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The map label for this gene is ycgM [C]

Identifier: 114800260

GI number: 114800260

Start: 2221394

End: 2222236

Strand: Direct

Name: ycgM [C]

Synonym: HNE_2137

Alternate gene names: 114800260

Gene position: 2221394-2222236 (Clockwise)

Preceding gene: 114799043

Following gene: 114797731

Centisome position: 59.96

GC content: 60.85

Gene sequence:

>843_bases
ATGAAGATCCTCAGAGTTGGCCCTCCGGGGCGCGAAAAGCCGGCAGTTCTTGATTCCAGCGGCAATATGCGGGACGTCAG
CGACCTGGTGGATGACTGGGATGGCCTGGCATTGTCCGATGCCGTGTTTGCGCAGTTGCGCAAGGTTGACCTTGCCACCC
TGCCCATGCTCCCGGCCGCCAGCCGGATCGGCCCCTGTGTCGCAGATGTCGGAAAATTCATCTGTATCGGGCTGAATTAT
GCCGATCACGCCGCCGAAACCGGCGCCGAAGTGCCTGCTGAACCCGTGGTGTTCTTCAAGGCGACGAGCGCCATCTGCGG
GCCGAATGACAATCTCGAAATCCCCCGCAAATCGGAGAAAACCGACTGGGAAGTCGAGCTCGGCATCGTCATCGGCAAAC
ACACAAAATACGTCTCGGAAGAAGACGCGATGGACCACATCGCCGGCTATTGCGTGGTTCACGACGTCTCCGAGCGCGCC
TTCCAGCTTGAGGGCACCGGCCAGTGGGTAAAGGGAAAAAGCGCCGATACGTTCGGCCCGATCGGCCCCTGGCTCGTCAC
CCGCGACGAGATTACCGACCCGCAAAACCTTACCATGTGGCTGGATGTTAACGGCGAAGCCATGCAGCGGGGGTCGACCT
CGACCATGATTTTCGGGGTGGCGCATATCGTCAGCTACCTCTCGCAATTCATGAGCCTTCAGCCGGGGGACGTGATTTCC
ACAGGCACGCCTCCGGGCGTGGGCCTGTCGCGCACACCGCCGCTCTATCTGAAGGCGGGCGACACGGTAACCCTTGGAAT
TCAAGGCCTTGGCGACCAGCGCCAGGTCTGCATCAACGCCTGA

Upstream 100 bases:

>100_bases
TCGCACACCTCGCCGTCTATCTCGCCTCAGATGAGGCATCCTTCACGACGGGCGCGATTCACGTCGTTGACGGCGGCTGG
ACAAATTAGGAGCGGATGCA

Downstream 100 bases:

>100_bases
CACAGGGCGTCGCGGCACGGACAAATACGGTCAGTTGCGGGACAAATCCGGACAAACTGGGACAATTTGGGACACGCTTG
CCTGCTGATAGCAGCCCCGC

Product: fumarylacetoacetate hydrolase family protein

Products: NA

Alternate protein names: UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKILRVGPPGREKPAVLDSSGNMRDVSDLVDDWDGLALSDAVFAQLRKVDLATLPMLPAASRIGPCVADVGKFICIGLNY
ADHAAETGAEVPAEPVVFFKATSAICGPNDNLEIPRKSEKTDWEVELGIVIGKHTKYVSEEDAMDHIAGYCVVHDVSERA
FQLEGTGQWVKGKSADTFGPIGPWLVTRDEITDPQNLTMWLDVNGEAMQRGSTSTMIFGVAHIVSYLSQFMSLQPGDVIS
TGTPPGVGLSRTPPLYLKAGDTVTLGIQGLGDQRQVCINA

Sequences:

>Translated_280_residues
MKILRVGPPGREKPAVLDSSGNMRDVSDLVDDWDGLALSDAVFAQLRKVDLATLPMLPAASRIGPCVADVGKFICIGLNY
ADHAAETGAEVPAEPVVFFKATSAICGPNDNLEIPRKSEKTDWEVELGIVIGKHTKYVSEEDAMDHIAGYCVVHDVSERA
FQLEGTGQWVKGKSADTFGPIGPWLVTRDEITDPQNLTMWLDVNGEAMQRGSTSTMIFGVAHIVSYLSQFMSLQPGDVIS
TGTPPGVGLSRTPPLYLKAGDTVTLGIQGLGDQRQVCINA
>Mature_280_residues
MKILRVGPPGREKPAVLDSSGNMRDVSDLVDDWDGLALSDAVFAQLRKVDLATLPMLPAASRIGPCVADVGKFICIGLNY
ADHAAETGAEVPAEPVVFFKATSAICGPNDNLEIPRKSEKTDWEVELGIVIGKHTKYVSEEDAMDHIAGYCVVHDVSERA
FQLEGTGQWVKGKSADTFGPIGPWLVTRDEITDPQNLTMWLDVNGEAMQRGSTSTMIFGVAHIVSYLSQFMSLQPGDVIS
TGTPPGVGLSRTPPLYLKAGDTVTLGIQGLGDQRQVCINA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=239, Percent_Identity=46.0251046025105, Blast_Score=226, Evalue=1e-59,
Organism=Homo sapiens, GI40786394, Length=239, Percent_Identity=45.1882845188285, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI215422413, Length=216, Percent_Identity=38.4259259259259, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI13654274, Length=216, Percent_Identity=38.4259259259259, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI66348062, Length=216, Percent_Identity=38.4259259259259, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1787428, Length=203, Percent_Identity=38.9162561576355, Blast_Score=141, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17557057, Length=199, Percent_Identity=36.1809045226131, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324161, Length=228, Percent_Identity=32.0175438596491, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28572127, Length=208, Percent_Identity=47.1153846153846, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24663695, Length=246, Percent_Identity=34.1463414634146, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI28571789, Length=203, Percent_Identity=38.423645320197, Blast_Score=141, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: =4.3.2.3 [H]

Molecular weight: Translated: 30040; Mature: 30040

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILRVGPPGREKPAVLDSSGNMRDVSDLVDDWDGLALSDAVFAQLRKVDLATLPMLPAA
CEEEECCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
SRIGPCVADVGKFICIGLNYADHAAETGAEVPAEPVVFFKATSAICGPNDNLEIPRKSEK
HHHCHHHHHCCCEEEEECCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
TDWEVELGIVIGKHTKYVSEEDAMDHIAGYCVVHDVSERAFQLEGTGQWVKGKSADTFGP
CCEEEEEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHEEEECCCCCEECCCCCCCCCC
IGPWLVTRDEITDPQNLTMWLDVNGEAMQRGSTSTMIFGVAHIVSYLSQFMSLQPGDVIS
CCCEEEECCCCCCCCCEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
TGTPPGVGLSRTPPLYLKAGDTVTLGIQGLGDQRQVCINA
CCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCEEEECC
>Mature Secondary Structure
MKILRVGPPGREKPAVLDSSGNMRDVSDLVDDWDGLALSDAVFAQLRKVDLATLPMLPAA
CEEEECCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCH
SRIGPCVADVGKFICIGLNYADHAAETGAEVPAEPVVFFKATSAICGPNDNLEIPRKSEK
HHHCHHHHHCCCEEEEECCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
TDWEVELGIVIGKHTKYVSEEDAMDHIAGYCVVHDVSERAFQLEGTGQWVKGKSADTFGP
CCEEEEEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHEEEECCCCCEECCCCCCCCCC
IGPWLVTRDEITDPQNLTMWLDVNGEAMQRGSTSTMIFGVAHIVSYLSQFMSLQPGDVIS
CCCEEEECCCCCCCCCEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEE
TGTPPGVGLSRTPPLYLKAGDTVTLGIQGLGDQRQVCINA
CCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA