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The map label for this gene is melB [C]

Identifier: 114798723

GI number: 114798723

Start: 614791

End: 616302

Strand: Direct

Name: melB [C]

Synonym: HNE_0615

Alternate gene names: 114798723

Gene position: 614791-616302 (Clockwise)

Preceding gene: 114797799

Following gene: 114798362

Centisome position: 16.59

GC content: 61.84

Gene sequence:

>1512_bases
ATGGCGTCGCCCGTCCTCCCTGCTTCTGGCGCCGCAGTTTGCGTGGCATCGGCGCCACGTCAAGCGAGGGCGCAGCTAAA
AAATGACTTGGCCGTCACCTTCGCTCAAGGCAGTGTGCGCGCCATGTCCCAGTCCCCCACCAAGCGTTTGTCGTTCCCGC
GAGTGCTCGCCTTTGCCTCGCTCAGCATTCCCATTGCCGGGGTCGGCCTGCCGCTGGGGGTCTACCTCGCGCCGCTCTAT
GCCAATGAAGCGCCTCATGGGGTTGGCCTCGGTCTGGAGCTGACCGGGCTCCTCTTCATGCTGCTGCGCTTCTGGGACAT
CTTCACCGATCCGATCATGGGCTACATGGTCGACCGCTACCGCACGCCGCTCGGGCGTGTGCGCCACTGGATCATCCTCT
GTGTACCGATCCTCGGCATCTCCACCTTCTTTGTCTACATGCCGCCGGCCGGGGCAGGACCCGTCTACTTCATCGGCTGG
ATGCTGCTGTTCTATGTCGGTTTCACGCTGCTCCAGACGTCACGCTCCTCCTGGGTGCCGGCCATTGCCAGCGATTATGA
CGACCGCTCACGGCTGTTCCTCTGGCCAGAGATCGTATCGGTGTTTGCCATGCTGGCTTTGCTGGCTACGCCGCTGATCC
TCTCCACGATTGGGGTGGAGGCAGACAGGTTCGGGCAGGTGGCCGTCATGGGCTGGGTGATGATTATCGCCCTGCCGATT
GCGGTGGCGCTGTCGTGTTTCTTCGTGCCCGATCCGCCTTTGCGGGGGGAGTCCAAACAGGTTGAGAAATTCGAGCTGCG
CCCGCTGCTGCAAGCCATTCGCGGGCCGATGTTCAGCCGCCTCCTGACGATTGAGCTGCTTGTATCGACGGCCATTTCAG
TGACGGCCGCAAACTTCCTCTTCGTCGCCGAATATGCGTTTGGCGCCAATGACGCGCAGACCAGCCTGACGCTGATGCTG
TTCTTCGTCATGGCCATCATCGCGCTGCCCTTCTGGCTCTGGCTGGCCAAGAAAACCGAAAAGCGGACCGCCTATTTCAT
CGCCACCACCTTTTCCGGTATCGCCTTCATCGCCTTCATTCCGCTGGCGCCCTATGGCAATTTCACGACCTTCCTGATCG
CCTCGCTGATTGCGGGCATCCCGTTCAGCGCGCCGATCTTCCTCGCCCGCGCGATGACGGCCGATGTCGTTGAATGGCAG
GCCGCAGAGACCGGGGAAAACCGCGCCGGTAATTTCTATGCGCTGCTGACGAGCTTCAACAAAGTTGGCTCCAGCCTCGC
CTTTGGTGTGGGCTATTTCATTGTTGGCCGGATCGCCGGTTTCCGCCCCGGCCAGGAAAATTCCGACGCGGCGATCTTTG
GTCTTGTCATGGTGTTCGGTTTCCTGCCGGGTCTGCTCTACCTGCTCGCCGGTTTCCTGGCGCGCGGCTATCCGCTGACC
CGCGCTGTGCAGGAAGAAACGGCCCGCAAGCTTGAGGGCCGGATAGAGGTCGCGCCCCCTCCGGTGATCTGA

Upstream 100 bases:

>100_bases
GCCACCGACAGGGTCGGCCCCATAGCTCGCGGTACGGAACAGAACGACGGCAATGATGATGCCGATGATGGCGCCAAGGC
CAACCAGTATATTGCGGATC

Downstream 100 bases:

>100_bases
AGGGCGGTTATCTGAAACCTAGAAGCCACCGCCCTCGGCGAGCCATTCCTTTTCGTCCGGGGTGCTTTCGCGGCCGACCA
CATCGTTGCGATGCGGGAAG

Product: major facilitator transporter

Products: Li (I) [Cytoplasm]; melibiose [Cytoplasm]; Na (I) [Cytoplasm]; melibiose [Cytoplasm]; Proton [Cytoplasm]; melibiose [Cytoplasm] [C]

Alternate protein names: Sugar Transporter; Facilitator Superfamily Protein; SodiumGalactoside Symporter Family Protein; Sugar Transporter Subfamily; Sugar Symporter; Melibiose Carrier Protein; Facilitator Superfamily Transporter; Na+/Melibiose Symporter And Related Transporter Protein; MelibioseSodium Symporter; Oligogalacturonide Transporter; Polysaccharide Deacetylase; SodiumGalactoside Symporter Protein; SugarCation Symporter; Glycoside/Pentoside/HexuronideCation Symporter GPH Family; Xylose-Proton Symporter; Facilitator Family Transporter; Facilitator Superfamily Permease; SodiumGlactoside Symporter Family Protein

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MASPVLPASGAAVCVASAPRQARAQLKNDLAVTFAQGSVRAMSQSPTKRLSFPRVLAFASLSIPIAGVGLPLGVYLAPLY
ANEAPHGVGLGLELTGLLFMLLRFWDIFTDPIMGYMVDRYRTPLGRVRHWIILCVPILGISTFFVYMPPAGAGPVYFIGW
MLLFYVGFTLLQTSRSSWVPAIASDYDDRSRLFLWPEIVSVFAMLALLATPLILSTIGVEADRFGQVAVMGWVMIIALPI
AVALSCFFVPDPPLRGESKQVEKFELRPLLQAIRGPMFSRLLTIELLVSTAISVTAANFLFVAEYAFGANDAQTSLTLML
FFVMAIIALPFWLWLAKKTEKRTAYFIATTFSGIAFIAFIPLAPYGNFTTFLIASLIAGIPFSAPIFLARAMTADVVEWQ
AAETGENRAGNFYALLTSFNKVGSSLAFGVGYFIVGRIAGFRPGQENSDAAIFGLVMVFGFLPGLLYLLAGFLARGYPLT
RAVQEETARKLEGRIEVAPPPVI

Sequences:

>Translated_503_residues
MASPVLPASGAAVCVASAPRQARAQLKNDLAVTFAQGSVRAMSQSPTKRLSFPRVLAFASLSIPIAGVGLPLGVYLAPLY
ANEAPHGVGLGLELTGLLFMLLRFWDIFTDPIMGYMVDRYRTPLGRVRHWIILCVPILGISTFFVYMPPAGAGPVYFIGW
MLLFYVGFTLLQTSRSSWVPAIASDYDDRSRLFLWPEIVSVFAMLALLATPLILSTIGVEADRFGQVAVMGWVMIIALPI
AVALSCFFVPDPPLRGESKQVEKFELRPLLQAIRGPMFSRLLTIELLVSTAISVTAANFLFVAEYAFGANDAQTSLTLML
FFVMAIIALPFWLWLAKKTEKRTAYFIATTFSGIAFIAFIPLAPYGNFTTFLIASLIAGIPFSAPIFLARAMTADVVEWQ
AAETGENRAGNFYALLTSFNKVGSSLAFGVGYFIVGRIAGFRPGQENSDAAIFGLVMVFGFLPGLLYLLAGFLARGYPLT
RAVQEETARKLEGRIEVAPPPVI
>Mature_502_residues
ASPVLPASGAAVCVASAPRQARAQLKNDLAVTFAQGSVRAMSQSPTKRLSFPRVLAFASLSIPIAGVGLPLGVYLAPLYA
NEAPHGVGLGLELTGLLFMLLRFWDIFTDPIMGYMVDRYRTPLGRVRHWIILCVPILGISTFFVYMPPAGAGPVYFIGWM
LLFYVGFTLLQTSRSSWVPAIASDYDDRSRLFLWPEIVSVFAMLALLATPLILSTIGVEADRFGQVAVMGWVMIIALPIA
VALSCFFVPDPPLRGESKQVEKFELRPLLQAIRGPMFSRLLTIELLVSTAISVTAANFLFVAEYAFGANDAQTSLTLMLF
FVMAIIALPFWLWLAKKTEKRTAYFIATTFSGIAFIAFIPLAPYGNFTTFLIASLIAGIPFSAPIFLARAMTADVVEWQA
AETGENRAGNFYALLTSFNKVGSSLAFGVGYFIVGRIAGFRPGQENSDAAIFGLVMVFGFLPGLLYLLAGFLARGYPLTR
AVQEETARKLEGRIEVAPPPVI

Specific function: Responsible For Melibiose Transport. It Is Capable Of Using Hydrogen, Sodium, And Lithium Cations As Coupling Cations For Cotransport, Depending On The Particular Sugar Transported (Symport System). [C]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI42713696, Length=484, Percent_Identity=21.900826446281, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI211063479, Length=430, Percent_Identity=22.093023255814, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790561, Length=435, Percent_Identity=22.2988505747126, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 54738; Mature: 54607

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPVLPASGAAVCVASAPRQARAQLKNDLAVTFAQGSVRAMSQSPTKRLSFPRVLAFAS
CCCCCCCCCCCEEEEECCCHHHHHHHHCCCEEEEECCCHHHHHCCCHHHCCCHHHHHHHH
LSIPIAGVGLPLGVYLAPLYANEAPHGVGLGLELTGLLFMLLRFWDIFTDPIMGYMVDRY
HCCCEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTPLGRVRHWIILCVPILGISTFFVYMPPAGAGPVYFIGWMLLFYVGFTLLQTSRSSWVP
CCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIASDYDDRSRLFLWPEIVSVFAMLALLATPLILSTIGVEADRFGQVAVMGWVMIIALPI
HHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHH
AVALSCFFVPDPPLRGESKQVEKFELRPLLQAIRGPMFSRLLTIELLVSTAISVTAANFL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
FVAEYAFGANDAQTSLTLMLFFVMAIIALPFWLWLAKKTEKRTAYFIATTFSGIAFIAFI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHH
PLAPYGNFTTFLIASLIAGIPFSAPIFLARAMTADVVEWQAAETGENRAGNFYALLTSFN
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KVGSSLAFGVGYFIVGRIAGFRPGQENSDAAIFGLVMVFGFLPGLLYLLAGFLARGYPLT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RAVQEETARKLEGRIEVAPPPVI
HHHHHHHHHHHCCEEECCCCCCC
>Mature Secondary Structure 
ASPVLPASGAAVCVASAPRQARAQLKNDLAVTFAQGSVRAMSQSPTKRLSFPRVLAFAS
CCCCCCCCCCEEEEECCCHHHHHHHHCCCEEEEECCCHHHHHCCCHHHCCCHHHHHHHH
LSIPIAGVGLPLGVYLAPLYANEAPHGVGLGLELTGLLFMLLRFWDIFTDPIMGYMVDRY
HCCCEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTPLGRVRHWIILCVPILGISTFFVYMPPAGAGPVYFIGWMLLFYVGFTLLQTSRSSWVP
CCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
AIASDYDDRSRLFLWPEIVSVFAMLALLATPLILSTIGVEADRFGQVAVMGWVMIIALPI
HHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHH
AVALSCFFVPDPPLRGESKQVEKFELRPLLQAIRGPMFSRLLTIELLVSTAISVTAANFL
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
FVAEYAFGANDAQTSLTLMLFFVMAIIALPFWLWLAKKTEKRTAYFIATTFSGIAFIAFI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHH
PLAPYGNFTTFLIASLIAGIPFSAPIFLARAMTADVVEWQAAETGENRAGNFYALLTSFN
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KVGSSLAFGVGYFIVGRIAGFRPGQENSDAAIFGLVMVFGFLPGLLYLLAGFLARGYPLT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RAVQEETARKLEGRIEVAPPPVI
HHHHHHHHHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Li (I) [Periplasm]; melibiose [Periplasm]; Na (I) [Periplasm]; melibiose [Periplasm]; Proton [Periplasm]; melibiose [Periplasm] [C]

Specific reaction: Li (I) [Periplasm] + melibiose [Periplasm] = Li (I) [Cytoplasm] + melibiose [Cytoplasm] Na (I) [Periplasm] + melibiose [Periplasm] = Na (I) [Cytoplasm] + melibiose [Cytoplasm] Proton [Periplasm] + melibiose [Periplasm] = Proton [Cytoplasm] + melibiose [Cy

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA