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The map label for this gene is cah [H]

Identifier: 114331614

GI number: 114331614

Start: 1712523

End: 1713320

Strand: Reverse

Name: cah [H]

Synonym: Neut_1628

Alternate gene names: 114331614

Gene position: 1713320-1712523 (Counterclockwise)

Preceding gene: 114331615

Following gene: 114331612

Centisome position: 64.38

GC content: 42.23

Gene sequence:

>798_bases
GTGAGAACTAAAATACTGGCAAATCTAGTTTCTATAATCTTTATAAGTTACACAGCAGTTGCAGTTTCTGCTCCACCTCA
TTGGTCTTATGAAGAGGAGCCTAACTGGGGAGCGATTGAAGACGCTACTCAATCGATACCATTGCGTTATCCCTACGCAG
AGTGTGGTATTGGTAAACATCAGTCACCGGTAGATCTGGCAGATGAAAAGATTGTGAAATCCAGGCCGCTAAATAAACTT
GCGGCACAGTATGGTACAGATACGCCATCTTTCTTCAATACAGGACATGCCATACAAGTTAATACTTCCCAGAATTTTAC
GGGTGGATTAAAAGTCGGGAAGGAATTGCTGCCGCTGGTTCAACTACATTTCCATGAGCCCAGCGAACATGTTGTTGAGG
GCAAAAAATTTCCTGCGGAATTACATTTTGTACATATCAATAAGGATGGAAGAATTGCGGTACTGGCTGTGACCATAAAT
ATCGGGAAAGAGAATGCGATGTTCCAGACTGTTCTGGATAATATGCCGTATGAAAGCGGCAAAGAAAATTCGACTTCCGG
GGTTAAGTTCAAACTAGCGAAGTTATTACCGTCAGGTATGAATGCGGCCAATCTGAAATATTTAACGCTGGCTGGTTCAT
TGACGACTCCGCCTTGTAGCGAAGGCGTGCAATGGTATATTTTGACAAAATCAATCACGATTTCAGCGGCTCAATTAGAG
CAAATGAAAACTTTCTACAGCAACAATGCCAGATCAGCACAGGATCTGAATGAAAGGTCAATTCTTTCAAACCAGTAA

Upstream 100 bases:

>100_bases
AGCCTTCACAAGAGATCGGCTTAGATAAAAAATCTTTAATGATCGACTATTGCAGGAAACATACCTGCTAATTTAATAAC
TATTATGATAGGAATTACTC

Downstream 100 bases:

>100_bases
TCGTGAGCTGTAAATAATTCTTCCCCGGCATGGCTCTGGCATCCGGGGAAGCTCCTTATTTGTTCGAATTTTTCTCGGTC
CCATCACGTATTTTGGTTCT

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MRTKILANLVSIIFISYTAVAVSAPPHWSYEEEPNWGAIEDATQSIPLRYPYAECGIGKHQSPVDLADEKIVKSRPLNKL
AAQYGTDTPSFFNTGHAIQVNTSQNFTGGLKVGKELLPLVQLHFHEPSEHVVEGKKFPAELHFVHINKDGRIAVLAVTIN
IGKENAMFQTVLDNMPYESGKENSTSGVKFKLAKLLPSGMNAANLKYLTLAGSLTTPPCSEGVQWYILTKSITISAAQLE
QMKTFYSNNARSAQDLNERSILSNQ

Sequences:

>Translated_265_residues
MRTKILANLVSIIFISYTAVAVSAPPHWSYEEEPNWGAIEDATQSIPLRYPYAECGIGKHQSPVDLADEKIVKSRPLNKL
AAQYGTDTPSFFNTGHAIQVNTSQNFTGGLKVGKELLPLVQLHFHEPSEHVVEGKKFPAELHFVHINKDGRIAVLAVTIN
IGKENAMFQTVLDNMPYESGKENSTSGVKFKLAKLLPSGMNAANLKYLTLAGSLTTPPCSEGVQWYILTKSITISAAQLE
QMKTFYSNNARSAQDLNERSILSNQ
>Mature_265_residues
MRTKILANLVSIIFISYTAVAVSAPPHWSYEEEPNWGAIEDATQSIPLRYPYAECGIGKHQSPVDLADEKIVKSRPLNKL
AAQYGTDTPSFFNTGHAIQVNTSQNFTGGLKVGKELLPLVQLHFHEPSEHVVEGKKFPAELHFVHINKDGRIAVLAVTIN
IGKENAMFQTVLDNMPYESGKENSTSGVKFKLAKLLPSGMNAANLKYLTLAGSLTTPPCSEGVQWYILTKSITISAAQLE
QMKTFYSNNARSAQDLNERSILSNQ

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI169636420, Length=268, Percent_Identity=31.7164179104478, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI4885099, Length=237, Percent_Identity=30.379746835443, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI258679498, Length=271, Percent_Identity=29.8892988929889, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI192447434, Length=271, Percent_Identity=29.8892988929889, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI192447432, Length=271, Percent_Identity=29.8892988929889, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI192447430, Length=271, Percent_Identity=29.8892988929889, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502517, Length=271, Percent_Identity=29.8892988929889, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI38348436, Length=245, Percent_Identity=29.3877551020408, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI6912284, Length=295, Percent_Identity=28.8135593220339, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4885101, Length=261, Percent_Identity=31.4176245210728, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557395, Length=238, Percent_Identity=32.7731092436975, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI70167127, Length=273, Percent_Identity=29.6703296703297, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI6005723, Length=240, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4502521, Length=240, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI45935383, Length=261, Percent_Identity=30.2681992337165, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4502515, Length=261, Percent_Identity=30.2681992337165, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI62240989, Length=205, Percent_Identity=32.1951219512195, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI91208428, Length=241, Percent_Identity=26.9709543568465, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI22027500, Length=244, Percent_Identity=29.9180327868852, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI130979954, Length=267, Percent_Identity=23.5955056179775, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI130979679, Length=267, Percent_Identity=23.5955056179775, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI9910366, Length=267, Percent_Identity=23.5955056179775, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI9951923, Length=283, Percent_Identity=23.6749116607774, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI194097398, Length=278, Percent_Identity=25.1798561151079, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4502519, Length=281, Percent_Identity=25.6227758007117, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=260, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17569163, Length=235, Percent_Identity=28.5106382978723, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569165, Length=233, Percent_Identity=28.3261802575107, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737413, Length=266, Percent_Identity=30.8270676691729, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358169, Length=248, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24645604, Length=292, Percent_Identity=25.3424657534247, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651619, Length=241, Percent_Identity=28.2157676348548, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650523, Length=255, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161079350, Length=284, Percent_Identity=26.056338028169, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116008410, Length=246, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 29177; Mature: 29177

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKILANLVSIIFISYTAVAVSAPPHWSYEEEPNWGAIEDATQSIPLRYPYAECGIGKH
CCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHCCCCCC
QSPVDLADEKIVKSRPLNKLAAQYGTDTPSFFNTGHAIQVNTSQNFTGGLKVGKELLPLV
CCCCCHHHHHHHHHCCHHHHHHHHCCCCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
QLHFHEPSEHVVEGKKFPAELHFVHINKDGRIAVLAVTINIGKENAMFQTVLDNMPYESG
HHHCCCCHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCCC
KENSTSGVKFKLAKLLPSGMNAANLKYLTLAGSLTTPPCSEGVQWYILTKSITISAAQLE
CCCCCCCCEEEEEHHCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEEEEEEHHHHH
QMKTFYSNNARSAQDLNERSILSNQ
HHHHHHCCCCCCHHHCCHHHHCCCC
>Mature Secondary Structure
MRTKILANLVSIIFISYTAVAVSAPPHWSYEEEPNWGAIEDATQSIPLRYPYAECGIGKH
CCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHCCCCCC
QSPVDLADEKIVKSRPLNKLAAQYGTDTPSFFNTGHAIQVNTSQNFTGGLKVGKELLPLV
CCCCCHHHHHHHHHCCHHHHHHHHCCCCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
QLHFHEPSEHVVEGKKFPAELHFVHINKDGRIAVLAVTINIGKENAMFQTVLDNMPYESG
HHHCCCCHHHHHCCCCCCEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHCCCCCCC
KENSTSGVKFKLAKLLPSGMNAANLKYLTLAGSLTTPPCSEGVQWYILTKSITISAAQLE
CCCCCCCCEEEEEHHCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEEEEEEHHHHH
QMKTFYSNNARSAQDLNERSILSNQ
HHHHHHCCCCCCHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]