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The map label for this gene is clpB [H]

Identifier: 114799774

GI number: 114799774

Start: 631509

End: 634127

Strand: Direct

Name: clpB [H]

Synonym: HNE_0631

Alternate gene names: 114799774

Gene position: 631509-634127 (Clockwise)

Preceding gene: 114797461

Following gene: 114798661

Centisome position: 17.04

GC content: 63.92

Gene sequence:

>2619_bases
ATGAACCTTGAGCAATACACAGAACGCGCCCGCGCTATCATCCAGGGCGCCCAGACCGCAGCCCTGGCCGCTGGCCATCA
GGTGCTGACCCCGGCGCATATCCTCAAAACGCTGCTGGACGACCGCGACCAGCTGGCTGTGAACCTCATCCGCGCGACCG
GTGGACGGCCTGAACTGGCCGTGCAGGGCGTTGACGCCGCGCTCGGCCGCGTGCCGAAAGTTTCCGGCGCCGGGGCAGGC
GGGCTGCGCCTCGAACAGGCGGGCGCCAAACTCTTCCAGGACGCTGAAGCCGGCGCCAAGAAGGCCGGCGACGCCTTCGT
CACCGCTGAGCGGCTGCTGCTTGCCATTGCCGGGCTGTCCGGAGATCCGGCGGCGGACGTGCTGAAGAACGCCGGCGTGA
CGCCCAAGACGCTGGAAGGCGCTATTGCACAGCTGCGCCAGGGCCGCACGGCCGACAGTCAGAATGCGGAAGAAGGCTAT
GAAGCCCTCAAGAAATACGCCCGCGACCTGACCAAGGACGCGCGCGAAGGCAAGCTCGACCCCGTGATCGGCCGTGACGA
GGAAATCCGCCGCGCCATCCAGGTCCTCTCGCGCCGTTCAAAAAACAACCCCGTGCTGATCGGGGAGCCGGGCGTGGGCA
AGACGGCGATTGCCGAAGGTCTCGCCCTGCGCATCGTCAATGGCGACGTGCCAGAAAGCCTCAAAGACAAGAAACTCCTC
GCGCTCGATATGGGCGCGCTGATCGCCGGGGCAAAATTCCGCGGCGAGTTCGAGGAGCGCCTGAAAGCGGTGTTGAACGA
AGTTCAGCAGGCAGACGGCGGCATCATCCTCTTCATTGACGAGATGCACACGCTCGTCGGCGCGGGAAAATCCGAAGGCG
CGATGGACGCGTCCAATCTTCTGAAGCCCGCACTGGCGCGCGGGGAGCTGCACTGTATCGGCGCCACCACGCTGGACGAA
TACCGCAAATATGTCGAAGGCGACGCGGCGCTGGCCCGTCGCTTCATGGCGGTATTTGTCGATGAGCCTACGGTGGAGGA
CACGATCTCGATCCTCCGGGGGCTGAAGGGCCGTTACGAAGCCCATCACGGCGTGCGAATTTCCGATGCGGCGATTGTGG
CCGCCGCTACGCTGTCCAACCGCTATATCACCGATCGTTTCCTGCCCGACAAAGCCATCGACCTGATGGACGAGGCCGGA
TCGCGCCTGCGCATGCAGGTCGATTCCAAGCCCGAGGAGCTCGACGAGATCGACCGGCGGATGCTGCAGCTGAAAATCGA
GGCCGAAGCTCTCAAGAAGGAGAAGGACACCGCCTCGCAGGACCGTCTGAAAACGCTGGAAGGCGAAATCGCCGGTCTTG
AAACCCGCTCACGCGAGCTGACCACCGCCTGGAGCGCCGAGAAGGACAAGCTGAAAGGCGCAGCCTCCGCTAAGGAGAAG
CTCGACCGGGCCTTCTCGGATATGGCTGAGGCCCAGCGCCAGGGCGATCTGGCCCGTGCGTCCGAGCTTAAATTCGCGAC
CATCCCGCAGCTTGAAAAACTGATCGCCGAAGTCGAAGCCAAGGGCGACGCCGAAGGCGGGCTCGTTTCCGAAGTCGTCC
GTCCAGAGGATATTGCCGGGGTCGTTTCCAAATGGACCGGCATTCCGGTCGACAAGATGATGGAAGGCGAGCGGGAGAAG
CTGCTGCGCATGGAAGATTCCCTGCGCGGGCGGGTTGTTGGCCAGGAAGACGCGCTGCTCGCGGTCTCCAATGCCGTGCG
CCGCGCGCGCGCCGGTCTGCAGGACCCGAACCGCCCCATCGGCTCGTTCCTGTTTGTCGGCCCCACGGGTGTTGGCAAGA
CAGAGCTCACCAAGGCGCTCGCCGAATTCATGTTCGATGATGACACCGCGATCCTGCGGCTCGATATGTCGGAATTTTCC
GAGAAGCATTCGGTTGCCCGCCTGATCGGCGCGCCGCCGGGCTATGTCGGCTATGATGAAGGCGGGGTTTTGACCGAATC
CGTCCGCAGGCGGCCTTATCAGGTCGTGCTGTTTGACGAGGTGGAGAAAGCCCACCCGGACCTCTTCAACACGCTGCTCC
AGGTGCTCGATGATGGCCGTCTCACCGATGGCCAGGGCCGCACGGTGGATTTCAAGAACACGATCATCATCATGACCTCA
AACCTCGGCGCCGACGCGCTGGCGAGCGGGGAAGAGGGGGAGGTGTCCGAGCAGGCCCGCGAGCATGTGATGGGCGCCAT
CCGCCGGCATTTCCGCCCGGAATTCATCAACCGGATCGACGAGATCGTCTTCTTCAAACGGCTTGGCCGCGGCGAGATCG
ACCATATCGTCGACATCCAGATGGGCCGCCTCGAGCAGCTTCTGAAGGACCGGAAGATGAAGCTCGACCTCAGCCTCGAC
GCCCGCAACTGGCTCGCGGCGCGGGGATACGATCCGGTCTATGGCGCGCGCCCCTTGAAGCGTGTCATCCAGAAAGAGCT
GCAGGACCCGCTCGCCCGGCTGCTGCTCGAAGGCCGCATCCTTGACGGCGAAACCATCCATGTCGGCGTGGAGGGCGATG
GCCTCGCCATCAACGGCGTGCCCAACGACTTTGCCAAAGGCCGGGCTGCGCTCAACTGA

Upstream 100 bases:

>100_bases
TGCGCAGCGCGCCTCGCGTTCCCAAATCCTCGTCAACACCGGTTGCCGCTGAGCGGGGCCGGGCGAACTTTTCAATCTGC
CTCCAGAAGGGGATGAATTC

Downstream 100 bases:

>100_bases
GCGGTGCCGGAACTCCGTGTAGACGGATTAAATCGCCTCGGCGCCCTCAAGGCGCCGGGGCGTTTGCCATCCGGGCGGAG
TTGGCGGCGGCGAAAAGCTG

Product: ATP-dependent chaperone protein ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 872; Mature: 872

Protein sequence:

>872_residues
MNLEQYTERARAIIQGAQTAALAAGHQVLTPAHILKTLLDDRDQLAVNLIRATGGRPELAVQGVDAALGRVPKVSGAGAG
GLRLEQAGAKLFQDAEAGAKKAGDAFVTAERLLLAIAGLSGDPAADVLKNAGVTPKTLEGAIAQLRQGRTADSQNAEEGY
EALKKYARDLTKDAREGKLDPVIGRDEEIRRAIQVLSRRSKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLL
ALDMGALIAGAKFRGEFEERLKAVLNEVQQADGGIILFIDEMHTLVGAGKSEGAMDASNLLKPALARGELHCIGATTLDE
YRKYVEGDAALARRFMAVFVDEPTVEDTISILRGLKGRYEAHHGVRISDAAIVAAATLSNRYITDRFLPDKAIDLMDEAG
SRLRMQVDSKPEELDEIDRRMLQLKIEAEALKKEKDTASQDRLKTLEGEIAGLETRSRELTTAWSAEKDKLKGAASAKEK
LDRAFSDMAEAQRQGDLARASELKFATIPQLEKLIAEVEAKGDAEGGLVSEVVRPEDIAGVVSKWTGIPVDKMMEGEREK
LLRMEDSLRGRVVGQEDALLAVSNAVRRARAGLQDPNRPIGSFLFVGPTGVGKTELTKALAEFMFDDDTAILRLDMSEFS
EKHSVARLIGAPPGYVGYDEGGVLTESVRRRPYQVVLFDEVEKAHPDLFNTLLQVLDDGRLTDGQGRTVDFKNTIIIMTS
NLGADALASGEEGEVSEQAREHVMGAIRRHFRPEFINRIDEIVFFKRLGRGEIDHIVDIQMGRLEQLLKDRKMKLDLSLD
ARNWLAARGYDPVYGARPLKRVIQKELQDPLARLLLEGRILDGETIHVGVEGDGLAINGVPNDFAKGRAALN

Sequences:

>Translated_872_residues
MNLEQYTERARAIIQGAQTAALAAGHQVLTPAHILKTLLDDRDQLAVNLIRATGGRPELAVQGVDAALGRVPKVSGAGAG
GLRLEQAGAKLFQDAEAGAKKAGDAFVTAERLLLAIAGLSGDPAADVLKNAGVTPKTLEGAIAQLRQGRTADSQNAEEGY
EALKKYARDLTKDAREGKLDPVIGRDEEIRRAIQVLSRRSKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLL
ALDMGALIAGAKFRGEFEERLKAVLNEVQQADGGIILFIDEMHTLVGAGKSEGAMDASNLLKPALARGELHCIGATTLDE
YRKYVEGDAALARRFMAVFVDEPTVEDTISILRGLKGRYEAHHGVRISDAAIVAAATLSNRYITDRFLPDKAIDLMDEAG
SRLRMQVDSKPEELDEIDRRMLQLKIEAEALKKEKDTASQDRLKTLEGEIAGLETRSRELTTAWSAEKDKLKGAASAKEK
LDRAFSDMAEAQRQGDLARASELKFATIPQLEKLIAEVEAKGDAEGGLVSEVVRPEDIAGVVSKWTGIPVDKMMEGEREK
LLRMEDSLRGRVVGQEDALLAVSNAVRRARAGLQDPNRPIGSFLFVGPTGVGKTELTKALAEFMFDDDTAILRLDMSEFS
EKHSVARLIGAPPGYVGYDEGGVLTESVRRRPYQVVLFDEVEKAHPDLFNTLLQVLDDGRLTDGQGRTVDFKNTIIIMTS
NLGADALASGEEGEVSEQAREHVMGAIRRHFRPEFINRIDEIVFFKRLGRGEIDHIVDIQMGRLEQLLKDRKMKLDLSLD
ARNWLAARGYDPVYGARPLKRVIQKELQDPLARLLLEGRILDGETIHVGVEGDGLAINGVPNDFAKGRAALN
>Mature_872_residues
MNLEQYTERARAIIQGAQTAALAAGHQVLTPAHILKTLLDDRDQLAVNLIRATGGRPELAVQGVDAALGRVPKVSGAGAG
GLRLEQAGAKLFQDAEAGAKKAGDAFVTAERLLLAIAGLSGDPAADVLKNAGVTPKTLEGAIAQLRQGRTADSQNAEEGY
EALKKYARDLTKDAREGKLDPVIGRDEEIRRAIQVLSRRSKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLL
ALDMGALIAGAKFRGEFEERLKAVLNEVQQADGGIILFIDEMHTLVGAGKSEGAMDASNLLKPALARGELHCIGATTLDE
YRKYVEGDAALARRFMAVFVDEPTVEDTISILRGLKGRYEAHHGVRISDAAIVAAATLSNRYITDRFLPDKAIDLMDEAG
SRLRMQVDSKPEELDEIDRRMLQLKIEAEALKKEKDTASQDRLKTLEGEIAGLETRSRELTTAWSAEKDKLKGAASAKEK
LDRAFSDMAEAQRQGDLARASELKFATIPQLEKLIAEVEAKGDAEGGLVSEVVRPEDIAGVVSKWTGIPVDKMMEGEREK
LLRMEDSLRGRVVGQEDALLAVSNAVRRARAGLQDPNRPIGSFLFVGPTGVGKTELTKALAEFMFDDDTAILRLDMSEFS
EKHSVARLIGAPPGYVGYDEGGVLTESVRRRPYQVVLFDEVEKAHPDLFNTLLQVLDDGRLTDGQGRTVDFKNTIIIMTS
NLGADALASGEEGEVSEQAREHVMGAIRRHFRPEFINRIDEIVFFKRLGRGEIDHIVDIQMGRLEQLLKDRKMKLDLSLD
ARNWLAARGYDPVYGARPLKRVIQKELQDPLARLLLEGRILDGETIHVGVEGDGLAINGVPNDFAKGRAALN

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=363, Percent_Identity=36.3636363636364, Blast_Score=211, Evalue=2e-54,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=57.8763127187865, Blast_Score=964, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=321, Percent_Identity=44.5482866043614, Blast_Score=289, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6320464, Length=713, Percent_Identity=55.2594670406732, Blast_Score=803, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=861, Percent_Identity=45.1800232288037, Blast_Score=703, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 94920; Mature: 94920

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEQYTERARAIIQGAQTAALAAGHQVLTPAHILKTLLDDRDQLAVNLIRATGGRPELA
CCHHHHHHHHHHHHHCCHHHHHHCCCHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
VQGVDAALGRVPKVSGAGAGGLRLEQAGAKLFQDAEAGAKKAGDAFVTAERLLLAIAGLS
EECHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
GDPAADVLKNAGVTPKTLEGAIAQLRQGRTADSQNAEEGYEALKKYARDLTKDAREGKLD
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PVIGRDEEIRRAIQVLSRRSKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLL
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCEEEEECCCCCCCCCCCEEH
ALDMGALIAGAKFRGEFEERLKAVLNEVQQADGGIILFIDEMHTLVGAGKSEGAMDASNL
EEEHHHHHHCHHHHCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCHHHH
LKPALARGELHCIGATTLDEYRKYVEGDAALARRFMAVFVDEPTVEDTISILRGLKGRYE
HHHHHHCCCEEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHH
AHHGVRISDAAIVAAATLSNRYITDRFLPDKAIDLMDEAGSRLRMQVDSKPEELDEIDRR
HCCCEEECCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
MLQLKIEAEALKKEKDTASQDRLKTLEGEIAGLETRSRELTTAWSAEKDKLKGAASAKEK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCHHHHHHH
LDRAFSDMAEAQRQGDLARASELKFATIPQLEKLIAEVEAKGDAEGGLVSEVVRPEDIAG
HHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHH
VVSKWTGIPVDKMMEGEREKLLRMEDSLRGRVVGQEDALLAVSNAVRRARAGLQDPNRPI
HHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
GSFLFVGPTGVGKTELTKALAEFMFDDDTAILRLDMSEFSEKHSVARLIGAPPGYVGYDE
CCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCC
GGVLTESVRRRPYQVVLFDEVEKAHPDLFNTLLQVLDDGRLTDGQGRTVDFKNTIIIMTS
CCCCHHHHHCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEC
NLGADALASGEEGEVSEQAREHVMGAIRRHFRPEFINRIDEIVFFKRLGRGEIDHIVDIQ
CCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHCC
MGRLEQLLKDRKMKLDLSLDARNWLAARGYDPVYGARPLKRVIQKELQDPLARLLLEGRI
HHHHHHHHHCCCEEEEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEE
LDGETIHVGVEGDGLAINGVPNDFAKGRAALN
ECCCEEEEEECCCCEEECCCCCHHHCCCCCCC
>Mature Secondary Structure
MNLEQYTERARAIIQGAQTAALAAGHQVLTPAHILKTLLDDRDQLAVNLIRATGGRPELA
CCHHHHHHHHHHHHHCCHHHHHHCCCHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
VQGVDAALGRVPKVSGAGAGGLRLEQAGAKLFQDAEAGAKKAGDAFVTAERLLLAIAGLS
EECHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
GDPAADVLKNAGVTPKTLEGAIAQLRQGRTADSQNAEEGYEALKKYARDLTKDAREGKLD
CCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PVIGRDEEIRRAIQVLSRRSKNNPVLIGEPGVGKTAIAEGLALRIVNGDVPESLKDKKLL
CCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCEEEEECCCCCCCCCCCEEH
ALDMGALIAGAKFRGEFEERLKAVLNEVQQADGGIILFIDEMHTLVGAGKSEGAMDASNL
EEEHHHHHHCHHHHCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCHHHH
LKPALARGELHCIGATTLDEYRKYVEGDAALARRFMAVFVDEPTVEDTISILRGLKGRYE
HHHHHHCCCEEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHH
AHHGVRISDAAIVAAATLSNRYITDRFLPDKAIDLMDEAGSRLRMQVDSKPEELDEIDRR
HCCCEEECCHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHH
MLQLKIEAEALKKEKDTASQDRLKTLEGEIAGLETRSRELTTAWSAEKDKLKGAASAKEK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHCCHHHHHHH
LDRAFSDMAEAQRQGDLARASELKFATIPQLEKLIAEVEAKGDAEGGLVSEVVRPEDIAG
HHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHH
VVSKWTGIPVDKMMEGEREKLLRMEDSLRGRVVGQEDALLAVSNAVRRARAGLQDPNRPI
HHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
GSFLFVGPTGVGKTELTKALAEFMFDDDTAILRLDMSEFSEKHSVARLIGAPPGYVGYDE
CCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCC
GGVLTESVRRRPYQVVLFDEVEKAHPDLFNTLLQVLDDGRLTDGQGRTVDFKNTIIIMTS
CCCCHHHHHCCCEEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEC
NLGADALASGEEGEVSEQAREHVMGAIRRHFRPEFINRIDEIVFFKRLGRGEIDHIVDIQ
CCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHCC
MGRLEQLLKDRKMKLDLSLDARNWLAARGYDPVYGARPLKRVIQKELQDPLARLLLEGRI
HHHHHHHHHCCCEEEEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEE
LDGETIHVGVEGDGLAINGVPNDFAKGRAALN
ECCCEEEEEECCCCEEECCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA