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The map label for this gene is lysA [H]

Identifier: 114331408

GI number: 114331408

Start: 1495942

End: 1497177

Strand: Direct

Name: lysA [H]

Synonym: Neut_1418

Alternate gene names: 114331408

Gene position: 1495942-1497177 (Clockwise)

Preceding gene: 114331407

Following gene: 114331409

Centisome position: 56.22

GC content: 50.08

Gene sequence:

>1236_bases
ATGACGACGAATCAACCTAAACATGCGCCGATGATACAGTTTCCGGTACAGGATCATTGTCTTGTCATCGGCGGCATTCC
ACTCACACGACTGGCTCAACGGATTGGAAGCACCCCTTTCTATGCCTACGATCGCCAGTTGATTTCCACACGTGTACAGT
CTCTGAGACAACATCTGCCACCAGACATACTTCTGCACTATGCGATGAAGGCCAATCCAATGCCGGCGGTGGTACAGCAC
CTGGCAGGCCTGGTAGATGGAATTGATGTTGCCTCAGTTGGTGAAATGAAAGTGGCACTGGATGCAGGCGTGACTCCAGA
GAATATCAGTTTCGCGGGCCCCGGCAAAAACCGTCAGGAACTGGCCTGTGCCATTGCCGCCGGCATTATTATTAATATGG
AATCCGAACAGGAGCTGGAAACAATTGCTCAACTGGCAGACGAAACCGGTTTCCATCCTAAAGTCGCAGTACGGGTCAAC
CCTGATTTTGAGCTGAAATCTTCCGGAATGAGGATGGGAGGAGGCTCCAAACAATTCGGTATCGATGCCGAGCGCATCCC
GGCCGTGTTGCAACGTATTGCGCAATTAAAACTAGATTTTGAGGGATTGCATATCTTCAGCGGCTCACAAAATCTCAGAG
TGGAAGCCATTCAGGAAGCACACGAAAAGACACTGCAGCTCGGTTTACAGCTTGCGTCAACCTCACCCGTTCCAATACGC
ACAATCAACATCGGCGGTGGATTTGGCGTTCCTTATTTCCCCGGTGAAAATCCGCTCGATTTGAGTGCCGTTGGCACTAA
TCTGAAACAATTGCTGGCAGAAATCCCTGCTTCTTCCCCGAATATCCGGTTCGTGGTTGAGCTGGGGCGCTATATCGTGG
CAGAAGCGGGTATTTATGTATGCCGTGTACTGGAAAAGAAACTATCAAGAGGGCAGGTTTTTCTTATTACCAATGGTGGT
TTACATCATCATCTTGCCGCTTCAGGAAATTTTGGCCAGGTTATCCGCAAAAATTACCCTGTTGCGGTCGGAAATAAAAT
GTACATCAGTGAAACTGAAACTGCCTCAGTGGTCGGGCCACTTTGCACGCCACTGGATTTACTCGCCAACCAGATGGAAC
TGTCCAAAGCTGAACCCGGGGATCTGATCGTTGTTTTCCAGTCCGGCGCCTATGGATTAACAGCCAGTCCCACCTCTTTT
CTTAGTCACCCTGCCCCGCTGGAAATACTGGCCTGA

Upstream 100 bases:

>100_bases
TCGAGTTACGACAGACCAGTCTACCGCGTAATCCAAATGGAAAGATCGATCGAAAGAGTCTGGCCAGTGAATTTCAGCAA
GTTTTCCAAACAGAAGAAAT

Downstream 100 bases:

>100_bases
GAATCTGCTGCCAAACTGATACCTTTCTCTGCAATGATACAACATGCAAATCAAATAGCCATTGGTAACCAGTACAAGAA
AGTAAATAAATTAAGTATAC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTTNQPKHAPMIQFPVQDHCLVIGGIPLTRLAQRIGSTPFYAYDRQLISTRVQSLRQHLPPDILLHYAMKANPMPAVVQH
LAGLVDGIDVASVGEMKVALDAGVTPENISFAGPGKNRQELACAIAAGIIINMESEQELETIAQLADETGFHPKVAVRVN
PDFELKSSGMRMGGGSKQFGIDAERIPAVLQRIAQLKLDFEGLHIFSGSQNLRVEAIQEAHEKTLQLGLQLASTSPVPIR
TINIGGGFGVPYFPGENPLDLSAVGTNLKQLLAEIPASSPNIRFVVELGRYIVAEAGIYVCRVLEKKLSRGQVFLITNGG
LHHHLAASGNFGQVIRKNYPVAVGNKMYISETETASVVGPLCTPLDLLANQMELSKAEPGDLIVVFQSGAYGLTASPTSF
LSHPAPLEILA

Sequences:

>Translated_411_residues
MTTNQPKHAPMIQFPVQDHCLVIGGIPLTRLAQRIGSTPFYAYDRQLISTRVQSLRQHLPPDILLHYAMKANPMPAVVQH
LAGLVDGIDVASVGEMKVALDAGVTPENISFAGPGKNRQELACAIAAGIIINMESEQELETIAQLADETGFHPKVAVRVN
PDFELKSSGMRMGGGSKQFGIDAERIPAVLQRIAQLKLDFEGLHIFSGSQNLRVEAIQEAHEKTLQLGLQLASTSPVPIR
TINIGGGFGVPYFPGENPLDLSAVGTNLKQLLAEIPASSPNIRFVVELGRYIVAEAGIYVCRVLEKKLSRGQVFLITNGG
LHHHLAASGNFGQVIRKNYPVAVGNKMYISETETASVVGPLCTPLDLLANQMELSKAEPGDLIVVFQSGAYGLTASPTSF
LSHPAPLEILA
>Mature_410_residues
TTNQPKHAPMIQFPVQDHCLVIGGIPLTRLAQRIGSTPFYAYDRQLISTRVQSLRQHLPPDILLHYAMKANPMPAVVQHL
AGLVDGIDVASVGEMKVALDAGVTPENISFAGPGKNRQELACAIAAGIIINMESEQELETIAQLADETGFHPKVAVRVNP
DFELKSSGMRMGGGSKQFGIDAERIPAVLQRIAQLKLDFEGLHIFSGSQNLRVEAIQEAHEKTLQLGLQLASTSPVPIRT
INIGGGFGVPYFPGENPLDLSAVGTNLKQLLAEIPASSPNIRFVVELGRYIVAEAGIYVCRVLEKKLSRGQVFLITNGGL
HHHLAASGNFGQVIRKNYPVAVGNKMYISETETASVVGPLCTPLDLLANQMELSKAEPGDLIVVFQSGAYGLTASPTSFL
SHPAPLEILA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=373, Percent_Identity=25.201072386059, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI22538418, Length=394, Percent_Identity=23.3502538071066, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI21361583, Length=394, Percent_Identity=23.3502538071066, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789203, Length=397, Percent_Identity=25.1889168765743, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562780, Length=394, Percent_Identity=23.8578680203046, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=385, Percent_Identity=23.1168831168831, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586472, Length=400, Percent_Identity=26.25, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24586474, Length=393, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44170; Mature: 44038

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNQPKHAPMIQFPVQDHCLVIGGIPLTRLAQRIGSTPFYAYDRQLISTRVQSLRQHLP
CCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PDILLHYAMKANPMPAVVQHLAGLVDGIDVASVGEMKVALDAGVTPENISFAGPGKNRQE
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCHHH
LACAIAAGIIINMESEQELETIAQLADETGFHPKVAVRVNPDFELKSSGMRMGGGSKQFG
HHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCEECCCCCCCCC
IDAERIPAVLQRIAQLKLDFEGLHIFSGSQNLRVEAIQEAHEKTLQLGLQLASTSPVPIR
CCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEE
TINIGGGFGVPYFPGENPLDLSAVGTNLKQLLAEIPASSPNIRFVVELGRYIVAEAGIYV
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHH
CRVLEKKLSRGQVFLITNGGLHHHLAASGNFGQVIRKNYPVAVGNKMYISETETASVVGP
HHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCEEECCEEEEECCCCHHHHCC
LCTPLDLLANQMELSKAEPGDLIVVFQSGAYGLTASPTSFLSHPAPLEILA
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCCCEECC
>Mature Secondary Structure 
TTNQPKHAPMIQFPVQDHCLVIGGIPLTRLAQRIGSTPFYAYDRQLISTRVQSLRQHLP
CCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PDILLHYAMKANPMPAVVQHLAGLVDGIDVASVGEMKVALDAGVTPENISFAGPGKNRQE
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCHHH
LACAIAAGIIINMESEQELETIAQLADETGFHPKVAVRVNPDFELKSSGMRMGGGSKQFG
HHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCEECCCCCCCCC
IDAERIPAVLQRIAQLKLDFEGLHIFSGSQNLRVEAIQEAHEKTLQLGLQLASTSPVPIR
CCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCEEE
TINIGGGFGVPYFPGENPLDLSAVGTNLKQLLAEIPASSPNIRFVVELGRYIVAEAGIYV
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHH
CRVLEKKLSRGQVFLITNGGLHHHLAASGNFGQVIRKNYPVAVGNKMYISETETASVVGP
HHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCEEECCEEEEECCCCHHHHCC
LCTPLDLLANQMELSKAEPGDLIVVFQSGAYGLTASPTSFLSHPAPLEILA
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]