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The map label for this gene is mutT [H]

Identifier: 114797108

GI number: 114797108

Start: 3348230

End: 3348646

Strand: Reverse

Name: mutT [H]

Synonym: HNE_3173

Alternate gene names: 114797108

Gene position: 3348646-3348230 (Counterclockwise)

Preceding gene: 114798075

Following gene: 114797894

Centisome position: 90.38

GC content: 63.07

Gene sequence:

>417_bases
ATGAGCCAGCGTCTCCTGCTGGTGGTGGCGGCCGCGCTGAAAGACGAGACGGGCCGTATCCTTCTCGCCCAGCGCCCGGA
AGGCAAGCAGCTCGCCGGGCTGTGGGAGTTTCCTGGTGGCAAGGTTGATCCGGGCGAGACGCCGGAGGCGGCGCTGGCGC
GCGAGCTTCACGAGGAGCTCTCCATTGTGGTTAAGGAAGAGGCACTCAAACCGCTGACATTTGCCAGCTTCACTTACCCC
GACTTTCACCTTCTCATGCCACTTTATGGCTGTGAAAGCTGGACCGGGGTAATTCATCCGCGCGAGGGGCAAGCCATCGC
CTGGGTCGAGCCTGCAAGGCTGCGAGACTATCCGGCGCCACCGGCAGACCTGCCTCTGTTCGACTGGTTGCTGGAGCAAG
CCCAAGCGGAGCTGTGA

Upstream 100 bases:

>100_bases
TTGCGATCCGTGTGTCGGTGGGTGCCGGGACCGGCCGGGCAACTGTGTGGACCTGCGATCTGACCCACGGCTATGTCGAC
ATCAACGGCGCCTACCGGAC

Downstream 100 bases:

>100_bases
TGCGCCTGACCAAGACCCTGATGCTGCGCCTTGCACGCGACGAGCGCGGCGCAACGGCGATTGAATACGGGCTCATTGCT
GGCCTGATGGTGCTTGCCAT

Product: putative mutator mutT protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 138; Mature: 137

Protein sequence:

>138_residues
MSQRLLLVVAAALKDETGRILLAQRPEGKQLAGLWEFPGGKVDPGETPEAALARELHEELSIVVKEEALKPLTFASFTYP
DFHLLMPLYGCESWTGVIHPREGQAIAWVEPARLRDYPAPPADLPLFDWLLEQAQAEL

Sequences:

>Translated_138_residues
MSQRLLLVVAAALKDETGRILLAQRPEGKQLAGLWEFPGGKVDPGETPEAALARELHEELSIVVKEEALKPLTFASFTYP
DFHLLMPLYGCESWTGVIHPREGQAIAWVEPARLRDYPAPPADLPLFDWLLEQAQAEL
>Mature_137_residues
SQRLLLVVAAALKDETGRILLAQRPEGKQLAGLWEFPGGKVDPGETPEAALARELHEELSIVVKEEALKPLTFASFTYPD
FHLLMPLYGCESWTGVIHPREGQAIAWVEPARLRDYPAPPADLPLFDWLLEQAQAEL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=136, Percent_Identity=36.7647058823529, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI1786288, Length=124, Percent_Identity=31.4516129032258, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15370; Mature: 15239

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRLLLVVAAALKDETGRILLAQRPEGKQLAGLWEFPGGKVDPGETPEAALARELHEEL
CCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
SIVVKEEALKPLTFASFTYPDFHLLMPLYGCESWTGVIHPREGQAIAWVEPARLRDYPAP
HHHHHHHCCCCEEEEECCCCCHHEEHHHHCCCCCCCCEECCCCCEEEEECCHHHCCCCCC
PADLPLFDWLLEQAQAEL
CCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SQRLLLVVAAALKDETGRILLAQRPEGKQLAGLWEFPGGKVDPGETPEAALARELHEEL
CCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
SIVVKEEALKPLTFASFTYPDFHLLMPLYGCESWTGVIHPREGQAIAWVEPARLRDYPAP
HHHHHHHCCCCEEEEECCCCCHHEEHHHHCCCCCCCCEECCCCCEEEEECCHHHCCCCCC
PADLPLFDWLLEQAQAEL
CCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]