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The map label for this gene is kinC [H]

Identifier: 114331740

GI number: 114331740

Start: 1865050

End: 1867131

Strand: Direct

Name: kinC [H]

Synonym: Neut_1763

Alternate gene names: 114331740

Gene position: 1865050-1867131 (Clockwise)

Preceding gene: 114331739

Following gene: 114331741

Centisome position: 70.09

GC content: 45.77

Gene sequence:

>2082_bases
ATGACAACCCTAAGTTACGCTGCGGCAGCGCTCGCTTTTTTCTTTTTATTCATGCTGCTGATAACCAGTTGGCGAGGCCG
TCTTTATGGCTTGCTGCTGGCAATCGCCTGCATCATATCCTCAATATGGGCGGCAGCAATCGCGGGATTATCCTATTGGG
ATTATTCAGATCCTCTGCTGCCTCAAATACTGGAAATATTACGAAATGCTGCCCTGACTACATTTCTGATTACCTTGCTG
GGGCCTTTCCAGTCCGGTAAAACAAATAAAACCTTTCCCAGAATCAGGCCGGTTGTTACTGCCATCGCTCTGTTCTACCT
GGTTTGTCTCGTACAAACAATCACTTTCAGTCACACTACCACTACCAGTGCTGATTCAGATCAACTCGGCTCCTCCTTCG
AGTTTCTTACATGGGTAACAATGGCCATCATTGGTATGATTCTGGTGGAGCAATATTACCGGAACACACCCCACGAGCAA
CGCTGGGGGATTAAATTCATTTGCCTGGGTATCGGGGGGTTATTTGTTTATGATTTTTATTTGTACAGCGATGCATTATT
ATTCAGAAAAATAAGCCCTGATATCTGGGCTGCTCGGGGGTGGGTCAATACACTTATCGTTCCCCTGATTGCACTTTCGG
CAGCACGCAACCCTAAATGGACAGTTGGCATTGCCGTTTCCAGACGCATCCTGTTTTACTCCACAGCACTATTTGGTGCC
GCGATTTACCTGCTGTTAATGGCTGCGGCCGGTTATTACCTCCGATTCTCGGGCGGGACCTGGGGTGCAGTATTTCAGCT
GACTTTCCTGTTTGGTGCAATTGTTCTACTGATCACTGTACTATTTTCCGGGACGACACGTTCCTGGCTCAAAGTGTTCA
TCAGCAAGCATTTTTTCAGCTATAACTATGATTATCGTGAAGAATGGCTGCGCTTTACGCGCACCCTGTCTGAAGAAGAA
ACGGAATTGAAGATTCGTGTGATTAAATCACTCGCGCAGCTGGTTGAAAGCCCAGCCGGAGCAGTGTGGTTCAAATCAGA
ACAAAATCATGCCTATCAACTGATTGCACGCTGGAATATTCCATATATTGATACATCTGTCGAAATTAACAGTCATTTTT
GCCGGTTTATGCAGGAAAGTTCCTGGGTAATTGATTTATATCAGCATGATTCCGGGCCTCAGCAATACGCAGCCATGATA
CTACCTGACTGGCTGCCCACTATTCCCAAGGCACGCTGGGTGGTACCACTAATATTGCATGGAGAGCTGCTGGGATTTGT
GGTGCTGACCGAACCCAGAAGTACGGTCAAATTTGATTGGGAAGTCAGGGATTTATTGAAAGTAGCAGGAAGCCAGGCAG
CAAGTTATCTAGCGCAGTACGAAGCAACTCAGGCGCTCTCTACGGCACGACAGTTTGAATCATTCAATCGCATGTCTACG
TTTATCGTGCACGACATCAAAAATCTGATTGCCCAGCTTTCGTTGTTGCTGACCAATGCGGTAAAGCATAAGGACAACCC
GGAATTTCAGCAGGATATGCTGGACACTGTAGCGTTATCTATCAACAAAATGAAACGTTTACTTGAAAAACTCAGCGACG
GAGGCATGCATGAAGAAAAAAACTCCTTGTTATCTCTAGATGAATTACTGCAACAAATCATTGAAAGCAAATCCTTCTGT
GAACCGAGGCCAGTACTTAATATCATCGATCCAAATCTAAATATACAAGCCGATCCATCACGCCTGGAGCGTGTGCTTGG
TCATCTGGTACAAAATGCAATCGAGGCCACTCCCAAAGACGGATATGTTGAGGTACGACTCGGGCGACAATCCGGATGGG
CAGTAATCAAGATTAAAGACAGTGGACATGGCATGAACGAACAATTTATCCGCGACAAATTATTTACTCCTTTCGAGTCG
ACCAAAACAGCCGGCATGGGCATTGGTGTGTTCGAGAGCAGGGAATATGTCGAACAAATTGGTGGAAAATTGCATGTATC
CAGTGAAGTATCAAAAGGAACTGTTTTCTCGGTCATGCTACCGATAGCAAAATCCATGCAATCTCCCGTTACACCGTTAT
AA

Upstream 100 bases:

>100_bases
ATCCTGATCAACACCGTAGGCGTCGTACTGCTGAGCAAAGGCAGTCGGTGAGCATCGGTAATCACGATGGCAGCTACATT
TTTTCTCCGTACTGACTGTC

Downstream 100 bases:

>100_bases
AAATATCTTGAAAAGAGCGCTGTCACGAACAGCCAGCGCACCTGTTATTCCTTCGTTACATGGTTCTTCTCTGAAACACA
ATTATGCTCCGTTATTTTGA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MTTLSYAAAALAFFFLFMLLITSWRGRLYGLLLAIACIISSIWAAAIAGLSYWDYSDPLLPQILEILRNAALTTFLITLL
GPFQSGKTNKTFPRIRPVVTAIALFYLVCLVQTITFSHTTTTSADSDQLGSSFEFLTWVTMAIIGMILVEQYYRNTPHEQ
RWGIKFICLGIGGLFVYDFYLYSDALLFRKISPDIWAARGWVNTLIVPLIALSAARNPKWTVGIAVSRRILFYSTALFGA
AIYLLLMAAAGYYLRFSGGTWGAVFQLTFLFGAIVLLITVLFSGTTRSWLKVFISKHFFSYNYDYREEWLRFTRTLSEEE
TELKIRVIKSLAQLVESPAGAVWFKSEQNHAYQLIARWNIPYIDTSVEINSHFCRFMQESSWVIDLYQHDSGPQQYAAMI
LPDWLPTIPKARWVVPLILHGELLGFVVLTEPRSTVKFDWEVRDLLKVAGSQAASYLAQYEATQALSTARQFESFNRMST
FIVHDIKNLIAQLSLLLTNAVKHKDNPEFQQDMLDTVALSINKMKRLLEKLSDGGMHEEKNSLLSLDELLQQIIESKSFC
EPRPVLNIIDPNLNIQADPSRLERVLGHLVQNAIEATPKDGYVEVRLGRQSGWAVIKIKDSGHGMNEQFIRDKLFTPFES
TKTAGMGIGVFESREYVEQIGGKLHVSSEVSKGTVFSVMLPIAKSMQSPVTPL

Sequences:

>Translated_693_residues
MTTLSYAAAALAFFFLFMLLITSWRGRLYGLLLAIACIISSIWAAAIAGLSYWDYSDPLLPQILEILRNAALTTFLITLL
GPFQSGKTNKTFPRIRPVVTAIALFYLVCLVQTITFSHTTTTSADSDQLGSSFEFLTWVTMAIIGMILVEQYYRNTPHEQ
RWGIKFICLGIGGLFVYDFYLYSDALLFRKISPDIWAARGWVNTLIVPLIALSAARNPKWTVGIAVSRRILFYSTALFGA
AIYLLLMAAAGYYLRFSGGTWGAVFQLTFLFGAIVLLITVLFSGTTRSWLKVFISKHFFSYNYDYREEWLRFTRTLSEEE
TELKIRVIKSLAQLVESPAGAVWFKSEQNHAYQLIARWNIPYIDTSVEINSHFCRFMQESSWVIDLYQHDSGPQQYAAMI
LPDWLPTIPKARWVVPLILHGELLGFVVLTEPRSTVKFDWEVRDLLKVAGSQAASYLAQYEATQALSTARQFESFNRMST
FIVHDIKNLIAQLSLLLTNAVKHKDNPEFQQDMLDTVALSINKMKRLLEKLSDGGMHEEKNSLLSLDELLQQIIESKSFC
EPRPVLNIIDPNLNIQADPSRLERVLGHLVQNAIEATPKDGYVEVRLGRQSGWAVIKIKDSGHGMNEQFIRDKLFTPFES
TKTAGMGIGVFESREYVEQIGGKLHVSSEVSKGTVFSVMLPIAKSMQSPVTPL
>Mature_692_residues
TTLSYAAAALAFFFLFMLLITSWRGRLYGLLLAIACIISSIWAAAIAGLSYWDYSDPLLPQILEILRNAALTTFLITLLG
PFQSGKTNKTFPRIRPVVTAIALFYLVCLVQTITFSHTTTTSADSDQLGSSFEFLTWVTMAIIGMILVEQYYRNTPHEQR
WGIKFICLGIGGLFVYDFYLYSDALLFRKISPDIWAARGWVNTLIVPLIALSAARNPKWTVGIAVSRRILFYSTALFGAA
IYLLLMAAAGYYLRFSGGTWGAVFQLTFLFGAIVLLITVLFSGTTRSWLKVFISKHFFSYNYDYREEWLRFTRTLSEEET
ELKIRVIKSLAQLVESPAGAVWFKSEQNHAYQLIARWNIPYIDTSVEINSHFCRFMQESSWVIDLYQHDSGPQQYAAMIL
PDWLPTIPKARWVVPLILHGELLGFVVLTEPRSTVKFDWEVRDLLKVAGSQAASYLAQYEATQALSTARQFESFNRMSTF
IVHDIKNLIAQLSLLLTNAVKHKDNPEFQQDMLDTVALSINKMKRLLEKLSDGGMHEEKNSLLSLDELLQQIIESKSFCE
PRPVLNIIDPNLNIQADPSRLERVLGHLVQNAIEATPKDGYVEVRLGRQSGWAVIKIKDSGHGMNEQFIRDKLFTPFEST
KTAGMGIGVFESREYVEQIGGKLHVSSEVSKGTVFSVMLPIAKSMQSPVTPL

Specific function: Phosphorylates the sporulation-regulatory protein spo0A [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=115, Percent_Identity=37.3913043478261, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78300; Mature: 78169

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLSYAAAALAFFFLFMLLITSWRGRLYGLLLAIACIISSIWAAAIAGLSYWDYSDPLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
PQILEILRNAALTTFLITLLGPFQSGKTNKTFPRIRPVVTAIALFYLVCLVQTITFSHTT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TTSADSDQLGSSFEFLTWVTMAIIGMILVEQYYRNTPHEQRWGIKFICLGIGGLFVYDFY
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEEHHHHHHHHHHH
LYSDALLFRKISPDIWAARGWVNTLIVPLIALSAARNPKWTVGIAVSRRILFYSTALFGA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHH
AIYLLLMAAAGYYLRFSGGTWGAVFQLTFLFGAIVLLITVLFSGTTRSWLKVFISKHFFS
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
YNYDYREEWLRFTRTLSEEETELKIRVIKSLAQLVESPAGAVWFKSEQNHAYQLIARWNI
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCC
PYIDTSVEINSHFCRFMQESSWVIDLYQHDSGPQQYAAMILPDWLPTIPKARWVVPLILH
CEECCEEEHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHCCCCCCCHHHHHHHH
GELLGFVVLTEPRSTVKFDWEVRDLLKVAGSQAASYLAQYEATQALSTARQFESFNRMST
HHHEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVHDIKNLIAQLSLLLTNAVKHKDNPEFQQDMLDTVALSINKMKRLLEKLSDGGMHEEK
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
NSLLSLDELLQQIIESKSFCEPRPVLNIIDPNLNIQADPSRLERVLGHLVQNAIEATPKD
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEECHHHHHHHHHHHHHHHHHCCCCC
GYVEVRLGRQSGWAVIKIKDSGHGMNEQFIRDKLFTPFESTKTAGMGIGVFESREYVEQI
CEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHC
GGKLHVSSEVSKGTVFSVMLPIAKSMQSPVTPL
CCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTLSYAAAALAFFFLFMLLITSWRGRLYGLLLAIACIISSIWAAAIAGLSYWDYSDPLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
PQILEILRNAALTTFLITLLGPFQSGKTNKTFPRIRPVVTAIALFYLVCLVQTITFSHTT
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TTSADSDQLGSSFEFLTWVTMAIIGMILVEQYYRNTPHEQRWGIKFICLGIGGLFVYDFY
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCEEEEEEHHHHHHHHHHH
LYSDALLFRKISPDIWAARGWVNTLIVPLIALSAARNPKWTVGIAVSRRILFYSTALFGA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHH
AIYLLLMAAAGYYLRFSGGTWGAVFQLTFLFGAIVLLITVLFSGTTRSWLKVFISKHFFS
HHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
YNYDYREEWLRFTRTLSEEETELKIRVIKSLAQLVESPAGAVWFKSEQNHAYQLIARWNI
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCC
PYIDTSVEINSHFCRFMQESSWVIDLYQHDSGPQQYAAMILPDWLPTIPKARWVVPLILH
CEECCEEEHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCHHHCCCCCCCHHHHHHHH
GELLGFVVLTEPRSTVKFDWEVRDLLKVAGSQAASYLAQYEATQALSTARQFESFNRMST
HHHEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVHDIKNLIAQLSLLLTNAVKHKDNPEFQQDMLDTVALSINKMKRLLEKLSDGGMHEEK
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
NSLLSLDELLQQIIESKSFCEPRPVLNIIDPNLNIQADPSRLERVLGHLVQNAIEATPKD
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEECHHHHHHHHHHHHHHHHHCCCCC
GYVEVRLGRQSGWAVIKIKDSGHGMNEQFIRDKLFTPFESTKTAGMGIGVFESREYVEQI
CEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHC
GGKLHVSSEVSKGTVFSVMLPIAKSMQSPVTPL
CCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8002615; 8002614; 8969500; 9384377 [H]