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The map label for this gene is rnr [H]

Identifier: 114800052

GI number: 114800052

Start: 2380722

End: 2383016

Strand: Direct

Name: rnr [H]

Synonym: HNE_2280

Alternate gene names: 114800052

Gene position: 2380722-2383016 (Clockwise)

Preceding gene: 114799106

Following gene: 114797540

Centisome position: 64.26

GC content: 64.92

Gene sequence:

>2295_bases
ATGAGTTTTCCAGATAGACAGACTGTCCTTGATTTTCTGAAAGAAAATCCGGACGCGACCAGTAAAGCCGACATCGCCAG
GGGCCTTAAAGTGAAGGGCCAGGAGCGCGCCGTGCTGCGCGATGTGCTCAAACAGCTTGAGGAAGAAGGCAAGCTGGAGC
GCACCGGCAAGCGCAGCTTTGCGCAGGCCGACCGCCCGCCCCCTTCGGGCCTCGTTGAATTTACCCGCCTCACCAAAGAG
GGCGATCTTGTCGGCCAGTGCGTCGGCGATAGCGGCCTTTTCGGGCCGGAGCTGATCTATGGCGGCCCCTCGGGCAAGAG
CCGGGGCCGCGCGCCGGGCAAGGGCGACCGGGCGGTCTGCAAGATCGTCGGCCGCGAGGATGGCGAATGGCGCGCCTATG
TCATCACGCTGCTGGAGAAGCGCCTCAGCGACCGCATCGTCGGCCTCTATGAACACGCCCCGCGCGGTGGCCGGGTCATC
CCCGCCAGCCGCAAGGAGCGGCGCGAGCTGCTGATCCAGGAGGGCGACCGCAAGGGCGCCAAGGATGGCGATCTCGTCGT
GGCAGAGCCAAAGCCGCAGGGCCGCCGCCAGCTTGGCCCGCCGCTGGGCGTGGTCAAAGAGGTGATCGGCCATATCACCG
ATGCCCGCTCGGCCAGCCTCATCGCGATCTATGCGCATGACATTCCGGTGGACTTTCCAGAAGCCGCGCTTGTCGAAGCA
CGCGAGAAGGAACCGGCGGACGCTCCGCGTACCGATCTTCGCAATACGCCGCTGATCACCATCGACCCGCATGACGCGCG
CGACCATGACGATGCCGTCTGGGCCGAGCAGACCGAAGATGGCGGCTGGAAGGTGATCGTGGCGATTGCCGATGTGGCCG
CCTATGTCACCGAAGGTTCCGCCCTCGACAAGGAAGCGGAGAAGCGGGGCAACTCGACCTACTTCCCCGACCGGGTCGTC
CCCATGCTGCCGTTTGAGCTGTCGGCGGACGCTTGTTCCCTGCGCGAGAATGAAGACCGGCCGTGCATGGCGGTGGAGAT
GATCTTCTCTGCTGACGGCCACAAGAAGCGCCACCGCTTCCTGCGCGCCACGATGCGCTCGGCGGCAAAGCTCTCCTATG
AGGAGGCGCAGGCCGCCATTGACGGCAAGCCCGGCGGCAAGGCCGAGGAGCTTCTGGAAACGGTGCTGAAGCCGCTCTGG
GGCGCCTATGCGGCCGTCTCCAAGGCGCGCGACATCCGCAGCCCGCTCGATCTCGACATGCCTGAGCGCCGGATCATGTT
CACCCCCGAGGGTGAGCTGGACGGCATCGTGACGAAAGTCCGCCTCGACGCGCACCGCCTGATCGAAGAGTTCATGATCC
AGGCCAATGTCGCGGCCGCTGAAACGCTGGAGCAGAAGAACAGCCCCGTCATGTACCGCGTGCATGATACCCCGTCGGAC
GCGAAAGTGGCGGCGTTTGCGGAGTTCCTGCAGACGCTCGACATGAAATGGAATATTGGCGAACGTCCGCAGACGCACAA
GTTCAACAAGCTGCTCGCAGAGATACGCGGCGGGGATTATGAAGGCATGATCTCCCAGATGGTGCTGCGCACGCAGGCGC
AGGCGATCTATTCGGAAGAAAACCTCGGCCACTTCGGCCTCAACCTCGCCAAATATGCCCACTTCACCTCGCCCATCCGC
CGCTACGCAGACCTGATCGTCCACCGCGCGTTGATCCGGGCGCATGATTTCGGCCCCGATGGCCTTTCCGAGCGCGGCGC
CGCGCGGCTTGAGGAAGTTGCCGAACATATCTCGATGACAGAGCGCCGCTCGATGGCCGCTGAACGCGACGCGACCGACC
GCTATCTGGCGATCTTCCTGTCAGACCGGGTCGGCGCCGAGTTTGATGGCCGCATCACGGGCGTCACGCCGGCCGGCCTC
TTTGTGGCGCTGGCAGGCTCAGGCGCCGATGGCTTCGTGCCGATCTCGTCCATCTCGGAAGATTACTGGATACATGACGA
GGCGGCGGTCGCCGTCTATGCGCGCGGCTCGGGGAAAACTTTCTCCATCGGCCAGATTGTGCGTGTACGTTTGCGCGAAG
TCACCCCGCTTCAGGGCGGGCTGCTGCTGGAGATGCTGTCAGAGCCTCTGCCGGCACCACCAGGCCGCCAGGCTGCGCGC
CAGGCGATCACCCGCGAGCGCGGCGGCCCACGCAGCCGTAGCGGCGGAGGCGGCGGTGGTGGCCCACCCCGCAGAGGCAA
ACCGAAATTCGACAAACGCACCCTGCCCAAGAAGGGCAAGCCGAAGCGGCGGTGA

Upstream 100 bases:

>100_bases
AGGGCGGCAGCACCGCCATCCTGGTGCAACTGGTACGCTAGAACCGGGTTTCGCATAAAAGGCCGCGCAATTGGGCGCGA
ATTCGCCTATATCCGGCTCC

Downstream 100 bases:

>100_bases
GCTTGCGCCGCGGCTCGGCCATGCTGCGCCGCAACGCGCAGACCTCTCCCAACGTCACGGTTTCAGAGGCCGGGATTCGC
CTATAGGATTGCCATATGTC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MSFPDRQTVLDFLKENPDATSKADIARGLKVKGQERAVLRDVLKQLEEEGKLERTGKRSFAQADRPPPSGLVEFTRLTKE
GDLVGQCVGDSGLFGPELIYGGPSGKSRGRAPGKGDRAVCKIVGREDGEWRAYVITLLEKRLSDRIVGLYEHAPRGGRVI
PASRKERRELLIQEGDRKGAKDGDLVVAEPKPQGRRQLGPPLGVVKEVIGHITDARSASLIAIYAHDIPVDFPEAALVEA
REKEPADAPRTDLRNTPLITIDPHDARDHDDAVWAEQTEDGGWKVIVAIADVAAYVTEGSALDKEAEKRGNSTYFPDRVV
PMLPFELSADACSLRENEDRPCMAVEMIFSADGHKKRHRFLRATMRSAAKLSYEEAQAAIDGKPGGKAEELLETVLKPLW
GAYAAVSKARDIRSPLDLDMPERRIMFTPEGELDGIVTKVRLDAHRLIEEFMIQANVAAAETLEQKNSPVMYRVHDTPSD
AKVAAFAEFLQTLDMKWNIGERPQTHKFNKLLAEIRGGDYEGMISQMVLRTQAQAIYSEENLGHFGLNLAKYAHFTSPIR
RYADLIVHRALIRAHDFGPDGLSERGAARLEEVAEHISMTERRSMAAERDATDRYLAIFLSDRVGAEFDGRITGVTPAGL
FVALAGSGADGFVPISSISEDYWIHDEAAVAVYARGSGKTFSIGQIVRVRLREVTPLQGGLLLEMLSEPLPAPPGRQAAR
QAITRERGGPRSRSGGGGGGGPPRRGKPKFDKRTLPKKGKPKRR

Sequences:

>Translated_764_residues
MSFPDRQTVLDFLKENPDATSKADIARGLKVKGQERAVLRDVLKQLEEEGKLERTGKRSFAQADRPPPSGLVEFTRLTKE
GDLVGQCVGDSGLFGPELIYGGPSGKSRGRAPGKGDRAVCKIVGREDGEWRAYVITLLEKRLSDRIVGLYEHAPRGGRVI
PASRKERRELLIQEGDRKGAKDGDLVVAEPKPQGRRQLGPPLGVVKEVIGHITDARSASLIAIYAHDIPVDFPEAALVEA
REKEPADAPRTDLRNTPLITIDPHDARDHDDAVWAEQTEDGGWKVIVAIADVAAYVTEGSALDKEAEKRGNSTYFPDRVV
PMLPFELSADACSLRENEDRPCMAVEMIFSADGHKKRHRFLRATMRSAAKLSYEEAQAAIDGKPGGKAEELLETVLKPLW
GAYAAVSKARDIRSPLDLDMPERRIMFTPEGELDGIVTKVRLDAHRLIEEFMIQANVAAAETLEQKNSPVMYRVHDTPSD
AKVAAFAEFLQTLDMKWNIGERPQTHKFNKLLAEIRGGDYEGMISQMVLRTQAQAIYSEENLGHFGLNLAKYAHFTSPIR
RYADLIVHRALIRAHDFGPDGLSERGAARLEEVAEHISMTERRSMAAERDATDRYLAIFLSDRVGAEFDGRITGVTPAGL
FVALAGSGADGFVPISSISEDYWIHDEAAVAVYARGSGKTFSIGQIVRVRLREVTPLQGGLLLEMLSEPLPAPPGRQAAR
QAITRERGGPRSRSGGGGGGGPPRRGKPKFDKRTLPKKGKPKRR
>Mature_763_residues
SFPDRQTVLDFLKENPDATSKADIARGLKVKGQERAVLRDVLKQLEEEGKLERTGKRSFAQADRPPPSGLVEFTRLTKEG
DLVGQCVGDSGLFGPELIYGGPSGKSRGRAPGKGDRAVCKIVGREDGEWRAYVITLLEKRLSDRIVGLYEHAPRGGRVIP
ASRKERRELLIQEGDRKGAKDGDLVVAEPKPQGRRQLGPPLGVVKEVIGHITDARSASLIAIYAHDIPVDFPEAALVEAR
EKEPADAPRTDLRNTPLITIDPHDARDHDDAVWAEQTEDGGWKVIVAIADVAAYVTEGSALDKEAEKRGNSTYFPDRVVP
MLPFELSADACSLRENEDRPCMAVEMIFSADGHKKRHRFLRATMRSAAKLSYEEAQAAIDGKPGGKAEELLETVLKPLWG
AYAAVSKARDIRSPLDLDMPERRIMFTPEGELDGIVTKVRLDAHRLIEEFMIQANVAAAETLEQKNSPVMYRVHDTPSDA
KVAAFAEFLQTLDMKWNIGERPQTHKFNKLLAEIRGGDYEGMISQMVLRTQAQAIYSEENLGHFGLNLAKYAHFTSPIRR
YADLIVHRALIRAHDFGPDGLSERGAARLEEVAEHISMTERRSMAAERDATDRYLAIFLSDRVGAEFDGRITGVTPAGLF
VALAGSGADGFVPISSISEDYWIHDEAAVAVYARGSGKTFSIGQIVRVRLREVTPLQGGLLLEMLSEPLPAPPGRQAARQ
AITRERGGPRSRSGGGGGGGPPRRGKPKFDKRTLPKKGKPKRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=421, Percent_Identity=30.4038004750594, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI190014625, Length=562, Percent_Identity=25.9786476868327, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI190014623, Length=562, Percent_Identity=25.9786476868327, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI219521928, Length=654, Percent_Identity=27.217125382263, Blast_Score=146, Evalue=9e-35,
Organism=Homo sapiens, GI19115966, Length=654, Percent_Identity=27.217125382263, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI156105695, Length=486, Percent_Identity=26.7489711934156, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI156105693, Length=486, Percent_Identity=26.7489711934156, Blast_Score=94, Evalue=7e-19,
Organism=Escherichia coli, GI87082383, Length=714, Percent_Identity=34.3137254901961, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1787542, Length=483, Percent_Identity=33.5403726708075, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI212645896, Length=573, Percent_Identity=27.2251308900524, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17553506, Length=445, Percent_Identity=29.438202247191, Blast_Score=152, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6324552, Length=438, Percent_Identity=28.9954337899543, Blast_Score=173, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6320499, Length=319, Percent_Identity=24.7648902821317, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24649634, Length=556, Percent_Identity=26.0791366906475, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922976, Length=347, Percent_Identity=30.5475504322767, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24654597, Length=347, Percent_Identity=30.5475504322767, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24654592, Length=347, Percent_Identity=30.5475504322767, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84032; Mature: 83900

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPDRQTVLDFLKENPDATSKADIARGLKVKGQERAVLRDVLKQLEEEGKLERTGKRSF
CCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
AQADRPPPSGLVEFTRLTKEGDLVGQCVGDSGLFGPELIYGGPSGKSRGRAPGKGDRAVC
HHCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEE
KIVGREDGEWRAYVITLLEKRLSDRIVGLYEHAPRGGRVIPASRKERRELLIQEGDRKGA
EEECCCCCCHHHHHHHHHHHHHHHHHEEHHHCCCCCCEECCCCHHHHHHHHHHCCCCCCC
KDGDLVVAEPKPQGRRQLGPPLGVVKEVIGHITDARSASLIAIYAHDIPVDFPEAALVEA
CCCCEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHH
REKEPADAPRTDLRNTPLITIDPHDARDHDDAVWAEQTEDGGWKVIVAIADVAAYVTEGS
HCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCC
ALDKEAEKRGNSTYFPDRVVPMLPFELSADACSLRENEDRPCMAVEMIFSADGHKKRHRF
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEHHHCCCCHHHHHHH
LRATMRSAAKLSYEEAQAAIDGKPGGKAEELLETVLKPLWGAYAAVSKARDIRSPLDLDM
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PERRIMFTPEGELDGIVTKVRLDAHRLIEEFMIQANVAAAETLEQKNSPVMYRVHDTPSD
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCC
AKVAAFAEFLQTLDMKWNIGERPQTHKFNKLLAEIRGGDYEGMISQMVLRTQAQAIYSEE
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
NLGHFGLNLAKYAHFTSPIRRYADLIVHRALIRAHDFGPDGLSERGAARLEEVAEHISMT
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ERRSMAAERDATDRYLAIFLSDRVGAEFDGRITGVTPAGLFVALAGSGADGFVPISSISE
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEECCCCCCEEEEEECCCCCCCEECCCCCC
DYWIHDEAAVAVYARGSGKTFSIGQIVRVRLREVTPLQGGLLLEMLSEPLPAPPGRQAAR
CCEECCCCEEEEEECCCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHH
QAITRERGGPRSRSGGGGGGGPPRRGKPKFDKRTLPKKGKPKRR
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SFPDRQTVLDFLKENPDATSKADIARGLKVKGQERAVLRDVLKQLEEEGKLERTGKRSF
CCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
AQADRPPPSGLVEFTRLTKEGDLVGQCVGDSGLFGPELIYGGPSGKSRGRAPGKGDRAVC
HHCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEE
KIVGREDGEWRAYVITLLEKRLSDRIVGLYEHAPRGGRVIPASRKERRELLIQEGDRKGA
EEECCCCCCHHHHHHHHHHHHHHHHHEEHHHCCCCCCEECCCCHHHHHHHHHHCCCCCCC
KDGDLVVAEPKPQGRRQLGPPLGVVKEVIGHITDARSASLIAIYAHDIPVDFPEAALVEA
CCCCEEEECCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHH
REKEPADAPRTDLRNTPLITIDPHDARDHDDAVWAEQTEDGGWKVIVAIADVAAYVTEGS
HCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCC
ALDKEAEKRGNSTYFPDRVVPMLPFELSADACSLRENEDRPCMAVEMIFSADGHKKRHRF
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEHHHCCCCHHHHHHH
LRATMRSAAKLSYEEAQAAIDGKPGGKAEELLETVLKPLWGAYAAVSKARDIRSPLDLDM
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PERRIMFTPEGELDGIVTKVRLDAHRLIEEFMIQANVAAAETLEQKNSPVMYRVHDTPSD
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCC
AKVAAFAEFLQTLDMKWNIGERPQTHKFNKLLAEIRGGDYEGMISQMVLRTQAQAIYSEE
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
NLGHFGLNLAKYAHFTSPIRRYADLIVHRALIRAHDFGPDGLSERGAARLEEVAEHISMT
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ERRSMAAERDATDRYLAIFLSDRVGAEFDGRITGVTPAGLFVALAGSGADGFVPISSISE
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEECCCCCCEEEEEECCCCCCCEECCCCCC
DYWIHDEAAVAVYARGSGKTFSIGQIVRVRLREVTPLQGGLLLEMLSEPLPAPPGRQAAR
CCEECCCCEEEEEECCCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHH
QAITRERGGPRSRSGGGGGGGPPRRGKPKFDKRTLPKKGKPKRR
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]