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The map label for this gene is mltA [H]

Identifier: 114331671

GI number: 114331671

Start: 1782409

End: 1783875

Strand: Direct

Name: mltA [H]

Synonym: Neut_1687

Alternate gene names: 114331671

Gene position: 1782409-1783875 (Clockwise)

Preceding gene: 114331670

Following gene: 114331674

Centisome position: 66.98

GC content: 49.35

Gene sequence:

>1467_bases
ATGACTAATCCATTAGCAATGCAGCAGAACAAAAGCAGGCAGCCGCTCTCAAATAGCAAACAAGGCATGATCTATTTTTT
TTCATCCTTGTTATCCAGTTGTTCCAATGGTTTATTTTTTTTACGGGGGAGCGTCCACCAGACGAGAAAAATGAACAGAC
TCAACGCCAAGATTGCTTCAAGTGCTAAAATCCACATATTCTTCCCTAAAAAAATGTTTTTACAAAACAGACACTTTAAC
CGAAATCTGCTAAAAACCCAATTCATCACCCTGCTGATCTTAATCCCACTCGGATTAACCAGCTGCAAAACTGAAACTAT
TTCCACCCAATCTTCCACATCCCAAACCCCTGCAAAAGTGGCTGCCATTCCCGCAGCGCCACAATCAGCAAGCCCTACTC
AAGATACCAGGGACAAGGAAGATAAAAAGCTGCTTAAAGCTGCTAGTTGGTCAATGCTACCAGGCTGGCAACATGAAAGC
CTTCTTCCGGCGTGGAATACCTTTATACAAAGCTGCAGATCTCTCGAACGACGCCCCTCCTGGCAGGATGTATGCACACA
AGCTACAATCATTCGGCACAGCAGTGAACAAGCTGTCCGAAATTTTCTTGAAAATCACTTTGCACCTTATCAGGTGATCA
ATCCGGATGGCACCACCACTGGCCTGGCAACCGGTTACTATGAACCTCTGCTTAAAGGCAGTCGCAAATATTCCAGTCGC
TTCCGCTACCCGATTTATTCCACTCCCGACAACCTGCTGGCAGTCGAGCTCAAAGACGCGCTGCCCGATGCAAATCAGGT
AGCGCTACGTGGCCGTCTACAGGGACGCAAAATTATTCCTTACTACACCCGCGCGGAAATCGAGAACAACCGCAGTCTGC
TGAAAGGAAAAGAACTGTTGTGGGTAGAGGATGAGGTCGAGCTGTTCTTTCTCCAGATACAAGGATCCGGCCGCGTCGTG
CTGGAAAATGGTGAAACCGTAAAAATCGGCTACGCGGATCACAACGGTTATCCCTACCGCTCTATCGGAAAAATATTGAT
TGATCGGGGTGAACTGCCCGCCTGGCAGGTATCCATGCAGTCCATCAAACAATGGGGCCGACAAAACCCTGCCAAATTGA
AATCCTTGTTGCAGCAGAATGCGCGTTATATTTTCTTTCGCGAACTGCCAGCCGATCTTGCCGGACCGATCGGTGCGCTG
GGAGTCCCTTTAACGGCGGGCAGAAGTCTGGCTATTGATCCGGAGAGTGTCCCACTGGGTGCCCCAGTTTATCTTTCCAC
CACTTGGCCCAATACAGCACAGCCACTTAACCGCCTGATGGTTGCCCAAGATACAGGCAGTGCTATCAAGGGTGGGGTGC
GTGCTGATTTCTTCTGGGGACACAGCCCGGAAGCTCAGGCCCAAGCGGGTAAAATGAAGCAGCAAGCCCAGATGTGGGTC
CTGCTTCCCAAGCAGTACAGGGAATAA

Upstream 100 bases:

>100_bases
GGCATCACGCCACCGAACGCTATGGAATTCAGGCGCTTGGTGATCATATCGCACAAAAATTCAGTATTGCACACCATTTT
ATTGATGCAGAAAACCCTGT

Downstream 100 bases:

>100_bases
AGGACTCAGAAGGTAGCCACTCAGGCGGATAAGGTTGTATCACTTACTCGTGGCCTGATCCAGCCGCTTTTCGATTTCTG
ATTGCGGGATAAAACCCGGC

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTNPLAMQQNKSRQPLSNSKQGMIYFFSSLLSSCSNGLFFLRGSVHQTRKMNRLNAKIASSAKIHIFFPKKMFLQNRHFN
RNLLKTQFITLLILIPLGLTSCKTETISTQSSTSQTPAKVAAIPAAPQSASPTQDTRDKEDKKLLKAASWSMLPGWQHES
LLPAWNTFIQSCRSLERRPSWQDVCTQATIIRHSSEQAVRNFLENHFAPYQVINPDGTTTGLATGYYEPLLKGSRKYSSR
FRYPIYSTPDNLLAVELKDALPDANQVALRGRLQGRKIIPYYTRAEIENNRSLLKGKELLWVEDEVELFFLQIQGSGRVV
LENGETVKIGYADHNGYPYRSIGKILIDRGELPAWQVSMQSIKQWGRQNPAKLKSLLQQNARYIFFRELPADLAGPIGAL
GVPLTAGRSLAIDPESVPLGAPVYLSTTWPNTAQPLNRLMVAQDTGSAIKGGVRADFFWGHSPEAQAQAGKMKQQAQMWV
LLPKQYRE

Sequences:

>Translated_488_residues
MTNPLAMQQNKSRQPLSNSKQGMIYFFSSLLSSCSNGLFFLRGSVHQTRKMNRLNAKIASSAKIHIFFPKKMFLQNRHFN
RNLLKTQFITLLILIPLGLTSCKTETISTQSSTSQTPAKVAAIPAAPQSASPTQDTRDKEDKKLLKAASWSMLPGWQHES
LLPAWNTFIQSCRSLERRPSWQDVCTQATIIRHSSEQAVRNFLENHFAPYQVINPDGTTTGLATGYYEPLLKGSRKYSSR
FRYPIYSTPDNLLAVELKDALPDANQVALRGRLQGRKIIPYYTRAEIENNRSLLKGKELLWVEDEVELFFLQIQGSGRVV
LENGETVKIGYADHNGYPYRSIGKILIDRGELPAWQVSMQSIKQWGRQNPAKLKSLLQQNARYIFFRELPADLAGPIGAL
GVPLTAGRSLAIDPESVPLGAPVYLSTTWPNTAQPLNRLMVAQDTGSAIKGGVRADFFWGHSPEAQAQAGKMKQQAQMWV
LLPKQYRE
>Mature_487_residues
TNPLAMQQNKSRQPLSNSKQGMIYFFSSLLSSCSNGLFFLRGSVHQTRKMNRLNAKIASSAKIHIFFPKKMFLQNRHFNR
NLLKTQFITLLILIPLGLTSCKTETISTQSSTSQTPAKVAAIPAAPQSASPTQDTRDKEDKKLLKAASWSMLPGWQHESL
LPAWNTFIQSCRSLERRPSWQDVCTQATIIRHSSEQAVRNFLENHFAPYQVINPDGTTTGLATGYYEPLLKGSRKYSSRF
RYPIYSTPDNLLAVELKDALPDANQVALRGRLQGRKIIPYYTRAEIENNRSLLKGKELLWVEDEVELFFLQIQGSGRVVL
ENGETVKIGYADHNGYPYRSIGKILIDRGELPAWQVSMQSIKQWGRQNPAKLKSLLQQNARYIFFRELPADLAGPIGALG
VPLTAGRSLAIDPESVPLGAPVYLSTTWPNTAQPLNRLMVAQDTGSAIKGGVRADFFWGHSPEAQAQAGKMKQQAQMWVL
LPKQYRE

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=290, Percent_Identity=32.4137931034483, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 54811; Mature: 54679

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLAMQQNKSRQPLSNSKQGMIYFFSSLLSSCSNGLFFLRGSVHQTRKMNRLNAKIAS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCC
SAKIHIFFPKKMFLQNRHFNRNLLKTQFITLLILIPLGLTSCKTETISTQSSTSQTPAKV
CCEEEEEECHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCEE
AAIPAAPQSASPTQDTRDKEDKKLLKAASWSMLPGWQHESLLPAWNTFIQSCRSLERRPS
EEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
WQDVCTQATIIRHSSEQAVRNFLENHFAPYQVINPDGTTTGLATGYYEPLLKGSRKYSSR
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHCC
FRYPIYSTPDNLLAVELKDALPDANQVALRGRLQGRKIIPYYTRAEIENNRSLLKGKELL
CCCCEECCCCCEEEEEEHHHCCCCHHHHHHHCCCCCEECCEEEEHHCCCCCHHHCCCEEE
WVEDEVELFFLQIQGSGRVVLENGETVKIGYADHNGYPYRSIGKILIDRGELPAWQVSMQ
EEECCEEEEEEEEECCCEEEEECCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
SIKQWGRQNPAKLKSLLQQNARYIFFRELPADLAGPIGALGVPLTAGRSLAIDPESVPLG
HHHHHCCCCHHHHHHHHHCCCCEEEEEECCHHHCCCCCCCCCCCCCCCEEEECCCCCCCC
APVYLSTTWPNTAQPLNRLMVAQDTGSAIKGGVRADFFWGHSPEAQAQAGKMKQQAQMWV
CCEEEEECCCCHHHHHHHEEEECCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCEEE
LLPKQYRE
ECCHHHCC
>Mature Secondary Structure 
TNPLAMQQNKSRQPLSNSKQGMIYFFSSLLSSCSNGLFFLRGSVHQTRKMNRLNAKIAS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCC
SAKIHIFFPKKMFLQNRHFNRNLLKTQFITLLILIPLGLTSCKTETISTQSSTSQTPAKV
CCEEEEEECHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCEE
AAIPAAPQSASPTQDTRDKEDKKLLKAASWSMLPGWQHESLLPAWNTFIQSCRSLERRPS
EEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
WQDVCTQATIIRHSSEQAVRNFLENHFAPYQVINPDGTTTGLATGYYEPLLKGSRKYSSR
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHCCCHHHHCC
FRYPIYSTPDNLLAVELKDALPDANQVALRGRLQGRKIIPYYTRAEIENNRSLLKGKELL
CCCCEECCCCCEEEEEEHHHCCCCHHHHHHHCCCCCEECCEEEEHHCCCCCHHHCCCEEE
WVEDEVELFFLQIQGSGRVVLENGETVKIGYADHNGYPYRSIGKILIDRGELPAWQVSMQ
EEECCEEEEEEEEECCCEEEEECCCEEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHH
SIKQWGRQNPAKLKSLLQQNARYIFFRELPADLAGPIGALGVPLTAGRSLAIDPESVPLG
HHHHHCCCCHHHHHHHHHCCCCEEEEEECCHHHCCCCCCCCCCCCCCCEEEECCCCCCCC
APVYLSTTWPNTAQPLNRLMVAQDTGSAIKGGVRADFFWGHSPEAQAQAGKMKQQAQMWV
CCEEEEECCCCHHHHHHHEEEECCCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCEEE
LLPKQYRE
ECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]