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The map label for this gene is gyrA [H]

Identifier: 114331560

GI number: 114331560

Start: 1649168

End: 1651714

Strand: Reverse

Name: gyrA [H]

Synonym: Neut_1573

Alternate gene names: 114331560

Gene position: 1651714-1649168 (Counterclockwise)

Preceding gene: 114331561

Following gene: 114331559

Centisome position: 62.07

GC content: 47.62

Gene sequence:

>2547_bases
ATGGAACAATTCGCAAAGGAAACATTGCCCGTCAGTCTTGAGGATGAGATGAAGCGCTCTTACCTCGATTATGCGATGAG
CGTTATCGTAGGACGAGCCTTGCCTGATGTGCGTGATGGGTTGAAACCGGTACACCGGCGTGTGCTTTACGCCATGCATG
AACTATCCAATGATTGGAACCGGCCATATAAAAAATCTGCACGTATCGTTGGTGATGTGATTGGTAAGTATCACCCGCAT
GGTGATACAGCTGTCTATGACACGATCGTGCGTATGGCACAACCTTTTTCTCTGCGTTACATGCTGATAGACGGGCAGGG
TAATTTTGGCTCGATTGATGGCGATAATGCAGCAGCTATGCGCTACACCGAAATCAGAATGTCGCGTATTGCCCATGAGT
TGCTGGCCGACCTGGATAAAAATACTGTTGATTTTGGCCCCAACTATGATGGCTCCGAACAGGAGCCATTGATTCTGCCG
GCAAAAATACCCAACTTGCTGATTAATGGTTCATCCGGTATTGCGGTGGGTATGGCAACCAACATCCCGCCTCATAATAT
CAGCGAAGTGATTGATGCTTGCTTGCTATTGCTAAGTGATCCAGATATCGATATCGCTGGGTTGATGGCTTGTATTCCGG
CCCCCGATTTTCCAACTGCCGGCATCATTTACGGTATATCTGGTATCAAGGATGGATACCAGACTGGAAGAGGGCGCGTC
ATTATGCGTGCCCGAACGCATTTTGAAGAGCTCGATAAAGGAAATCGCCACAGCATCATTATCGATGAATTACCTTATCA
GGTGAACAAGGCCAATCTATTGGTACGTATCGGAGAGCTGGTAAGAGATAAAAGGATAGAGGGTATTTCAGATTTGCGCG
ATGAATCGGATAAATCCGGTATGCGCGTGGTCATTGAACTCAAGCGTGGAGAGGTACCTGAGGTTATCCTGAACAATCTG
TACAAAGAGACGCAGATGCAGGATACATTTGGCATAAATATGGTGGCGCTGGTCGATGGACAGCCGCGTTTGCTCAATCT
GAAGCAGATGCTGGATTATTTCCTACGTCATCGTCGCGAAGTTATAACACGGCGCACCGTATTTGAACTCAGGAAAGCGC
GGGAACGTGGCCATTTACTGGAAGGATTGGCAGTCGCGTTATCTAACGTCGATGAGATTATTGCCTTGATCAAGGCAGCC
CCGACTCCGGCTGAAGCTAAAAGAGGATTGATGGCCAGAACATGGCGGTCATCCCTAGTTGAAGAAATGCTCCGCCGTGC
AATGATTGATGCAGCCGCATTTCGTCCTGAAACACTGGCAACCGGGTTCGGGATGTCAAACCAGGAATATCGCTTATCCG
ATGCGCAAGCCCAGGCGATTCTTGATCTCAGGTTGCAACGTCTTACCGGACTGGAGCAGGAAAAAATTGTCTCCGAGTAT
AAAGAGATACTGGATAAAATTCGGGACCTCCTCAATATGTTGGCAAATTCAGAACGTATCACTGCTATTATTATTGAAGA
ATTGACGGCTATCAAAGGGCAGTTCGGCGATCCCAGGCGCAGTGAGGTAGTGATCGATGCACAAGATTTAAGTACGGAAG
ATCTGATTACACCCACTGATATGGTAGTGACTCTGTCACACGCAGGCTACATTAAATCTCAGTTGCTTGACGATTACCAG
GCACAGAAACGTGGAGGACGTGGTAAGCAAGCGATTACTACTCGCGAGGATGATTTCATTGATAATCTGTTTATTGCCAA
TACCCATGATTTTATCCTGTGTTTCTCCAGCCTCGGGCGGGTTTACTGGATAAAGGTATACAACGTGCCGCAAGGCAGCC
GTACTTCCCGCGGCAGGCCCATTAATAACCTTGTCCCATTGGAACAGCATGAAAAGATCAATGCTGTTCTGCCGGTCAAG
TCATTTGATGATACCCGCTACGTATTTATGGCAACTGCTGGTGGTACAGTCAAGAAAACACCGTTATCAGAGTTTTCCCG
GCCACGGACCAATGGGATCATTGCGGTCGCTCTGGATGAAGGGGATTATCTGATTGGTGTTGCGCTTACCGAAGGCAAGC
ATGACGTCATGCTTTTTTCTGATGCAGGCAAGGCAATGCGTTTCGATGAAAATGATGTGCGCCCGACCGGACGTAATGCG
CGCGGGGTCAGGGGCATGAAGCTTGGGGCAGAACAAAAAGTTATCTCTCTGCTGGTTGCAGATAGTGAAAATATGACAGT
ATTGACCGCAACTGAGAATGGTTATGGAAAACGCACCTCCATTACTGAATATACCCGGCATAACCGAGGTACTCAGGGTA
TGATCGCGATCAATACCAATAAACGTAATGGTAAAGTTGTCGCTGCGCAACTCGTTGAACCCAATGATGAAATCATGTTA
ATTACCACTGGAGGTGTCATGATTCGTACTCGTGTCAGTGAAATTCGTGAAATGGGCCGGGCAACTCAGGGGGTTATACT
GATTAATCTGGATGCCGGCGAGAAACTTGCTGGACTGGAAAGAATCGTTGAAACGGATGAGAACTAA

Upstream 100 bases:

>100_bases
AACTGCTTATATTGAGCAGAGCCATCAGTAATTCTTGCGCAGCAGTTGCTTCGCCCGTATGGGTATAACCTGAATATTTC
ACCACTAAAGTAGTTTATAC

Downstream 100 bases:

>100_bases
TTCAACCCGGTGACACAATGAGGAAAATATACAATTTCAGTGCAGGACCGGCTGTTTTGCCGGAGGAAGTATTGGAACAG
GCTCGCGAGGAAATGCTGGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MEQFAKETLPVSLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMSRIAHELLADLDKNTVDFGPNYDGSEQEPLILP
AKIPNLLINGSSGIAVGMATNIPPHNISEVIDACLLLLSDPDIDIAGLMACIPAPDFPTAGIIYGISGIKDGYQTGRGRV
IMRARTHFEELDKGNRHSIIIDELPYQVNKANLLVRIGELVRDKRIEGISDLRDESDKSGMRVVIELKRGEVPEVILNNL
YKETQMQDTFGINMVALVDGQPRLLNLKQMLDYFLRHRREVITRRTVFELRKARERGHLLEGLAVALSNVDEIIALIKAA
PTPAEAKRGLMARTWRSSLVEEMLRRAMIDAAAFRPETLATGFGMSNQEYRLSDAQAQAILDLRLQRLTGLEQEKIVSEY
KEILDKIRDLLNMLANSERITAIIIEELTAIKGQFGDPRRSEVVIDAQDLSTEDLITPTDMVVTLSHAGYIKSQLLDDYQ
AQKRGGRGKQAITTREDDFIDNLFIANTHDFILCFSSLGRVYWIKVYNVPQGSRTSRGRPINNLVPLEQHEKINAVLPVK
SFDDTRYVFMATAGGTVKKTPLSEFSRPRTNGIIAVALDEGDYLIGVALTEGKHDVMLFSDAGKAMRFDENDVRPTGRNA
RGVRGMKLGAEQKVISLLVADSENMTVLTATENGYGKRTSITEYTRHNRGTQGMIAINTNKRNGKVVAAQLVEPNDEIML
ITTGGVMIRTRVSEIREMGRATQGVILINLDAGEKLAGLERIVETDEN

Sequences:

>Translated_848_residues
MEQFAKETLPVSLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMSRIAHELLADLDKNTVDFGPNYDGSEQEPLILP
AKIPNLLINGSSGIAVGMATNIPPHNISEVIDACLLLLSDPDIDIAGLMACIPAPDFPTAGIIYGISGIKDGYQTGRGRV
IMRARTHFEELDKGNRHSIIIDELPYQVNKANLLVRIGELVRDKRIEGISDLRDESDKSGMRVVIELKRGEVPEVILNNL
YKETQMQDTFGINMVALVDGQPRLLNLKQMLDYFLRHRREVITRRTVFELRKARERGHLLEGLAVALSNVDEIIALIKAA
PTPAEAKRGLMARTWRSSLVEEMLRRAMIDAAAFRPETLATGFGMSNQEYRLSDAQAQAILDLRLQRLTGLEQEKIVSEY
KEILDKIRDLLNMLANSERITAIIIEELTAIKGQFGDPRRSEVVIDAQDLSTEDLITPTDMVVTLSHAGYIKSQLLDDYQ
AQKRGGRGKQAITTREDDFIDNLFIANTHDFILCFSSLGRVYWIKVYNVPQGSRTSRGRPINNLVPLEQHEKINAVLPVK
SFDDTRYVFMATAGGTVKKTPLSEFSRPRTNGIIAVALDEGDYLIGVALTEGKHDVMLFSDAGKAMRFDENDVRPTGRNA
RGVRGMKLGAEQKVISLLVADSENMTVLTATENGYGKRTSITEYTRHNRGTQGMIAINTNKRNGKVVAAQLVEPNDEIML
ITTGGVMIRTRVSEIREMGRATQGVILINLDAGEKLAGLERIVETDEN
>Mature_848_residues
MEQFAKETLPVSLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWNRPYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMSRIAHELLADLDKNTVDFGPNYDGSEQEPLILP
AKIPNLLINGSSGIAVGMATNIPPHNISEVIDACLLLLSDPDIDIAGLMACIPAPDFPTAGIIYGISGIKDGYQTGRGRV
IMRARTHFEELDKGNRHSIIIDELPYQVNKANLLVRIGELVRDKRIEGISDLRDESDKSGMRVVIELKRGEVPEVILNNL
YKETQMQDTFGINMVALVDGQPRLLNLKQMLDYFLRHRREVITRRTVFELRKARERGHLLEGLAVALSNVDEIIALIKAA
PTPAEAKRGLMARTWRSSLVEEMLRRAMIDAAAFRPETLATGFGMSNQEYRLSDAQAQAILDLRLQRLTGLEQEKIVSEY
KEILDKIRDLLNMLANSERITAIIIEELTAIKGQFGDPRRSEVVIDAQDLSTEDLITPTDMVVTLSHAGYIKSQLLDDYQ
AQKRGGRGKQAITTREDDFIDNLFIANTHDFILCFSSLGRVYWIKVYNVPQGSRTSRGRPINNLVPLEQHEKINAVLPVK
SFDDTRYVFMATAGGTVKKTPLSEFSRPRTNGIIAVALDEGDYLIGVALTEGKHDVMLFSDAGKAMRFDENDVRPTGRNA
RGVRGMKLGAEQKVISLLVADSENMTVLTATENGYGKRTSITEYTRHNRGTQGMIAINTNKRNGKVVAAQLVEPNDEIML
ITTGGVMIRTRVSEIREMGRATQGVILINLDAGEKLAGLERIVETDEN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=322, Percent_Identity=27.3291925465839, Blast_Score=84, Evalue=8e-16,
Organism=Homo sapiens, GI19913406, Length=353, Percent_Identity=25.7790368271955, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=844, Percent_Identity=62.3222748815166, Blast_Score=1075, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=738, Percent_Identity=34.8238482384824, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI212645657, Length=352, Percent_Identity=25.2840909090909, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=351, Percent_Identity=25.6410256410256, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=188, Percent_Identity=29.7872340425532, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=177, Percent_Identity=29.3785310734463, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136538, Length=353, Percent_Identity=26.628895184136, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94647; Mature: 94647

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQFAKETLPVSLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLIDGQGNFGSIDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHH
RYTEIRMSRIAHELLADLDKNTVDFGPNYDGSEQEPLILPAKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCEEEEEEC
NIPPHNISEVIDACLLLLSDPDIDIAGLMACIPAPDFPTAGIIYGISGIKDGYQTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHEEECCCCCCHHHCCCCEE
IMRARTHFEELDKGNRHSIIIDELPYQVNKANLLVRIGELVRDKRIEGISDLRDESDKSG
EEEEHHHHHHHCCCCCCEEEEECCCCEECCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
MRVVIELKRGEVPEVILNNLYKETQMQDTFGINMVALVDGQPRLLNLKQMLDYFLRHRRE
CEEEEEECCCCCHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VITRRTVFELRKARERGHLLEGLAVALSNVDEIIALIKAAPTPAEAKRGLMARTWRSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHH
EEMLRRAMIDAAAFRPETLATGFGMSNQEYRLSDAQAQAILDLRLQRLTGLEQEKIVSEY
HHHHHHHHHHHHHCCCHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCHHHHHHHH
KEILDKIRDLLNMLANSERITAIIIEELTAIKGQFGDPRRSEVVIDAQDLSTEDLITPTD
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
MVVTLSHAGYIKSQLLDDYQAQKRGGRGKQAITTREDDFIDNLFIANTHDFILCFSSLGR
EEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEECCCHHHHHHHHCCC
VYWIKVYNVPQGSRTSRGRPINNLVPLEQHEKINAVLPVKSFDDTRYVFMATAGGTVKKT
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCEECC
PLSEFSRPRTNGIIAVALDEGDYLIGVALTEGKHDVMLFSDAGKAMRFDENDVRPTGRNA
CHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEECCCCEEECCCCCCCCCCCCC
RGVRGMKLGAEQKVISLLVADSENMTVLTATENGYGKRTSITEYTRHNRGTQGMIAINTN
CCCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEECC
KRNGKVVAAQLVEPNDEIMLITTGGVMIRTRVSEIREMGRATQGVILINLDAGEKLAGLE
CCCCEEEEEEEECCCCCEEEEEECCEEEEHHHHHHHHHCCCCCCEEEEEECCCCHHHHHH
RIVETDEN
HHHHCCCC
>Mature Secondary Structure
MEQFAKETLPVSLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLIDGQGNFGSIDGDNAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHH
RYTEIRMSRIAHELLADLDKNTVDFGPNYDGSEQEPLILPAKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCEEEEEEC
NIPPHNISEVIDACLLLLSDPDIDIAGLMACIPAPDFPTAGIIYGISGIKDGYQTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHEEECCCCCCHHHCCCCEE
IMRARTHFEELDKGNRHSIIIDELPYQVNKANLLVRIGELVRDKRIEGISDLRDESDKSG
EEEEHHHHHHHCCCCCCEEEEECCCCEECCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
MRVVIELKRGEVPEVILNNLYKETQMQDTFGINMVALVDGQPRLLNLKQMLDYFLRHRRE
CEEEEEECCCCCHHHHHHHHHHHHHCCHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VITRRTVFELRKARERGHLLEGLAVALSNVDEIIALIKAAPTPAEAKRGLMARTWRSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHH
EEMLRRAMIDAAAFRPETLATGFGMSNQEYRLSDAQAQAILDLRLQRLTGLEQEKIVSEY
HHHHHHHHHHHHHCCCHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCHHHHHHHH
KEILDKIRDLLNMLANSERITAIIIEELTAIKGQFGDPRRSEVVIDAQDLSTEDLITPTD
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
MVVTLSHAGYIKSQLLDDYQAQKRGGRGKQAITTREDDFIDNLFIANTHDFILCFSSLGR
EEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCEEEECCCHHHHHHHHCCC
VYWIKVYNVPQGSRTSRGRPINNLVPLEQHEKINAVLPVKSFDDTRYVFMATAGGTVKKT
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCEECC
PLSEFSRPRTNGIIAVALDEGDYLIGVALTEGKHDVMLFSDAGKAMRFDENDVRPTGRNA
CHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCEEEEEECCCCEEECCCCCCCCCCCCC
RGVRGMKLGAEQKVISLLVADSENMTVLTATENGYGKRTSITEYTRHNRGTQGMIAINTN
CCCCCCCCCCHHHEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEECC
KRNGKVVAAQLVEPNDEIMLITTGGVMIRTRVSEIREMGRATQGVILINLDAGEKLAGLE
CCCCEEEEEEEECCCCCEEEEEECCEEEEHHHHHHHHHCCCCCCEEEEEECCCCHHHHHH
RIVETDEN
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]