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The map label for this gene is ahcY [H]

Identifier: 113476230

GI number: 113476230

Start: 4057414

End: 4058691

Strand: Reverse

Name: ahcY [H]

Synonym: Tery_2623

Alternate gene names: 113476230

Gene position: 4058691-4057414 (Counterclockwise)

Preceding gene: 113476231

Following gene: 113476229

Centisome position: 52.37

GC content: 39.91

Gene sequence:

>1278_bases
ATGGTTGCAACACCAGTTAAAATTAAATACGAAGTTAAAGACGAGTCCTTGGCTGTTTTAGGTAAACAAAGAATTGAGTG
GGCAGGTAGAGAAATGCCTGTTCTACGCCAAATTCAAGAACGCTTTGCTAAGGAAAAGCCATTAAGCGGGATTAAATTAG
CAGCTTGCTGTCATGTTACTACTGAAACTGCTCACTTAGCGATCGCTCTGAAAAATGGTGGGGCTGATGCTGTATTAATT
GCTAGTAACCCTCTATCTACTCAAGATGACGTAGCTGCTAGTTTGGTTGTAGATCATGGTATCTCTGTGTATGCTATCAA
GGGAGAGGATGAAAAAACCTATCTGCGTCACGTAGAAATAGCTTTAGACCACAGGCCAAATATTATTATTGATGATGGTA
GTGATGTTGTCGCTACTCTAGTAAAAAATAGACAAGATCAACTTCCTGAACTTATTGGTACTACGGAAGAAACTACTACC
GGTATTGTTCGTTTGCGAGCAATGTTTAATGATGGGGTATTGACTTTTCCGGCGATGAATGTTAACGATGCTGATACTAA
GCACTTCTTTGATAACCGCTACGGTACAGGTCAATCAACTCTTGATGGTATTATCCGTGCTACTAATGTTTTATTAGCTG
GTAAAACTACTGTTGTTGTAGGTTATGGATGGTGCGGTAAAGGTACAGCACTTCGCGCTAGAGGTTTAGGTGCTAATGTT
ATTGTAACTGAAGTTGACCCAGTTCGCGCTATTGAGGCGATCATGGATGGTTTCCGAGTTATGCCAATGGCAGAAGCGGC
TCCATTAGGGGATCTATTTATTACTGTGACTGGTAATAAGCACGTTATTCGCGGCGAACATTTCAATGTCATGAAAGATG
GAGCGATCGTTTGTAATTCCGGTCACTTTGATATTGAAATTGACCTGGAAACTTTGGGTAAGAATGCTGATAATGTCAAG
ACAGTTAGACCTTTCACTCAACAGTACACACTTAAGAATGGTAAGTCTGTAATTGTATTAGGTGAAGGACGGTTAATTAA
TTTAGCTGCAGCAGAAGGTCATCCTAGTGCGGTTATGGATATGAGTTTTGCTAACCAAGCATTGGCTTGCGAATATTTGG
TTAAGAATAAAGGTAAATTACAGCCTGGTTTACATTCTATTCCTACCGAAGTTGATAAGGAAATTGCTCGTTTGAAATTA
CAAGCTATGGGTATTGGTATTGATACTTTGACTGATGAACAGCTTGAATACATGAATTCCTGGACTGTTGGTACCTAA

Upstream 100 bases:

>100_bases
AAAATAAATTTTGTCGTATTAACACTCCTGATAAAGATTTGCAAAATTATAAAAAATTAGTTAAGCTAAGTAAAATCATG
ATCTATAAGGAAGTAGCTAA

Downstream 100 bases:

>100_bases
TTGTTTCTTTTCAGAAGTAATAATTGGCTTGAACTAGTACTTAGTATTTGCTGACGAACTATTAGCTTCTGAAGGTTACT
TAGGATATATAATGGGGGTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MVATPVKIKYEVKDESLAVLGKQRIEWAGREMPVLRQIQERFAKEKPLSGIKLAACCHVTTETAHLAIALKNGGADAVLI
ASNPLSTQDDVAASLVVDHGISVYAIKGEDEKTYLRHVEIALDHRPNIIIDDGSDVVATLVKNRQDQLPELIGTTEETTT
GIVRLRAMFNDGVLTFPAMNVNDADTKHFFDNRYGTGQSTLDGIIRATNVLLAGKTTVVVGYGWCGKGTALRARGLGANV
IVTEVDPVRAIEAIMDGFRVMPMAEAAPLGDLFITVTGNKHVIRGEHFNVMKDGAIVCNSGHFDIEIDLETLGKNADNVK
TVRPFTQQYTLKNGKSVIVLGEGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLQPGLHSIPTEVDKEIARLKL
QAMGIGIDTLTDEQLEYMNSWTVGT

Sequences:

>Translated_425_residues
MVATPVKIKYEVKDESLAVLGKQRIEWAGREMPVLRQIQERFAKEKPLSGIKLAACCHVTTETAHLAIALKNGGADAVLI
ASNPLSTQDDVAASLVVDHGISVYAIKGEDEKTYLRHVEIALDHRPNIIIDDGSDVVATLVKNRQDQLPELIGTTEETTT
GIVRLRAMFNDGVLTFPAMNVNDADTKHFFDNRYGTGQSTLDGIIRATNVLLAGKTTVVVGYGWCGKGTALRARGLGANV
IVTEVDPVRAIEAIMDGFRVMPMAEAAPLGDLFITVTGNKHVIRGEHFNVMKDGAIVCNSGHFDIEIDLETLGKNADNVK
TVRPFTQQYTLKNGKSVIVLGEGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLQPGLHSIPTEVDKEIARLKL
QAMGIGIDTLTDEQLEYMNSWTVGT
>Mature_425_residues
MVATPVKIKYEVKDESLAVLGKQRIEWAGREMPVLRQIQERFAKEKPLSGIKLAACCHVTTETAHLAIALKNGGADAVLI
ASNPLSTQDDVAASLVVDHGISVYAIKGEDEKTYLRHVEIALDHRPNIIIDDGSDVVATLVKNRQDQLPELIGTTEETTT
GIVRLRAMFNDGVLTFPAMNVNDADTKHFFDNRYGTGQSTLDGIIRATNVLLAGKTTVVVGYGWCGKGTALRARGLGANV
IVTEVDPVRAIEAIMDGFRVMPMAEAAPLGDLFITVTGNKHVIRGEHFNVMKDGAIVCNSGHFDIEIDLETLGKNADNVK
TVRPFTQQYTLKNGKSVIVLGEGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLQPGLHSIPTEVDKEIARLKL
QAMGIGIDTLTDEQLEYMNSWTVGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=415, Percent_Identity=44.3373493975904, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=44.8717948717949, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI195539349, Length=413, Percent_Identity=37.5302663438257, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI298286489, Length=413, Percent_Identity=37.5302663438257, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI195539337, Length=413, Percent_Identity=37.5302663438257, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI24308043, Length=413, Percent_Identity=37.5302663438257, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI21361647, Length=413, Percent_Identity=37.772397094431, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17506425, Length=419, Percent_Identity=43.436754176611, Blast_Score=330, Evalue=7e-91,
Organism=Saccharomyces cerevisiae, GI6320882, Length=428, Percent_Identity=41.8224299065421, Blast_Score=323, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24642172, Length=416, Percent_Identity=43.5096153846154, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24656245, Length=403, Percent_Identity=38.2133995037221, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45553387, Length=412, Percent_Identity=37.621359223301, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI45553385, Length=412, Percent_Identity=37.621359223301, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46085; Mature: 46085

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01034 GLYCOSYL_HYDROL_F16 ; PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATPVKIKYEVKDESLAVLGKQRIEWAGREMPVLRQIQERFAKEKPLSGIKLAACCHVT
CCCCCEEEEEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEE
TETAHLAIALKNGGADAVLIASNPLSTQDDVAASLVVDHGISVYAIKGEDEKTYLRHVEI
ECCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHEEECCEEEEEEECCCCCEEEEEEEE
ALDHRPNIIIDDGSDVVATLVKNRQDQLPELIGTTEETTTGIVRLRAMFNDGVLTFPAMN
EEECCCCEEEECCCHHHHHHHHCHHHHHHHHHCCCCHHHHHEEEEEEECCCCEEEEEECC
VNDADTKHFFDNRYGTGQSTLDGIIRATNVLLAGKTTVVVGYGWCGKGTALRARGLGANV
CCCCCCHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEEECCCCCCCEEEECCCCCEE
IVTEVDPVRAIEAIMDGFRVMPMAEAAPLGDLFITVTGNKHVIRGEHFNVMKDGAIVCNS
EEECCCHHHHHHHHHCCCEECCCCCCCCCCEEEEEEECCEEEEECCCCCEEECCEEEECC
GHFDIEIDLETLGKNADNVKTVRPFTQQYTLKNGKSVIVLGEGRLINLAAAEGHPSAVMD
CCEEEEEEHHHCCCCCCCCEEECCHHHHHEECCCCEEEEEECCCEEEEEECCCCCCEEEE
MSFANQALACEYLVKNKGKLQPGLHSIPTEVDKEIARLKLQAMGIGIDTLTDEQLEYMNS
HHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCCCHHHHHHHCC
WTVGT
CCCCC
>Mature Secondary Structure
MVATPVKIKYEVKDESLAVLGKQRIEWAGREMPVLRQIQERFAKEKPLSGIKLAACCHVT
CCCCCEEEEEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEE
TETAHLAIALKNGGADAVLIASNPLSTQDDVAASLVVDHGISVYAIKGEDEKTYLRHVEI
ECCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHEEECCEEEEEEECCCCCEEEEEEEE
ALDHRPNIIIDDGSDVVATLVKNRQDQLPELIGTTEETTTGIVRLRAMFNDGVLTFPAMN
EEECCCCEEEECCCHHHHHHHHCHHHHHHHHHCCCCHHHHHEEEEEEECCCCEEEEEECC
VNDADTKHFFDNRYGTGQSTLDGIIRATNVLLAGKTTVVVGYGWCGKGTALRARGLGANV
CCCCCCHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEEECCCCCCCEEEECCCCCEE
IVTEVDPVRAIEAIMDGFRVMPMAEAAPLGDLFITVTGNKHVIRGEHFNVMKDGAIVCNS
EEECCCHHHHHHHHHCCCEECCCCCCCCCCEEEEEEECCEEEEECCCCCEEECCEEEECC
GHFDIEIDLETLGKNADNVKTVRPFTQQYTLKNGKSVIVLGEGRLINLAAAEGHPSAVMD
CCEEEEEEHHHCCCCCCCCEEECCHHHHHEECCCCEEEEEECCCEEEEEECCCCCCEEEE
MSFANQALACEYLVKNKGKLQPGLHSIPTEVDKEIARLKLQAMGIGIDTLTDEQLEYMNS
HHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCCCHHHHHHHCC
WTVGT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]