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The map label for this gene is hutU

Identifier: 114799077

GI number: 114799077

Start: 2503594

End: 2505261

Strand: Direct

Name: hutU

Synonym: HNE_2398

Alternate gene names: 114799077

Gene position: 2503594-2505261 (Clockwise)

Preceding gene: 114800063

Following gene: 114800498

Centisome position: 67.57

GC content: 61.03

Gene sequence:

>1668_bases
ATGCCCTATCCTGCAAATGTCCGCGAAATCCGCGCACCACGGGGCACGACGCTGAATACCCAAAGCTGGCTTACCGAAGC
GCCGCTCCGGATGCTGATGAATAACCTTGATCCCGATGTGGCCGAACGTCCGGAAGACTTGGTCGTCTATGGCGGTATAG
GTCGCGCCGCCCGCAACTGGGAAGCCTTTGACGCGATTGTTGCCGCGCTCAAACGCCTGAAAGAAGACGAAACGCTCCTG
ATCCAGTCCGGCAAACCCGTCGGCGTCTTCCGTACTCATGCGGATGCACCTCGCGTGCTTCTGGCAAATTCAAACCTCGT
TCCCAGATGGGCAAACTGGGACCATTTCAACGAGCTCGACCGCAAGGGGCTCATGATGTACGGCCAGATGACCGCGGGTA
GCTGGATATACATTGGCGCTCAGGGCATCGTTCAGGGAACGTATGAAACCTTTGTCGAAATGGGCCGGCAGCACCATGGC
GGAAATCTCAAGGGCAAATGGCTTCTGACGGCCGGTCTGGGCGGCATGGGCGGCGCTCAACCACTTGCCTCGGTTATGGC
AGGGACAGCCTGCCTTGCCATAGAATGCCAGCCTTCCAGCATCGAGATGCGGATGCGGACTGGCTACCTCGATGCGTGGA
CGGACGACCTTGAGAAGGCCCTCGCCATGATCGACGAGAGCTGCGCCTCCGGTACGCCCAAATCCGTCGGGCTGTTGGGG
AACGCCTGCGAAATTCTGCCGAAGATTCTGGAGCTTGGCCGCCTGCCAGACCTCCTGACCGACCAGACTTCGGCGCACGA
TCCGGTCAATGGATACCTACCCGAGGATTGGAACGTGGAAGACTGGAAGGCGCGCCGCCTCAGCGATCCCAAAGCTGTGG
AAAAAGCGGCGCGTGCCTCCATGGCCAAACATGTCCGCGCGATGCTTGAATTCCAGAGGCGCGGCGTGCCCACGGTCGAT
TATGGCAACAACATCCGTCAGGTCGCGCTGGATGAAGGCGTCGCTGATGCCTTCGATTTTCCAGGTTTCGTGCCCGCCTA
TATCCGCCCGCTTTTCTGCCGGGGCATCGGCCCCTTTCGCTGGGCGGCACTCTCGGGTGATCCGGAAGACATCTACCGCA
CGGACCAGAAGGTGAAGGAACTCATCCCCGACAACCCTCATCTCCACACCTGGCTGGACATGGCGCGTGAACGGATCAAG
TTCCAGGGTCTCCCCGCACGCATCTGCTGGGTTGGCTTGGGGGATCGCCACCGCCTCGGCCTCGCCTTCAATGAGATGGT
TGCCAGCGGCGAGCTGAAAGCCCCCGTTGTCATTGGGCGCGATCATCTCGATTCCGGTTCGGTGGCATCGCCCAACCGGG
AAACCGAAGCGATGCGCGACGGTTCTGACGCGGTATCAGACTGGCCACTCCTGAATGCGCTGCTCAACTGCGCTTCGGGC
GCAACATGGGTGTCTTTGCATCACGGCGGCGGCGTGGGCATGGGCTATTCCCAACATGCTGGCATGGTCATCTGCTGTGA
TGGCACGGAGGCCGCCGCCCGCCGCATAGAACGCGTCCTGTGGAATGACCCTGCCAGCGGCGTCATGCGCCATGCCGATG
CCGGCTATGACATTGCCATCGACAGTGCACGCGAACATGGCCTGGACCTGCCCAGCCTGAAGGGGTGA

Upstream 100 bases:

>100_bases
TTCCTTTCGATGCGGACTATGCCGCCCCCATGACAGACATCCTGAAACAGGTGCTAGGCGCCTGTCTCGCCTTTGCCGAA
AACGCCTGAGGAGACTGCCG

Downstream 100 bases:

>100_bases
GAAAATCCCTGATTTACGCCGGATTTCCGGCGTAAGTCAGGGGGTCCGTTTCAAACCCCAAGTCTTCTGCTTTCTTCAGG
ATACGGTCAATCATCGCCTT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MPYPANVREIRAPRGTTLNTQSWLTEAPLRMLMNNLDPDVAERPEDLVVYGGIGRAARNWEAFDAIVAALKRLKEDETLL
IQSGKPVGVFRTHADAPRVLLANSNLVPRWANWDHFNELDRKGLMMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHHG
GNLKGKWLLTAGLGGMGGAQPLASVMAGTACLAIECQPSSIEMRMRTGYLDAWTDDLEKALAMIDESCASGTPKSVGLLG
NACEILPKILELGRLPDLLTDQTSAHDPVNGYLPEDWNVEDWKARRLSDPKAVEKAARASMAKHVRAMLEFQRRGVPTVD
YGNNIRQVALDEGVADAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYRTDQKVKELIPDNPHLHTWLDMARERIK
FQGLPARICWVGLGDRHRLGLAFNEMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNCASG
ATWVSLHHGGGVGMGYSQHAGMVICCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAIDSAREHGLDLPSLKG

Sequences:

>Translated_555_residues
MPYPANVREIRAPRGTTLNTQSWLTEAPLRMLMNNLDPDVAERPEDLVVYGGIGRAARNWEAFDAIVAALKRLKEDETLL
IQSGKPVGVFRTHADAPRVLLANSNLVPRWANWDHFNELDRKGLMMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHHG
GNLKGKWLLTAGLGGMGGAQPLASVMAGTACLAIECQPSSIEMRMRTGYLDAWTDDLEKALAMIDESCASGTPKSVGLLG
NACEILPKILELGRLPDLLTDQTSAHDPVNGYLPEDWNVEDWKARRLSDPKAVEKAARASMAKHVRAMLEFQRRGVPTVD
YGNNIRQVALDEGVADAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYRTDQKVKELIPDNPHLHTWLDMARERIK
FQGLPARICWVGLGDRHRLGLAFNEMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNCASG
ATWVSLHHGGGVGMGYSQHAGMVICCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAIDSAREHGLDLPSLKG
>Mature_554_residues
PYPANVREIRAPRGTTLNTQSWLTEAPLRMLMNNLDPDVAERPEDLVVYGGIGRAARNWEAFDAIVAALKRLKEDETLLI
QSGKPVGVFRTHADAPRVLLANSNLVPRWANWDHFNELDRKGLMMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHHGG
NLKGKWLLTAGLGGMGGAQPLASVMAGTACLAIECQPSSIEMRMRTGYLDAWTDDLEKALAMIDESCASGTPKSVGLLGN
ACEILPKILELGRLPDLLTDQTSAHDPVNGYLPEDWNVEDWKARRLSDPKAVEKAARASMAKHVRAMLEFQRRGVPTVDY
GNNIRQVALDEGVADAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYRTDQKVKELIPDNPHLHTWLDMARERIKF
QGLPARICWVGLGDRHRLGLAFNEMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNCASGA
TWVSLHHGGGVGMGYSQHAGMVICCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAIDSAREHGLDLPSLKG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=579, Percent_Identity=34.1968911917098, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI260306182, Length=214, Percent_Identity=39.7196261682243, Blast_Score=164, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71997891, Length=554, Percent_Identity=34.6570397111913, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_HYPNA (Q0BZK0)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761093.1
- ProteinModelPortal:   Q0BZK0
- SMR:   Q0BZK0
- STRING:   Q0BZK0
- GeneID:   4287731
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2398
- NMPDR:   fig|228405.5.peg.2312
- TIGR:   HNE_2398
- eggNOG:   COG2987
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   HNEP81032:HNE_2398-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60777; Mature: 60646

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYPANVREIRAPRGTTLNTQSWLTEAPLRMLMNNLDPDVAERPEDLVVYGGIGRAARNW
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCHHCCH
EAFDAIVAALKRLKEDETLLIQSGKPVGVFRTHADAPRVLLANSNLVPRWANWDHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHH
RKGLMMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHHGGNLKGKWLLTAGLGGMGGAQ
HCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHH
PLASVMAGTACLAIECQPSSIEMRMRTGYLDAWTDDLEKALAMIDESCASGTPKSVGLLG
HHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
NACEILPKILELGRLPDLLTDQTSAHDPVNGYLPEDWNVEDWKARRLSDPKAVEKAARAS
HHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
MAKHVRAMLEFQRRGVPTVDYGNNIRQVALDEGVADAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCHHHHCCCCCCHHHHHHHHHCCCCCCE
WAALSGDPEDIYRTDQKVKELIPDNPHLHTWLDMARERIKFQGLPARICWVGLGDRHRLG
EEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEC
LAFNEMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNCASG
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHCCHHHHHHHHHCCC
ATWVSLHHGGGVGMGYSQHAGMVICCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAI
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEE
DSAREHGLDLPSLKG
CCHHHCCCCCCCCCC
>Mature Secondary Structure 
PYPANVREIRAPRGTTLNTQSWLTEAPLRMLMNNLDPDVAERPEDLVVYGGIGRAARNW
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCHHCCH
EAFDAIVAALKRLKEDETLLIQSGKPVGVFRTHADAPRVLLANSNLVPRWANWDHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHH
RKGLMMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHHGGNLKGKWLLTAGLGGMGGAQ
HCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHH
PLASVMAGTACLAIECQPSSIEMRMRTGYLDAWTDDLEKALAMIDESCASGTPKSVGLLG
HHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
NACEILPKILELGRLPDLLTDQTSAHDPVNGYLPEDWNVEDWKARRLSDPKAVEKAARAS
HHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
MAKHVRAMLEFQRRGVPTVDYGNNIRQVALDEGVADAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCHHHHCCCCCCHHHHHHHHHCCCCCCE
WAALSGDPEDIYRTDQKVKELIPDNPHLHTWLDMARERIKFQGLPARICWVGLGDRHRLG
EEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEC
LAFNEMVASGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNCASG
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHCCHHHHHHHHHCCC
ATWVSLHHGGGVGMGYSQHAGMVICCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAI
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEE
DSAREHGLDLPSLKG
CCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA