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The map label for this gene is ilvC

Identifier: 114331255

GI number: 114331255

Start: 1315885

End: 1316901

Strand: Reverse

Name: ilvC

Synonym: Neut_1260

Alternate gene names: 114331255

Gene position: 1316901-1315885 (Counterclockwise)

Preceding gene: 114331256

Following gene: 114331254

Centisome position: 49.49

GC content: 47.0

Gene sequence:

>1017_bases
ATGAAAGTCTATTACGATAAAGATGCGGATCTGTCCCTCATCAAGAAAAAGAAAATTGCTATCATCGGTTATGGCTCACA
AGGACATGCGCACGCTAACAATCTAAATGATTCGGGAGTCGAAGTTATCATTGGTCTGCGTAAAGATGGAGCGTCATGGG
ATAAAGCAAAGAAAGCTGGTTTGACTGTAAAGGAAGTAAGTGAAGCGGTCAAGGATGCCGATATTGTCATGCTGTTGTTA
CCGGATGAGCAGATGGCATCGATCTATCAGACTGAAGTTGAGCCGGCACTGAAGAAAAATGCCACACTGGCTTTTGCACA
TGGTTTCAACATTCATTATGGACAGATCATCCCCCGTGAAGATTTGGATATCATCATGATTGCGCCCAAGGGGCCTGGCC
ATCTGGTACGTTCTACTTATATCCAGGGGGGAGGGGTTCCATCTCTCATCGCTGTTCATCAGGATAAGTCTGGCAAGGCG
CGTGATTTAGCACTTTCTTATGCTGCCGCAAATGGCGGTACCCGTGGTGGCGTGATTGAAACCACTTTCAAGGAAGAGAC
AGAAACGGACCTATTTGGTGAACAGGTGGTGCTGTGCGGTGGATTAACGTCACTGATTCAGGCGGGGTTTGAAACCCTGG
TGGAAGCCGGTTACGCACCAGAAATGGCCTATTTTGAATGCCTGCATGAAGTCAAGCTGATAGTGGATTTGATCTATGAA
GGCGGTATCGCCAACATGCGTTATTCCGTATCAAACAATGCAGAATATGGTGATGTATCCAGAGGCCCCCGTATTATCAC
TGAAGCAACCCGCAATGAAATGCGCAAGATTCTGCGCGAAATTCAGACGGGTGAATATGCTCGTGAATTTATTCTGGAAC
ACCGTGCTGGTGCACCTGTACTTAAATCGAGTCGTCGCCTTGCTTCCGAACACCTGATTGAAACAGTCGGTTCCAGATTG
CGTGACATGATGCCATGGATCAAGAAAAACAAACTGGTTGACCAGGCGAAGAACTGA

Upstream 100 bases:

>100_bases
TTAGAACTATAAATTTTTTACCGGGATCTGTCGGTAGATTCTGATTTCATCGATAGCTCATCTGTCGATGTGGCTGCATA
AACACTCAGGAAGGAAAATA

Downstream 100 bases:

>100_bases
ATATATGTCGACTTCTTACTATCCACACCCGATTATTGCACGCGAAGGCTGGCCTTTTATCGCTGGAGCATTTGTTGTTG
CATTAGTAGTACAATTTTTT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKVYYDKDADLSLIKKKKIAIIGYGSQGHAHANNLNDSGVEVIIGLRKDGASWDKAKKAGLTVKEVSEAVKDADIVMLLL
PDEQMASIYQTEVEPALKKNATLAFAHGFNIHYGQIIPREDLDIIMIAPKGPGHLVRSTYIQGGGVPSLIAVHQDKSGKA
RDLALSYAAANGGTRGGVIETTFKEETETDLFGEQVVLCGGLTSLIQAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYE
GGIANMRYSVSNNAEYGDVSRGPRIITEATRNEMRKILREIQTGEYAREFILEHRAGAPVLKSSRRLASEHLIETVGSRL
RDMMPWIKKNKLVDQAKN

