSGYMGVELSYKTLGLIGCGNIGSRVAERAIGLKMKVVAYDPFLTEERAIE
CCCCCCCCCCCCEEEEEEEEEEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCCCHHHH
LGVEKVDLDTLLARADFITLHVPLTDQTKNVLSREALEKTKKGLILVNCARGGLVDEEAV
HCCCCCCHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHH
RDLLESGHLAGAAFDVFAVEPAKENVLFGAKNFVATPHLGAATAEAQENVALQVAEQMAD
HHHHHCCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YILTGAVTNALNMPSVTAEEAPRLKPFATLAEKLGSFAGQISDYGYEEVVIEYEGEVSEL
HHHHHHHHHCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHC
NRKPITAALLAGLLRASRGDVNMVSAPAILADSGVKLTETKTETSPVYDSLIRIKVKTKA
CCCCHHHHHHHHHHHCCCCCCEEEECCEEEECCCCEEEECCCCCCHHHEEEEEEEEEECC
TKNSPEGGWRTLAGALIAGKPRIVEVKGMALEGDFSPVTLYVNNIDKPGFIGALGQMLGE
CCCCCCCCHHHHHHHHCCCCCEEEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCC
AKVNIATFHLGRQEAGGEAIALIGIDSTPPASLVEKLDALPQVRYVKVLSF
CCEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]