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The map label for this gene is murE [H]

Identifier: 113477570

GI number: 113477570

Start: 6400631

End: 6402160

Strand: Reverse

Name: murE [H]

Synonym: Tery_4151

Alternate gene names: 113477570

Gene position: 6402160-6400631 (Counterclockwise)

Preceding gene: 113477571

Following gene: 113477566

Centisome position: 82.61

GC content: 40.72

Gene sequence:

>1530_bases
ATGACTACAAAAACTATTGGAGTTCCTAATATGAAATTGAGAGAATTATTAGCAAAAGTTTCAAGTATTTCACTGACTAA
TAATTACCAAGCTTTAGAAACAGAAATCAAAGGTTTGGCGACAAATTCACATGCTTGTCAAACAGGGGATTTATTTTTAG
GAATGCCAGGCACCCGTGTTGATGGGGGAGATTTCTGGAAAAGTGCGATCGCTAATGGCGCAGTGGGAGCTATAGTTTCA
GTCTCGGCAGCAACAAAACATCCAGCTAAAAATGAGTGTGTTATTCCAGTTGCGGATATGAGCCAAACCTGCCCAGAAAT
TGCTGCTGCTTTCTATGACTACCCTGGGCAAAAAATGAAAATGGTTGGCATCACTGGTACTAATGGCAAAACGACTACTA
CTCATTTAGTCGAATTTATCTTGAATAATGCTCAACTACCTACCGCTTTATTTGGTACTCTTTATATGCGTTGGCCAGGA
TTTCAAAAAACGGCAGCTTACACCACATCTTTCCCAGTGGAATTACAAAATCAACTAGCACAAGCATTAGCAGCAGGGAG
TAAATATGGAATCATGGAAGTTAGTTCCCATTCTCTAGATCAAAAACGAGTTTGGGGTTGTACTTATGAGGTGGCGGTAT
TTACAAATTTGACGCAAGACCATTTGGACTATCACAAAGATATGGATGATTACTTTGAAGCTAAAGCACGGCTTTTTAGT
TCTGACTATCTCAAGGGTCGGGCGATAGTTAATGCTGATGATCCTTATGGCCAAAAGTTAATTGCCAGACTAGAGTCAGA
AAAGGTTTGGAGTTATAGCACGAGTGATACTTCTACAGATTTATGGGCATCAGATTTGGAATATAAGCCGACAGGAGTTA
AGGGGATGCTGCATACTCCCAAGGGGGAGATGATTTTTAGTTTGCCATTGGTAGGGCAGTACAATTTATCTAATATGTTG
GCTGCGGTAGGGACGACGTTGCATTTAGGTTTAGATTTGTCAATGGTGGTTACTCAGTTATCAGATTTTCCGGGAGTACC
TGGTCGTATGGAAAGGGTACAGGTTACTGAGGGCCAGGATGTAAGTGTAATTGTTGATTATGCTCATACTCCTGATAGTT
TAGAGAATTTGTTAAAGGCAGCCCGACCTTTTATTCCTGGTCGCATGATTTGTGTGTTTGGTTGTGGAGGCGATCGTGAT
CGTACTAAGCGACCCAAAATGGGTAAAATTGCTGCTGAGTTATCAGATTTAGCTGTGGTGAGTTCTGATAACCCTCGCAC
TGAAGATCCCGAAAGAATTTTACAGGATATATTGGAGGGAATATCCCCAGAAGTTAAGCCTTTGGTTATCAGCGATCGCG
CTGAAGCTATTCGTACTGCTATTATGGAAGCTCAGTCTGGAGATGGGGTATTAATAGCTGGAAAAGGTCACGAAGATTAT
CAAATTCTCGGTACAGAAAAAATTCATTTTGATGACCGAGAGCAGGCAAGAAATACTTTGAGAGATAAGTATGGTTTAAG
TCAAAAATAA

Upstream 100 bases:

>100_bases
TGAGAGAATTATTAGCAAAAGTTTCAAGTATTTCACTGACTAATAATTACCAAGCTTTAGAAACAGAAATCAAATTGTGA
TATCTTTAAGGTGAATTGGT

Downstream 100 bases:

>100_bases
ATTAAAGGAGTCTATCCCACTGATAAGAATTTTCAGGGGACTTGACAGTTAAATGAAAATTTACTCAGGTTATTTGCTTT
GTTGCACTGCGGATGCCCAT

Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase

Products: NA

Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTTKTIGVPNMKLRELLAKVSSISLTNNYQALETEIKGLATNSHACQTGDLFLGMPGTRVDGGDFWKSAIANGAVGAIVS
VSAATKHPAKNECVIPVADMSQTCPEIAAAFYDYPGQKMKMVGITGTNGKTTTTHLVEFILNNAQLPTALFGTLYMRWPG
FQKTAAYTTSFPVELQNQLAQALAAGSKYGIMEVSSHSLDQKRVWGCTYEVAVFTNLTQDHLDYHKDMDDYFEAKARLFS
SDYLKGRAIVNADDPYGQKLIARLESEKVWSYSTSDTSTDLWASDLEYKPTGVKGMLHTPKGEMIFSLPLVGQYNLSNML
AAVGTTLHLGLDLSMVVTQLSDFPGVPGRMERVQVTEGQDVSVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRD
RTKRPKMGKIAAELSDLAVVSSDNPRTEDPERILQDILEGISPEVKPLVISDRAEAIRTAIMEAQSGDGVLIAGKGHEDY
QILGTEKIHFDDREQARNTLRDKYGLSQK

Sequences:

>Translated_509_residues
MTTKTIGVPNMKLRELLAKVSSISLTNNYQALETEIKGLATNSHACQTGDLFLGMPGTRVDGGDFWKSAIANGAVGAIVS
VSAATKHPAKNECVIPVADMSQTCPEIAAAFYDYPGQKMKMVGITGTNGKTTTTHLVEFILNNAQLPTALFGTLYMRWPG
FQKTAAYTTSFPVELQNQLAQALAAGSKYGIMEVSSHSLDQKRVWGCTYEVAVFTNLTQDHLDYHKDMDDYFEAKARLFS
SDYLKGRAIVNADDPYGQKLIARLESEKVWSYSTSDTSTDLWASDLEYKPTGVKGMLHTPKGEMIFSLPLVGQYNLSNML
AAVGTTLHLGLDLSMVVTQLSDFPGVPGRMERVQVTEGQDVSVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRD
RTKRPKMGKIAAELSDLAVVSSDNPRTEDPERILQDILEGISPEVKPLVISDRAEAIRTAIMEAQSGDGVLIAGKGHEDY
QILGTEKIHFDDREQARNTLRDKYGLSQK
>Mature_508_residues
TTKTIGVPNMKLRELLAKVSSISLTNNYQALETEIKGLATNSHACQTGDLFLGMPGTRVDGGDFWKSAIANGAVGAIVSV
SAATKHPAKNECVIPVADMSQTCPEIAAAFYDYPGQKMKMVGITGTNGKTTTTHLVEFILNNAQLPTALFGTLYMRWPGF
QKTAAYTTSFPVELQNQLAQALAAGSKYGIMEVSSHSLDQKRVWGCTYEVAVFTNLTQDHLDYHKDMDDYFEAKARLFSS
DYLKGRAIVNADDPYGQKLIARLESEKVWSYSTSDTSTDLWASDLEYKPTGVKGMLHTPKGEMIFSLPLVGQYNLSNMLA
AVGTTLHLGLDLSMVVTQLSDFPGVPGRMERVQVTEGQDVSVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRDR
TKRPKMGKIAAELSDLAVVSSDNPRTEDPERILQDILEGISPEVKPLVISDRAEAIRTAIMEAQSGDGVLIAGKGHEDYQ
ILGTEKIHFDDREQARNTLRDKYGLSQK

Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family. MurE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786273, Length=467, Percent_Identity=39.8286937901499, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786274, Length=351, Percent_Identity=26.2108262108262, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR005761 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.13 [H]

Molecular weight: Translated: 55679; Mature: 55548

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS01011 FOLYLPOLYGLU_SYNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKTIGVPNMKLRELLAKVSSISLTNNYQALETEIKGLATNSHACQTGDLFLGMPGTRV
CCCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
DGGDFWKSAIANGAVGAIVSVSAATKHPAKNECVIPVADMSQTCPEIAAAFYDYPGQKMK
CCHHHHHHHHCCCCCHHEEEEEHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEE
MVGITGTNGKTTTTHLVEFILNNAQLPTALFGTLYMRWPGFQKTAAYTTSFPVELQNQLA
EEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHH
QALAAGSKYGIMEVSSHSLDQKRVWGCTYEVAVFTNLTQDHLDYHKDMDDYFEAKARLFS
HHHHCCCCCCEEEECCCCCCCHHHCCEEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHHH
SDYLKGRAIVNADDPYGQKLIARLESEKVWSYSTSDTSTDLWASDLEYKPTGVKGMLHTP
HHCCCCCEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEECC
KGEMIFSLPLVGQYNLSNMLAAVGTTLHLGLDLSMVVTQLSDFPGVPGRMERVQVTEGQD
CCCEEEEECCCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCC
VSVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRDRTKRPKMGKIAAELSDLAVV
EEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHEEEE
SSDNPRTEDPERILQDILEGISPEVKPLVISDRAEAIRTAIMEAQSGDGVLIAGKGHEDY
ECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEECCCCCCE
QILGTEKIHFDDREQARNTLRDKYGLSQK
EEEECEEECCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTKTIGVPNMKLRELLAKVSSISLTNNYQALETEIKGLATNSHACQTGDLFLGMPGTRV
CCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
DGGDFWKSAIANGAVGAIVSVSAATKHPAKNECVIPVADMSQTCPEIAAAFYDYPGQKMK
CCHHHHHHHHCCCCCHHEEEEEHHCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEE
MVGITGTNGKTTTTHLVEFILNNAQLPTALFGTLYMRWPGFQKTAAYTTSFPVELQNQLA
EEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHH
QALAAGSKYGIMEVSSHSLDQKRVWGCTYEVAVFTNLTQDHLDYHKDMDDYFEAKARLFS
HHHHCCCCCCEEEECCCCCCCHHHCCEEEEEEEEECCCHHHHHHHCCHHHHHHHHHHHHH
SDYLKGRAIVNADDPYGQKLIARLESEKVWSYSTSDTSTDLWASDLEYKPTGVKGMLHTP
HHCCCCCEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEECC
KGEMIFSLPLVGQYNLSNMLAAVGTTLHLGLDLSMVVTQLSDFPGVPGRMERVQVTEGQD
CCCEEEEECCCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHCCCCCCCCCEEEECCCCC
VSVIVDYAHTPDSLENLLKAARPFIPGRMICVFGCGGDRDRTKRPKMGKIAAELSDLAVV
EEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHEEEE
SSDNPRTEDPERILQDILEGISPEVKPLVISDRAEAIRTAIMEAQSGDGVLIAGKGHEDY
ECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEECCCCCCE
QILGTEKIHFDDREQARNTLRDKYGLSQK
EEEECEEECCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA