Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 113475696

GI number: 113475696

Start: 3181525

End: 3182670

Strand: Reverse

Name: gcvT [H]

Synonym: Tery_2041

Alternate gene names: 113475696

Gene position: 3182670-3181525 (Counterclockwise)

Preceding gene: 113475705

Following gene: 113475695

Centisome position: 41.07

GC content: 39.97

Gene sequence:

>1146_bases
GTGGCCAAATCAACAGAATCTAATACACAACCTCTTTCTCGTACACCTCTATATGACTTAAGCACTGAACTTAAGGCTAG
AATGGTAGAATTTTCTGGGTGGGAGATGCCGGTACAATACACTAGTATCAGCAACGAACATGAGGCAGTACGGACAAAAG
CAGGAATGTTTGACATTTCTCATATGGGCAAGTTCATTGCTCAAGGCCATGATTTAATTGAGAAAATTCAATATTTAGTA
CCTTCGGACCTGAGCGGCTTAGAACCTGGTAAAGCTCAATATACTGTCTTATTAAATTCTCAAGGAGGCATTATTGATGA
CTTCATTTTCTATCGTCAAAGTGATGACCCTCTAACTAATGAAGCACGGGGTTTTATGATTGTTAATGCTGCCACTAAAG
CTAATGATAAAGGATGGATATTAAGTCATCTAGAAAATAGTGGTGTTAAATTCCAAGATATCTCTGAGGAAAAAGTGTTA
TTAGCTGTCCAAGGTCCGGATGCAGAGTCTTATATACAGCAGTTTGTCAAGGAAAATTTGGCATCAATTGGATTTTTTGG
GCATGCAGATATTACTGTATTGGATAAACCTGGTTTCATTGCTAGAACTGGTTACACTGGGGAAGATGGGTTTGAAATTA
TGGTTGACCCCCCGGTGGGTGTAGAGTTATGGCGCAGTTTGTTGAATGCTGGGGTGACTCCCTGCGGTTTGGGAGCAAGA
GATACTTTGCGTTTAGAAGCTGCTATGGCGCTTTATGGTCAAGATATTGATATTAAGACTACTCCTTTAGAAGCAGGTTT
AAGTTGGTTAGTTCACTTGGATAAAAAGGGGGAGTTTATTGCTCGTGAGGTATTAGAAACACAAAAGAGGGAAGGAGTAT
CAAAACGTTTAGTGGGTTTGGAAATGCTCGATCGCGGTATTGCTCGTCATGGTTATCCTGTTTTGAGTGATGGCAAAGTG
GTAGGGGAAGTTACTAGCGGTACTAAGTCTCCTACTTTAGGGAAAGCGATCGCTCTGGCTTATGTACCTAAAAAATTAGC
TAAGGTAGGTCAAAAGTTAGAGGTGGAAATTAGGGGTAAAAATTATGCAGCTATTGTTGTTAAGCGCCCCTTTTATAGAA
GTCAAAAGTCAAAAGTTAAAAGTTAA

Upstream 100 bases:

>100_bases
CTCTCCTAGCTCCTGACTCCTAACTCCTGAGTTATGACTTCTGTGAATACCCACAATGTCCTAAAATCAATAAAGTTTAT
AATAAATTAGGAAAATACTA

Downstream 100 bases:

>100_bases
AAGTTAAAGGTAGGAAGTAGTGTGTAGTGGGAGTCTATAGGGTGCTGCAGGTGCAATTATGTTTACATAGTTGTATCTCA
AAAGATAAAATTGCGCCGTA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MAKSTESNTQPLSRTPLYDLSTELKARMVEFSGWEMPVQYTSISNEHEAVRTKAGMFDISHMGKFIAQGHDLIEKIQYLV
PSDLSGLEPGKAQYTVLLNSQGGIIDDFIFYRQSDDPLTNEARGFMIVNAATKANDKGWILSHLENSGVKFQDISEEKVL
LAVQGPDAESYIQQFVKENLASIGFFGHADITVLDKPGFIARTGYTGEDGFEIMVDPPVGVELWRSLLNAGVTPCGLGAR
DTLRLEAAMALYGQDIDIKTTPLEAGLSWLVHLDKKGEFIAREVLETQKREGVSKRLVGLEMLDRGIARHGYPVLSDGKV
VGEVTSGTKSPTLGKAIALAYVPKKLAKVGQKLEVEIRGKNYAAIVVKRPFYRSQKSKVKS

Sequences:

>Translated_381_residues
MAKSTESNTQPLSRTPLYDLSTELKARMVEFSGWEMPVQYTSISNEHEAVRTKAGMFDISHMGKFIAQGHDLIEKIQYLV
PSDLSGLEPGKAQYTVLLNSQGGIIDDFIFYRQSDDPLTNEARGFMIVNAATKANDKGWILSHLENSGVKFQDISEEKVL
LAVQGPDAESYIQQFVKENLASIGFFGHADITVLDKPGFIARTGYTGEDGFEIMVDPPVGVELWRSLLNAGVTPCGLGAR
DTLRLEAAMALYGQDIDIKTTPLEAGLSWLVHLDKKGEFIAREVLETQKREGVSKRLVGLEMLDRGIARHGYPVLSDGKV
VGEVTSGTKSPTLGKAIALAYVPKKLAKVGQKLEVEIRGKNYAAIVVKRPFYRSQKSKVKS
>Mature_380_residues
AKSTESNTQPLSRTPLYDLSTELKARMVEFSGWEMPVQYTSISNEHEAVRTKAGMFDISHMGKFIAQGHDLIEKIQYLVP
SDLSGLEPGKAQYTVLLNSQGGIIDDFIFYRQSDDPLTNEARGFMIVNAATKANDKGWILSHLENSGVKFQDISEEKVLL
AVQGPDAESYIQQFVKENLASIGFFGHADITVLDKPGFIARTGYTGEDGFEIMVDPPVGVELWRSLLNAGVTPCGLGARD
TLRLEAAMALYGQDIDIKTTPLEAGLSWLVHLDKKGEFIAREVLETQKREGVSKRLVGLEMLDRGIARHGYPVLSDGKVV
GEVTSGTKSPTLGKAIALAYVPKKLAKVGQKLEVEIRGKNYAAIVVKRPFYRSQKSKVKS

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=383, Percent_Identity=36.0313315926893, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI257796258, Length=369, Percent_Identity=35.5013550135501, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI257796254, Length=377, Percent_Identity=33.9522546419098, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI257796256, Length=314, Percent_Identity=36.3057324840764, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI24797151, Length=384, Percent_Identity=29.1666666666667, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI197927446, Length=323, Percent_Identity=27.2445820433437, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI21361378, Length=323, Percent_Identity=27.2445820433437, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI194306651, Length=368, Percent_Identity=25.2717391304348, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=42.1333333333333, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17560118, Length=376, Percent_Identity=35.3723404255319, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32563613, Length=349, Percent_Identity=26.9340974212034, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71994052, Length=369, Percent_Identity=24.6612466124661, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994045, Length=369, Percent_Identity=24.6612466124661, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=37.3368146214099, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=38.6243386243386, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI28571104, Length=348, Percent_Identity=26.4367816091954, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20130091, Length=366, Percent_Identity=25.6830601092896, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41927; Mature: 41795

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSTESNTQPLSRTPLYDLSTELKARMVEFSGWEMPVQYTSISNEHEAVRTKAGMFDIS
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCEEHH
HMGKFIAQGHDLIEKIQYLVPSDLSGLEPGKAQYTVLLNSQGGIIDDFIFYRQSDDPLTN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEHEEEEECCCCCCCC
EARGFMIVNAATKANDKGWILSHLENSGVKFQDISEEKVLLAVQGPDAESYIQQFVKENL
CCCCEEEEEECCCCCCCCEEEEECCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
ASIGFFGHADITVLDKPGFIARTGYTGEDGFEIMVDPPVGVELWRSLLNAGVTPCGLGAR
HHCCCCCCCCEEEEECCCEEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCC
DTLRLEAAMALYGQDIDIKTTPLEAGLSWLVHLDKKGEFIAREVLETQKREGVSKRLVGL
HHHHHHHHHHHHCCCCCEEECCHHHCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHH
EMLDRGIARHGYPVLSDGKVVGEVTSGTKSPTLGKAIALAYVPKKLAKVGQKLEVEIRGK
HHHHHHHHHCCCCEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
NYAAIVVKRPFYRSQKSKVKS
CEEEEEEECCCHHCHHHHCCC
>Mature Secondary Structure 
AKSTESNTQPLSRTPLYDLSTELKARMVEFSGWEMPVQYTSISNEHEAVRTKAGMFDIS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCEEHH
HMGKFIAQGHDLIEKIQYLVPSDLSGLEPGKAQYTVLLNSQGGIIDDFIFYRQSDDPLTN
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEHEEEEECCCCCCCC
EARGFMIVNAATKANDKGWILSHLENSGVKFQDISEEKVLLAVQGPDAESYIQQFVKENL
CCCCEEEEEECCCCCCCCEEEEECCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
ASIGFFGHADITVLDKPGFIARTGYTGEDGFEIMVDPPVGVELWRSLLNAGVTPCGLGAR
HHCCCCCCCCEEEEECCCEEEECCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCC
DTLRLEAAMALYGQDIDIKTTPLEAGLSWLVHLDKKGEFIAREVLETQKREGVSKRLVGL
HHHHHHHHHHHHCCCCCEEECCHHHCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHH
EMLDRGIARHGYPVLSDGKVVGEVTSGTKSPTLGKAIALAYVPKKLAKVGQKLEVEIRGK
HHHHHHHHHCCCCEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
NYAAIVVKRPFYRSQKSKVKS
CEEEEEEECCCHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]