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The map label for this gene is dinB [H]

Identifier: 114798874

GI number: 114798874

Start: 2387408

End: 2388682

Strand: Direct

Name: dinB [H]

Synonym: HNE_2286

Alternate gene names: 114798874

Gene position: 2387408-2388682 (Clockwise)

Preceding gene: 114798587

Following gene: 114798769

Centisome position: 64.44

GC content: 63.69

Gene sequence:

>1275_bases
ATGTCGAGTCTTTGCCGCGATTGCCAGTACAGGTCCGAGGCGGAACTCACCGCCTGCCCCGCCTGTGGCAGCCGCAGGAT
CGTCTCTCACGCCGCCCTTTTCAGCCTGACAATCGCGCATGTGGACTGTGACGCCTTCTACGCTTCTGTAGAAAAGCGAG
ATAATCCAACGCTTAAGGACAAGCCCCTGATCGTGGGCGGAGGCCAGCGGGGCGTGGTGACGACCTGCTGCTACATTGCC
CGGCTTTATGGCGTGCGCTCGGCCATGCCCATGTTCAAGGCACTGAAAGCCTGCCCGGACGCGGTTGTGGTGCCGCCAGA
CTTCCGGAAATACCGGGAAGCGGCCAAAGCGATTCGCGCCGAAATGGACCATCTCACGCCCCTCGTGCAGCAGGTTTCCA
TCGATGAGGCCTATCTGGACCTGTCCGGAACGGACCGCCTCCACGGCGCCCCGCCGGCTGCCAGCCTCGCCCGGCTGGCC
AAAAACGTGGAACGGGAAGTGGGCGTGACGGTCTCCGTCGGCCTCTCCTCCAACAAATTCCTCGCCAAGACGGCCAGCGA
ACTCGACAAGCCGCGCGGCTTTGCCATCATCGCGCCGGAGGAGGCCGAAGCCTTCCTGGCACCCCATCCGGTCGGCTTCC
TGCACGGGGTTGGCCCGAAATTCGCCGAGTCGCTTAACAAGGACGGCTTCTACACCATTGAGGACATCCAGAAGGCGGAC
CTTAAAAGCCTGATCCGGCGCTATGGCGAAACCGGCGACTGGCTCAAACGCTGCGCCCATGGCCGAGACAACCGGAAAGT
GAACCCGCATGAAGACCGCAAATCGGTCTCCAGCGAGACGACCTTCTTCGAGGACACTGCCGACATCGGCATTCTGGAGG
ATCACCTCTGGCGCCTCAGCGTGAAAACCGCTGACCGGGCCAAGGCCGAAGGCGTCTCAGGCCGCGTGGTGACGCTGAAA
CTGAAAACCTCAGACTTCCACCCGCTGACCCGCCGCCTGTCCCTCACCGAGCCGACACAGCTGGCCCAGGTGGTGTTCCG
GGCGTCCCGGCCCCTGCTGCTGAAGGAAGCCACCGGCCGCGTGAAATACCGGCTGATCGGCGTTGGCCTGTCAGACCTGT
CGGACTTCCGCGCTGATGGCACCGATCTCATCGACCCCAAAGTCGCCAAACGCGCCGCCGCCGAACGCGCCTCCGACCAG
GCCCGCGCCAAGTTCGGCACCGGCGCTGTCGTGACCGGACGAGCTGCAAAATACATCCGGAAACCTGAGGGCTGA

Upstream 100 bases:

>100_bases
GCGCCAGCTTCAGCTATACTGCAAATTATTAACGCGCCTTTACGCCTGCCGCAGGGCGTGTTTGCGGCGACGGCGGGAAC
ATGGCAGGAACACGTCTGTC

Downstream 100 bases:

>100_bases
CTCTGCCTTTGCGGCAGGTTAGGACGGGCGCGAAGACTTTACAGGAGCTGCCCCCATGTCCACGCCCGAAGCCCGCCTTG
AAGCCCTTGGCATCGTTCTG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSSLCRDCQYRSEAELTACPACGSRRIVSHAALFSLTIAHVDCDAFYASVEKRDNPTLKDKPLIVGGGQRGVVTTCCYIA
RLYGVRSAMPMFKALKACPDAVVVPPDFRKYREAAKAIRAEMDHLTPLVQQVSIDEAYLDLSGTDRLHGAPPAASLARLA
KNVEREVGVTVSVGLSSNKFLAKTASELDKPRGFAIIAPEEAEAFLAPHPVGFLHGVGPKFAESLNKDGFYTIEDIQKAD
LKSLIRRYGETGDWLKRCAHGRDNRKVNPHEDRKSVSSETTFFEDTADIGILEDHLWRLSVKTADRAKAEGVSGRVVTLK
LKTSDFHPLTRRLSLTEPTQLAQVVFRASRPLLLKEATGRVKYRLIGVGLSDLSDFRADGTDLIDPKVAKRAAAERASDQ
ARAKFGTGAVVTGRAAKYIRKPEG

Sequences:

>Translated_424_residues
MSSLCRDCQYRSEAELTACPACGSRRIVSHAALFSLTIAHVDCDAFYASVEKRDNPTLKDKPLIVGGGQRGVVTTCCYIA
RLYGVRSAMPMFKALKACPDAVVVPPDFRKYREAAKAIRAEMDHLTPLVQQVSIDEAYLDLSGTDRLHGAPPAASLARLA
KNVEREVGVTVSVGLSSNKFLAKTASELDKPRGFAIIAPEEAEAFLAPHPVGFLHGVGPKFAESLNKDGFYTIEDIQKAD
LKSLIRRYGETGDWLKRCAHGRDNRKVNPHEDRKSVSSETTFFEDTADIGILEDHLWRLSVKTADRAKAEGVSGRVVTLK
LKTSDFHPLTRRLSLTEPTQLAQVVFRASRPLLLKEATGRVKYRLIGVGLSDLSDFRADGTDLIDPKVAKRAAAERASDQ
ARAKFGTGAVVTGRAAKYIRKPEG
>Mature_423_residues
SSLCRDCQYRSEAELTACPACGSRRIVSHAALFSLTIAHVDCDAFYASVEKRDNPTLKDKPLIVGGGQRGVVTTCCYIAR
LYGVRSAMPMFKALKACPDAVVVPPDFRKYREAAKAIRAEMDHLTPLVQQVSIDEAYLDLSGTDRLHGAPPAASLARLAK
NVEREVGVTVSVGLSSNKFLAKTASELDKPRGFAIIAPEEAEAFLAPHPVGFLHGVGPKFAESLNKDGFYTIEDIQKADL
KSLIRRYGETGDWLKRCAHGRDNRKVNPHEDRKSVSSETTFFEDTADIGILEDHLWRLSVKTADRAKAEGVSGRVVTLKL
KTSDFHPLTRRLSLTEPTQLAQVVFRASRPLLLKEATGRVKYRLIGVGLSDLSDFRADGTDLIDPKVAKRAAAERASDQA
RAKFGTGAVVTGRAAKYIRKPEG

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=338, Percent_Identity=27.810650887574, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI7705344, Length=109, Percent_Identity=47.7064220183486, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI7706681, Length=339, Percent_Identity=27.4336283185841, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI154350220, Length=287, Percent_Identity=29.616724738676, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI5729982, Length=138, Percent_Identity=34.0579710144928, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1786425, Length=251, Percent_Identity=42.6294820717131, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1787432, Length=393, Percent_Identity=23.6641221374046, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193205700, Length=393, Percent_Identity=30.2798982188295, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193205702, Length=345, Percent_Identity=28.4057971014493, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17537959, Length=196, Percent_Identity=27.5510204081633, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534089, Length=121, Percent_Identity=34.7107438016529, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324921, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355641, Length=282, Percent_Identity=30.8510638297872, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644984, Length=282, Percent_Identity=30.8510638297872, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19923006, Length=347, Percent_Identity=25.6484149855908, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 46381; Mature: 46249

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLCRDCQYRSEAELTACPACGSRRIVSHAALFSLTIAHVDCDAFYASVEKRDNPTLKD
CCHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
KPLIVGGGQRGVVTTCCYIARLYGVRSAMPMFKALKACPDAVVVPPDFRKYREAAKAIRA
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHH
EMDHLTPLVQQVSIDEAYLDLSGTDRLHGAPPAASLARLAKNVEREVGVTVSVGLSSNKF
HHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCH
LAKTASELDKPRGFAIIAPEEAEAFLAPHPVGFLHGVGPKFAESLNKDGFYTIEDIQKAD
HHHHHHHHCCCCCEEEECCCCCCCEECCCCCHHHHCCCHHHHHHCCCCCCEEHHHHHHHH
LKSLIRRYGETGDWLKRCAHGRDNRKVNPHEDRKSVSSETTFFEDTADIGILEDHLWRLS
HHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEECCCCCCCHHHHHHEEEE
VKTADRAKAEGVSGRVVTLKLKTSDFHPLTRRLSLTEPTQLAQVVFRASRPLLLKEATGR
ECCCHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCC
VKYRLIGVGLSDLSDFRADGTDLIDPKVAKRAAAERASDQARAKFGTGAVVTGRAAKYIR
EEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHC
KPEG
CCCC
>Mature Secondary Structure 
SSLCRDCQYRSEAELTACPACGSRRIVSHAALFSLTIAHVDCDAFYASVEKRDNPTLKD
CHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
KPLIVGGGQRGVVTTCCYIARLYGVRSAMPMFKALKACPDAVVVPPDFRKYREAAKAIRA
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHH
EMDHLTPLVQQVSIDEAYLDLSGTDRLHGAPPAASLARLAKNVEREVGVTVSVGLSSNKF
HHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCH
LAKTASELDKPRGFAIIAPEEAEAFLAPHPVGFLHGVGPKFAESLNKDGFYTIEDIQKAD
HHHHHHHHCCCCCEEEECCCCCCCEECCCCCHHHHCCCHHHHHHCCCCCCEEHHHHHHHH
LKSLIRRYGETGDWLKRCAHGRDNRKVNPHEDRKSVSSETTFFEDTADIGILEDHLWRLS
HHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCEECCCCCCCHHHHHHEEEE
VKTADRAKAEGVSGRVVTLKLKTSDFHPLTRRLSLTEPTQLAQVVFRASRPLLLKEATGR
ECCCHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCC
VKYRLIGVGLSDLSDFRADGTDLIDPKVAKRAAAERASDQARAKFGTGAVVTGRAAKYIR
EEEEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHC
KPEG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]