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The map label for this gene is lysC [H]

Identifier: 114798362

GI number: 114798362

Start: 617800

End: 619047

Strand: Direct

Name: lysC [H]

Synonym: HNE_0618

Alternate gene names: 114798362

Gene position: 617800-619047 (Clockwise)

Preceding gene: 114798723

Following gene: 114798877

Centisome position: 16.67

GC content: 63.06

Gene sequence:

>1248_bases
ATGGCGCGGACAGTACTCAAATTCGGCGGCACATCGGTCGGCGATCTCGACCGTATTGCGAATGTAGCAGAGATCGTCGC
TGCGCGCGCCGCAAAGGGCGAGAAGATGGCCGTGATTGTCTCGGCCATGTCGGGCGAGACCAACAAGCTGGTTGCCCTGG
CAGACGGGGCGGCAGGCAAGGATCTGCCGCGCAGCCTCTATGATGACGAGTACGACGTGGTCGTCGCCTCGGGCGAGCAG
GTGACCGCAGGGCTTCTCGCGCTGGCGCTGCGCCGCCGGGGGCTGAAAGCCCGCTCCTGGCTCGGCTGGCAGCTGCGCCT
GAAGACCGATAACAGCCATGGCCGCGCTCGCATCATGGGCTTTGACGACAGCTCGCTGCCCGATTCCATCGACAGCGGCG
AGATTGCCGTCGTCGCCGGTTTCCAGGGCGTGACCGATGACTTCCGGGTCACCACGCTCGGCCGGGGCGGGTCTGACACC
AGCGCCGTGGCCGTGGCCGCCGCCCTTGGCGCGCAGGTGTGTGATATCTATACCGATGTGGACGGCGTCTACACGACCGA
CCCCCGCATCGTTCCCAAAGCCCGCCGCATCGACAAGATTTCCTATGAGGAAATGCTCGAAATGGCCTCCCTGGGCGCCA
AAGTGCTTCAGACGCGCTCGGTCGAGCTGGCGATGAACCATGGTGTGCCGGTGCGCGTGCTGTCCAGTTTTGTAAAACCC
GGCGAGGAGAGCCCCGGCACCCTCGTCTGTTCAGAGGAAGAGATCGTGGAAAAACAGGTCGTCAGCGGCGTTGCCTATTC
GCGGGATGAGGCGAAGGTCACCCTCTATGGCGTGCCCGACAAGCCCGGCTCCTCGGCCAAGATCTTCTCTGCGCTCGCCC
GCGCCGGCGTCAATGTGGACATGATCGTCCAGGCCTCCTCGCGCGAAGCCTCCAAGGCGAACCTCGTTTTCACCTGCACC
GACCGCGACAGCCCGTTTGCCCGCGAGACGCTGGAAGGCCTTCAGGCCGAGGTCGGCTATGACCGGATCGAGGTGATCCG
CGACGTGTCGAAGATCTCGATCATCGGCGTCGGCATGAAAAGCCATACCGGCGTTGCCGAAAAGATGTTCACCGCCCTCT
CGGAAAAGAGCATCAACATTGATGTCATCGCCACATCCGAGATCAAGATTTCCGTTCTGATCGCCGCGCCCTATACAGAA
CTGGCGGTCCGGGCACTTCATACAGCATTCGGGCTGGACGCAGACTGA

Upstream 100 bases:

>100_bases
CGCCATTGTTTAGCAATCCTGTTTGATCCCGGCCCGACTTTCTTCTAGAGGGGCCGATAAATGAGCGGGCCTCAAGGGGC
CAGAAGGTATTTGGGGCGAA

Downstream 100 bases:

>100_bases
CGGGTCACCGTAGACCGGGAGAGCATGCCGTATAACCTGCCGGCCACCCGAGTTCTGATGAACAACCTCCGCCAGGTGAT
GGCAGAGGAGGGTGACGCAC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MARTVLKFGGTSVGDLDRIANVAEIVAARAAKGEKMAVIVSAMSGETNKLVALADGAAGKDLPRSLYDDEYDVVVASGEQ
VTAGLLALALRRRGLKARSWLGWQLRLKTDNSHGRARIMGFDDSSLPDSIDSGEIAVVAGFQGVTDDFRVTTLGRGGSDT
SAVAVAAALGAQVCDIYTDVDGVYTTDPRIVPKARRIDKISYEEMLEMASLGAKVLQTRSVELAMNHGVPVRVLSSFVKP
GEESPGTLVCSEEEIVEKQVVSGVAYSRDEAKVTLYGVPDKPGSSAKIFSALARAGVNVDMIVQASSREASKANLVFTCT
DRDSPFARETLEGLQAEVGYDRIEVIRDVSKISIIGVGMKSHTGVAEKMFTALSEKSINIDVIATSEIKISVLIAAPYTE
LAVRALHTAFGLDAD

Sequences:

>Translated_415_residues
MARTVLKFGGTSVGDLDRIANVAEIVAARAAKGEKMAVIVSAMSGETNKLVALADGAAGKDLPRSLYDDEYDVVVASGEQ
VTAGLLALALRRRGLKARSWLGWQLRLKTDNSHGRARIMGFDDSSLPDSIDSGEIAVVAGFQGVTDDFRVTTLGRGGSDT
SAVAVAAALGAQVCDIYTDVDGVYTTDPRIVPKARRIDKISYEEMLEMASLGAKVLQTRSVELAMNHGVPVRVLSSFVKP
GEESPGTLVCSEEEIVEKQVVSGVAYSRDEAKVTLYGVPDKPGSSAKIFSALARAGVNVDMIVQASSREASKANLVFTCT
DRDSPFARETLEGLQAEVGYDRIEVIRDVSKISIIGVGMKSHTGVAEKMFTALSEKSINIDVIATSEIKISVLIAAPYTE
LAVRALHTAFGLDAD
>Mature_414_residues
ARTVLKFGGTSVGDLDRIANVAEIVAARAAKGEKMAVIVSAMSGETNKLVALADGAAGKDLPRSLYDDEYDVVVASGEQV
TAGLLALALRRRGLKARSWLGWQLRLKTDNSHGRARIMGFDDSSLPDSIDSGEIAVVAGFQGVTDDFRVTTLGRGGSDTS
AVAVAAALGAQVCDIYTDVDGVYTTDPRIVPKARRIDKISYEEMLEMASLGAKVLQTRSVELAMNHGVPVRVLSSFVKPG
EESPGTLVCSEEEIVEKQVVSGVAYSRDEAKVTLYGVPDKPGSSAKIFSALARAGVNVDMIVQASSREASKANLVFTCTD
RDSPFARETLEGLQAEVGYDRIEVIRDVSKISIIGVGMKSHTGVAEKMFTALSEKSINIDVIATSEIKISVLIAAPYTEL
AVRALHTAFGLDAD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=472, Percent_Identity=29.0254237288136, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790455, Length=453, Percent_Identity=30.242825607064, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790376, Length=456, Percent_Identity=22.3684210526316, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=368, Percent_Identity=25, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44048; Mature: 43916

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTVLKFGGTSVGDLDRIANVAEIVAARAAKGEKMAVIVSAMSGETNKLVALADGAAGK
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCCCC
DLPRSLYDDEYDVVVASGEQVTAGLLALALRRRGLKARSWLGWQLRLKTDNSHGRARIMG
CCCHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEE
FDDSSLPDSIDSGEIAVVAGFQGVTDDFRVTTLGRGGSDTSAVAVAAALGAQVCDIYTDV
CCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
DGVYTTDPRIVPKARRIDKISYEEMLEMASLGAKVLQTRSVELAMNHGVPVRVLSSFVKP
CCEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCC
GEESPGTLVCSEEEIVEKQVVSGVAYSRDEAKVTLYGVPDKPGSSAKIFSALARAGVNVD
CCCCCCEEEECHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEE
MIVQASSREASKANLVFTCTDRDSPFARETLEGLQAEVGYDRIEVIRDVSKISIIGVGMK
EEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCC
SHTGVAEKMFTALSEKSINIDVIATSEIKISVLIAAPYTELAVRALHTAFGLDAD
CCCCHHHHHHHHHHCCCCEEEEEEECCEEEEEEEECCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARTVLKFGGTSVGDLDRIANVAEIVAARAAKGEKMAVIVSAMSGETNKLVALADGAAGK
CCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCCCC
DLPRSLYDDEYDVVVASGEQVTAGLLALALRRRGLKARSWLGWQLRLKTDNSHGRARIMG
CCCHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEE
FDDSSLPDSIDSGEIAVVAGFQGVTDDFRVTTLGRGGSDTSAVAVAAALGAQVCDIYTDV
CCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
DGVYTTDPRIVPKARRIDKISYEEMLEMASLGAKVLQTRSVELAMNHGVPVRVLSSFVKP
CCEEECCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCC
GEESPGTLVCSEEEIVEKQVVSGVAYSRDEAKVTLYGVPDKPGSSAKIFSALARAGVNVD
CCCCCCEEEECHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEE
MIVQASSREASKANLVFTCTDRDSPFARETLEGLQAEVGYDRIEVIRDVSKISIIGVGMK
EEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCC
SHTGVAEKMFTALSEKSINIDVIATSEIKISVLIAAPYTELAVRALHTAFGLDAD
CCCCHHHHHHHHHHCCCCEEEEEEECCEEEEEEEECCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]