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The map label for this gene is divL [H]

Identifier: 114797839

GI number: 114797839

Start: 393820

End: 396267

Strand: Direct

Name: divL [H]

Synonym: HNE_0399

Alternate gene names: 114797839

Gene position: 393820-396267 (Clockwise)

Preceding gene: 114800234

Following gene: 114797192

Centisome position: 10.63

GC content: 64.5

Gene sequence:

>2448_bases
ATGACCGCTGAACAGATGCCCATTCTGATGGCTATTGGCACCGCGCTGCTGGCGCTTGGGGCGTTGCTCTGGGCGCTGCG
GGTGTCGGATGGCGCGCGCGGGGCGGCCAAACGCTACCGCGAAGTGGCCGGGGACCGCGAAACCGAGAATGCCGGGCTTA
AATCTGTGTTAGGTGCGCATCCGGGCGTTATCCTTGTCTGGCAGGGCGACGCGCTGGAGCTGGACGGGGACGAGATTACT
CCGCCGGAGCTTTATGGTTCGCCGGTGGCGCTGGCGGGGCTTTTGAGTTTTACCGATGATGCGATCTCGCCGGACCCGGC
GGTGCGCATCGTTGAGGGGCTCGCCGATCTGGAAGCGCGCGACTCGGCAGGGCAGGACACGACGCTGCGCATCCGCCTGC
GGGAACTGCGCGAGAGCGGCCAGCCTTTCTCGCTGACGATCATCGGCACCTCGGGACGTTTCCTGGAAGCTGACGGGCGC
ACGGCGGGCGTGCGCGCGGTGGTCTGGATCAACGACACGACGATCAAGGGGCTGGAGGAAAGCTCGGCCCGCGGCAAGCT
GGAAGAGGCGCGGCAGGTGATTGCGCGCGACCCGACGGCGTTCCTCGACATGCTGGGCAAGGCGCCGTTCCCGGCCTGGC
GGGTTTCGGGCATGGGGCGCCTGCAATGGGCCAACCCTGCCTATATCGAAGCGGTTGATGGCGGCAATCTCGACCGCGTG
CTGGAGCGTCAGCTGATGCTCGACCAGGCGGTCAGCGAGCAGGCGCGCAAGACGATCACCGACGGCGCCGAGCATGACGA
GACCCGGCATATCGTGGTCAACAACCAGCGCCGGGCCATGCGCGTGCTGACCTTTGCCCTGTCGGGCGGGGCCGGGTGTA
TGGCGTTTGACGTGACCGAGCAGGAGAACTCCCGTGAGGAGCTCAACCGCCATGTGCGCGCCCATGACGAGACGCTGAAC
CATGTGGCCGACGCGGTGGCGATCTTCGGGCCGGACCGGAAGCTGAACTTCTACAACAAGGCGTTCCGCGACATGTGGGA
CCTGGAGGAGACCTTCCTCCTCGACCGGCCAAGCCATGGCCAGCTGCTGGACCGGCTGCGCGAGAAGAAAAAGCTCCCGG
CCCGGATGAACTATGCCGAATGGCGCGCCGAGGAGATTTCCTATTATCTCGACATCGACGGGGTGAAGGAAGACAAGTGG
TCGCTGCCCGATAACCGCACGCTTTCTGTCACACGCCAGCGCCACCCGATGGGCGGTTTGCTGGTCCTGTTCAAGGACAT
CACCGACCACCTTTCGCTGCAGACGCGCTTCAACGCGCTGATCAAGACGCAGTCTTCGACGCTGGACAATCTGCATGAGG
CCGTTGCCGTGTTCGGATCGGACGGGCGGCTGCGCCTGCACAACCGGGCGTTCGAGCGGGTGTGGGATATTCCCGCCGAC
CGGCTGAAAGACCGCCCTGATTATGCCGATGTGATCAGCGGCTGCGTGCCGTTGTTTCATGACATGGACATCTGGGACGC
GATCAAGGTGCACATCACTGACCCCACCGCGCGCCAGTCCACCACTGGTGAGATGCGCCGGTCTGACGGCTCGCTGCTGA
CCTATCTGACCCATCCGCTGCCGGATGGAAATACGATGATCGCCTTTGCCGATGTCACGGCCACGCGCCGGGTGGAATCG
GCGCTGCGCGACCGGGCCGAAGCGTTCGAGGCGGCCGACCGGCTGAAGACCGAGTTTGTGCGCAATGTGAGCTATCAGCT
GCGCTCGCCGCTCACCACGATCTTTGGCTATGCCGAACTGCTGGAGACCCAGCGCAATGGCCCGCTGACCGAGCGGCAGA
CAGACCACGTCCGCGCCATTCTTTCCGCGTCGGACCATCTCAACAAGCTGATCGAGAACATTCTGGATCTTGCGCTGATC
GAGGCCGGGCGTCTCGATCTGGAGCTCAGCGAGCTGGATCTGGAAGAGGTGATCCATCAGAGCGTGGAACTGGTCGTGTC
GAAGGCCGAAGACACCGAGGTTTCGGTGCGCGCCGACATTACCGGGCGGCTCGGCCAGATGCGGGGCGATGAGCGCCGGA
TCAAACAGGTATTGTTCAACCTCATCTCCAACTCGCTGCGCTTTACCGAGCCGGGCGGGGAGATTGTGGTGTCCGCACAG
CGCATGGGCGACATGATTACCCTCAGTGTACGGGACAATGGATCGGGCCTTGAGGCCGACAAGCGCGCCACCAGCTTTGA
CAGCTTTGTCTCCGGTGACCAGCGCGGCGCGGGGCTCGGCCTGGCGCTCGTGAAACACTTCATCCATCTGCATGGCGGCA
CGGTGGGCATGAAATCGGTCGATGGCGGCGGGCTGGAGGTGACCTGCTGGTTGCCCTCGCAGGCGCCGGTTACCGCGTCG
CTGCCCCCCAGCCAAAGCGCGTTCGAGCCCCAGCCCACGGCGCACTGA

