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The map label for this gene is mrdA [H]

Identifier: 113476583

GI number: 113476583

Start: 4665302

End: 4667113

Strand: Reverse

Name: mrdA [H]

Synonym: Tery_3016

Alternate gene names: 113476583

Gene position: 4667113-4665302 (Counterclockwise)

Preceding gene: 113476585

Following gene: 113476579

Centisome position: 60.22

GC content: 38.74

Gene sequence:

>1812_bases
ATGGTACGTGAATTTTCTTTTTCTTCTTGGTTTCGGAAAACAGAAGAGAATAACCTCCCAGATCAGGAACGCCAGTCACC
TTTAATATTCCGAACAATAGTCATAGTTTTATTGACCACAACTACCATAGGTCTACAAGTGACTCGTCTGGCTCAAATAC
AATTAATTCAAGGTCAACAAAATAGGGAACGAGCAGAAAACAACCGAATTCGACCCATTCCAGTCCCTTCTAATAGAGGA
CTAATTCTAGACCGTAATGGCAAAGCCTTTGCATCTAACCGTCTTAAGCATGCCATATATTTATGGCCAAAAGAACAACC
ATTACAGCAATGGAAAATTACTGCAGCTAAACTCAGCCCCATTATTGATATACCAGCCGACAAAATTATTAAAAAAGTAG
AACAGGCAATTACTTCAGGAGAAAGGAATATACATCTTAGCGATCAAGTTAGCCGTAATACTTTTATCACTTTACAAGAA
AAGACTGGGGAGTTTCCTGGTGTAGAAGTTAGACCAGAGTCAACTCGTTATTATCCTTATGGACAATTAGCATCCCATGT
GATAGGATATCTTGGTGAAGTTACACCAGCAGAACTAGAAGCTAACCCAGAATACCAACTAAGAATGATGGTTGGTAGAA
TAGGAGTTGAAGCTAGTGCTAATGATGTACTAGCAGGAAAATGGGGTCAGGACTTGATAGAAGTCAATGCCCAAAACCGC
GAAGTAAGAATTTTTGAAGAAGAAGAAAAAGAGGCTAAAAGTGGAAAAACGGTCAAGTTAACCCTTGATATAAACCTTCA
AAAAGCAGCAGAAACAGCTCTGGGTTTTCGCAAGGGAGCAGTAGTTGTGTTAGATGTGAATACAGGGGAAGTTTTAGCAA
TGGCAAGTTATCCCAGATTCAACCCCAATGTCTTTACAAAGCCTATGCCTGAAGAAAAATGGCGAAGTCTTCACAGTGAA
GAACAATCATTTTTAAATCGGTCTCTCCAAGGTTACCCTCCAGGTAGTACATTTAAAATAGTTACTGCTGCTGCTGCTTT
AGGGTCTGGCAAGTTTTCTCCCTACTCAATTATTCAAACTTCTGATTCTATTTATGTTGGAGGTATTCTTTTCAATGAAC
ATAGTGGGGGATATGGTGCTATTGGTTTTAGAACTGCATTAGCTTATAGTAGTAATACTTTCTTTTATCATGCTGGTATG
ACTATTGGTCACGAACAGATAGCTCAATGGGCATATAAACTTGGTTTAGGGGGCAAAAAATTAAACCTTCTGGGCATACC
TTCTGCATATAATGGTCTCATTCCTACTGAAGAAGATAAACGGAGAATTTATAATGATGCCTGGTATTTGGGTGATACAA
TTACAATGGCAATTGGTCAGGGTTTGGTTTTGGTGACGCCTTTAGAGTTAGCAACAGCAACAGCAACGATCGCTAATAGT
GGTAAACAGGTTACACCTCACTTGTTTGCACATGAAACTAACTCTCCAGAAATGAAACCTATTCCCATAGGGTTGAAACC
AGAATATGTCAATACGATTAAAAAAGGAATGATTGATGTTGTTGAATACGGTACAGCACAATTACTTAATGATGGCACAA
TTCCACTCACAGGAGGAAAAACAGGTACATCAGAAGTAATGGGACAAAAGTCTCATTCATTGTATGTGGGATTTGGGCCT
GCCGAAGAATCAAAAATTGCGATCGCTGTGATTGTTGAAAATGGTGGTTATGGTTCTTTTTCCGCTGCTCCAGTTGCGAA
AAAGGTTTTTCAAACTTATTTCAGTAAATATAGCCAAGCTAAACTGAATTAG

Upstream 100 bases:

>100_bases
CTACTCCCTCAAAAAAATTGTAGCTTATCACTATGATATTTTTCAGGTCAAAAAAATTAAATGATTAACCTTAAAATCCT
ACTTTATAAATTAAAAACCT

Downstream 100 bases:

>100_bases
TTTCATGGGAAAGCAATAAACATCTCCAAAAACTCTCACTTCCCTTACTATAACTATCTTTACTGGAGCCAGCAAGCGCT
CCTCCAGATAGTTATTTTTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MVREFSFSSWFRKTEENNLPDQERQSPLIFRTIVIVLLTTTTIGLQVTRLAQIQLIQGQQNRERAENNRIRPIPVPSNRG
LILDRNGKAFASNRLKHAIYLWPKEQPLQQWKITAAKLSPIIDIPADKIIKKVEQAITSGERNIHLSDQVSRNTFITLQE
KTGEFPGVEVRPESTRYYPYGQLASHVIGYLGEVTPAELEANPEYQLRMMVGRIGVEASANDVLAGKWGQDLIEVNAQNR
EVRIFEEEEKEAKSGKTVKLTLDINLQKAAETALGFRKGAVVVLDVNTGEVLAMASYPRFNPNVFTKPMPEEKWRSLHSE
EQSFLNRSLQGYPPGSTFKIVTAAAALGSGKFSPYSIIQTSDSIYVGGILFNEHSGGYGAIGFRTALAYSSNTFFYHAGM
TIGHEQIAQWAYKLGLGGKKLNLLGIPSAYNGLIPTEEDKRRIYNDAWYLGDTITMAIGQGLVLVTPLELATATATIANS
GKQVTPHLFAHETNSPEMKPIPIGLKPEYVNTIKKGMIDVVEYGTAQLLNDGTIPLTGGKTGTSEVMGQKSHSLYVGFGP
AEESKIAIAVIVENGGYGSFSAAPVAKKVFQTYFSKYSQAKLN

Sequences:

>Translated_603_residues
MVREFSFSSWFRKTEENNLPDQERQSPLIFRTIVIVLLTTTTIGLQVTRLAQIQLIQGQQNRERAENNRIRPIPVPSNRG
LILDRNGKAFASNRLKHAIYLWPKEQPLQQWKITAAKLSPIIDIPADKIIKKVEQAITSGERNIHLSDQVSRNTFITLQE
KTGEFPGVEVRPESTRYYPYGQLASHVIGYLGEVTPAELEANPEYQLRMMVGRIGVEASANDVLAGKWGQDLIEVNAQNR
EVRIFEEEEKEAKSGKTVKLTLDINLQKAAETALGFRKGAVVVLDVNTGEVLAMASYPRFNPNVFTKPMPEEKWRSLHSE
EQSFLNRSLQGYPPGSTFKIVTAAAALGSGKFSPYSIIQTSDSIYVGGILFNEHSGGYGAIGFRTALAYSSNTFFYHAGM
TIGHEQIAQWAYKLGLGGKKLNLLGIPSAYNGLIPTEEDKRRIYNDAWYLGDTITMAIGQGLVLVTPLELATATATIANS
GKQVTPHLFAHETNSPEMKPIPIGLKPEYVNTIKKGMIDVVEYGTAQLLNDGTIPLTGGKTGTSEVMGQKSHSLYVGFGP
AEESKIAIAVIVENGGYGSFSAAPVAKKVFQTYFSKYSQAKLN
>Mature_603_residues
MVREFSFSSWFRKTEENNLPDQERQSPLIFRTIVIVLLTTTTIGLQVTRLAQIQLIQGQQNRERAENNRIRPIPVPSNRG
LILDRNGKAFASNRLKHAIYLWPKEQPLQQWKITAAKLSPIIDIPADKIIKKVEQAITSGERNIHLSDQVSRNTFITLQE
KTGEFPGVEVRPESTRYYPYGQLASHVIGYLGEVTPAELEANPEYQLRMMVGRIGVEASANDVLAGKWGQDLIEVNAQNR
EVRIFEEEEKEAKSGKTVKLTLDINLQKAAETALGFRKGAVVVLDVNTGEVLAMASYPRFNPNVFTKPMPEEKWRSLHSE
EQSFLNRSLQGYPPGSTFKIVTAAAALGSGKFSPYSIIQTSDSIYVGGILFNEHSGGYGAIGFRTALAYSSNTFFYHAGM
TIGHEQIAQWAYKLGLGGKKLNLLGIPSAYNGLIPTEEDKRRIYNDAWYLGDTITMAIGQGLVLVTPLELATATATIANS
GKQVTPHLFAHETNSPEMKPIPIGLKPEYVNTIKKGMIDVVEYGTAQLLNDGTIPLTGGKTGTSEVMGQKSHSLYVGFGP
AEESKIAIAVIVENGGYGSFSAAPVAKKVFQTYFSKYSQAKLN

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=609, Percent_Identity=29.5566502463054, Blast_Score=244, Evalue=2e-65,
Organism=Escherichia coli, GI1786272, Length=606, Percent_Identity=25.2475247524752, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66521; Mature: 66521

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREFSFSSWFRKTEENNLPDQERQSPLIFRTIVIVLLTTTTIGLQVTRLAQIQLIQGQQ
CCCCCCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEEEEEECCCC
NRERAENNRIRPIPVPSNRGLILDRNGKAFASNRLKHAIYLWPKEQPLQQWKITAAKLSP
HHHHHHCCCCCEEECCCCCCEEEECCCCCHHHCCCCEEEEECCCCCCHHHHEEEHHHCCC
IIDIPADKIIKKVEQAITSGERNIHLSDQVSRNTFITLQEKTGEFPGVEVRPESTRYYPY
EEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCH
GQLASHVIGYLGEVTPAELEANPEYQLRMMVGRIGVEASANDVLAGKWGQDLIEVNAQNR
HHHHHHHHHHHCCCCCHHCCCCCCEEEEEEEHHHCCCCCCCCEEECCCCCCCEEECCCCC
EVRIFEEEEKEAKSGKTVKLTLDINLQKAAETALGFRKGAVVVLDVNTGEVLAMASYPRF
EEEEEECHHHHHHCCCEEEEEEEECHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCC
NPNVFTKPMPEEKWRSLHSEEQSFLNRSLQGYPPGSTFKIVTAAAALGSGKFSPYSIIQT
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEEEE
SDSIYVGGILFNEHSGGYGAIGFRTALAYSSNTFFYHAGMTIGHEQIAQWAYKLGLGGKK
CCCEEEEEEEEECCCCCCCCHHHHEEEEECCCEEEEECCCEECHHHHHHHHHHHCCCCCE
LNLLGIPSAYNGLIPTEEDKRRIYNDAWYLGDTITMAIGQGLVLVTPLELATATATIANS
EEEEECCHHHCCCCCCCHHHHHHHCCCEEECCEEEEHHCCCEEEEECHHHHHHHHHHHCC
GKQVTPHLFAHETNSPEMKPIPIGLKPEYVNTIKKGMIDVVEYGTAQLLNDGTIPLTGGK
CCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEECCCC
TGTSEVMGQKSHSLYVGFGPAEESKIAIAVIVENGGYGSFSAAPVAKKVFQTYFSKYSQA
CCHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHC
KLN
CCC
>Mature Secondary Structure
MVREFSFSSWFRKTEENNLPDQERQSPLIFRTIVIVLLTTTTIGLQVTRLAQIQLIQGQQ
CCCCCCHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEEEEEECCCC
NRERAENNRIRPIPVPSNRGLILDRNGKAFASNRLKHAIYLWPKEQPLQQWKITAAKLSP
HHHHHHCCCCCEEECCCCCCEEEECCCCCHHHCCCCEEEEECCCCCCHHHHEEEHHHCCC
IIDIPADKIIKKVEQAITSGERNIHLSDQVSRNTFITLQEKTGEFPGVEVRPESTRYYPY
EEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCH
GQLASHVIGYLGEVTPAELEANPEYQLRMMVGRIGVEASANDVLAGKWGQDLIEVNAQNR
HHHHHHHHHHHCCCCCHHCCCCCCEEEEEEEHHHCCCCCCCCEEECCCCCCCEEECCCCC
EVRIFEEEEKEAKSGKTVKLTLDINLQKAAETALGFRKGAVVVLDVNTGEVLAMASYPRF
EEEEEECHHHHHHCCCEEEEEEEECHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCC
NPNVFTKPMPEEKWRSLHSEEQSFLNRSLQGYPPGSTFKIVTAAAALGSGKFSPYSIIQT
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEEEE
SDSIYVGGILFNEHSGGYGAIGFRTALAYSSNTFFYHAGMTIGHEQIAQWAYKLGLGGKK
CCCEEEEEEEEECCCCCCCCHHHHEEEEECCCEEEEECCCEECHHHHHHHHHHHCCCCCE
LNLLGIPSAYNGLIPTEEDKRRIYNDAWYLGDTITMAIGQGLVLVTPLELATATATIANS
EEEEECCHHHCCCCCCCHHHHHHHCCCEEECCEEEEHHCCCEEEEECHHHHHHHHHHHCC
GKQVTPHLFAHETNSPEMKPIPIGLKPEYVNTIKKGMIDVVEYGTAQLLNDGTIPLTGGK
CCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEECCCC
TGTSEVMGQKSHSLYVGFGPAEESKIAIAVIVENGGYGSFSAAPVAKKVFQTYFSKYSQA
CCHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHC
KLN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 8930920 [H]