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The map label for this gene is prfC

Identifier: 113476484

GI number: 113476484

Start: 4514600

End: 4516228

Strand: Reverse

Name: prfC

Synonym: Tery_2904

Alternate gene names: 113476484

Gene position: 4516228-4514600 (Counterclockwise)

Preceding gene: 113476485

Following gene: 113476483

Centisome position: 58.27

GC content: 36.65

Gene sequence:

>1629_bases
ATGTCCATTGAAATTGAAGCAGAATTGCAAACAGCAGTAGATAAACGGCGTAACTTTGCAATTATCTCCCATCCTGATGC
TGGTAAAACCACTCTTACAGAAAAACTATTATTGTACGGAGGTGCTATTCAAGAGGCTGGTGCAGTCAAAGCTAAAAGAG
CACAACGTCATGCCACCTCAGACTGGATGGCAATGGAACAACAAAGAGGCATTTCTATCACTTCCACAGTTCTACAATTT
GATTATCAAAACTGTCAAATAAACCTCCTAGATACTCCAGGACACCAAGATTTTAGTGAAGATACATATAGAACATTAGC
AGCTGCCGATAATGCTGTAATGTTAGAAGATAGTGCTAAAGGTTTAGAACCTCAAACTCGCAAATTATTTGAAGTTTGTA
AGATGCGAAAACTACCCATTTTTACCTTTATTAATAAAATGGATAGACCAGGACGAGAACCATTAGAACTCTTAGATGAA
ATTGAACAGGAATTAGGCTTAAAAACATATCCGGTAAATTGGCCTATAGGTATGGGCGATCGCTTCAAAGGAGTATTTGA
TCGAAGAAAAGAACAAATTCACTTATTTGAGCGGAGTATTCATGGTAGGAAAGCAGCAGTAAATACAGTAGTAAATTTAG
GCGATCCTCAAATAGAAAAACTATTAGATCAAGACCTTTATTATCAACTCAAAGAAGATTTAGAATTGCTAGACGAATTA
GGCTCAGCTTTAGACTTAGAACAGATACATACAGGAGAAATGACCCCTGTATTTTTTGGTAGTGCAATGACTAATTTTGG
GGTGCAATTATTCCTGGATGCTTTCTTAGAATATGCTCTTAAACCAGGTATTCATAAAAGTACAGTTGGGGAAGTTTCTC
CTACTTATCCAAACTTCACTGGATTTGTGTTTAAATTGCAAGCTAATATGGATCCAAAACATCGAGATCGAGTTGCATTT
ATTAGAGTTTGCACAGGAAAATTTGAAAAAGACATGACAGTTAGTCATGCTCGAACAGGTAAAACAGTACGATTATCTCG
TCCCCAAAAGCTATTTGCTCAAGACAGAGCATCTATCGAAAATGCCTATCCTGGTGACATAATTGGTTTAAATAATCCTG
GAGTATTTGCCATAGGAGATACTATTTATAATGGCAAAAAAATAGAATACGAAGGTATCCCCTGTTTCTCACCAGAAATA
TTTGCTTATTTAAGAAATCCTAACCCTTCTAAATTTAAGCAATTTCGTAAGGGAGTTAATGAATTACGAGAAGAAGGTGC
AGTGCAAATTATGTACTCAGCAGATGAGGCAAAAAGAGACCCTATTTTAGCTGCTGTTGGGCAGTTACAATTAGAGGTAG
TTCAGTTTAGAATGCAAAATGAATATGGAGTAGAAACTAGAGTAGAAATGTTACCTTTTACTGTCGCACGTTGGGTAGAT
GGTGGTTGGGAAATACTGCAAAAAGTGGGTAGGTTATTTAATACTGTGGCGGTCAAAGATAGCTGGGGTAGACCTGTTTT
GCTATTTAAAAATCAGTGGAATTGTCAACAGGTTGAATCTGAGCATCCAGAGTTAAAATTAAATAATACTGCACCAGTTG
TTTCTGGTCAAGAACCAGAATCTTTATAA

Upstream 100 bases:

>100_bases
TTATATCATAATGAGAAATATATTAAATTTAGCCTAGATAAATATATATAAATATATAATATTACGAACGATTCTAGATT
CTATAAATATAGGTTAACTT

Downstream 100 bases:

>100_bases
GGATAAGTACAATTTAAACCTTTAAAAAAAAAGATATAAATAAGAAAATAGGGTTGAAGATTAATACCTTTCTTTTCTCC
TTCCTTCTCCAAGTAAAATG

Product: peptide chain release factor 3

Products: NA

Alternate protein names: RF-3

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSIEIEAELQTAVDKRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKAKRAQRHATSDWMAMEQQRGISITSTVLQF
DYQNCQINLLDTPGHQDFSEDTYRTLAAADNAVMLEDSAKGLEPQTRKLFEVCKMRKLPIFTFINKMDRPGREPLELLDE
IEQELGLKTYPVNWPIGMGDRFKGVFDRRKEQIHLFERSIHGRKAAVNTVVNLGDPQIEKLLDQDLYYQLKEDLELLDEL
GSALDLEQIHTGEMTPVFFGSAMTNFGVQLFLDAFLEYALKPGIHKSTVGEVSPTYPNFTGFVFKLQANMDPKHRDRVAF
IRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQDRASIENAYPGDIIGLNNPGVFAIGDTIYNGKKIEYEGIPCFSPEI
FAYLRNPNPSKFKQFRKGVNELREEGAVQIMYSADEAKRDPILAAVGQLQLEVVQFRMQNEYGVETRVEMLPFTVARWVD
GGWEILQKVGRLFNTVAVKDSWGRPVLLFKNQWNCQQVESEHPELKLNNTAPVVSGQEPESL

Sequences:

>Translated_542_residues
MSIEIEAELQTAVDKRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKAKRAQRHATSDWMAMEQQRGISITSTVLQF
DYQNCQINLLDTPGHQDFSEDTYRTLAAADNAVMLEDSAKGLEPQTRKLFEVCKMRKLPIFTFINKMDRPGREPLELLDE
IEQELGLKTYPVNWPIGMGDRFKGVFDRRKEQIHLFERSIHGRKAAVNTVVNLGDPQIEKLLDQDLYYQLKEDLELLDEL
GSALDLEQIHTGEMTPVFFGSAMTNFGVQLFLDAFLEYALKPGIHKSTVGEVSPTYPNFTGFVFKLQANMDPKHRDRVAF
IRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQDRASIENAYPGDIIGLNNPGVFAIGDTIYNGKKIEYEGIPCFSPEI
FAYLRNPNPSKFKQFRKGVNELREEGAVQIMYSADEAKRDPILAAVGQLQLEVVQFRMQNEYGVETRVEMLPFTVARWVD
GGWEILQKVGRLFNTVAVKDSWGRPVLLFKNQWNCQQVESEHPELKLNNTAPVVSGQEPESL
>Mature_541_residues
SIEIEAELQTAVDKRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKAKRAQRHATSDWMAMEQQRGISITSTVLQFD
YQNCQINLLDTPGHQDFSEDTYRTLAAADNAVMLEDSAKGLEPQTRKLFEVCKMRKLPIFTFINKMDRPGREPLELLDEI
EQELGLKTYPVNWPIGMGDRFKGVFDRRKEQIHLFERSIHGRKAAVNTVVNLGDPQIEKLLDQDLYYQLKEDLELLDELG
SALDLEQIHTGEMTPVFFGSAMTNFGVQLFLDAFLEYALKPGIHKSTVGEVSPTYPNFTGFVFKLQANMDPKHRDRVAFI
RVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQDRASIENAYPGDIIGLNNPGVFAIGDTIYNGKKIEYEGIPCFSPEIF
AYLRNPNPSKFKQFRKGVNELREEGAVQIMYSADEAKRDPILAAVGQLQLEVVQFRMQNEYGVETRVEMLPFTVARWVDG
GWEILQKVGRLFNTVAVKDSWGRPVLLFKNQWNCQQVESEHPELKLNNTAPVVSGQEPESL

Specific function: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-

COG id: COG4108

COG function: function code J; Peptide chain release factor RF-3

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. PrfC subfamily

Homologues:

Organism=Homo sapiens, GI18390331, Length=492, Percent_Identity=29.0650406504065, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI19923640, Length=583, Percent_Identity=26.0720411663808, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI25306283, Length=397, Percent_Identity=29.7229219143577, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI25306287, Length=555, Percent_Identity=26.8468468468468, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI157426893, Length=156, Percent_Identity=32.0512820512821, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4503483, Length=161, Percent_Identity=29.8136645962733, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI94966754, Length=152, Percent_Identity=29.6052631578947, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI310132016, Length=131, Percent_Identity=31.2977099236641, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI310110807, Length=131, Percent_Identity=31.2977099236641, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI310123363, Length=131, Percent_Identity=31.2977099236641, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790835, Length=468, Percent_Identity=50.6410256410256, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1789738, Length=502, Percent_Identity=29.4820717131474, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788922, Length=156, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI48994988, Length=149, Percent_Identity=34.2281879194631, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17533571, Length=498, Percent_Identity=29.3172690763052, Blast_Score=179, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17556745, Length=482, Percent_Identity=25.3112033195021, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17557151, Length=138, Percent_Identity=35.5072463768116, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17506493, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323098, Length=484, Percent_Identity=27.8925619834711, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322359, Length=517, Percent_Identity=25.9187620889749, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324707, Length=157, Percent_Identity=31.8471337579618, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320593, Length=157, Percent_Identity=31.8471337579618, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323320, Length=145, Percent_Identity=31.7241379310345, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24582462, Length=481, Percent_Identity=29.9376299376299, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI221458488, Length=512, Percent_Identity=25.390625, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI78706572, Length=159, Percent_Identity=37.1069182389937, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585709, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585711, Length=153, Percent_Identity=30.0653594771242, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24585713, Length=153, Percent_Identity=30.0653594771242, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28574573, Length=150, Percent_Identity=32.6666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357743, Length=152, Percent_Identity=28.2894736842105, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RF3_TRIEI (Q110K2)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_722545.1
- ProteinModelPortal:   Q110K2
- SMR:   Q110K2
- STRING:   Q110K2
- GeneID:   4244741
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2904
- NMPDR:   fig|203124.1.peg.1863
- eggNOG:   COG4108
- HOGENOM:   HBG285678
- OMA:   LQFEVVQ
- PhylomeDB:   Q110K2
- ProtClustDB:   PRK00741
- BioCyc:   TERY203124:TERY_2904-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00072
- InterPro:   IPR009022
- InterPro:   IPR004548
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR00503
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; SSF54980 EFG_III_V; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 61417; Mature: 61286

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEIEAELQTAVDKRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKAKRAQRHATS
CCEEEEHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHCCH
DWMAMEQQRGISITSTVLQFDYQNCQINLLDTPGHQDFSEDTYRTLAAADNAVMLEDSAK
HHHHHHHHCCCCHHHHHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCC
GLEPQTRKLFEVCKMRKLPIFTFINKMDRPGREPLELLDEIEQELGLKTYPVNWPIGMGD
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCC
RFKGVFDRRKEQIHLFERSIHGRKAAVNTVVNLGDPQIEKLLDQDLYYQLKEDLELLDEL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSALDLEQIHTGEMTPVFFGSAMTNFGVQLFLDAFLEYALKPGIHKSTVGEVSPTYPNFT
CCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GFVFKLQANMDPKHRDRVAFIRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQDRASIE
EEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHC
NAYPGDIIGLNNPGVFAIGDTIYNGKKIEYEGIPCFSPEIFAYLRNPNPSKFKQFRKGVN
CCCCCCEEECCCCCEEEECCEEECCCEEEECCCCCCCHHHHHEECCCCHHHHHHHHHHHH
ELREEGAVQIMYSADEAKRDPILAAVGQLQLEVVQFRMQNEYGVETRVEMLPFTVARWVD
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
GGWEILQKVGRLFNTVAVKDSWGRPVLLFKNQWNCQQVESEHPELKLNNTAPVVSGQEPE
CHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCC
SL
CC
>Mature Secondary Structure 
SIEIEAELQTAVDKRRNFAIISHPDAGKTTLTEKLLLYGGAIQEAGAVKAKRAQRHATS
CEEEEHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHHHCCH
DWMAMEQQRGISITSTVLQFDYQNCQINLLDTPGHQDFSEDTYRTLAAADNAVMLEDSAK
HHHHHHHHCCCCHHHHHHHEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCC
GLEPQTRKLFEVCKMRKLPIFTFINKMDRPGREPLELLDEIEQELGLKTYPVNWPIGMGD
CCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCC
RFKGVFDRRKEQIHLFERSIHGRKAAVNTVVNLGDPQIEKLLDQDLYYQLKEDLELLDEL
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GSALDLEQIHTGEMTPVFFGSAMTNFGVQLFLDAFLEYALKPGIHKSTVGEVSPTYPNFT
CCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GFVFKLQANMDPKHRDRVAFIRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQDRASIE
EEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHC
NAYPGDIIGLNNPGVFAIGDTIYNGKKIEYEGIPCFSPEIFAYLRNPNPSKFKQFRKGVN
CCCCCCEEECCCCCEEEECCEEECCCEEEECCCCCCCHHHHHEECCCCHHHHHHHHHHHH
ELREEGAVQIMYSADEAKRDPILAAVGQLQLEVVQFRMQNEYGVETRVEMLPFTVARWVD
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
GGWEILQKVGRLFNTVAVKDSWGRPVLLFKNQWNCQQVESEHPELKLNNTAPVVSGQEPE
CHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCHHHHHCCCCCEEECCCCCCCCCCCCC
SL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA