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The map label for this gene is pepQ [H]

Identifier: 114798047

GI number: 114798047

Start: 372504

End: 374315

Strand: Direct

Name: pepQ [H]

Synonym: HNE_0381

Alternate gene names: 114798047

Gene position: 372504-374315 (Clockwise)

Preceding gene: 114798858

Following gene: 114797296

Centisome position: 10.05

GC content: 65.29

Gene sequence:

>1812_bases
ATGAGACAGACATTTGACATCAAGGGCGGGCCGCAGGACGGCCGTACCCATCTTCCGCTTCTTCGCCGCCAGCTCGAGCG
CCAGGGCCTTGATGGCCTCTACGTGCCCCATGACGACGAGTATCAGAACGAATACCTGCCCGACGCGAATGAGCGTCTGG
CCTGGGCGACCGGTTTCACCGGCTCGTTTGGCTCGGCGTTTGTGTTCCTGGACACGGCGGTGCTGTTTGCCGACGGGCGC
TATACGCTGCAGGCCGCCGACCAGACCGATCCGGCGCTGTTTGAGGTGGTGGGCATTCCCGATCCCGGTGCGTTCGGCTG
GCTGGCCCAGCAGGCGCTCAAGGGCAAACGGGTGGGCTATGACGCGCGCCTGATGAGCCCGAATGATGTGGCCGCGCTGG
CCGCGGCGGCGGCAAAGGCCGGGGCCGAGCTGGTGTCGGTTGAGGAAAACCCAATCGATGCGGCCTGGCAGGATCGCCCG
CCCCAGCCGATGGCGAAGGTGGTGCCCCATGCGGTGAAGCATGCCGGCGTTGCCCATACCGACAAGCTGGAAGCGGTCGG
CGCGCAGCTGGCGCGCGACGGGGCGGATGCTGCCGTCTTGACCTCGCCGGCCTCGCTGGCCTGGGCGTTCAATATCCGGG
GCGGAGATGTGAGCTGTACGCCGCTGCCGCTGGGCCGGGCCATTCTCAATGCGGACGGTTCGGCAGAGCTGTTCATTGAT
GAGGAAAAGACCGACGCGGCGCTGCGCCGGCATCTGGGCAACAGGGTGACCCTCCGTCCTCTGAGCAAGCTGGACGAGGG
GCTGAAAGGCCTGGCCGGCAAGACGGTGAGCCTTGACCCGGATGTGGCATCGTCCTGGTTTTTTGACGAGCTGAAGGCAG
CCGGGGCACGGGTGCTGCGCCAGCGCGACCCCGTGGCGATCCCGCGCGCCTGCAAGAATGACGCGGAAATCAAGGGCACG
ACGGCGGCGCACGCACGCGACGGCATTGCGCTGACCCGGTTTCTCCACTGGCTGGATACGGCAGCCCAGAGCGGGGAGGT
GACCGAGATCGAAGCGGTGATGAAGCTGGAAGCGTTCCGTGAGGAACTCGGCTCGATGACCGATCTGTCCTTCCCGTCAA
TCTCCGGCGCAGGGCCCCATGGCGCGCTGCCCCATTACCGTGTCTCGACCGCGTCTGACCGCAAGCTGGAGCGGGGCTCG
CTGTTCCTGATCGATTCGGGCGGGCAGTATCTGGACGGGACAACGGACGTGACCCGGACGGTGCCGATCGGCGAGGCGAC
GGACGAAATGCGCGCCAACTATACCCGCGTGCTGAAGGGGCATATTGCGCTCGCCGCGGTGCGCTTTCCGCCCGGCACTA
CGGGCACGCATCTTGATGTGCTGGCGCGCCATGCCCTCTGGCAGGCCGGGCTGGACTATCAGCACGGCACCGGCCACGGC
GTGGGCGTATATCTGGGCGTGCATGAAGGTCCCCACCGGATCGCCAAGCCGTGGAACGCGGTGCCGCTGATGCCGGGGAT
GATCGTGTCCAACGAGCCGGGCTTCTACAAGGCCGGCGAATACGGCATCCGGATCGAGAATCTGCAATATGTAACGCCTG
CGGAGGATATTCTGGGCGGCGAGATTGCGATGCACGGCTTTGAATGCCTGACCTTTGCCCCGCTCGCGCGGGACCTGATC
GACATCAAGATGCTCTCCAAAGACGAGCGCAAATGGGTGAACGATTACCACAAGCGCGTGATGAAGGTTCTTGGCCGCAA
GCTCGACGGCGAGGTCAAGGAATGGCTGAAGGCGGCGTGTGCCCGAATTTGA

Upstream 100 bases:

>100_bases
GTGCGAGCTAAACAAAACAGTATGGAAAGTGACATTTTTCCATGCGCATTTGCATAGCTCGCTTGCTTCCCGGCGGCGTC
AGATGGCGCTATGAAGGGGC

Downstream 100 bases:

>100_bases
GGCAGCGCCGCTTTTCTGGGCAGGGAAAGCCCCGTTCCATCTTCAGGCGGCGGAGGGGCCGGTCTAATCCTGAGTCTGCT
TGAGGGAGGCAGACTTGGAT

Product: M24 family peptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MRQTFDIKGGPQDGRTHLPLLRRQLERQGLDGLYVPHDDEYQNEYLPDANERLAWATGFTGSFGSAFVFLDTAVLFADGR
YTLQAADQTDPALFEVVGIPDPGAFGWLAQQALKGKRVGYDARLMSPNDVAALAAAAAKAGAELVSVEENPIDAAWQDRP
PQPMAKVVPHAVKHAGVAHTDKLEAVGAQLARDGADAAVLTSPASLAWAFNIRGGDVSCTPLPLGRAILNADGSAELFID
EEKTDAALRRHLGNRVTLRPLSKLDEGLKGLAGKTVSLDPDVASSWFFDELKAAGARVLRQRDPVAIPRACKNDAEIKGT
TAAHARDGIALTRFLHWLDTAAQSGEVTEIEAVMKLEAFREELGSMTDLSFPSISGAGPHGALPHYRVSTASDRKLERGS
LFLIDSGGQYLDGTTDVTRTVPIGEATDEMRANYTRVLKGHIALAAVRFPPGTTGTHLDVLARHALWQAGLDYQHGTGHG
VGVYLGVHEGPHRIAKPWNAVPLMPGMIVSNEPGFYKAGEYGIRIENLQYVTPAEDILGGEIAMHGFECLTFAPLARDLI
DIKMLSKDERKWVNDYHKRVMKVLGRKLDGEVKEWLKAACARI

Sequences:

>Translated_603_residues
MRQTFDIKGGPQDGRTHLPLLRRQLERQGLDGLYVPHDDEYQNEYLPDANERLAWATGFTGSFGSAFVFLDTAVLFADGR
YTLQAADQTDPALFEVVGIPDPGAFGWLAQQALKGKRVGYDARLMSPNDVAALAAAAAKAGAELVSVEENPIDAAWQDRP
PQPMAKVVPHAVKHAGVAHTDKLEAVGAQLARDGADAAVLTSPASLAWAFNIRGGDVSCTPLPLGRAILNADGSAELFID
EEKTDAALRRHLGNRVTLRPLSKLDEGLKGLAGKTVSLDPDVASSWFFDELKAAGARVLRQRDPVAIPRACKNDAEIKGT
TAAHARDGIALTRFLHWLDTAAQSGEVTEIEAVMKLEAFREELGSMTDLSFPSISGAGPHGALPHYRVSTASDRKLERGS
LFLIDSGGQYLDGTTDVTRTVPIGEATDEMRANYTRVLKGHIALAAVRFPPGTTGTHLDVLARHALWQAGLDYQHGTGHG
VGVYLGVHEGPHRIAKPWNAVPLMPGMIVSNEPGFYKAGEYGIRIENLQYVTPAEDILGGEIAMHGFECLTFAPLARDLI
DIKMLSKDERKWVNDYHKRVMKVLGRKLDGEVKEWLKAACARI
>Mature_603_residues
MRQTFDIKGGPQDGRTHLPLLRRQLERQGLDGLYVPHDDEYQNEYLPDANERLAWATGFTGSFGSAFVFLDTAVLFADGR
YTLQAADQTDPALFEVVGIPDPGAFGWLAQQALKGKRVGYDARLMSPNDVAALAAAAAKAGAELVSVEENPIDAAWQDRP
PQPMAKVVPHAVKHAGVAHTDKLEAVGAQLARDGADAAVLTSPASLAWAFNIRGGDVSCTPLPLGRAILNADGSAELFID
EEKTDAALRRHLGNRVTLRPLSKLDEGLKGLAGKTVSLDPDVASSWFFDELKAAGARVLRQRDPVAIPRACKNDAEIKGT
TAAHARDGIALTRFLHWLDTAAQSGEVTEIEAVMKLEAFREELGSMTDLSFPSISGAGPHGALPHYRVSTASDRKLERGS
LFLIDSGGQYLDGTTDVTRTVPIGEATDEMRANYTRVLKGHIALAAVRFPPGTTGTHLDVLARHALWQAGLDYQHGTGHG
VGVYLGVHEGPHRIAKPWNAVPLMPGMIVSNEPGFYKAGEYGIRIENLQYVTPAEDILGGEIAMHGFECLTFAPLARDLI
DIKMLSKDERKWVNDYHKRVMKVLGRKLDGEVKEWLKAACARI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=587, Percent_Identity=37.3083475298126, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI264681565, Length=587, Percent_Identity=35.7751277683135, Blast_Score=342, Evalue=8e-94,
Organism=Homo sapiens, GI93141226, Length=596, Percent_Identity=33.2214765100671, Blast_Score=320, Evalue=4e-87,
Organism=Escherichia coli, GI1788728, Length=284, Percent_Identity=32.3943661971831, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17509539, Length=590, Percent_Identity=35.7627118644068, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI25149105, Length=604, Percent_Identity=27.8145695364238, Blast_Score=221, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6322999, Length=637, Percent_Identity=31.0832025117739, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17137632, Length=603, Percent_Identity=36.4842454394693, Blast_Score=344, Evalue=9e-95,
Organism=Drosophila melanogaster, GI161078230, Length=584, Percent_Identity=28.5958904109589, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21357287, Length=584, Percent_Identity=28.5958904109589, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65331; Mature: 65331

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTFDIKGGPQDGRTHLPLLRRQLERQGLDGLYVPHDDEYQNEYLPDANERLAWATGFT
CCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEEECCC
GSFGSAFVFLDTAVLFADGRYTLQAADQTDPALFEVVGIPDPGAFGWLAQQALKGKRVGY
CCCCCEEHEEEEEEEEECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCC
DARLMSPNDVAALAAAAAKAGAELVSVEENPIDAAWQDRPPQPMAKVVPHAVKHAGVAHT
CEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCH
DKLEAVGAQLARDGADAAVLTSPASLAWAFNIRGGDVSCTPLPLGRAILNADGSAELFID
HHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCEECCCCCCCHHHHCCCCCEEEEEE
EEKTDAALRRHLGNRVTLRPLSKLDEGLKGLAGKTVSLDPDVASSWFFDELKAAGARVLR
CCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHH
QRDPVAIPRACKNDAEIKGTTAAHARDGIALTRFLHWLDTAAQSGEVTEIEAVMKLEAFR
HCCCCCCCHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EELGSMTDLSFPSISGAGPHGALPHYRVSTASDRKLERGSLFLIDSGGQYLDGTTDVTRT
HHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCEEE
VPIGEATDEMRANYTRVLKGHIALAAVRFPPGTTGTHLDVLARHALWQAGLDYQHGTGHG
ECCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
VGVYLGVHEGPHRIAKPWNAVPLMPGMIVSNEPGFYKAGEYGIRIENLQYVTPAEDILGG
EEEEEECCCCCHHHCCCCCCCCCCCCEEECCCCCCEECCCCCEEEECEEEECCHHHHCCC
EIAMHGFECLTFAPLARDLIDIKMLSKDERKWVNDYHKRVMKVLGRKLDGEVKEWLKAAC
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ARI
HCC
>Mature Secondary Structure
MRQTFDIKGGPQDGRTHLPLLRRQLERQGLDGLYVPHDDEYQNEYLPDANERLAWATGFT
CCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCEEEEECCC
GSFGSAFVFLDTAVLFADGRYTLQAADQTDPALFEVVGIPDPGAFGWLAQQALKGKRVGY
CCCCCEEHEEEEEEEEECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCC
DARLMSPNDVAALAAAAAKAGAELVSVEENPIDAAWQDRPPQPMAKVVPHAVKHAGVAHT
CEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCH
DKLEAVGAQLARDGADAAVLTSPASLAWAFNIRGGDVSCTPLPLGRAILNADGSAELFID
HHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCEECCCCCCCHHHHCCCCCEEEEEE
EEKTDAALRRHLGNRVTLRPLSKLDEGLKGLAGKTVSLDPDVASSWFFDELKAAGARVLR
CCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHH
QRDPVAIPRACKNDAEIKGTTAAHARDGIALTRFLHWLDTAAQSGEVTEIEAVMKLEAFR
HCCCCCCCHHCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
EELGSMTDLSFPSISGAGPHGALPHYRVSTASDRKLERGSLFLIDSGGQYLDGTTDVTRT
HHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCEEE
VPIGEATDEMRANYTRVLKGHIALAAVRFPPGTTGTHLDVLARHALWQAGLDYQHGTGHG
ECCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
VGVYLGVHEGPHRIAKPWNAVPLMPGMIVSNEPGFYKAGEYGIRIENLQYVTPAEDILGG
EEEEEECCCCCHHHCCCCCCCCCCCCEEECCCCCCEECCCCCEEEECEEEECCHHHHCCC
EIAMHGFECLTFAPLARDLIDIKMLSKDERKWVNDYHKRVMKVLGRKLDGEVKEWLKAAC
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ARI
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]