Upstream 100 bases:

>100_bases
ATTCATTAACCAGTATAAACCTTCGCGAGTCGCGGCGTCGTTGGCGCGCGGCCGGCAATGATCGGCGTATGGCGCGCCAA
AATAGAGGCCCGGTAGCTCG

Downstream 100 bases:

>100_bases
TCCGGCATTTCCGGCCCAAAGAAAAAGCCCGGCCTCATCGTGAGGCCGGGCTTTTGCGTTGAGGGGCATTACGGGCGCCT
TACTCTTTTAAGGGCAAAGG

Product: putative tyrosine kinase DivL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 815; Mature: 814

Protein sequence:

>815_residues
MTAEQMPILMAIGTALLALGALLWALRVSDGARGAAKRYREVAGDRETENAGLKSVLGAHPGVILVWQGDALELDGDEIT
PPELYGSPVALAGLLSFTDDAISPDPAVRIVEGLADLEARDSAGQDTTLRIRLRELRESGQPFSLTIIGTSGRFLEADGR
TAGVRAVVWINDTTIKGLEESSARGKLEEARQVIARDPTAFLDMLGKAPFPAWRVSGMGRLQWANPAYIEAVDGGNLDRV
LERQLMLDQAVSEQARKTITDGAEHDETRHIVVNNQRRAMRVLTFALSGGAGCMAFDVTEQENSREELNRHVRAHDETLN
HVADAVAIFGPDRKLNFYNKAFRDMWDLEETFLLDRPSHGQLLDRLREKKKLPARMNYAEWRAEEISYYLDIDGVKEDKW
SLPDNRTLSVTRQRHPMGGLLVLFKDITDHLSLQTRFNALIKTQSSTLDNLHEAVAVFGSDGRLRLHNRAFERVWDIPAD
RLKDRPDYADVISGCVPLFHDMDIWDAIKVHITDPTARQSTTGEMRRSDGSLLTYLTHPLPDGNTMIAFADVTATRRVES
ALRDRAEAFEAADRLKTEFVRNVSYQLRSPLTTIFGYAELLETQRNGPLTERQTDHVRAILSASDHLNKLIENILDLALI
EAGRLDLELSELDLEEVIHQSVELVVSKAEDTEVSVRADITGRLGQMRGDERRIKQVLFNLISNSLRFTEPGGEIVVSAQ
RMGDMITLSVRDNGSGLEADKRATSFDSFVSGDQRGAGLGLALVKHFIHLHGGTVGMKSVDGGGLEVTCWLPSQAPVTAS
LPPSQSAFEPQPTAH

Sequences:

>Translated_815_residues
MTAEQMPILMAIGTALLALGALLWALRVSDGARGAAKRYREVAGDRETENAGLKSVLGAHPGVILVWQGDALELDGDEIT
PPELYGSPVALAGLLSFTDDAISPDPAVRIVEGLADLEARDSAGQDTTLRIRLRELRESGQPFSLTIIGTSGRFLEADGR
TAGVRAVVWINDTTIKGLEESSARGKLEEARQVIARDPTAFLDMLGKAPFPAWRVSGMGRLQWANPAYIEAVDGGNLDRV
LERQLMLDQAVSEQARKTITDGAEHDETRHIVVNNQRRAMRVLTFALSGGAGCMAFDVTEQENSREELNRHVRAHDETLN
HVADAVAIFGPDRKLNFYNKAFRDMWDLEETFLLDRPSHGQLLDRLREKKKLPARMNYAEWRAEEISYYLDIDGVKEDKW
SLPDNRTLSVTRQRHPMGGLLVLFKDITDHLSLQTRFNALIKTQSSTLDNLHEAVAVFGSDGRLRLHNRAFERVWDIPAD
RLKDRPDYADVISGCVPLFHDMDIWDAIKVHITDPTARQSTTGEMRRSDGSLLTYLTHPLPDGNTMIAFADVTATRRVES
ALRDRAEAFEAADRLKTEFVRNVSYQLRSPLTTIFGYAELLETQRNGPLTERQTDHVRAILSASDHLNKLIENILDLALI
EAGRLDLELSELDLEEVIHQSVELVVSKAEDTEVSVRADITGRLGQMRGDERRIKQVLFNLISNSLRFTEPGGEIVVSAQ
RMGDMITLSVRDNGSGLEADKRATSFDSFVSGDQRGAGLGLALVKHFIHLHGGTVGMKSVDGGGLEVTCWLPSQAPVTAS
LPPSQSAFEPQPTAH
>Mature_814_residues
TAEQMPILMAIGTALLALGALLWALRVSDGARGAAKRYREVAGDRETENAGLKSVLGAHPGVILVWQGDALELDGDEITP
PELYGSPVALAGLLSFTDDAISPDPAVRIVEGLADLEARDSAGQDTTLRIRLRELRESGQPFSLTIIGTSGRFLEADGRT
AGVRAVVWINDTTIKGLEESSARGKLEEARQVIARDPTAFLDMLGKAPFPAWRVSGMGRLQWANPAYIEAVDGGNLDRVL
ERQLMLDQAVSEQARKTITDGAEHDETRHIVVNNQRRAMRVLTFALSGGAGCMAFDVTEQENSREELNRHVRAHDETLNH
VADAVAIFGPDRKLNFYNKAFRDMWDLEETFLLDRPSHGQLLDRLREKKKLPARMNYAEWRAEEISYYLDIDGVKEDKWS
LPDNRTLSVTRQRHPMGGLLVLFKDITDHLSLQTRFNALIKTQSSTLDNLHEAVAVFGSDGRLRLHNRAFERVWDIPADR
LKDRPDYADVISGCVPLFHDMDIWDAIKVHITDPTARQSTTGEMRRSDGSLLTYLTHPLPDGNTMIAFADVTATRRVESA
LRDRAEAFEAADRLKTEFVRNVSYQLRSPLTTIFGYAELLETQRNGPLTERQTDHVRAILSASDHLNKLIENILDLALIE
AGRLDLELSELDLEEVIHQSVELVVSKAEDTEVSVRADITGRLGQMRGDERRIKQVLFNLISNSLRFTEPGGEIVVSAQR
MGDMITLSVRDNGSGLEADKRATSFDSFVSGDQRGAGLGLALVKHFIHLHGGTVGMKSVDGGGLEVTCWLPSQAPVTASL
PPSQSAFEPQPTAH

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=33.0739299610895, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1790436, Length=210, Percent_Identity=31.4285714285714, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI87081816, Length=352, Percent_Identity=29.2613636363636, Blast_Score=104, Evalue=3e-23,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=26.8, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=28.099173553719, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=29.7071129707113, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=363, Percent_Identity=25.6198347107438, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=28.4046692607004, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1790861, Length=237, Percent_Identity=29.1139240506329, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1786600, Length=263, Percent_Identity=26.2357414448669, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1790300, Length=276, Percent_Identity=26.8115942028986, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=25.1046025104602, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=269, Percent_Identity=28.996282527881, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=271, Percent_Identity=27.3062730627306, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=248, Percent_Identity=26.2096774193548, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=214, Percent_Identity=24.2990654205607, Blast_Score=63, Evalue=9e-11,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=24.2424242424242, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 90188; Mature: 90057

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEQMPILMAIGTALLALGALLWALRVSDGARGAAKRYREVAGDRETENAGLKSVLGAH
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCC
PGVILVWQGDALELDGDEITPPELYGSPVALAGLLSFTDDAISPDPAVRIVEGLADLEAR
CCEEEEECCCEEEECCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
DSAGQDTTLRIRLRELRESGQPFSLTIIGTSGRFLEADGRTAGVRAVVWINDTTIKGLEE
CCCCCCCEEEEEEHHHHHCCCCEEEEEEECCCCEEECCCCCCCEEEEEEEECCEECCCHH
SSARGKLEEARQVIARDPTAFLDMLGKAPFPAWRVSGMGRLQWANPAYIEAVDGGNLDRV
HHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHH
LERQLMLDQAVSEQARKTITDGAEHDETRHIVVNNQRRAMRVLTFALSGGAGCMAFDVTE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCC
QENSREELNRHVRAHDETLNHVADAVAIFGPDRKLNFYNKAFRDMWDLEETFLLDRPSHG
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCHHHHEECCCCCH
QLLDRLREKKKLPARMNYAEWRAEEISYYLDIDGVKEDKWSLPDNRTLSVTRQRHPMGGL
HHHHHHHHHHCCCCCCCHHHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCH
LVLFKDITDHLSLQTRFNALIKTQSSTLDNLHEAVAVFGSDGRLRLHNRAFERVWDIPAD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHCCCHH
RLKDRPDYADVISGCVPLFHDMDIWDAIKVHITDPTARQSTTGEMRRSDGSLLTYLTHPL
HHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCCEEEEEECCC
PDGNTMIAFADVTATRRVESALRDRAEAFEAADRLKTEFVRNVSYQLRSPLTTIFGYAEL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LETQRNGPLTERQTDHVRAILSASDHLNKLIENILDLALIEAGRLDLELSELDLEEVIHQ
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCHHHHHHH
SVELVVSKAEDTEVSVRADITGRLGQMRGDERRIKQVLFNLISNSLRFTEPGGEIVVSAQ
HHHHHHCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEHH
RMGDMITLSVRDNGSGLEADKRATSFDSFVSGDQRGAGLGLALVKHFIHLHGGTVGMKSV
HCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEECCCC
DGGGLEVTCWLPSQAPVTASLPPSQSAFEPQPTAH
CCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAEQMPILMAIGTALLALGALLWALRVSDGARGAAKRYREVAGDRETENAGLKSVLGAH
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCC
PGVILVWQGDALELDGDEITPPELYGSPVALAGLLSFTDDAISPDPAVRIVEGLADLEAR
CCEEEEECCCEEEECCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
DSAGQDTTLRIRLRELRESGQPFSLTIIGTSGRFLEADGRTAGVRAVVWINDTTIKGLEE
CCCCCCCEEEEEEHHHHHCCCCEEEEEEECCCCEEECCCCCCCEEEEEEEECCEECCCHH
SSARGKLEEARQVIARDPTAFLDMLGKAPFPAWRVSGMGRLQWANPAYIEAVDGGNLDRV
HHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHH
LERQLMLDQAVSEQARKTITDGAEHDETRHIVVNNQRRAMRVLTFALSGGAGCMAFDVTE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCC
QENSREELNRHVRAHDETLNHVADAVAIFGPDRKLNFYNKAFRDMWDLEETFLLDRPSHG
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCHHHHEECCCCCH
QLLDRLREKKKLPARMNYAEWRAEEISYYLDIDGVKEDKWSLPDNRTLSVTRQRHPMGGL
HHHHHHHHHHCCCCCCCHHHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCH
LVLFKDITDHLSLQTRFNALIKTQSSTLDNLHEAVAVFGSDGRLRLHNRAFERVWDIPAD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHCCCHH
RLKDRPDYADVISGCVPLFHDMDIWDAIKVHITDPTARQSTTGEMRRSDGSLLTYLTHPL
HHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCCEEEEEECCC
PDGNTMIAFADVTATRRVESALRDRAEAFEAADRLKTEFVRNVSYQLRSPLTTIFGYAEL
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LETQRNGPLTERQTDHVRAILSASDHLNKLIENILDLALIEAGRLDLELSELDLEEVIHQ
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCHHHHHHH
SVELVVSKAEDTEVSVRADITGRLGQMRGDERRIKQVLFNLISNSLRFTEPGGEIVVSAQ
HHHHHHCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEHH
RMGDMITLSVRDNGSGLEADKRATSFDSFVSGDQRGAGLGLALVKHFIHLHGGTVGMKSV
HCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEECCCC
DGGGLEVTCWLPSQAPVTASLPPSQSAFEPQPTAH
CCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]