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The map label for this gene is zitB [H]

Identifier: 114331283

GI number: 114331283

Start: 1348830

End: 1349786

Strand: Reverse

Name: zitB [H]

Synonym: Neut_1289

Alternate gene names: 114331283

Gene position: 1349786-1348830 (Counterclockwise)

Preceding gene: 114331284

Following gene: 114331282

Centisome position: 50.72

GC content: 52.98

Gene sequence:

>957_bases
GTGACTGTTCCACAACCTCACCCGCACCCTGAGCATGGCAAGAATGGTCATGATGACCGGGACCGCAACCATGATCATAA
CCATAAGCAGGTCATCACAGCCGGTAACGAGCGCCGCATTCGGTTTGTCTTCTTTTTTACTGCTGGTTATGCGCTGATAC
AGGCAATCGGTGGGTGGCTGTCCGGATCGCTGGCGCTGATCGCTGATTCAGGTCACATGATCTCGGATGCGGCTGCACTG
TTATTGGCGCTGGTGGCTTATCGCATTGCCAGGAAACCGGCTGATAGTACGAGAACTTATGGTTTTCACCGCGTGCGTGT
ACTGGCAGCTTTGGCCAATGGCGTGACTTTGTTGCTTCTGGTAGTCTGGATCATCCTGGAAGCGATCGGGCGGATGCACA
CACCGACGGAGATTCTGGCTGGGCCCATGTTGATCGTGGCTGTGATTGGCCTGGTTATAAATCTGGTCGGGGCATGGGTT
TTGTGGTCAGGTAACAAGGAAGATGGCAATCTGCGCGGCGCCCTACTGCACATAATCGGCGATTTGCTCGGGTCAGTGGG
TGCAGTTGCAGCGGCTGTTGGCATCATGTTTACTGGCTGGACGATTCTTGACCCGATTCTGTCGGTGCTTGTTGCCTTAC
TGATCATCCGTTCTGCCTGGGTGCTGGTCAAGGATTCAGTACATGTGCTGCTGCAGGTTGTTCCTCGTGGCATGGATACA
CGAGTGGTAGAGAACGGCCTGACACAACTACCGGAAATTGAAGAAGCTGGGCATTTCCATGCCTGGATTCTGGCGGATGA
AACCACTATTGCAACTGTTCATGTCAGTCCTGCTCGTGGTGTTGATCCACTTTCTCTACCTCCTTTGGTATCGTCCTGGT
TGCGGGAACGTTATGCCATTGATCATGTTACTGTACAGATTGATCCGCCCGGACAGCTTGAACATGAGCATCGATAA

Upstream 100 bases:

>100_bases
AATGTCAAGTGTGTTTGTGTTGGGCAACGCGCTGCGCTTGCGCCGGTTCCAGCCGCCTTCGCTGATAGCTTCGTAAGATT
TTCGGTTGGAAAAATAACCT

Downstream 100 bases:

>100_bases
AATTCCGCTCGATCAGGGCTTTCATGCCATGTTATTGGTAATAAAGAAGCCCAATTTATTTTTCTGGGAAATCGTTTTCT
GATTTTTCAGGAATAATTGT

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTVPQPHPHPEHGKNGHDDRDRNHDHNHKQVITAGNERRIRFVFFFTAGYALIQAIGGWLSGSLALIADSGHMISDAAAL
LLALVAYRIARKPADSTRTYGFHRVRVLAALANGVTLLLLVVWIILEAIGRMHTPTEILAGPMLIVAVIGLVINLVGAWV
LWSGNKEDGNLRGALLHIIGDLLGSVGAVAAAVGIMFTGWTILDPILSVLVALLIIRSAWVLVKDSVHVLLQVVPRGMDT
RVVENGLTQLPEIEEAGHFHAWILADETTIATVHVSPARGVDPLSLPPLVSSWLRERYAIDHVTVQIDPPGQLEHEHR

Sequences:

>Translated_318_residues
MTVPQPHPHPEHGKNGHDDRDRNHDHNHKQVITAGNERRIRFVFFFTAGYALIQAIGGWLSGSLALIADSGHMISDAAAL
LLALVAYRIARKPADSTRTYGFHRVRVLAALANGVTLLLLVVWIILEAIGRMHTPTEILAGPMLIVAVIGLVINLVGAWV
LWSGNKEDGNLRGALLHIIGDLLGSVGAVAAAVGIMFTGWTILDPILSVLVALLIIRSAWVLVKDSVHVLLQVVPRGMDT
RVVENGLTQLPEIEEAGHFHAWILADETTIATVHVSPARGVDPLSLPPLVSSWLRERYAIDHVTVQIDPPGQLEHEHR
>Mature_317_residues
TVPQPHPHPEHGKNGHDDRDRNHDHNHKQVITAGNERRIRFVFFFTAGYALIQAIGGWLSGSLALIADSGHMISDAAALL
LALVAYRIARKPADSTRTYGFHRVRVLAALANGVTLLLLVVWIILEAIGRMHTPTEILAGPMLIVAVIGLVINLVGAWVL
WSGNKEDGNLRGALLHIIGDLLGSVGAVAAAVGIMFTGWTILDPILSVLVALLIIRSAWVLVKDSVHVLLQVVPRGMDTR
VVENGLTQLPEIEEAGHFHAWILADETTIATVHVSPARGVDPLSLPPLVSSWLRERYAIDHVTVQIDPPGQLEHEHR

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=315, Percent_Identity=25.3968253968254, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI20070323, Length=329, Percent_Identity=24.3161094224924, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=26.8608414239482, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21359890, Length=249, Percent_Identity=27.3092369477912, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI64762489, Length=276, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI289803013, Length=276, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI289803009, Length=276, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI289803007, Length=276, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI289803003, Length=276, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI52351208, Length=130, Percent_Identity=36.1538461538462, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI14210520, Length=217, Percent_Identity=25.3456221198157, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI222080086, Length=133, Percent_Identity=29.3233082706767, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI40255009, Length=133, Percent_Identity=29.3233082706767, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1786966, Length=276, Percent_Identity=42.7536231884058, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17555794, Length=310, Percent_Identity=29.6774193548387, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17555796, Length=285, Percent_Identity=30.1754385964912, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI193210990, Length=319, Percent_Identity=26.6457680250784, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI32564488, Length=307, Percent_Identity=28.6644951140065, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17550440, Length=115, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17550442, Length=116, Percent_Identity=36.2068965517241, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320411, Length=184, Percent_Identity=36.9565217391304, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324892, Length=118, Percent_Identity=42.3728813559322, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=130, Percent_Identity=40, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24656728, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656724, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656720, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24656715, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357035, Length=302, Percent_Identity=28.8079470198675, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24583858, Length=304, Percent_Identity=22.6973684210526, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645863, Length=156, Percent_Identity=28.8461538461538, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585900, Length=136, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585898, Length=136, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585896, Length=136, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921672, Length=136, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584409, Length=147, Percent_Identity=27.891156462585, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28574430, Length=147, Percent_Identity=27.891156462585, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34629; Mature: 34498

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPQPHPHPEHGKNGHDDRDRNHDHNHKQVITAGNERRIRFVFFFTAGYALIQAIGGWL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEHHHHHHHHHHHHHHH
SGSLALIADSGHMISDAAALLLALVAYRIARKPADSTRTYGFHRVRVLAALANGVTLLLL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VVWIILEAIGRMHTPTEILAGPMLIVAVIGLVINLVGAWVLWSGNKEDGNLRGALLHIIG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
DLLGSVGAVAAAVGIMFTGWTILDPILSVLVALLIIRSAWVLVKDSVHVLLQVVPRGMDT
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RVVENGLTQLPEIEEAGHFHAWILADETTIATVHVSPARGVDPLSLPPLVSSWLRERYAI
HHHHHHHHCCCCHHHCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
DHVTVQIDPPGQLEHEHR
EEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TVPQPHPHPEHGKNGHDDRDRNHDHNHKQVITAGNERRIRFVFFFTAGYALIQAIGGWL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEHHHHHHHHHHHHHHH
SGSLALIADSGHMISDAAALLLALVAYRIARKPADSTRTYGFHRVRVLAALANGVTLLLL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VVWIILEAIGRMHTPTEILAGPMLIVAVIGLVINLVGAWVLWSGNKEDGNLRGALLHIIG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
DLLGSVGAVAAAVGIMFTGWTILDPILSVLVALLIIRSAWVLVKDSVHVLLQVVPRGMDT
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RVVENGLTQLPEIEEAGHFHAWILADETTIATVHVSPARGVDPLSLPPLVSSWLRERYAI
HHHHHHHHCCCCHHHCCCEEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
DHVTVQIDPPGQLEHEHR
EEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]