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The map label for this gene is phoR [H]

Identifier: 113477356

GI number: 113477356

Start: 6044701

End: 6046089

Strand: Reverse

Name: phoR [H]

Synonym: Tery_3912

Alternate gene names: 113477356

Gene position: 6046089-6044701 (Counterclockwise)

Preceding gene: 113477358

Following gene: 113477355

Centisome position: 78.01

GC content: 32.69

Gene sequence:

>1389_bases
ATGCCCACAAGTACAGAATTTATTGGACTTTGTAGAACCCAGATATCTCTGGTATCTAGTTTGGGTGCAACTTTAAGTAT
AGTTTACTTGACAGAAAAACTGGCTGAAGGGGGTGAAGCCAAGCTAATTCCTATTATTGTATATCCAGAAATACCCCAAG
ATGAGAAAAAAACTTCAGTTTTAAAGGTCAACTCAGAAATACAAACACTAGATAACCTTCCAAAATTGTCAGCAGCCCCC
CTAATGATGGGCAAAAATTATCCGATTTTAGAAGCAAGCAATTATACAAAAGAATCAAATTCTGGGAGTCAAAATCATCC
TTGGCCAAAATGTCAAATTGTTTTACCCTTAATCCATGATGGAGTAGTTATAGGATTACTGGTAACAGCAAGAGAAGACC
GACCCTGGACTCAAAAAGAAGAAACTCAAATTCAAAAAGTAGCTCATACTATTACTGTAGCCTGTATTCTAGATCAACGT
TCTCAATGGTTAAAACAGCAATTTCAGCAACAACAGGAGTTGCAAGTCCAACAGTTTGATACGATGCATAATATACTGCA
TCAGTTAAAAAGTCCATTAACTGCCCTACGAACTTTTGGTAAGTTATTACTAAAAAAATTTTTACCAGAAGACAAAAACT
GGAATATAACTAATAGTATTTTACGGGAAAGTGATCGACTTAGAGAATTAATTGAACAAATTGATGAAACTGTTGATGCT
GGGAAAGAAATATTGAGTATTTCTGCTGAAAATCAGTATTTTCAAGGTGAAGAAATCATAGATGTTCATCAAGAAGCTAA
TCAAAAATATAAACCTCTGGGACTTTTACCTGGAGCGAATTTTTTAGAATCAGTTTTTGTACAACAAGTTTTAGAACCTT
TATTAGTTTCTGCTAAAGCAATTGCTAATGAAAATAATATAGATTTACAAGTTGATTTTCCTGATAGTTTACCAACCATA
AAAGCTAATTCTAAAGCTTTACGAGAAGTATTAAGTAATATTATTGATAATGCTTTAAAATATACTCCTATTCAAGGAAA
TATTTATATTAAGTTAGCAACTTTAGCTCCGCAAACAAGTCATCATAAATCAATTAATAGTGAAACAGAAGAAATGTTAG
CTATAGCTGTTAGCGATACAGGTTATGGCATTTCAGCAAAAGATTTAGAACACTTATTTGAACGAAACTATCGAGGAGAA
AAAGCTAAAACAAATATTCCAGGAACAGGATTAGGATTAGCTATTGCTCGTGATTTGATAAATGAAATGCAAGGTAAAAT
TCAAGTATATTCTCCTGTAGAGACTGAATGGTTACCTAGTTATTTAAAAGAGCAAGATTTAGTAATTAATGGTGGTACTA
CAGTTATTATATGGTTGCGTTGCGAATAA

Upstream 100 bases:

>100_bases
AGTGTTTTTAATATTTTGATACAAAATATAAGCTGCGTTATCTAAAATCTAAAAAATACTGATATAACCGTGGAAAATAC
GACAAATAGCTCTAATTCTC

Downstream 100 bases:

>100_bases
TGTTAAACATTCGCCAGGTAAGTTACCTTACCCGACTCGTCTTCAAAACCGGACTTGAGACTTTAACCTCATCTGGCTCC
TCTGTTAAATGTCTCAAGTC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MPTSTEFIGLCRTQISLVSSLGATLSIVYLTEKLAEGGEAKLIPIIVYPEIPQDEKKTSVLKVNSEIQTLDNLPKLSAAP
LMMGKNYPILEASNYTKESNSGSQNHPWPKCQIVLPLIHDGVVIGLLVTAREDRPWTQKEETQIQKVAHTITVACILDQR
SQWLKQQFQQQQELQVQQFDTMHNILHQLKSPLTALRTFGKLLLKKFLPEDKNWNITNSILRESDRLRELIEQIDETVDA
GKEILSISAENQYFQGEEIIDVHQEANQKYKPLGLLPGANFLESVFVQQVLEPLLVSAKAIANENNIDLQVDFPDSLPTI
KANSKALREVLSNIIDNALKYTPIQGNIYIKLATLAPQTSHHKSINSETEEMLAIAVSDTGYGISAKDLEHLFERNYRGE
KAKTNIPGTGLGLAIARDLINEMQGKIQVYSPVETEWLPSYLKEQDLVINGGTTVIIWLRCE

Sequences:

>Translated_462_residues
MPTSTEFIGLCRTQISLVSSLGATLSIVYLTEKLAEGGEAKLIPIIVYPEIPQDEKKTSVLKVNSEIQTLDNLPKLSAAP
LMMGKNYPILEASNYTKESNSGSQNHPWPKCQIVLPLIHDGVVIGLLVTAREDRPWTQKEETQIQKVAHTITVACILDQR
SQWLKQQFQQQQELQVQQFDTMHNILHQLKSPLTALRTFGKLLLKKFLPEDKNWNITNSILRESDRLRELIEQIDETVDA
GKEILSISAENQYFQGEEIIDVHQEANQKYKPLGLLPGANFLESVFVQQVLEPLLVSAKAIANENNIDLQVDFPDSLPTI
KANSKALREVLSNIIDNALKYTPIQGNIYIKLATLAPQTSHHKSINSETEEMLAIAVSDTGYGISAKDLEHLFERNYRGE
KAKTNIPGTGLGLAIARDLINEMQGKIQVYSPVETEWLPSYLKEQDLVINGGTTVIIWLRCE
>Mature_461_residues
PTSTEFIGLCRTQISLVSSLGATLSIVYLTEKLAEGGEAKLIPIIVYPEIPQDEKKTSVLKVNSEIQTLDNLPKLSAAPL
MMGKNYPILEASNYTKESNSGSQNHPWPKCQIVLPLIHDGVVIGLLVTAREDRPWTQKEETQIQKVAHTITVACILDQRS
QWLKQQFQQQQELQVQQFDTMHNILHQLKSPLTALRTFGKLLLKKFLPEDKNWNITNSILRESDRLRELIEQIDETVDAG
KEILSISAENQYFQGEEIIDVHQEANQKYKPLGLLPGANFLESVFVQQVLEPLLVSAKAIANENNIDLQVDFPDSLPTIK
ANSKALREVLSNIIDNALKYTPIQGNIYIKLATLAPQTSHHKSINSETEEMLAIAVSDTGYGISAKDLEHLFERNYRGEK
AKTNIPGTGLGLAIARDLINEMQGKIQVYSPVETEWLPSYLKEQDLVINGGTTVIIWLRCE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=289, Percent_Identity=24.5674740484429, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51826; Mature: 51695

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00037 MYB_1 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSTEFIGLCRTQISLVSSLGATLSIVYLTEKLAEGGEAKLIPIIVYPEIPQDEKKTSV
CCCCHHHHHHHHHHHHHHHHHCHHEEHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEE
LKVNSEIQTLDNLPKLSAAPLMMGKNYPILEASNYTKESNSGSQNHPWPKCQIVLPLIHD
EEECCHHHHHHCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHC
GVVIGLLVTAREDRPWTQKEETQIQKVAHTITVACILDQRSQWLKQQFQQQQELQVQQFD
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMHNILHQLKSPLTALRTFGKLLLKKFLPEDKNWNITNSILRESDRLRELIEQIDETVDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GKEILSISAENQYFQGEEIIDVHQEANQKYKPLGLLPGANFLESVFVQQVLEPLLVSAKA
CHHHEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IANENNIDLQVDFPDSLPTIKANSKALREVLSNIIDNALKYTPIQGNIYIKLATLAPQTS
HCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCC
HHKSINSETEEMLAIAVSDTGYGISAKDLEHLFERNYRGEKAKTNIPGTGLGLAIARDLI
HHCCCCCCHHHEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
NEMQGKIQVYSPVETEWLPSYLKEQDLVINGGTTVIIWLRCE
HHHCCCEEEECCCCHHHHHHHHCCCCEEEECCCEEEEEEEEC
>Mature Secondary Structure 
PTSTEFIGLCRTQISLVSSLGATLSIVYLTEKLAEGGEAKLIPIIVYPEIPQDEKKTSV
CCCHHHHHHHHHHHHHHHHHCHHEEHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEE
LKVNSEIQTLDNLPKLSAAPLMMGKNYPILEASNYTKESNSGSQNHPWPKCQIVLPLIHD
EEECCHHHHHHCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEHHHC
GVVIGLLVTAREDRPWTQKEETQIQKVAHTITVACILDQRSQWLKQQFQQQQELQVQQFD
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMHNILHQLKSPLTALRTFGKLLLKKFLPEDKNWNITNSILRESDRLRELIEQIDETVDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GKEILSISAENQYFQGEEIIDVHQEANQKYKPLGLLPGANFLESVFVQQVLEPLLVSAKA
CHHHEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IANENNIDLQVDFPDSLPTIKANSKALREVLSNIIDNALKYTPIQGNIYIKLATLAPQTS
HCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCC
HHKSINSETEEMLAIAVSDTGYGISAKDLEHLFERNYRGEKAKTNIPGTGLGLAIARDLI
HHCCCCCCHHHEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
NEMQGKIQVYSPVETEWLPSYLKEQDLVINGGTTVIIWLRCE
HHHCCCEEEECCCCHHHHHHHHCCCCEEEECCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]