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The map label for this gene is kdsA [H]

Identifier: 114797175

GI number: 114797175

Start: 825754

End: 826605

Strand: Reverse

Name: kdsA [H]

Synonym: HNE_0806

Alternate gene names: 114797175

Gene position: 826605-825754 (Counterclockwise)

Preceding gene: 114799321

Following gene: 114798009

Centisome position: 22.31

GC content: 60.33

Gene sequence:

>852_bases
ATGGCAGCACTCACTCACACGCCGTCCGGCTGGACCATTGGCGGAAAGGGTCCGCTCGCCGTGATGGCAGGACTGAACGT
TCTGGAAGATGAGGGACTGGCACTGGAAGTCGGAACTGAGTTGAAGCGCATCTGCGTCTCTCTTGGGCTGCCCTACGTGT
TCAAGGCCAGTTTCGACAAGGCCAACCGCTCCTCTATCACATCCTATAGAGGGCCGGGTCTGGAAACGGGCCTGAAAATC
CTCTCCTCGGTCAAGGCGAAGCTCGGGGTGCCGGTCGTCACAGATCTGCATGAACCCGCCCAGGCCGAACCGGTTGCCGC
CGTTGCCGACATTATCCAGCTGCCGGCCTTTCTGGTTCGACAGACCGACCTCGTCATCGCCACCGCCAGGGCCGCTGCGA
GAGAAAAAGCCCTGATCCAGGCCAAGAAGGCGCAGTTCATGGCGCCGTGGGACGCTAAGAATATCCTCACGAAGATCGCC
GAAGTGGCACCGGAAACCGGCGTAATCATGTGCGAACGCGGCGTCAGCTTTGGCTACAACAATCTTGTGGTCGACATGCT
GGCCATTCCCGAGATGAAAAAGCTTGGCTGTCCCGTAACGATCGATGCGACCCACGCCGTGCAGCTGCCCGGCGCCGATC
CGAGGACCGCTGGCGCTTCCACGGGCGGCCGGAGGGACGGCGTGGCGATCATCGCAAAGTCAGCCATCGCCGCAGGCGCA
GACGGCGTTTTTCTGGAATTCCATACCGATCCGGACAAAGCGCTGTGTGATGGTCCGAGCTGTCTGGCACTTTCCGGGGC
TGAAGCGCTTCTTTCTACACTGAAATCCATTCACTCAGCCGCAAACGGTTGA

Upstream 100 bases:

>100_bases
TCGACAGGGCGGCTTCTTTGTTTTCGGGGGTGAGGAAACTGGTTCGCGGACGCGATGAATTCCGCTAACTAGCCCCCTTA
GGGCATTCCGGAGCGATATC

Downstream 100 bases:

>100_bases
TTCCCACAGGCAGCGCGCATGAATCCACCCGAAATCTCTGTTATCATCATCAACTACAATGGTGGCGCCTTCCTTCAGGA
GGCGGTCAATTCTCTTGGCC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAALTHTPSGWTIGGKGPLAVMAGLNVLEDEGLALEVGTELKRICVSLGLPYVFKASFDKANRSSITSYRGPGLETGLKI
LSSVKAKLGVPVVTDLHEPAQAEPVAAVADIIQLPAFLVRQTDLVIATARAAAREKALIQAKKAQFMAPWDAKNILTKIA
EVAPETGVIMCERGVSFGYNNLVVDMLAIPEMKKLGCPVTIDATHAVQLPGADPRTAGASTGGRRDGVAIIAKSAIAAGA
DGVFLEFHTDPDKALCDGPSCLALSGAEALLSTLKSIHSAANG

Sequences:

>Translated_283_residues
MAALTHTPSGWTIGGKGPLAVMAGLNVLEDEGLALEVGTELKRICVSLGLPYVFKASFDKANRSSITSYRGPGLETGLKI
LSSVKAKLGVPVVTDLHEPAQAEPVAAVADIIQLPAFLVRQTDLVIATARAAAREKALIQAKKAQFMAPWDAKNILTKIA
EVAPETGVIMCERGVSFGYNNLVVDMLAIPEMKKLGCPVTIDATHAVQLPGADPRTAGASTGGRRDGVAIIAKSAIAAGA
DGVFLEFHTDPDKALCDGPSCLALSGAEALLSTLKSIHSAANG
>Mature_282_residues
AALTHTPSGWTIGGKGPLAVMAGLNVLEDEGLALEVGTELKRICVSLGLPYVFKASFDKANRSSITSYRGPGLETGLKIL
SSVKAKLGVPVVTDLHEPAQAEPVAAVADIIQLPAFLVRQTDLVIATARAAAREKALIQAKKAQFMAPWDAKNILTKIAE
VAPETGVIMCERGVSFGYNNLVVDMLAIPEMKKLGCPVTIDATHAVQLPGADPRTAGASTGGRRDGVAIIAKSAIAAGAD
GVFLEFHTDPDKALCDGPSCLALSGAEALLSTLKSIHSAANG

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=268, Percent_Identity=50.7462686567164, Blast_Score=258, Evalue=2e-70,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29288; Mature: 29157

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALTHTPSGWTIGGKGPLAVMAGLNVLEDEGLALEVGTELKRICVSLGLPYVFKASFDK
CCCCCCCCCCCEECCCCCHHHHHCCCEECCCCCEEEHHHHHHHHHHHHCCCCEEECCCCC
ANRSSITSYRGPGLETGLKILSSVKAKLGVPVVTDLHEPAQAEPVAAVADIIQLPAFLVR
CCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
QTDLVIATARAAAREKALIQAKKAQFMAPWDAKNILTKIAEVAPETGVIMCERGVSFGYN
HCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCH
NLVVDMLAIPEMKKLGCPVTIDATHAVQLPGADPRTAGASTGGRRDGVAIIAKSAIAAGA
HHHHHHHHCCCHHHCCCCEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCC
DGVFLEFHTDPDKALCDGPSCLALSGAEALLSTLKSIHSAANG
CCEEEEEECCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AALTHTPSGWTIGGKGPLAVMAGLNVLEDEGLALEVGTELKRICVSLGLPYVFKASFDK
CCCCCCCCCCEECCCCCHHHHHCCCEECCCCCEEEHHHHHHHHHHHHCCCCEEECCCCC
ANRSSITSYRGPGLETGLKILSSVKAKLGVPVVTDLHEPAQAEPVAAVADIIQLPAFLVR
CCCHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
QTDLVIATARAAAREKALIQAKKAQFMAPWDAKNILTKIAEVAPETGVIMCERGVSFGYN
HCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCH
NLVVDMLAIPEMKKLGCPVTIDATHAVQLPGADPRTAGASTGGRRDGVAIIAKSAIAAGA
HHHHHHHHCCCHHHCCCCEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCC
DGVFLEFHTDPDKALCDGPSCLALSGAEALLSTLKSIHSAANG
CCEEEEEECCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA