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The map label for this gene is gdhII [H]

Identifier: 114798493

GI number: 114798493

Start: 2452659

End: 2453417

Strand: Direct

Name: gdhII [H]

Synonym: HNE_2353

Alternate gene names: 114798493

Gene position: 2452659-2453417 (Clockwise)

Preceding gene: 114798122

Following gene: 114799117

Centisome position: 66.2

GC content: 62.98

Gene sequence:

>759_bases
ATGCCAGACCAGAAACGACCGGACAGAAACGCCACCTGCGCCATCATCGGCGCGGGCGATTTCATCGGCTCCGCCATCGC
CCACAAATTCGCGACCGAAGGCTACACCGTATTTGCAGGCCGCCGCACGGCAGAGAAGCTCGAGAAACTGAAAAGCGAGA
TTGAAGCGGCCGGTGGCAAATGCGTCGCGCGCGGCCTGGATGCGCGCAGGGAAGAAGATGTCACCGCCTTCCTGCAAGAG
GCAGACGCTCATGCACCGCTGGAAGTCGTCATCTCCAATCCCGGCGCCAACGTAAACTTCCCCCTGCTCGACACCAGCGA
GCGGGTCTTCTTCAAGGTGTGGGAAATGGCCTGCAAGGCGGGCTTCCTGACTGGCCGGGAGGCGGCCCGTTTGATGCTGG
CGCGTGGCAAGGGCTCAATCTTCTTCACCGGGGCAACTGCCAGCCTGCGCGGCGGATCAGGCTACGCCGCCTTTGCCAGC
GCCAAGGGCGGCCTGCGGCTGCTGGCTCAAGCCATGGCGCGCGAGCTTGGCCCCCAGAACATCCATGTCGCTCACCTCAT
CATCGATGCAGGGGTCGATACAGATTTCGTCCGGGACCGGATCAAGTCTGCTCGCGGCGAAGAAGCGGTTGCCGCTCTGG
CGCCGGACACCCTCATGGAGCCGGCCTCCATCGCCGACGCCTACTGGTATCTCCATCAGCAGAACCGCGATGCCTGGACA
TTCGAGATGGACCTGCGCCCCTATAAGGAAACCTGGTAA

Upstream 100 bases:

>100_bases
CAATTTTCCCGATCAAGTTCCTGCCACTTCATGCATCGCTTTTTATCATTGACTTGGTCTTATTTCAAGACTTACTCATC
GGAAAAAGAGGGAGGCAAAA

Downstream 100 bases:

>100_bases
TGAAAACCGTAGAATTCCAGTTCGATTTCGGCAGCCCGAATGCCTATCTCGCCCACCGCATCATCCCGCAGATCGAAGCG
CGCACCGGCGCCACCTTCGT

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPDQKRPDRNATCAIIGAGDFIGSAIAHKFATEGYTVFAGRRTAEKLEKLKSEIEAAGGKCVARGLDARREEDVTAFLQE
ADAHAPLEVVISNPGANVNFPLLDTSERVFFKVWEMACKAGFLTGREAARLMLARGKGSIFFTGATASLRGGSGYAAFAS
AKGGLRLLAQAMARELGPQNIHVAHLIIDAGVDTDFVRDRIKSARGEEAVAALAPDTLMEPASIADAYWYLHQQNRDAWT
FEMDLRPYKETW

Sequences:

>Translated_252_residues
MPDQKRPDRNATCAIIGAGDFIGSAIAHKFATEGYTVFAGRRTAEKLEKLKSEIEAAGGKCVARGLDARREEDVTAFLQE
ADAHAPLEVVISNPGANVNFPLLDTSERVFFKVWEMACKAGFLTGREAARLMLARGKGSIFFTGATASLRGGSGYAAFAS
AKGGLRLLAQAMARELGPQNIHVAHLIIDAGVDTDFVRDRIKSARGEEAVAALAPDTLMEPASIADAYWYLHQQNRDAWT
FEMDLRPYKETW
>Mature_251_residues
PDQKRPDRNATCAIIGAGDFIGSAIAHKFATEGYTVFAGRRTAEKLEKLKSEIEAAGGKCVARGLDARREEDVTAFLQEA
DAHAPLEVVISNPGANVNFPLLDTSERVFFKVWEMACKAGFLTGREAARLMLARGKGSIFFTGATASLRGGSGYAAFASA
KGGLRLLAQAMARELGPQNIHVAHLIIDAGVDTDFVRDRIKSARGEEAVAALAPDTLMEPASIADAYWYLHQQNRDAWTF
EMDLRPYKETW

Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=189, Percent_Identity=28.042328042328, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=23.9669421487603, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 27394; Mature: 27263

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQKRPDRNATCAIIGAGDFIGSAIAHKFATEGYTVFAGRRTAEKLEKLKSEIEAAGGK
CCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCC
CVARGLDARREEDVTAFLQEADAHAPLEVVISNPGANVNFPLLDTSERVFFKVWEMACKA
EEHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECCEECCCHHHHHHHHHHHHHH
GFLTGREAARLMLARGKGSIFFTGATASLRGGSGYAAFASAKGGLRLLAQAMARELGPQN
CCCCCHHHHHHHEECCCCCEEEECCCEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
IHVAHLIIDAGVDTDFVRDRIKSARGEEAVAALAPDTLMEPASIADAYWYLHQQNRDAWT
EEEEEEEEECCCCHHHHHHHHHHCCCCHHEEHCCCHHHCCCHHHHHHHHEEEECCCCEEE
FEMDLRPYKETW
EEECCCCCCCCC
>Mature Secondary Structure 
PDQKRPDRNATCAIIGAGDFIGSAIAHKFATEGYTVFAGRRTAEKLEKLKSEIEAAGGK
CCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCC
CVARGLDARREEDVTAFLQEADAHAPLEVVISNPGANVNFPLLDTSERVFFKVWEMACKA
EEHHCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECCEECCCHHHHHHHHHHHHHH
GFLTGREAARLMLARGKGSIFFTGATASLRGGSGYAAFASAKGGLRLLAQAMARELGPQN
CCCCCHHHHHHHEECCCCCEEEECCCEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
IHVAHLIIDAGVDTDFVRDRIKSARGEEAVAALAPDTLMEPASIADAYWYLHQQNRDAWT
EEEEEEEEECCCCHHHHHHHHHHCCCCHHEEHCCCHHHCCCHHHHHHHHEEEECCCCEEE
FEMDLRPYKETW
EEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA