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The map label for this gene is cvrA [H]

Identifier: 114799296

GI number: 114799296

Start: 200728

End: 202539

Strand: Direct

Name: cvrA [H]

Synonym: HNE_0214

Alternate gene names: 114799296

Gene position: 200728-202539 (Clockwise)

Preceding gene: 114798703

Following gene: 114800314

Centisome position: 5.42

GC content: 64.02

Gene sequence:

>1812_bases
GTGGCCCTGGCTGCATTGACGAGCCTCGTATCACAGCGCTTTGGCGCGCCGTTGCTGCTCGTATTCCTCGGGATCGGCCT
GTTGGCAGGCGAAGACGGACTTCTGGGCATCCAGTTTGACAGCGGCTCGGCCGCTTACTTCATCGGGTCACTGGCGCTGG
CGATCATCCTGTTTGACAGCGGGTTCGAGACGCCGATGCGCAGCTATAAGGTGGCGGCAGCGCCGGCGCTGAGTCTGGCG
ACGTTCGGGGTGGTCCTGACAGCGGGTCTGACGGGTGTGGCGGCGCACTTCCTGTTCGGGGTTGGCTGGCTGGAGGCGTT
CCTGCTGGGCTCGATCGTGGCGTCGACGGATGCGGCGGCGGTCTTCTTCCTGCTGAGGGCAGGGGGGATCAGGCTGAGGG
AGAAGGTCGGCTCCACCCTGGAGATCGAGTCCGGGGCGAACGATCCGATGGCGATCTTTCTCACCATCCTGCTGATCGAG
CTGATTGTGGCAGATGCGGGCACCGACGCGCTGTTCGGCTTTGAAGTGCTGATGACCTTCGTGCAGCAGATGGGCCTGGG
CATCCTGTTTGGCATCGTCGGCGGCTTTGGAATCTCGTGGTTCCTGCACAAGCTCGTCAATGTCGATCCGGGGCTGTATC
CGATTTCCGGTCTGGCAGCGGCGCTGGTTGTCTTCTCGGTCTGCGCGCTTCTGGGGGGCAGCGGGTTTCTGGCAGCCTAT
GTGGCCGGCGTGGTCGCGGGTAACCGGAAGGTCAAATTTGCTCATCGGCTCCGGCGGTTCCAGGTGGGGATGACCTGGCT
TGCGCAGATCGGGATGTTTCTGGCGCTGGGCCTTCTGGCCACCCCGTCCGAGTTTCCGCGCATTCTCGTTCCGGCGCTCA
TATTGGCGGGCGTTCTTATCTTCGTGGCCCGGCCGCTGGCGGTATGGCTGTGCTTGCTGCCCTTCGATTTCAGGTCGCGG
GAGACCCTGTTTACGGGCTGGGTTGGTTTGCGCGGGGCAGTTTCGATCCTGCTGGCGATCCTGCCAGGCCTGGCGGGCAT
CGAGAATGGCAGTTTCTATTTCAACGTCGTGTTCGTGATGGTGCTGGTGTCGCTGCTGGTGCAGGGCTGGACCATCCAGC
CTGCGGCAAAGCTGCTGAAGATGAGCCTGCCCTCCGAGCAGGGGCTGGTGGACCGGGTGGAGCTGGAGCTGCGCGGGGCA
ACCGAGATGGAGCTCGTCGGTTACAAGATCCATCCCGACAGCGCGATTGCCAAGGGCGAGCGCGTGCCCCGCTGGGCGCG
GCCGGTGATGGTGATCCGGGACGGGCTTTCCTATTCGGTCCACACGATCGGCCCGCTGCAGGCCAATGACCAGGTGTATC
TCTTCGCCTCTGCCCGGCGTGTGCGCCTGCTGGACCAGATTTATGCCAGCCCCTGGGATGAAATGACGGTCGAATCCGAC
ATCCAGTTTCGCGTCAAGGGCGCGACGAAGATGTCCGATCTGGTGCGCCAGTATGGGCTGGAAGGGATCGATACAAGCGA
CGCGGTCACGGCCAGCCAGTTCCTCGACCGGTCGTTCGATGGAAAGCCGGTGCTGGGAGACCGTGTCACAATCGGGGACG
TGGACATTGTCGTTTGCGCGCTTGATGACGCCGGCGGCGTGGGCACGGTCGGCATTGTCATCGGCGAAGAGGACCCTGGC
GCCGGTGCGCTGATGGCAGACCTTGTGCGCCGGGGCGGGGCGCGAATCGCGGGTCTTGTCCGCAGACCAAAGCCCATATC
AGCCGGGCCGGCCGAGAGCGCGCCGGCAAAGGATATTGGCGACCAGGCGTGA

Upstream 100 bases:

>100_bases
GTCAGTCACATATCATTTTTTCTCCCACCGCGACAGAGACGAGGAGGTCCGGACACTGTTCGAGTCTGTAAATATCGCCA
TCCTGATCGGCTCGGCCCTT

Downstream 100 bases:

>100_bases
GGGCCGGACTGTCAGATAACTGTCATGTTTGGTGTCCGTACGAACTAAGTATATTCTAAAAAAGATACATTATTTTGTAT
CTCCGTGGCTGTGTAGACAC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MALAALTSLVSQRFGAPLLLVFLGIGLLAGEDGLLGIQFDSGSAAYFIGSLALAIILFDSGFETPMRSYKVAAAPALSLA
TFGVVLTAGLTGVAAHFLFGVGWLEAFLLGSIVASTDAAAVFFLLRAGGIRLREKVGSTLEIESGANDPMAIFLTILLIE
LIVADAGTDALFGFEVLMTFVQQMGLGILFGIVGGFGISWFLHKLVNVDPGLYPISGLAAALVVFSVCALLGGSGFLAAY
VAGVVAGNRKVKFAHRLRRFQVGMTWLAQIGMFLALGLLATPSEFPRILVPALILAGVLIFVARPLAVWLCLLPFDFRSR
ETLFTGWVGLRGAVSILLAILPGLAGIENGSFYFNVVFVMVLVSLLVQGWTIQPAAKLLKMSLPSEQGLVDRVELELRGA
TEMELVGYKIHPDSAIAKGERVPRWARPVMVIRDGLSYSVHTIGPLQANDQVYLFASARRVRLLDQIYASPWDEMTVESD
IQFRVKGATKMSDLVRQYGLEGIDTSDAVTASQFLDRSFDGKPVLGDRVTIGDVDIVVCALDDAGGVGTVGIVIGEEDPG
AGALMADLVRRGGARIAGLVRRPKPISAGPAESAPAKDIGDQA

Sequences:

>Translated_603_residues
MALAALTSLVSQRFGAPLLLVFLGIGLLAGEDGLLGIQFDSGSAAYFIGSLALAIILFDSGFETPMRSYKVAAAPALSLA
TFGVVLTAGLTGVAAHFLFGVGWLEAFLLGSIVASTDAAAVFFLLRAGGIRLREKVGSTLEIESGANDPMAIFLTILLIE
LIVADAGTDALFGFEVLMTFVQQMGLGILFGIVGGFGISWFLHKLVNVDPGLYPISGLAAALVVFSVCALLGGSGFLAAY
VAGVVAGNRKVKFAHRLRRFQVGMTWLAQIGMFLALGLLATPSEFPRILVPALILAGVLIFVARPLAVWLCLLPFDFRSR
ETLFTGWVGLRGAVSILLAILPGLAGIENGSFYFNVVFVMVLVSLLVQGWTIQPAAKLLKMSLPSEQGLVDRVELELRGA
TEMELVGYKIHPDSAIAKGERVPRWARPVMVIRDGLSYSVHTIGPLQANDQVYLFASARRVRLLDQIYASPWDEMTVESD
IQFRVKGATKMSDLVRQYGLEGIDTSDAVTASQFLDRSFDGKPVLGDRVTIGDVDIVVCALDDAGGVGTVGIVIGEEDPG
AGALMADLVRRGGARIAGLVRRPKPISAGPAESAPAKDIGDQA
>Mature_602_residues
ALAALTSLVSQRFGAPLLLVFLGIGLLAGEDGLLGIQFDSGSAAYFIGSLALAIILFDSGFETPMRSYKVAAAPALSLAT
FGVVLTAGLTGVAAHFLFGVGWLEAFLLGSIVASTDAAAVFFLLRAGGIRLREKVGSTLEIESGANDPMAIFLTILLIEL
IVADAGTDALFGFEVLMTFVQQMGLGILFGIVGGFGISWFLHKLVNVDPGLYPISGLAAALVVFSVCALLGGSGFLAAYV
AGVVAGNRKVKFAHRLRRFQVGMTWLAQIGMFLALGLLATPSEFPRILVPALILAGVLIFVARPLAVWLCLLPFDFRSRE
TLFTGWVGLRGAVSILLAILPGLAGIENGSFYFNVVFVMVLVSLLVQGWTIQPAAKLLKMSLPSEQGLVDRVELELRGAT
EMELVGYKIHPDSAIAKGERVPRWARPVMVIRDGLSYSVHTIGPLQANDQVYLFASARRVRLLDQIYASPWDEMTVESDI
QFRVKGATKMSDLVRQYGLEGIDTSDAVTASQFLDRSFDGKPVLGDRVTIGDVDIVVCALDDAGGVGTVGIVIGEEDPGA
GALMADLVRRGGARIAGLVRRPKPISAGPAESAPAKDIGDQA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=554, Percent_Identity=40.7942238267148, Blast_Score=323, Evalue=1e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 63843; Mature: 63712

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAALTSLVSQRFGAPLLLVFLGIGLLAGEDGLLGIQFDSGSAAYFIGSLALAIILFDS
CHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
GFETPMRSYKVAAAPALSLATFGVVLTAGLTGVAAHFLFGVGWLEAFLLGSIVASTDAAA
CCCCHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VFFLLRAGGIRLREKVGSTLEIESGANDPMAIFLTILLIELIVADAGTDALFGFEVLMTF
HHHHHHCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VQQMGLGILFGIVGGFGISWFLHKLVNVDPGLYPISGLAAALVVFSVCALLGGSGFLAAY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
VAGVVAGNRKVKFAHRLRRFQVGMTWLAQIGMFLALGLLATPSEFPRILVPALILAGVLI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FVARPLAVWLCLLPFDFRSRETLFTGWVGLRGAVSILLAILPGLAGIENGSFYFNVVFVM
HHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
VLVSLLVQGWTIQPAAKLLKMSLPSEQGLVDRVELELRGATEMELVGYKIHPDSAIAKGE
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHEEEEECCCCCEEEEEEEECCCHHHHCCC
RVPRWARPVMVIRDGLSYSVHTIGPLQANDQVYLFASARRVRLLDQIYASPWDEMTVESD
CCCHHHCCHHEEECCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCEECCC
IQFRVKGATKMSDLVRQYGLEGIDTSDAVTASQFLDRSFDGKPVLGDRVTIGDVDIVVCA
CEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEE
LDDAGGVGTVGIVIGEEDPGAGALMADLVRRGGARIAGLVRRPKPISAGPAESAPAKDIG
ECCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCC
DQA
CCC
>Mature Secondary Structure 
ALAALTSLVSQRFGAPLLLVFLGIGLLAGEDGLLGIQFDSGSAAYFIGSLALAIILFDS
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCC
GFETPMRSYKVAAAPALSLATFGVVLTAGLTGVAAHFLFGVGWLEAFLLGSIVASTDAAA
CCCCHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VFFLLRAGGIRLREKVGSTLEIESGANDPMAIFLTILLIELIVADAGTDALFGFEVLMTF
HHHHHHCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VQQMGLGILFGIVGGFGISWFLHKLVNVDPGLYPISGLAAALVVFSVCALLGGSGFLAAY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
VAGVVAGNRKVKFAHRLRRFQVGMTWLAQIGMFLALGLLATPSEFPRILVPALILAGVLI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FVARPLAVWLCLLPFDFRSRETLFTGWVGLRGAVSILLAILPGLAGIENGSFYFNVVFVM
HHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
VLVSLLVQGWTIQPAAKLLKMSLPSEQGLVDRVELELRGATEMELVGYKIHPDSAIAKGE
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHEEEEECCCCCEEEEEEEECCCHHHHCCC
RVPRWARPVMVIRDGLSYSVHTIGPLQANDQVYLFASARRVRLLDQIYASPWDEMTVESD
CCCHHHCCHHEEECCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCEECCC
IQFRVKGATKMSDLVRQYGLEGIDTSDAVTASQFLDRSFDGKPVLGDRVTIGDVDIVVCA
CEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEE
LDDAGGVGTVGIVIGEEDPGAGALMADLVRRGGARIAGLVRRPKPISAGPAESAPAKDIG
ECCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCC
DQA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA