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The map label for this gene is ldc [H]

Identifier: 114331378

GI number: 114331378

Start: 1458222

End: 1459394

Strand: Reverse

Name: ldc [H]

Synonym: Neut_1387

Alternate gene names: 114331378

Gene position: 1459394-1458222 (Counterclockwise)

Preceding gene: 114331390

Following gene: 114331375

Centisome position: 54.84

GC content: 50.72

Gene sequence:

>1173_bases
ATGAAAAAACTATCCGCAGCCGTACAGCAACAAACAGAAAATGCCATTTTCGATACTCACCCTGAAATCAGTATCGATCC
CTCCTTGGTGGAAGCCAAGTTAAAACAAGGTTATCTGAAGCCTTTTCTGATGGTGGATACCGCCATCATTCGCAATAAAG
CCCGACGATTCAAGGCAGCCATGCCACGCGTACATCCGCATTATGCAGCCAAAGCCAATCCTGATCCGCGCGTGCTGAAA
ACGTTGATTGAAGAAGGCGTTGGGTTTGAAATCGCGTCGATTGCCGAGCTTGACCTCCTGATGGGTTTTGGCGTGCCGGC
TGCCGAAATTTTTTACAGCAATCCGATGAAATCACGCGCCTACCTCCAGTATGCTGCTGCGAAAGGCGTGGAGTGGTACG
TGCTGGATAGCGTTGAGGAGCTGCGCAAGATCGTCAGCATCAAAGCGGATGCCAAGCTTTATTTGCGGATCGACACTCCC
AATATCGGCAGCGACTGGCCGTTGGCAGGAAAATTTGGAACACATCTGGGAGACGTGCGCGAAATTATTGATGAAGCTGT
GAAGCTGAATGCGGATCTGGCAGGTGTTACTTTTCATGTGGGTTCCCAATGCCGCAATCCACAGAACTGGCGGGTTGGGA
TCGAACGTGCCAAAACCGTGTTTGCCAGCATGCGCGAAGCCGGTCTTAATCCCCGGTTGTTGAATCTGGGTGGCGGTTAT
CCGGTGCGTTACGTCAAGCCGATCCCATCCATTGAAATCATTGCCGAGGTTATTAACGAGGCCATTGCTGATTTGCCGCA
AAATATTCGCATCATGGCAGAACCTGGACGTTATCTGGTATCCGACTCAGCGTGTTTTGTGTGCCGCGTGGTCGGTACTG
CGACCCGTAATGGCAAGCGCTGGATGTATTGGGATGCAGGGATCTTCGGTGGCATCATTGAGGTAAGCGAAGGGTTGCGT
TATGAAATCTTGACTCAACGCAATGGTTCTTTGGTTCCCTGGTCAGTTGCTGGTCCGACATGCGATTCTGTGGATGTGCT
GATGCACGACGAGATGCTGCCTGAAGATGTGCGGGAAGATGATTTCATTTTTATCCCCAACGCAGGCGCTTACACAACGT
CGTATGCAAGCAATTTCAACGGCTTCCCATTGCCAGATGTCATTGTAGTTTGA

Upstream 100 bases:

>100_bases
ATAAGGAGGTCATCATGAGAAGCAAGATAAACCTGTTTGTTCCAACTGATTGGGTTCAAATTCATATTCCCGAAACGTAG
CGATTCCAGGAGAAACCCTC

Downstream 100 bases:

>100_bases
TGGAGCCATGAACTGCCATGCCAGTAGAGGAGATGGCGGCATTTTTATCAAACTTGCCGCTTATCCGTATTAAGGATGGT
GGATGGCATCGTCATTGTGA

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKKLSAAVQQQTENAIFDTHPEISIDPSLVEAKLKQGYLKPFLMVDTAIIRNKARRFKAAMPRVHPHYAAKANPDPRVLK
TLIEEGVGFEIASIAELDLLMGFGVPAAEIFYSNPMKSRAYLQYAAAKGVEWYVLDSVEELRKIVSIKADAKLYLRIDTP
NIGSDWPLAGKFGTHLGDVREIIDEAVKLNADLAGVTFHVGSQCRNPQNWRVGIERAKTVFASMREAGLNPRLLNLGGGY
PVRYVKPIPSIEIIAEVINEAIADLPQNIRIMAEPGRYLVSDSACFVCRVVGTATRNGKRWMYWDAGIFGGIIEVSEGLR
YEILTQRNGSLVPWSVAGPTCDSVDVLMHDEMLPEDVREDDFIFIPNAGAYTTSYASNFNGFPLPDVIVV

Sequences:

>Translated_390_residues
MKKLSAAVQQQTENAIFDTHPEISIDPSLVEAKLKQGYLKPFLMVDTAIIRNKARRFKAAMPRVHPHYAAKANPDPRVLK
TLIEEGVGFEIASIAELDLLMGFGVPAAEIFYSNPMKSRAYLQYAAAKGVEWYVLDSVEELRKIVSIKADAKLYLRIDTP
NIGSDWPLAGKFGTHLGDVREIIDEAVKLNADLAGVTFHVGSQCRNPQNWRVGIERAKTVFASMREAGLNPRLLNLGGGY
PVRYVKPIPSIEIIAEVINEAIADLPQNIRIMAEPGRYLVSDSACFVCRVVGTATRNGKRWMYWDAGIFGGIIEVSEGLR
YEILTQRNGSLVPWSVAGPTCDSVDVLMHDEMLPEDVREDDFIFIPNAGAYTTSYASNFNGFPLPDVIVV
>Mature_390_residues
MKKLSAAVQQQTENAIFDTHPEISIDPSLVEAKLKQGYLKPFLMVDTAIIRNKARRFKAAMPRVHPHYAAKANPDPRVLK
TLIEEGVGFEIASIAELDLLMGFGVPAAEIFYSNPMKSRAYLQYAAAKGVEWYVLDSVEELRKIVSIKADAKLYLRIDTP
NIGSDWPLAGKFGTHLGDVREIIDEAVKLNADLAGVTFHVGSQCRNPQNWRVGIERAKTVFASMREAGLNPRLLNLGGGY
PVRYVKPIPSIEIIAEVINEAIADLPQNIRIMAEPGRYLVSDSACFVCRVVGTATRNGKRWMYWDAGIFGGIIEVSEGLR
YEILTQRNGSLVPWSVAGPTCDSVDVLMHDEMLPEDVREDDFIFIPNAGAYTTSYASNFNGFPLPDVIVV

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=371, Percent_Identity=34.2318059299191, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI16506287, Length=363, Percent_Identity=33.6088154269972, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI22538418, Length=374, Percent_Identity=28.6096256684492, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI21361583, Length=374, Percent_Identity=28.6096256684492, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1789203, Length=414, Percent_Identity=22.9468599033816, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789307, Length=255, Percent_Identity=26.2745098039216, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=366, Percent_Identity=29.5081967213115, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25141365, Length=271, Percent_Identity=25.4612546125461, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25141367, Length=207, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=374, Percent_Identity=29.6791443850267, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24586472, Length=363, Percent_Identity=30.0275482093664, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24586474, Length=358, Percent_Identity=31.5642458100559, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43200; Mature: 43200

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLSAAVQQQTENAIFDTHPEISIDPSLVEAKLKQGYLKPFLMVDTAIIRNKARRFKAA
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MPRVHPHYAAKANPDPRVLKTLIEEGVGFEIASIAELDLLMGFGVPAAEIFYSNPMKSRA
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHHHCCCCCCHHH
YLQYAAAKGVEWYVLDSVEELRKIVSIKADAKLYLRIDTPNIGSDWPLAGKFGTHLGDVR
HHHHHHHCCCEEEEHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHH
EIIDEAVKLNADLAGVTFHVGSQCRNPQNWRVGIERAKTVFASMREAGLNPRLLNLGGGY
HHHHHHHHCCCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
PVRYVKPIPSIEIIAEVINEAIADLPQNIRIMAEPGRYLVSDSACFVCRVVGTATRNGKR
CEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCEEEEEEEHHCCCCCCE
WMYWDAGIFGGIIEVSEGLRYEILTQRNGSLVPWSVAGPTCDSVDVLMHDEMLPEDVRED
EEEECCCHHCCHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCHHHHCCCCCHHHCCCC
DFIFIPNAGAYTTSYASNFNGFPLPDVIVV
CEEEECCCCCCEEHHCCCCCCCCCCCEEEC
>Mature Secondary Structure
MKKLSAAVQQQTENAIFDTHPEISIDPSLVEAKLKQGYLKPFLMVDTAIIRNKARRFKAA
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MPRVHPHYAAKANPDPRVLKTLIEEGVGFEIASIAELDLLMGFGVPAAEIFYSNPMKSRA
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCHHHHHCCCCCCHHH
YLQYAAAKGVEWYVLDSVEELRKIVSIKADAKLYLRIDTPNIGSDWPLAGKFGTHLGDVR
HHHHHHHCCCEEEEHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHH
EIIDEAVKLNADLAGVTFHVGSQCRNPQNWRVGIERAKTVFASMREAGLNPRLLNLGGGY
HHHHHHHHCCCCCEEEEEECCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
PVRYVKPIPSIEIIAEVINEAIADLPQNIRIMAEPGRYLVSDSACFVCRVVGTATRNGKR
CEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCEEEEEEEHHCCCCCCE
WMYWDAGIFGGIIEVSEGLRYEILTQRNGSLVPWSVAGPTCDSVDVLMHDEMLPEDVRED
EEEECCCHHCCHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCHHHHCCCCCHHHCCCC
DFIFIPNAGAYTTSYASNFNGFPLPDVIVV
CEEEECCCCCCEEHHCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]