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The map label for this gene is fumC [H]

Identifier: 114799865

GI number: 114799865

Start: 3107044

End: 3108444

Strand: Reverse

Name: fumC [H]

Synonym: HNE_2950

Alternate gene names: 114799865

Gene position: 3108444-3107044 (Counterclockwise)

Preceding gene: 114797360

Following gene: 114797295

Centisome position: 83.9

GC content: 62.31

Gene sequence:

>1401_bases
ATGGCCAAGACCCCCACACGCACAGAATCGGACACTTTCGGCCCTATCGAGGTTGAGGCGGACAAGTATTGGGGCGCGCA
GGCGCAGCGCTCGCTGGGCAACTTCAAGATAGGCTGGGAGAAACAGCCCCAGCCCATCGTGCGCGCGCTCGGCATCGTCA
AGAAAGCCGCCGCCGAAGTGAACATGGCGATGGAGAAAATGGACCGTCTGGTCGGCCGCGCCATCGTTCAGGCCGCCGAT
GAAGTCATCGAGGGCAAGCTCGACGCGCATTTCCCGCTGGTCGTCTGGCAGACCGGCTCGGGCACCCAGTCGAACATGAA
CGCCAATGAGGTGATCTCCAACCGCGCCATCGAGATCCTGAACGGCAAGGTCGGCTCCAAGGCGCCGGTTCACCCGAACG
ATCATGTGAACATGTCCCAGTCGTCCAACGACACCTTCCCGACCGCCATGCACATCGCCTGCGCCGAGCAGGTCGTGCAC
AAGCTGGTCCCCGCCCTGCAACAGCTCCAGAACGCTCTGAACGACAAGGCACAGGCCTGGAAGGACATCATCAAGATCGG
GCGCACGCATACGCAGGATGCCACCCCGGTCACCCTCGGACAGGAATTCTCCGGCTACGCCAAACAGCTCGAAAACGGCA
TCAAGCGGATCGAGATGACCCTGCCGATGCTGATGGAACTCGCCCAGGGCGGCACGGCGGTGGGCACCGGCCTTGCCTCG
CCGGAGGGCTTTGCCGAGCTGGTGGCCGACAAGATCGCCCAGATCACCGGCCTGAACTTCACCTCCGCGCCCAACAAGTT
CGAGGCGCTTGCCGCCCATGACGCGATGGTGATGACCCACGGCGCCATCACGACCGTGGCGATGAGCTGCTTCAAGATCG
CCAACGACATCCGTTTCCTCGGCTCTGGCCCGCGCTCGGGCCTTGGCGAGCTGGCCCTGCCGGAGAACGAGCCGGGCTCC
TCGATCATGCCGGGTAAGGTGAACCCGACCCAGTGCGAAGCCCTCACCCAGGTCTGCGCGCATATTCACGGCAACAACGC
CGCCATCGGCTTTGCCGGCAGCCAGGGTCATTTCGAGCTGAACGTGTTCAACCCGATGATGGCCTACAACTTCCTGCAAT
CTGTCCAGCTGCTGGCAGATGCGGCCGTGTCCTTCACCGAGAACTGCGTTGTCGGCATCGAGCCGCGCCTCGACAATATC
CAGCGCGGCCTTGAAAATTCGCTGATGCTGGTGACGCCGCTGAAGGAAAAGTATGGCTACGATCTGGCCGCAAAAGTAGC
CAAGACCGCGCACAAGAATGGCACCACACTGAAGGTCGAAGCCCTGGCGCTCGGCATTTCGGAGGAAGATTTCGACGCCA
TCGTGCGGCCTGAGAAAATGATCGGACCGGACCCGGCATAA

Upstream 100 bases:

>100_bases
CATCCCGTGGGAAAGCGGGGCTATCGCGGCTTGATGAGCGCAGAGCAGGGGGCTAAACCGCCCGGCGACATTGCTTAAGC
CGAGCTTCAGGAGCGCCCCC

Downstream 100 bases:

>100_bases
GGGCGCCAAGACCCTCGGTAATTTCCCATGGCGGCGTTGTTCCTTCTGGCTCTTGTGATACTGGCGGCGGCGCTGAGCGG
GGCCGCCTACTTTTATCTGC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MAKTPTRTESDTFGPIEVEADKYWGAQAQRSLGNFKIGWEKQPQPIVRALGIVKKAAAEVNMAMEKMDRLVGRAIVQAAD
EVIEGKLDAHFPLVVWQTGSGTQSNMNANEVISNRAIEILNGKVGSKAPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVH
KLVPALQQLQNALNDKAQAWKDIIKIGRTHTQDATPVTLGQEFSGYAKQLENGIKRIEMTLPMLMELAQGGTAVGTGLAS
PEGFAELVADKIAQITGLNFTSAPNKFEALAAHDAMVMTHGAITTVAMSCFKIANDIRFLGSGPRSGLGELALPENEPGS
SIMPGKVNPTQCEALTQVCAHIHGNNAAIGFAGSQGHFELNVFNPMMAYNFLQSVQLLADAAVSFTENCVVGIEPRLDNI
QRGLENSLMLVTPLKEKYGYDLAAKVAKTAHKNGTTLKVEALALGISEEDFDAIVRPEKMIGPDPA

Sequences:

>Translated_466_residues
MAKTPTRTESDTFGPIEVEADKYWGAQAQRSLGNFKIGWEKQPQPIVRALGIVKKAAAEVNMAMEKMDRLVGRAIVQAAD
EVIEGKLDAHFPLVVWQTGSGTQSNMNANEVISNRAIEILNGKVGSKAPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVH
KLVPALQQLQNALNDKAQAWKDIIKIGRTHTQDATPVTLGQEFSGYAKQLENGIKRIEMTLPMLMELAQGGTAVGTGLAS
PEGFAELVADKIAQITGLNFTSAPNKFEALAAHDAMVMTHGAITTVAMSCFKIANDIRFLGSGPRSGLGELALPENEPGS
SIMPGKVNPTQCEALTQVCAHIHGNNAAIGFAGSQGHFELNVFNPMMAYNFLQSVQLLADAAVSFTENCVVGIEPRLDNI
QRGLENSLMLVTPLKEKYGYDLAAKVAKTAHKNGTTLKVEALALGISEEDFDAIVRPEKMIGPDPA
>Mature_465_residues
AKTPTRTESDTFGPIEVEADKYWGAQAQRSLGNFKIGWEKQPQPIVRALGIVKKAAAEVNMAMEKMDRLVGRAIVQAADE
VIEGKLDAHFPLVVWQTGSGTQSNMNANEVISNRAIEILNGKVGSKAPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHK
LVPALQQLQNALNDKAQAWKDIIKIGRTHTQDATPVTLGQEFSGYAKQLENGIKRIEMTLPMLMELAQGGTAVGTGLASP
EGFAELVADKIAQITGLNFTSAPNKFEALAAHDAMVMTHGAITTVAMSCFKIANDIRFLGSGPRSGLGELALPENEPGSS
IMPGKVNPTQCEALTQVCAHIHGNNAAIGFAGSQGHFELNVFNPMMAYNFLQSVQLLADAAVSFTENCVVGIEPRLDNIQ
RGLENSLMLVTPLKEKYGYDLAAKVAKTAHKNGTTLKVEALALGISEEDFDAIVRPEKMIGPDPA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=64.1304347826087, Blast_Score=577, Evalue=1e-165,
Organism=Homo sapiens, GI266458395, Length=70, Percent_Identity=51.4285714285714, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=57.9868708971554, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.3947939262473, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1790398, Length=226, Percent_Identity=28.7610619469027, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17553882, Length=466, Percent_Identity=66.3090128755365, Blast_Score=618, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=66.0550458715596, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=63.9130434782609, Blast_Score=578, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24640179, Length=467, Percent_Identity=63.3832976445396, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=61.7204301075269, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640177, Length=467, Percent_Identity=63.169164882227, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=60.3036876355748, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.4838012958963, Blast_Score=493, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50017; Mature: 49886

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTPTRTESDTFGPIEVEADKYWGAQAQRSLGNFKIGWEKQPQPIVRALGIVKKAAAEV
CCCCCCCCCCCCCCCEEEECCHHCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
NMAMEKMDRLVGRAIVQAADEVIEGKLDAHFPLVVWQTGSGTQSNMNANEVISNRAIEIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
NGKVGSKAPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHKLVPALQQLQNALNDKAQAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDIIKIGRTHTQDATPVTLGQEFSGYAKQLENGIKRIEMTLPMLMELAQGGTAVGTGLAS
HHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
PEGFAELVADKIAQITGLNFTSAPNKFEALAAHDAMVMTHGAITTVAMSCFKIANDIRFL
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHH
GSGPRSGLGELALPENEPGSSIMPGKVNPTQCEALTQVCAHIHGNNAAIGFAGSQGHFEL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
NVFNPMMAYNFLQSVQLLADAAVSFTENCVVGIEPRLDNIQRGLENSLMLVTPLKEKYGY
EECCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCEEEEEECHHHHCC
DLAAKVAKTAHKNGTTLKVEALALGISEEDFDAIVRPEKMIGPDPA
HHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
AKTPTRTESDTFGPIEVEADKYWGAQAQRSLGNFKIGWEKQPQPIVRALGIVKKAAAEV
CCCCCCCCCCCCCCEEEECCHHCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
NMAMEKMDRLVGRAIVQAADEVIEGKLDAHFPLVVWQTGSGTQSNMNANEVISNRAIEIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHH
NGKVGSKAPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHKLVPALQQLQNALNDKAQAW
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDIIKIGRTHTQDATPVTLGQEFSGYAKQLENGIKRIEMTLPMLMELAQGGTAVGTGLAS
HHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
PEGFAELVADKIAQITGLNFTSAPNKFEALAAHDAMVMTHGAITTVAMSCFKIANDIRFL
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHH
GSGPRSGLGELALPENEPGSSIMPGKVNPTQCEALTQVCAHIHGNNAAIGFAGSQGHFEL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEE
NVFNPMMAYNFLQSVQLLADAAVSFTENCVVGIEPRLDNIQRGLENSLMLVTPLKEKYGY
EECCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCCEEEEEECHHHHCC
DLAAKVAKTAHKNGTTLKVEALALGISEEDFDAIVRPEKMIGPDPA
HHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]