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The map label for this gene is mutS [H]

Identifier: 114331332

GI number: 114331332

Start: 1405812

End: 1407467

Strand: Reverse

Name: mutS [H]

Synonym: Neut_1339

Alternate gene names: 114331332

Gene position: 1407467-1405812 (Counterclockwise)

Preceding gene: 114331338

Following gene: 114331331

Centisome position: 52.89

GC content: 49.58

Gene sequence:

>1656_bases
ATGAATGATACATCACAAGCTGTTACTGCTTCTGTCTGGCGCGAAAGTTTCATTTTGTCATCCGGCAAACATCAGACGCA
GATACGGGATACAAAACCCACTGCAGATAATTACGGGGCACTGGATGCCAAGACTTTTGTTGCGGTGGAGGCTGATGCCC
TGTTTGATGAAATCAACCATGCACAGACCCGGGTAGGGCAATCCGTATTGTACCGCTCAATTGCGCGCCCGGTGACCGAT
GCTGCATTATTACAAAGCAAGCAGGAAGCGTTGCGTGAACTTGAATCCAATCCTGAGCTGTTGGACGCCCTGGAAAAGTA
CATCAAACGAATGGCGTTCGATGAAACCTCACTATACCATCTGCTTTACGGCGAGTTTGCAGGCGGACTGACGACCGATG
ATCCCAAAGATAAAACCGGTAAGGAAAGACTGGAATTTGGTGGATACGGCTATCGTCAGTTTGTTGATGGCACTGGTTTT
GCTGTAGATATGGTAGATCAGGCAGAAGCGCTTCCCACTCCCAATAGTGATTACCTGCGCACGCTGGTGCAAGCGTTGCG
TGATTTTGCCCGGACACGTACTTATTCACTCATGCATGGACCCATCTATGTCTCGGAAAGAAAATTTCTGACAAGAGAAG
AAAAATCTCGCTTACCTATTCCGCGATTTCGCCCCTCTGTGTTCAAGTGGCCGTTTATCGGTTTCTTTCTGGTTTTTATG
GCCGGTCTGCTTTTTTTCTTTCAGAGTACACTGAGCGAGCTGGGTGCCAGCTACATTGGCTATGGGGTTTTGATCCTGCT
TGTGCCGATCATTCCGATCATTTTACAAGCAGTCAGTGCATCCGACCGGGATTCGGTCATCTACCCGCTGCAGAAACTGT
TTCGGAGTAGTCCGGAATTGGCTAGAGCAATTGAAGCACTGGGGATGATTGATGAATTGCTGGCATTGCGTCGGCATGCG
CATTCCATACCAGGAGATTCCGTTCTGCCGGAAATCTATAGGAACGAACGTCACACACTGGTTGCTTCTGCCGCCAAAAA
CCCATTGCTGGTACGGACGCATCCGGATTATGTTCCCAACGATATTACGCTGGATAACAATAAACGCTTGCTGATCGTGA
CGGGGCCAAACAGCGGTGGAAAAACCGCCTACTGCAAAACGGTTGCTCAGATTCAGCTGCTGGCGCAAGCCGGAGCGTAT
ATCCCAGCAACGCAAGCACGAATAGTGCCTGCAGAGCATATTTTTTATCAGATTCCTGCTCCCGGCCAACTGGAGGAAGG
AATGGGGCGTTTTGCACATGAGCTGAAACAAACCCGCGAAATCTTCTTCAATTCGACACCACGTTCTCTGGTGATACTGG
ATGAACTGGCGGAAGGCACCACCTTTGAAGAAAAAATGACACTTTCGGAGTATGTGCTGAAAGGATTTCATCAGCTGGGT
GCCACCACGCTGCTGGTGACCCATAATCACGAATTGTGCGAACGTTTGCAGCAGGAAGAAATCGGAGACTATCTGCAAGT
TGAATTCGTTTCAGAGAAGCCGACACACCGGCTTGTTCCGGGTGTCTCGCGCATCAGCCATGCAGACCGTATTGCCAGTG
CAATCGGTTTCAGCAAGGAAGATGTGGCCAGTCATCTGGCTTCGTTACAGGAATGA

Upstream 100 bases:

>100_bases
ATGAGGGAGGTTTTATCACCATTAATCCCTGCATGAGGTAGTAAAATCGTCTAAAGTTGTACGAGCTAAGTTCAATTGCA
ATCCATCAATATATAAAAAT

Downstream 100 bases:

>100_bases
TGGAGATTAGCGAGACATCGCAGTAAAATAGACCTACTTGTTAAGGCAGAGCTGAACCACATAATGTAACAGTGAACAGT
GGATAGTACGTTTTTGTGGA

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNDTSQAVTASVWRESFILSSGKHQTQIRDTKPTADNYGALDAKTFVAVEADALFDEINHAQTRVGQSVLYRSIARPVTD
AALLQSKQEALRELESNPELLDALEKYIKRMAFDETSLYHLLYGEFAGGLTTDDPKDKTGKERLEFGGYGYRQFVDGTGF
AVDMVDQAEALPTPNSDYLRTLVQALRDFARTRTYSLMHGPIYVSERKFLTREEKSRLPIPRFRPSVFKWPFIGFFLVFM
AGLLFFFQSTLSELGASYIGYGVLILLVPIIPIILQAVSASDRDSVIYPLQKLFRSSPELARAIEALGMIDELLALRRHA
HSIPGDSVLPEIYRNERHTLVASAAKNPLLVRTHPDYVPNDITLDNNKRLLIVTGPNSGGKTAYCKTVAQIQLLAQAGAY
IPATQARIVPAEHIFYQIPAPGQLEEGMGRFAHELKQTREIFFNSTPRSLVILDELAEGTTFEEKMTLSEYVLKGFHQLG
ATTLLVTHNHELCERLQQEEIGDYLQVEFVSEKPTHRLVPGVSRISHADRIASAIGFSKEDVASHLASLQE

Sequences:

>Translated_551_residues
MNDTSQAVTASVWRESFILSSGKHQTQIRDTKPTADNYGALDAKTFVAVEADALFDEINHAQTRVGQSVLYRSIARPVTD
AALLQSKQEALRELESNPELLDALEKYIKRMAFDETSLYHLLYGEFAGGLTTDDPKDKTGKERLEFGGYGYRQFVDGTGF
AVDMVDQAEALPTPNSDYLRTLVQALRDFARTRTYSLMHGPIYVSERKFLTREEKSRLPIPRFRPSVFKWPFIGFFLVFM
AGLLFFFQSTLSELGASYIGYGVLILLVPIIPIILQAVSASDRDSVIYPLQKLFRSSPELARAIEALGMIDELLALRRHA
HSIPGDSVLPEIYRNERHTLVASAAKNPLLVRTHPDYVPNDITLDNNKRLLIVTGPNSGGKTAYCKTVAQIQLLAQAGAY
IPATQARIVPAEHIFYQIPAPGQLEEGMGRFAHELKQTREIFFNSTPRSLVILDELAEGTTFEEKMTLSEYVLKGFHQLG
ATTLLVTHNHELCERLQQEEIGDYLQVEFVSEKPTHRLVPGVSRISHADRIASAIGFSKEDVASHLASLQE
>Mature_551_residues
MNDTSQAVTASVWRESFILSSGKHQTQIRDTKPTADNYGALDAKTFVAVEADALFDEINHAQTRVGQSVLYRSIARPVTD
AALLQSKQEALRELESNPELLDALEKYIKRMAFDETSLYHLLYGEFAGGLTTDDPKDKTGKERLEFGGYGYRQFVDGTGF
AVDMVDQAEALPTPNSDYLRTLVQALRDFARTRTYSLMHGPIYVSERKFLTREEKSRLPIPRFRPSVFKWPFIGFFLVFM
AGLLFFFQSTLSELGASYIGYGVLILLVPIIPIILQAVSASDRDSVIYPLQKLFRSSPELARAIEALGMIDELLALRRHA
HSIPGDSVLPEIYRNERHTLVASAAKNPLLVRTHPDYVPNDITLDNNKRLLIVTGPNSGGKTAYCKTVAQIQLLAQAGAY
IPATQARIVPAEHIFYQIPAPGQLEEGMGRFAHELKQTREIFFNSTPRSLVILDELAEGTTFEEKMTLSEYVLKGFHQLG
ATTLLVTHNHELCERLQQEEIGDYLQVEFVSEKPTHRLVPGVSRISHADRIASAIGFSKEDVASHLASLQE

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=241, Percent_Identity=33.195020746888, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI36949366, Length=195, Percent_Identity=32.3076923076923, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4504191, Length=209, Percent_Identity=30.1435406698565, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI26638666, Length=543, Percent_Identity=24.8618784530387, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4505253, Length=543, Percent_Identity=24.8618784530387, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4557761, Length=194, Percent_Identity=28.3505154639175, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI26638664, Length=544, Percent_Identity=24.8161764705882, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI262231786, Length=475, Percent_Identity=24.8421052631579, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789089, Length=262, Percent_Identity=28.6259541984733, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=221, Percent_Identity=28.5067873303167, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17534743, Length=192, Percent_Identity=31.25, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=210, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17539736, Length=192, Percent_Identity=28.125, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=228, Percent_Identity=29.8245614035088, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=162, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=270, Percent_Identity=28.1481481481481, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320302, Length=265, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321109, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320047, Length=181, Percent_Identity=27.0718232044199, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24584320, Length=192, Percent_Identity=29.6875, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664545, Length=138, Percent_Identity=34.7826086956522, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62471629, Length=138, Percent_Identity=27.536231884058, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 61637; Mature: 61637

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTSQAVTASVWRESFILSSGKHQTQIRDTKPTADNYGALDAKTFVAVEADALFDEINH
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHH
AQTRVGQSVLYRSIARPVTDAALLQSKQEALRELESNPELLDALEKYIKRMAFDETSLYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
LLYGEFAGGLTTDDPKDKTGKERLEFGGYGYRQFVDGTGFAVDMVDQAEALPTPNSDYLR
HHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCEEEEHHHHHCCCCCCHHHHH
TLVQALRDFARTRTYSLMHGPIYVSERKFLTREEKSRLPIPRFRPSVFKWPFIGFFLVFM
HHHHHHHHHHHHHHHHEEECCEEECCCHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHH
AGLLFFFQSTLSELGASYIGYGVLILLVPIIPIILQAVSASDRDSVIYPLQKLFRSSPEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHH
ARAIEALGMIDELLALRRHAHSIPGDSVLPEIYRNERHTLVASAAKNPLLVRTHPDYVPN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEECCCCCCEEEEECCCCCCC
DITLDNNKRLLIVTGPNSGGKTAYCKTVAQIQLLAQAGAYIPATQARIVPAEHIFYQIPA
CEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHEEEECCC
PGQLEEGMGRFAHELKQTREIFFNSTPRSLVILDELAEGTTFEEKMTLSEYVLKGFHQLG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHC
ATTLLVTHNHELCERLQQEEIGDYLQVEFVSEKPTHRLVPGVSRISHADRIASAIGFSKE
CEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHCCCHH
DVASHLASLQE
HHHHHHHHHCC
>Mature Secondary Structure
MNDTSQAVTASVWRESFILSSGKHQTQIRDTKPTADNYGALDAKTFVAVEADALFDEINH
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHH
AQTRVGQSVLYRSIARPVTDAALLQSKQEALRELESNPELLDALEKYIKRMAFDETSLYH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
LLYGEFAGGLTTDDPKDKTGKERLEFGGYGYRQFVDGTGFAVDMVDQAEALPTPNSDYLR
HHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCEEEEHHHHHCCCCCCHHHHH
TLVQALRDFARTRTYSLMHGPIYVSERKFLTREEKSRLPIPRFRPSVFKWPFIGFFLVFM
HHHHHHHHHHHHHHHHEEECCEEECCCHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHH
AGLLFFFQSTLSELGASYIGYGVLILLVPIIPIILQAVSASDRDSVIYPLQKLFRSSPEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHH
ARAIEALGMIDELLALRRHAHSIPGDSVLPEIYRNERHTLVASAAKNPLLVRTHPDYVPN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEECCCCCCEEEEECCCCCCC
DITLDNNKRLLIVTGPNSGGKTAYCKTVAQIQLLAQAGAYIPATQARIVPAEHIFYQIPA
CEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHEEEECCC
PGQLEEGMGRFAHELKQTREIFFNSTPRSLVILDELAEGTTFEEKMTLSEYVLKGFHQLG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHC
ATTLLVTHNHELCERLQQEEIGDYLQVEFVSEKPTHRLVPGVSRISHADRIASAIGFSKE
CEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHCCCHH
DVASHLASLQE
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA