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The map label for this gene is glcD [H]

Identifier: 114797514

GI number: 114797514

Start: 1116379

End: 1117959

Strand: Reverse

Name: glcD [H]

Synonym: HNE_1109

Alternate gene names: 114797514

Gene position: 1117959-1116379 (Counterclockwise)

Preceding gene: 114798507

Following gene: 114799768

Centisome position: 30.17

GC content: 63.19

Gene sequence:

>1581_bases
ATGGAAGCCGCCACCACCCCCAAGACCATCACCTCCGCCCTCAAACAGATTCTCGGCCCGGCGGGCCTCAATGAAGATCT
CGCCGCCCGCGAATTGATGAGCCAGGACATCTGGGCCGCCGGCGTAACGGCCGATTTCATCGCCTCGCCGGGGACCATCG
AGCAACTCCAGCAAACCGTAGAAGCCTGCCACCAGCACGGCGTTGCGCTCAACCCGCGCGGCGGCGGCATGTCCTACACC
AGCAGCACCACGCCGGACCGTCCGGGCGTCGGCATCCTTGATCTCTCCCGCCTCGACAAGATCGTGGAGATCAACAAGGA
CGACATGTATGTCACCGCGCAGGCGGGCGTGACCTGGAAACAGCTCTACGACGCGCTGAAGCCGCTGGGTCTGCGCACGC
CGTTCTGGGGCCCGCTCTCGGGCCTCAACTCCACCGTCGGCGGCGGACTTTCGCAGGGCAATGCCATCTTCGGCGCGGGC
ATTTATGGCACGACCGCCGACAGCGTGACGGGCCTCACCGTGATCCTCGCCGATGGCACGCGCGTGCGCACCGGCACGGG
CGCCACCAAGGTCGGCAAACCCTTCTGGCGTTATTACGGGCCGGACCTGACCGGTCTTTTCTGCGGCGATTCCGGCGCGC
TCGGTTTCAAGGCAGAAATCACCTTCCGCCTCATTCCGTGGCCGGAACATGAAGACTGGGCGACGTTCGAATTTGCCACC
CGCGAGGCCTGCGCCGAAGCGACAGCCGCTGTCGCCCGTCAGAACCTTGCCTGCGAAGTCTTCGGCTTCGATCCTGCGCT
CACCCGCGTGCGCCTGAAGCGCGCCTCGCTCGCCGCCGACACCAAGACCTTGGCGAATGTCGTCAAGGCCCAGGGCAATC
TGCTGAAGGGTCTTCAGGAAGGCGCCAAGATCGCCATGGCCGGGCGCAGCTTCATGGAAGCTGACAGCTGGAGCCTGCAT
TTCGTGGTCGAAGGCCGCTCCAAAGCGGGCGTGGCCGATGATATGAAGCGCCTGAAAGCTGCCTGCACGGCCGCTGGCGG
CAAGGAGTCTGAAAACTCCATTCCAAAAATCGTCCGCGCAAATCCCTTCACGCCGCCCAACACGATCCTCGGCGCCGAAG
GCGAACGCTGGGTGCCGGTGCATGGCATTGTGGCGATCTCAGATGGCCCGAAGGTCTGGAAGGCGCTGGAAGACTATTTC
GCCTCTCTTTCAGATGTGTTCGACAAATACGAAATCCAGACCGGCTTCCTCATCAGCACGCTGGGCACGACGGCCTACCT
CATCGAGCCTGTGTTCATGTGGCCCGAGGAGCTCCTGGCGATCCATGAGCAGACCGTTGAACCGGCCCATCTGAAAAAGC
TCAAACGCTTCCCCTCCAATCCGGAGGCAACAGCGGCGGTCACCAAGGCGCGGCGCGGCGTGGTGGATATTTTCGACTCC
TATGGCGCGGCCCATTTCCAGATCGGGCGCTGCTATCCGTATTCGGAAGTTCTCAGCGATGCCTCGCTTTCCCTGCTCAA
GGCCGTGAAGGCTACCCTTGATCCCAAAGGCAACGTCAATCCCGGAGCCCTCGGCCTGTGA

Upstream 100 bases:

>100_bases
GAACCGTGCCCGCCCGCTCGTCACCGGCATCTGGGCGCTGCTCATCGCTGCGGCCCTTCTTGCCCTTTTCAAACCCGTTT
GACCCTCCCGGAGACCCGCC

Downstream 100 bases:

>100_bases
CGTCCCGAACGCTTCCCGTCCGCAATCCTCGCACCGGCGAACTGGACTATAAAATCCAGGCCGCCGGCGCAGAGGAAATC
GCCGCGACCGCCCAGCGCCT

Product: putative oxidoreductase, FAD-binding

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MEAATTPKTITSALKQILGPAGLNEDLAARELMSQDIWAAGVTADFIASPGTIEQLQQTVEACHQHGVALNPRGGGMSYT
SSTTPDRPGVGILDLSRLDKIVEINKDDMYVTAQAGVTWKQLYDALKPLGLRTPFWGPLSGLNSTVGGGLSQGNAIFGAG
IYGTTADSVTGLTVILADGTRVRTGTGATKVGKPFWRYYGPDLTGLFCGDSGALGFKAEITFRLIPWPEHEDWATFEFAT
REACAEATAAVARQNLACEVFGFDPALTRVRLKRASLAADTKTLANVVKAQGNLLKGLQEGAKIAMAGRSFMEADSWSLH
FVVEGRSKAGVADDMKRLKAACTAAGGKESENSIPKIVRANPFTPPNTILGAEGERWVPVHGIVAISDGPKVWKALEDYF
ASLSDVFDKYEIQTGFLISTLGTTAYLIEPVFMWPEELLAIHEQTVEPAHLKKLKRFPSNPEATAAVTKARRGVVDIFDS
YGAAHFQIGRCYPYSEVLSDASLSLLKAVKATLDPKGNVNPGALGL

Sequences:

>Translated_526_residues
MEAATTPKTITSALKQILGPAGLNEDLAARELMSQDIWAAGVTADFIASPGTIEQLQQTVEACHQHGVALNPRGGGMSYT
SSTTPDRPGVGILDLSRLDKIVEINKDDMYVTAQAGVTWKQLYDALKPLGLRTPFWGPLSGLNSTVGGGLSQGNAIFGAG
IYGTTADSVTGLTVILADGTRVRTGTGATKVGKPFWRYYGPDLTGLFCGDSGALGFKAEITFRLIPWPEHEDWATFEFAT
REACAEATAAVARQNLACEVFGFDPALTRVRLKRASLAADTKTLANVVKAQGNLLKGLQEGAKIAMAGRSFMEADSWSLH
FVVEGRSKAGVADDMKRLKAACTAAGGKESENSIPKIVRANPFTPPNTILGAEGERWVPVHGIVAISDGPKVWKALEDYF
ASLSDVFDKYEIQTGFLISTLGTTAYLIEPVFMWPEELLAIHEQTVEPAHLKKLKRFPSNPEATAAVTKARRGVVDIFDS
YGAAHFQIGRCYPYSEVLSDASLSLLKAVKATLDPKGNVNPGALGL
>Mature_526_residues
MEAATTPKTITSALKQILGPAGLNEDLAARELMSQDIWAAGVTADFIASPGTIEQLQQTVEACHQHGVALNPRGGGMSYT
SSTTPDRPGVGILDLSRLDKIVEINKDDMYVTAQAGVTWKQLYDALKPLGLRTPFWGPLSGLNSTVGGGLSQGNAIFGAG
IYGTTADSVTGLTVILADGTRVRTGTGATKVGKPFWRYYGPDLTGLFCGDSGALGFKAEITFRLIPWPEHEDWATFEFAT
REACAEATAAVARQNLACEVFGFDPALTRVRLKRASLAADTKTLANVVKAQGNLLKGLQEGAKIAMAGRSFMEADSWSLH
FVVEGRSKAGVADDMKRLKAACTAAGGKESENSIPKIVRANPFTPPNTILGAEGERWVPVHGIVAISDGPKVWKALEDYF
ASLSDVFDKYEIQTGFLISTLGTTAYLIEPVFMWPEELLAIHEQTVEPAHLKKLKRFPSNPEATAAVTKARRGVVDIFDS
YGAAHFQIGRCYPYSEVLSDASLSLLKAVKATLDPKGNVNPGALGL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=247, Percent_Identity=29.9595141700405, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI37595754, Length=266, Percent_Identity=28.1954887218045, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI48994907, Length=189, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789351, Length=185, Percent_Identity=27.027027027027, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17556096, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320027, Length=205, Percent_Identity=31.7073170731707, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24653753, Length=213, Percent_Identity=26.2910798122066, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 56210; Mature: 56210

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAATTPKTITSALKQILGPAGLNEDLAARELMSQDIWAAGVTADFIASPGTIEQLQQTV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHH
EACHQHGVALNPRGGGMSYTSSTTPDRPGVGILDLSRLDKIVEINKDDMYVTAQAGVTWK
HHHHHCCCEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCEEEEEECCCCHH
QLYDALKPLGLRTPFWGPLSGLNSTVGGGLSQGNAIFGAGIYGTTADSVTGLTVILADGT
HHHHHHHCCCCCCCCCCCHHCCCHHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCC
RVRTGTGATKVGKPFWRYYGPDLTGLFCGDSGALGFKAEITFRLIPWPEHEDWATFEFAT
EEECCCCCCCCCCHHHHHCCCCCCEEEECCCCCCEEEEEEEEEEECCCCCCCCEEHHHHH
REACAEATAAVARQNLACEVFGFDPALTRVRLKRASLAADTKTLANVVKAQGNLLKGLQE
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GAKIAMAGRSFMEADSWSLHFVVEGRSKAGVADDMKRLKAACTAAGGKESENSIPKIVRA
CCEEEECCCHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
NPFTPPNTILGAEGERWVPVHGIVAISDGPKVWKALEDYFASLSDVFDKYEIQTGFLIST
CCCCCCCCEECCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
LGTTAYLIEPVFMWPEELLAIHEQTVEPAHLKKLKRFPSNPEATAAVTKARRGVVDIFDS
HCCHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHC
YGAAHFQIGRCYPYSEVLSDASLSLLKAVKATLDPKGNVNPGALGL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEAATTPKTITSALKQILGPAGLNEDLAARELMSQDIWAAGVTADFIASPGTIEQLQQTV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHH
EACHQHGVALNPRGGGMSYTSSTTPDRPGVGILDLSRLDKIVEINKDDMYVTAQAGVTWK
HHHHHCCCEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCEEEEEECCCCHH
QLYDALKPLGLRTPFWGPLSGLNSTVGGGLSQGNAIFGAGIYGTTADSVTGLTVILADGT
HHHHHHHCCCCCCCCCCCHHCCCHHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCC
RVRTGTGATKVGKPFWRYYGPDLTGLFCGDSGALGFKAEITFRLIPWPEHEDWATFEFAT
EEECCCCCCCCCCHHHHHCCCCCCEEEECCCCCCEEEEEEEEEEECCCCCCCCEEHHHHH
REACAEATAAVARQNLACEVFGFDPALTRVRLKRASLAADTKTLANVVKAQGNLLKGLQE
HHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
GAKIAMAGRSFMEADSWSLHFVVEGRSKAGVADDMKRLKAACTAAGGKESENSIPKIVRA
CCEEEECCCHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
NPFTPPNTILGAEGERWVPVHGIVAISDGPKVWKALEDYFASLSDVFDKYEIQTGFLIST
CCCCCCCCEECCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
LGTTAYLIEPVFMWPEELLAIHEQTVEPAHLKKLKRFPSNPEATAAVTKARRGVVDIFDS
HCCHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHC
YGAAHFQIGRCYPYSEVLSDASLSLLKAVKATLDPKGNVNPGALGL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]