Sequences:

>Translated_338_residues
MKVYYDKDADLSLIKKKKIAIIGYGSQGHAHANNLNDSGVEVIIGLRKDGASWDKAKKAGLTVKEVSEAVKDADIVMLLL
PDEQMASIYQTEVEPALKKNATLAFAHGFNIHYGQIIPREDLDIIMIAPKGPGHLVRSTYIQGGGVPSLIAVHQDKSGKA
RDLALSYAAANGGTRGGVIETTFKEETETDLFGEQVVLCGGLTSLIQAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYE
GGIANMRYSVSNNAEYGDVSRGPRIITEATRNEMRKILREIQTGEYAREFILEHRAGAPVLKSSRRLASEHLIETVGSRL
RDMMPWIKKNKLVDQAKN
>Mature_338_residues
MKVYYDKDADLSLIKKKKIAIIGYGSQGHAHANNLNDSGVEVIIGLRKDGASWDKAKKAGLTVKEVSEAVKDADIVMLLL
PDEQMASIYQTEVEPALKKNATLAFAHGFNIHYGQIIPREDLDIIMIAPKGPGHLVRSTYIQGGGVPSLIAVHQDKSGKA
RDLALSYAAANGGTRGGVIETTFKEETETDLFGEQVVLCGGLTSLIQAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYE
GGIANMRYSVSNNAEYGDVSRGPRIITEATRNEMRKILREIQTGEYAREFILEHRAGAPVLKSSRRLASEHLIETVGSRL
RDMMPWIKKNKLVDQAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=254, Percent_Identity=40.9448818897638, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=267, Percent_Identity=37.0786516853933, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_NITEC (Q0AGM0)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747477.1
- ProteinModelPortal:   Q0AGM0
- SMR:   Q0AGM0
- STRING:   Q0AGM0
- GeneID:   4273931
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1260
- NMPDR:   fig|335283.3.peg.2170
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q0AGM0
- ProtClustDB:   PRK05479
- BioCyc:   NEUT335283:NEUT_1260-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37145; Mature: 37145

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYDKDADLSLIKKKKIAIIGYGSQGHAHANNLNDSGVEVIIGLRKDGASWDKAKKAG
CEEEECCCCCHHHEECCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHC
LTVKEVSEAVKDADIVMLLLPDEQMASIYQTEVEPALKKNATLAFAHGFNIHYGQIIPRE
CCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCC
DLDIIMIAPKGPGHLVRSTYIQGGGVPSLIAVHQDKSGKARDLALSYAAANGGTRGGVIE
CCCEEEECCCCCCHHHHHHEECCCCCCEEEEEECCCCCCHHHHEEEEEECCCCCCCCEEE
TTFKEETETDLFGEQVVLCGGLTSLIQAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYE
ECCCCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMRYSVSNNAEYGDVSRGPRIITEATRNEMRKILREIQTGEYAREFILEHRAGAPV
CCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
LKSSRRLASEHLIETVGSRLRDMMPWIKKNKLVDQAKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVYYDKDADLSLIKKKKIAIIGYGSQGHAHANNLNDSGVEVIIGLRKDGASWDKAKKAG
CEEEECCCCCHHHEECCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHC
LTVKEVSEAVKDADIVMLLLPDEQMASIYQTEVEPALKKNATLAFAHGFNIHYGQIIPRE
CCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCC
DLDIIMIAPKGPGHLVRSTYIQGGGVPSLIAVHQDKSGKARDLALSYAAANGGTRGGVIE
CCCEEEECCCCCCHHHHHHEECCCCCCEEEEEECCCCCCHHHHEEEEEECCCCCCCCEEE
TTFKEETETDLFGEQVVLCGGLTSLIQAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYE
ECCCCCHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GGIANMRYSVSNNAEYGDVSRGPRIITEATRNEMRKILREIQTGEYAREFILEHRAGAPV
CCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCH
LKSSRRLASEHLIETVGSRLRDMMPWIKKNKLVDQAKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA