Click here to switch to the map view.

The map label for this gene is iscS [H]

Identifier: 113477470

GI number: 113477470

Start: 6249775

End: 6250944

Strand: Reverse

Name: iscS [H]

Synonym: Tery_4044

Alternate gene names: 113477470

Gene position: 6250944-6249775 (Counterclockwise)

Preceding gene: 113477471

Following gene: 113477463

Centisome position: 80.66

GC content: 38.63

Gene sequence:

>1170_bases
ATGTTTAAACGTCCTATATATCTCGACTGTAATGCAACTACTCCCCTTGATGAACGAGTATTAAAAACAATGTTGCCCTA
CTTCACAGAACATTTTGGCAACCCCGCTAGCATTACCCATCAATATGGTTGGGAAGCAGAAGCAGCAGTGAAAAAAGCTA
GAGAAATTTTGGCTACAGGTATTAATGCTAGTCCTGAAGAAATTATCTTTACCAGTGGTGCAACAGAATCAAATAATTTA
GCCATCAAAGGAATAGCTGAAGCTTACTTTAATAAAGGCAAACATATTATTACGATCACTACTGAACATAATGCAGTTCT
CGACCCCTGTGCCTATTTACAAAATTTGGGATTTGAAGTAACTTATTTACCTGTAAATAGAGATGGAATTATCGATATAA
CTCGTCTTGAAACAGCTTTGCGTGATGATACAATTCTCGTATCTATTATGGCAGCAAATAATGAAATTGGAGTCTTACAA
CCCTTAGCAAAAATAGGAGAAATATGCAAAGAAAATTCGATTATTTTCCATACTGATGCTGCACAAGCTATTGGTAAAAT
TTCTCTTGACGTACAGGCAATGAATATTGATTTAATGTCATTAACTGCCCATAAAATTTACGGACCAAAAGGTATTGGTG
CTATCTATGTGCGTCGTCGCCATCCGAGAGTCAAAATAGCGCCTCAAATACATGGAGGTGGACACGAACGAGGAATACGT
TCTGGTACTTTGTGTACGCCTCAAATAGTTGGTTTTAGTAAAGCGGTGGCATTGGCGTTAGCAGAAATAAAGTCGGAGGC
AAAACGGTTAACTAGTTTACGACAACAGTTATGGGAGAAGTTACAAACATTAGAAAATATTTTTCTCAACGGACATCCGA
CTCAGCGTTTACCAGGAAATTTAAACATTAGTGTTGAGGGTGTAGATGGCCAAGCTTTATTGTTGGGCTTACAAAGTGTG
ATGGCGGTTTCTTCTGGTTCTGCTTGCACTTCTGCCAAAATCTCACCTTCCCATGTTTTGCAAGCTTTAGGGCGTTCAGA
AAAGTTAGCTTATGCTTCTGTGCGCTTTGGTATTGGGCGGTTTAATACTGCCGAAGAAATAGATCTAGTAGCAGAACAGG
CGATCGCCACAATTAAATCTTTACGTCAAGCAACTACGAGTATTAAATAA

Upstream 100 bases:

>100_bases
GATACATCTCACAATACCTAAATTTGCTCCCAAGAACCTAGTTTTTGATACTATAAAATATGAGAACATAAAATAATTAA
CTAATTATTAAGCGATCGCT

Downstream 100 bases:

>100_bases
TAGTAGGCTTATATTTGGTATAAAACTAATAATTTACTAATCATAAAAACCTAACCTTTTTCTTTGCTCAGAAAATAGTT
AGGAGGTAAATTTAATCATT

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MFKRPIYLDCNATTPLDERVLKTMLPYFTEHFGNPASITHQYGWEAEAAVKKAREILATGINASPEEIIFTSGATESNNL
AIKGIAEAYFNKGKHIITITTEHNAVLDPCAYLQNLGFEVTYLPVNRDGIIDITRLETALRDDTILVSIMAANNEIGVLQ
PLAKIGEICKENSIIFHTDAAQAIGKISLDVQAMNIDLMSLTAHKIYGPKGIGAIYVRRRHPRVKIAPQIHGGGHERGIR
SGTLCTPQIVGFSKAVALALAEIKSEAKRLTSLRQQLWEKLQTLENIFLNGHPTQRLPGNLNISVEGVDGQALLLGLQSV
MAVSSGSACTSAKISPSHVLQALGRSEKLAYASVRFGIGRFNTAEEIDLVAEQAIATIKSLRQATTSIK

Sequences:

>Translated_389_residues
MFKRPIYLDCNATTPLDERVLKTMLPYFTEHFGNPASITHQYGWEAEAAVKKAREILATGINASPEEIIFTSGATESNNL
AIKGIAEAYFNKGKHIITITTEHNAVLDPCAYLQNLGFEVTYLPVNRDGIIDITRLETALRDDTILVSIMAANNEIGVLQ
PLAKIGEICKENSIIFHTDAAQAIGKISLDVQAMNIDLMSLTAHKIYGPKGIGAIYVRRRHPRVKIAPQIHGGGHERGIR
SGTLCTPQIVGFSKAVALALAEIKSEAKRLTSLRQQLWEKLQTLENIFLNGHPTQRLPGNLNISVEGVDGQALLLGLQSV
MAVSSGSACTSAKISPSHVLQALGRSEKLAYASVRFGIGRFNTAEEIDLVAEQAIATIKSLRQATTSIK
>Mature_389_residues
MFKRPIYLDCNATTPLDERVLKTMLPYFTEHFGNPASITHQYGWEAEAAVKKAREILATGINASPEEIIFTSGATESNNL
AIKGIAEAYFNKGKHIITITTEHNAVLDPCAYLQNLGFEVTYLPVNRDGIIDITRLETALRDDTILVSIMAANNEIGVLQ
PLAKIGEICKENSIIFHTDAAQAIGKISLDVQAMNIDLMSLTAHKIYGPKGIGAIYVRRRHPRVKIAPQIHGGGHERGIR
SGTLCTPQIVGFSKAVALALAEIKSEAKRLTSLRQQLWEKLQTLENIFLNGHPTQRLPGNLNISVEGVDGQALLLGLQSV
MAVSSGSACTSAKISPSHVLQALGRSEKLAYASVRFGIGRFNTAEEIDLVAEQAIATIKSLRQATTSIK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=383, Percent_Identity=54.8302872062663, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI156713448, Length=418, Percent_Identity=35.1674641148325, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI48994898, Length=384, Percent_Identity=54.9479166666667, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1787970, Length=230, Percent_Identity=29.1304347826087, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789175, Length=213, Percent_Identity=28.6384976525822, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=381, Percent_Identity=52.755905511811, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17533177, Length=333, Percent_Identity=34.5345345345345, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319831, Length=380, Percent_Identity=54.7368421052632, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI20129463, Length=383, Percent_Identity=54.5691906005222, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42288; Mature: 42288

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRPIYLDCNATTPLDERVLKTMLPYFTEHFGNPASITHQYGWEAEAAVKKAREILATG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHC
INASPEEIIFTSGATESNNLAIKGIAEAYFNKGKHIITITTEHNAVLDPCAYLQNLGFEV
CCCCCCCEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCEE
TYLPVNRDGIIDITRLETALRDDTILVSIMAANNEIGVLQPLAKIGEICKENSIIFHTDA
EEEEECCCCCEEHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECH
AQAIGKISLDVQAMNIDLMSLTAHKIYGPKGIGAIYVRRRHPRVKIAPQIHGGGHERGIR
HHHHCEEEEEEEEEEEEEEEEHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCC
SGTLCTPQIVGFSKAVALALAEIKSEAKRLTSLRQQLWEKLQTLENIFLNGHPTQRLPGN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LNISVEGVDGQALLLGLQSVMAVSSGSACTSAKISPSHVLQALGRSEKLAYASVRFGIGR
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCC
FNTAEEIDLVAEQAIATIKSLRQATTSIK
CCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKRPIYLDCNATTPLDERVLKTMLPYFTEHFGNPASITHQYGWEAEAAVKKAREILATG
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHC
INASPEEIIFTSGATESNNLAIKGIAEAYFNKGKHIITITTEHNAVLDPCAYLQNLGFEV
CCCCCCCEEEECCCCCCCCEEEEEHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCEE
TYLPVNRDGIIDITRLETALRDDTILVSIMAANNEIGVLQPLAKIGEICKENSIIFHTDA
EEEEECCCCCEEHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECH
AQAIGKISLDVQAMNIDLMSLTAHKIYGPKGIGAIYVRRRHPRVKIAPQIHGGGHERGIR
HHHHCEEEEEEEEEEEEEEEEHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCC
SGTLCTPQIVGFSKAVALALAEIKSEAKRLTSLRQQLWEKLQTLENIFLNGHPTQRLPGN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LNISVEGVDGQALLLGLQSVMAVSSGSACTSAKISPSHVLQALGRSEKLAYASVRFGIGR
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCC
FNTAEEIDLVAEQAIATIKSLRQATTSIK
CCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA