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The map label for this gene is hisA

Identifier: 113477199

GI number: 113477199

Start: 5722164

End: 5722937

Strand: Reverse

Name: hisA

Synonym: Tery_3731

Alternate gene names: 113477199

Gene position: 5722937-5722164 (Counterclockwise)

Preceding gene: 113477200

Following gene: 113477194

Centisome position: 73.84

GC content: 39.66

Gene sequence:

>774_bases
ATGAATATAATTCCAGCGATCGACATATTAGGTGGACGTTGTGTAAGATTGTATCAAGGAGATTATAAGCAAACCCAAAT
CTTTAATGATAATCCAGTTGATGTAGCAAAAAGGTGGGCAGATGAAGGGGCAACTAAGCTACACCTAGTAGACTTAGACG
CTGCTAAAGTAGGTCAACCTGTCAATCAAAAGACTATTGAAGCAATCATCAAAGCAGTAGATATACCAATACAAGTAGGC
GGTGGGTTACGGAACTATTCCACAGTTGCGAGTCTACTTGCTCTTGGAGTACAGCAGGCTATTTTGGGTACTGTTGCTAT
AGAACAACCTGAGTTAGTTTCTGATTTTTGCCAAAAGTTTCCTGGTCAAATTATTGTAGGTATTGATGCTAGAGATGGCA
AGGTTGCCACTAAAGGTTGGTTAGAAACTTCACAAGTGTTAGCAACTGACCTAGCACTTCAAATGGCCAAATTGAAAGTT
GCAGCAATTATCTATACTGATATTCACCGGGATGGTACTCTCAAAGGACCTAATATAGAAGCATTAAGGGAGTTAGCTAC
TGCGGTTAGTATTCCAGTAATTGCTTCTGGCGGAATTAGTTCAATTAACGATTTATTAAATTTACTAGCATTAGAAACCA
TTGGCGTTAAAGGTGCGATTGTTGGTCGTGCCTTGTATACTGGAGGTATTAGTCTTAAAGAAGCAAATCAAGCAGTAGGT
CAAGGGCGTTGGCAAGATGTACCTCCAAATTTGGGCTCTTCTACATTTGTCTAA

Upstream 100 bases:

>100_bases
CAGGAGTAAAAATTTCTTTATAGTTTCGATTGTGTATTATGTTAACAGTCGGTGCAACTATTGACAAAGTTAGTAGTTTT
GTATACAAAACATAGAATCT

Downstream 100 bases:

>100_bases
TCCTAATCAGATAATTGGTGTTGCTCATGGGTAGTTTGTAATACTTCCTTTGATAAAAGCATTCAAGGAGTTAGTTATTG
TGGTCGGTATTCAGTGTGAT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MNIIPAIDILGGRCVRLYQGDYKQTQIFNDNPVDVAKRWADEGATKLHLVDLDAAKVGQPVNQKTIEAIIKAVDIPIQVG
GGLRNYSTVASLLALGVQQAILGTVAIEQPELVSDFCQKFPGQIIVGIDARDGKVATKGWLETSQVLATDLALQMAKLKV
AAIIYTDIHRDGTLKGPNIEALRELATAVSIPVIASGGISSINDLLNLLALETIGVKGAIVGRALYTGGISLKEANQAVG
QGRWQDVPPNLGSSTFV

Sequences:

>Translated_257_residues
MNIIPAIDILGGRCVRLYQGDYKQTQIFNDNPVDVAKRWADEGATKLHLVDLDAAKVGQPVNQKTIEAIIKAVDIPIQVG
GGLRNYSTVASLLALGVQQAILGTVAIEQPELVSDFCQKFPGQIIVGIDARDGKVATKGWLETSQVLATDLALQMAKLKV
AAIIYTDIHRDGTLKGPNIEALRELATAVSIPVIASGGISSINDLLNLLALETIGVKGAIVGRALYTGGISLKEANQAVG
QGRWQDVPPNLGSSTFV
>Mature_257_residues
MNIIPAIDILGGRCVRLYQGDYKQTQIFNDNPVDVAKRWADEGATKLHLVDLDAAKVGQPVNQKTIEAIIKAVDIPIQVG
GGLRNYSTVASLLALGVQQAILGTVAIEQPELVSDFCQKFPGQIIVGIDARDGKVATKGWLETSQVLATDLALQMAKLKV
AAIIYTDIHRDGTLKGPNIEALRELATAVSIPVIASGGISSINDLLNLLALETIGVKGAIVGRALYTGGISLKEANQAVG
QGRWQDVPPNLGSSTFV

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=36.25, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788336, Length=244, Percent_Identity=27.0491803278689, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_TRIEI (Q10Y87)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_723260.1
- ProteinModelPortal:   Q10Y87
- SMR:   Q10Y87
- STRING:   Q10Y87
- GeneID:   4243907
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_3731
- NMPDR:   fig|203124.1.peg.6013
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   Q10Y87
- ProtClustDB:   PRK00748
- BioCyc:   TERY203124:TERY_3731-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 27215; Mature: 27215

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIPAIDILGGRCVRLYQGDYKQTQIFNDNPVDVAKRWADEGATKLHLVDLDAAKVGQP
CCCCCCHHHCCCEEEEEECCCCCCCEECCCCCHHHHHHHHCCCCCEEEEEECCHHHHCCC
VNQKTIEAIIKAVDIPIQVGGGLRNYSTVASLLALGVQQAILGTVAIEQPELVSDFCQKF
CCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
PGQIIVGIDARDGKVATKGWLETSQVLATDLALQMAKLKVAAIIYTDIHRDGTLKGPNIE
CCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCHH
ALRELATAVSIPVIASGGISSINDLLNLLALETIGVKGAIVGRALYTGGISLKEANQAVG
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHC
QGRWQDVPPNLGSSTFV
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIIPAIDILGGRCVRLYQGDYKQTQIFNDNPVDVAKRWADEGATKLHLVDLDAAKVGQP
CCCCCCHHHCCCEEEEEECCCCCCCEECCCCCHHHHHHHHCCCCCEEEEEECCHHHHCCC
VNQKTIEAIIKAVDIPIQVGGGLRNYSTVASLLALGVQQAILGTVAIEQPELVSDFCQKF
CCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
PGQIIVGIDARDGKVATKGWLETSQVLATDLALQMAKLKVAAIIYTDIHRDGTLKGPNIE
CCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCHH
ALRELATAVSIPVIASGGISSINDLLNLLALETIGVKGAIVGRALYTGGISLKEANQAVG
HHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHC
QGRWQDVPPNLGSSTFV
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA