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The map label for this gene is atoC [H]

Identifier: 114331406

GI number: 114331406

Start: 1492957

End: 1494315

Strand: Direct

Name: atoC [H]

Synonym: Neut_1416

Alternate gene names: 114331406

Gene position: 1492957-1494315 (Clockwise)

Preceding gene: 114331405

Following gene: 114331407

Centisome position: 56.1

GC content: 49.08

Gene sequence:

>1359_bases
ATGAAAGCAAATGAAATACAAAAAAAATTGCTTGTTGTGGAAGATGATCCCGGGCTCCAAAAACAATTGCGCTGGAGTTT
TGATGATTGCAACGTGGCTGTTGCTTCCGATCGTGAAAGTGCGCTGGCACAAATCCGCCGACATGAACCCGCAGTCGTAA
CCATGGATCTTGGTTTGCCTCCTGATCCGGATGGGGCAACGGAAGGCCTGGCAACCTTGCAGCAGATTCTTGCATTGGCT
CCCGACACCAAGGTTATTGTGCTGACCGGCAATCAGAATCATGAGAATGCGCTGAAAGCAATTGACATGGGTGCTTATGA
TTTTCATCAAAAACCCCTTGATGCGGGTGTACTTAATTTGATCGTAAATCGGGCCTTTTATCTGCACCGGTTACAAAGGG
AAAATTATAAGCTGCGGCAAGCTGGCCTGATTTCATCAGTTCCTGGATTTATTACCGGAGATCCGGAAATAGCCAGAATT
TGTCAACAGATTGAACGTATTGCATCTTCCGATGTTGCCGTCGCATTACTGGGCGAGAGCGGCACTGGAAAGGAAGTACT
GGCTAAAGCACTTCACCTGCTCAGTGGCAGAAACAGTAAACGCATGGTTGCAGTAAATTGCGCAGCGATTCCGGAATCAT
TACTGGAAGCCGAATTGTTTGGTTACGAAAAAGGGGCTTTTACCAATGCTGCAAAACAGACTCTCGGTAAAATAGAAACC
GCGCAAGGGGGCACATTTTTTCTGGATGAAGTTGGTGATCTGCCTCTCTCACTGCAGGCCAAGCTGCTAAGGTTTTTACA
GGAACGCGTCATTGAACGCATTGGTGGCAGAGAAGAGATTCCGGTGGATGTGCGTATTATCTGTGCAACCCATCAGGATC
TGAAGAAAATGATCGATGCCGGTACTTTCCGCGAAGATTTATTCTATCGGCTGTGCGAGATCAGCATTCATATACCGCCA
GTGCGTGAACGCATTGGCGACGCTGTATTGCTTGCGCATCACTTCAAGAATCAATACCGTATCAAGGAAAAGCGCCAGAC
ACTCAACTTCAGTCAGGATGCACTGAATGCAATCAGCAGCCACCGCTGGCCGGGTAATGTCCGAGAAATTGAAAACTGCA
TCAAACGTGCTGTCATCATGGCGGAGGGCTCCCAAATTACGGCCCAGGATCTGGGACTGCAATCAGCAGACAATCCTGAG
CAACCCGCCACCCTGCGCGAAGTCCGGGAACAGGCAGAACGCGAAGTAGTCGCCAAGGCTTTGGCCCGGATGGATGGTAA
TATCGTTAAAGCTGCAGAACTGCTCGGCGTCACCCGGCCAACACTTTACGACCTGATGAATCGCCACGGACTTAAATAG

Upstream 100 bases:

>100_bases
TTTCAGCAGAAAGGCTGCTAGTTTTAATGTCAGTAAATTACGCATAAAACAGCAAAATTATTCCATATATTCATATTAAA
TTCACAATGACAGTCACGCT

Downstream 100 bases:

>100_bases
CCTATAAAACCTACCAACCTCGTTATTACCCAGCCCACTCATGACTTCTCTTTTTCACGAACTGGTTTATCAGTCTGCCG
ATCGGAATATAGATTCTGTA

Product: two component, sigma54 specific, transcriptional regulator, Fis family protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKANEIQKKLLVVEDDPGLQKQLRWSFDDCNVAVASDRESALAQIRRHEPAVVTMDLGLPPDPDGATEGLATLQQILALA
PDTKVIVLTGNQNHENALKAIDMGAYDFHQKPLDAGVLNLIVNRAFYLHRLQRENYKLRQAGLISSVPGFITGDPEIARI
CQQIERIASSDVAVALLGESGTGKEVLAKALHLLSGRNSKRMVAVNCAAIPESLLEAELFGYEKGAFTNAAKQTLGKIET
AQGGTFFLDEVGDLPLSLQAKLLRFLQERVIERIGGREEIPVDVRIICATHQDLKKMIDAGTFREDLFYRLCEISIHIPP
VRERIGDAVLLAHHFKNQYRIKEKRQTLNFSQDALNAISSHRWPGNVREIENCIKRAVIMAEGSQITAQDLGLQSADNPE
QPATLREVREQAEREVVAKALARMDGNIVKAAELLGVTRPTLYDLMNRHGLK

Sequences:

>Translated_452_residues
MKANEIQKKLLVVEDDPGLQKQLRWSFDDCNVAVASDRESALAQIRRHEPAVVTMDLGLPPDPDGATEGLATLQQILALA
PDTKVIVLTGNQNHENALKAIDMGAYDFHQKPLDAGVLNLIVNRAFYLHRLQRENYKLRQAGLISSVPGFITGDPEIARI
CQQIERIASSDVAVALLGESGTGKEVLAKALHLLSGRNSKRMVAVNCAAIPESLLEAELFGYEKGAFTNAAKQTLGKIET
AQGGTFFLDEVGDLPLSLQAKLLRFLQERVIERIGGREEIPVDVRIICATHQDLKKMIDAGTFREDLFYRLCEISIHIPP
VRERIGDAVLLAHHFKNQYRIKEKRQTLNFSQDALNAISSHRWPGNVREIENCIKRAVIMAEGSQITAQDLGLQSADNPE
QPATLREVREQAEREVVAKALARMDGNIVKAAELLGVTRPTLYDLMNRHGLK
>Mature_452_residues
MKANEIQKKLLVVEDDPGLQKQLRWSFDDCNVAVASDRESALAQIRRHEPAVVTMDLGLPPDPDGATEGLATLQQILALA
PDTKVIVLTGNQNHENALKAIDMGAYDFHQKPLDAGVLNLIVNRAFYLHRLQRENYKLRQAGLISSVPGFITGDPEIARI
CQQIERIASSDVAVALLGESGTGKEVLAKALHLLSGRNSKRMVAVNCAAIPESLLEAELFGYEKGAFTNAAKQTLGKIET
AQGGTFFLDEVGDLPLSLQAKLLRFLQERVIERIGGREEIPVDVRIICATHQDLKKMIDAGTFREDLFYRLCEISIHIPP
VRERIGDAVLLAHHFKNQYRIKEKRQTLNFSQDALNAISSHRWPGNVREIENCIKRAVIMAEGSQITAQDLGLQSADNPE
QPATLREVREQAEREVVAKALARMDGNIVKAAELLGVTRPTLYDLMNRHGLK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=39.2543859649123, Blast_Score=314, Evalue=8e-87,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=38.255033557047, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI1788905, Length=446, Percent_Identity=37.6681614349776, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1789087, Length=329, Percent_Identity=44.0729483282675, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=42.1511627906977, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=34.5338983050847, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI87082152, Length=312, Percent_Identity=41.9871794871795, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789233, Length=306, Percent_Identity=43.1372549019608, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87081872, Length=307, Percent_Identity=38.1107491856677, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786524, Length=325, Percent_Identity=37.5384615384615, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787583, Length=315, Percent_Identity=32.3809523809524, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87081858, Length=306, Percent_Identity=31.6993464052288, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=271, Percent_Identity=30.9963099630996, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50090; Mature: 50090

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKANEIQKKLLVVEDDPGLQKQLRWSFDDCNVAVASDRESALAQIRRHEPAVVTMDLGLP
CCCHHHHHEEEEEECCCCHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEECCCC
PDPDGATEGLATLQQILALAPDTKVIVLTGNQNHENALKAIDMGAYDFHQKPLDAGVLNL
CCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHCCCCHHHHHHHH
IVNRAFYLHRLQRENYKLRQAGLISSVPGFITGDPEIARICQQIERIASSDVAVALLGES
HHHHHHHHHHHHHCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCC
GTGKEVLAKALHLLSGRNSKRMVAVNCAAIPESLLEAELFGYEKGAFTNAAKQTLGKIET
CCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
AQGGTFFLDEVGDLPLSLQAKLLRFLQERVIERIGGREEIPVDVRIICATHQDLKKMIDA
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHC
GTFREDLFYRLCEISIHIPPVRERIGDAVLLAHHFKNQYRIKEKRQTLNFSQDALNAISS
CCHHHHHHHHHHHHEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
HRWPGNVREIENCIKRAVIMAEGSQITAQDLGLQSADNPEQPATLREVREQAEREVVAKA
CCCCCCHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LARMDGNIVKAAELLGVTRPTLYDLMNRHGLK
HHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKANEIQKKLLVVEDDPGLQKQLRWSFDDCNVAVASDRESALAQIRRHEPAVVTMDLGLP
CCCHHHHHEEEEEECCCCHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEECCCC
PDPDGATEGLATLQQILALAPDTKVIVLTGNQNHENALKAIDMGAYDFHQKPLDAGVLNL
CCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCHHHCCCCHHHHHHHH
IVNRAFYLHRLQRENYKLRQAGLISSVPGFITGDPEIARICQQIERIASSDVAVALLGES
HHHHHHHHHHHHHCCCHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCC
GTGKEVLAKALHLLSGRNSKRMVAVNCAAIPESLLEAELFGYEKGAFTNAAKQTLGKIET
CCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
AQGGTFFLDEVGDLPLSLQAKLLRFLQERVIERIGGREEIPVDVRIICATHQDLKKMIDA
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHC
GTFREDLFYRLCEISIHIPPVRERIGDAVLLAHHFKNQYRIKEKRQTLNFSQDALNAISS
CCHHHHHHHHHHHHEECCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
HRWPGNVREIENCIKRAVIMAEGSQITAQDLGLQSADNPEQPATLREVREQAEREVVAKA
CCCCCCHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LARMDGNIVKAAELLGVTRPTLYDLMNRHGLK
HHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]