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The map label for this gene is shc [H]

Identifier: 113474571

GI number: 113474571

Start: 1175476

End: 1177374

Strand: Reverse

Name: shc [H]

Synonym: Tery_0727

Alternate gene names: 113474571

Gene position: 1177374-1175476 (Counterclockwise)

Preceding gene: 113474572

Following gene: 113474570

Centisome position: 15.19

GC content: 40.02

Gene sequence:

>1899_bases
ATGATAGAAAAAAACAAAGTAAAACAGTCTATATTAGCTAGTCAAAAGCACTTATTAAGTTTACAAGAAACAGAAGGATA
CTGGTGGGGTCAACTAGAATCAAATGTCACAATAACAGCAGAAATAATTTTACTACATAAAATTTGGCAAACTGATAAAA
AAATACCATTGAATAAGGCAAAAAATTACCTAATATCTCAACAACGAGAACATGGTGGTTGGGAACTATTTTATGGGGAT
GGAGGAGACTTAAGCACTTCTATTGAAGCTTATATGGCTTTGAGATTATTGGGTGTTTCAAGAACAGATCCAATTATGAT
TGAAGCACAAAATTTTATTATTAAAAAAGGTGGTATTAGTTGCAGCAGAATTTTTACTAAATTACATTTGGCTTTAATTG
GATGCTACAGCTGGCAGGGTATTCCTTCTATTCCTTCTAGCATAATGCTACTTCCTGAAGATTTTCCATTTACTATTTAT
GAAATGTCAAGTTGGGCAAGAAGTAGTACTGTTCCACTATTAATTGTGTTTGATAAAAAGCCGATTTTTTCTGTTAACCC
CACTATTAATCTTGATGAGCTTTATGCCGAAGGAATTAACAATGCTAGTTTTGAATTACCTCGTAAATACGATCTGACAG
ATTTATTTTTGGGACTAGATAAGGCTTTTAAATTTGCAGAAAATTTGAATTTGATGCCTTTGCAACAGGAAGGATTAAAA
GCAGCAGAAAAATGGATTTTAGAAAGGCAAGAGGTTACGGGTGACTGGGGGGGTATTATTCCGGCTATGTTAAATTCTAT
GTTGGCATTAAAATGCTTGGAATATGATGTGGCTGACCCTGTGGTGGTGCGGGGACTGGAGGCTATAGATAGGTTTGCTA
TAGAAAATGAGGATAGTTATCGGGTACAAGCCTGTGTATCTCCAGTGTGGGATACCGCTTGGGTAATACGTTCGTTGGTT
GATTCTGGTATTTCTCCTAGTCATCCGGCAATGGTTAAGGCTGGACAATGGTTGTTGCAACAGCAAATTTTGGATTATGG
TGATTGGGTGTTTAAGAATAAATTTGGTAAACCGGGGGGTTGGGCGTTTGAATTTATGAATCGTTTTTATCCAGATATAG
ATGATACGGCGGTAGTGGTTATGGCTTTGGATGTTGTAGAGTTGCCTGATGAGGATCTGAAAGGTAAGGCGATCGCTCGT
GGCATGGAGTGGATAGCTTCGATGCAATGTGAAGCTGGTGGTTGGGCAGCTTTTGATGTAGATAATAATCAAGACTGGTT
GAATGCTACTCCTTATGGAGATTTAAAGGCGATGATCGATCCGAATACGGCAGATGTGACGGGGCGGGTATTGGAAATGG
TTGGTTGTTGTGGGTTAGCTATGGATAGTTGGCGGGTGAAACGGGGGATCGATTTTTTGGTAAGGGAGCAGGAAGAGGAA
GGTTGTTGGTTTGGTCGGTGGGGAGTTAATTATATATACGGTACGAGTGGAGTTATTTTGGCTTTGGCTGTTATGGCACG
GGAAAGTCACCGAGGTTATATAGAGAGGGGGGCAAGTTGGTTGGTTGGTTGTCAAAATTCGGATGGTGGATGGGGTGAAA
GTTGTTGGAGTTATAATGATCCGTCGTTGAAGGGGAAGGGGAAAAGTACGGCTTCTCAGACTGCTTGGGCGTTAATTGGT
TTATTGGCTGCGGGGGAGGGGACTGGTAATTTTGCTAGGGATGCTATTGATGGGGGTGTGGGTTTTTTAGTTTCGACTCA
GAATGATGATGGGAGTTGGCTGGAGGATGAGTTTACTGGTACTGGGTTTCCTGGTCATTTTTATATTAAGTATCATTTTT
ATTCACAGTATTTTCCTTTGATGGCTTTGGGAAGGTATGAGAGTTTGTTAAGTGGTTGA

Upstream 100 bases:

>100_bases
CCTCGCATTGCATAATTATTATCATAGATAAATAGAGATAATTACTATTGATTAATTATTGCTTTGAATAACAATATTAT
ATTTTCAATTATTGATAAAA

Downstream 100 bases:

>100_bases
TGTTTTTTGAGTGGGATGAATAAGAGGCAGGGAATTGAGATTAAAGTTATACTGTTTGTTTTACGGAAGTTAAAGTTCAT
CCATTCAAAGGCTAAAAGTA

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MIEKNKVKQSILASQKHLLSLQETEGYWWGQLESNVTITAEIILLHKIWQTDKKIPLNKAKNYLISQQREHGGWELFYGD
GGDLSTSIEAYMALRLLGVSRTDPIMIEAQNFIIKKGGISCSRIFTKLHLALIGCYSWQGIPSIPSSIMLLPEDFPFTIY
EMSSWARSSTVPLLIVFDKKPIFSVNPTINLDELYAEGINNASFELPRKYDLTDLFLGLDKAFKFAENLNLMPLQQEGLK
AAEKWILERQEVTGDWGGIIPAMLNSMLALKCLEYDVADPVVVRGLEAIDRFAIENEDSYRVQACVSPVWDTAWVIRSLV
DSGISPSHPAMVKAGQWLLQQQILDYGDWVFKNKFGKPGGWAFEFMNRFYPDIDDTAVVVMALDVVELPDEDLKGKAIAR
GMEWIASMQCEAGGWAAFDVDNNQDWLNATPYGDLKAMIDPNTADVTGRVLEMVGCCGLAMDSWRVKRGIDFLVREQEEE
GCWFGRWGVNYIYGTSGVILALAVMARESHRGYIERGASWLVGCQNSDGGWGESCWSYNDPSLKGKGKSTASQTAWALIG
LLAAGEGTGNFARDAIDGGVGFLVSTQNDDGSWLEDEFTGTGFPGHFYIKYHFYSQYFPLMALGRYESLLSG

Sequences:

>Translated_632_residues
MIEKNKVKQSILASQKHLLSLQETEGYWWGQLESNVTITAEIILLHKIWQTDKKIPLNKAKNYLISQQREHGGWELFYGD
GGDLSTSIEAYMALRLLGVSRTDPIMIEAQNFIIKKGGISCSRIFTKLHLALIGCYSWQGIPSIPSSIMLLPEDFPFTIY
EMSSWARSSTVPLLIVFDKKPIFSVNPTINLDELYAEGINNASFELPRKYDLTDLFLGLDKAFKFAENLNLMPLQQEGLK
AAEKWILERQEVTGDWGGIIPAMLNSMLALKCLEYDVADPVVVRGLEAIDRFAIENEDSYRVQACVSPVWDTAWVIRSLV
DSGISPSHPAMVKAGQWLLQQQILDYGDWVFKNKFGKPGGWAFEFMNRFYPDIDDTAVVVMALDVVELPDEDLKGKAIAR
GMEWIASMQCEAGGWAAFDVDNNQDWLNATPYGDLKAMIDPNTADVTGRVLEMVGCCGLAMDSWRVKRGIDFLVREQEEE
GCWFGRWGVNYIYGTSGVILALAVMARESHRGYIERGASWLVGCQNSDGGWGESCWSYNDPSLKGKGKSTASQTAWALIG
LLAAGEGTGNFARDAIDGGVGFLVSTQNDDGSWLEDEFTGTGFPGHFYIKYHFYSQYFPLMALGRYESLLSG
>Mature_632_residues
MIEKNKVKQSILASQKHLLSLQETEGYWWGQLESNVTITAEIILLHKIWQTDKKIPLNKAKNYLISQQREHGGWELFYGD
GGDLSTSIEAYMALRLLGVSRTDPIMIEAQNFIIKKGGISCSRIFTKLHLALIGCYSWQGIPSIPSSIMLLPEDFPFTIY
EMSSWARSSTVPLLIVFDKKPIFSVNPTINLDELYAEGINNASFELPRKYDLTDLFLGLDKAFKFAENLNLMPLQQEGLK
AAEKWILERQEVTGDWGGIIPAMLNSMLALKCLEYDVADPVVVRGLEAIDRFAIENEDSYRVQACVSPVWDTAWVIRSLV
DSGISPSHPAMVKAGQWLLQQQILDYGDWVFKNKFGKPGGWAFEFMNRFYPDIDDTAVVVMALDVVELPDEDLKGKAIAR
GMEWIASMQCEAGGWAAFDVDNNQDWLNATPYGDLKAMIDPNTADVTGRVLEMVGCCGLAMDSWRVKRGIDFLVREQEEE
GCWFGRWGVNYIYGTSGVILALAVMARESHRGYIERGASWLVGCQNSDGGWGESCWSYNDPSLKGKGKSTASQTAWALIG
LLAAGEGTGNFARDAIDGGVGFLVSTQNDDGSWLEDEFTGTGFPGHFYIKYHFYSQYFPLMALGRYESLLSG

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=658, Percent_Identity=24.1641337386018, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI47933395, Length=654, Percent_Identity=23.7003058103976, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI47933397, Length=654, Percent_Identity=23.7003058103976, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI224177556, Length=581, Percent_Identity=24.4406196213425, Blast_Score=129, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321863, Length=611, Percent_Identity=23.7315875613748, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 70618; Mature: 70618

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKNKVKQSILASQKHLLSLQETEGYWWGQLESNVTITAEIILLHKIWQTDKKIPLNKA
CCCHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCEEEEEHHHHHHHHHHCCCCCCHHHH
KNYLISQQREHGGWELFYGDGGDLSTSIEAYMALRLLGVSRTDPIMIEAQNFIIKKGGIS
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECEEEEECCCCH
CSRIFTKLHLALIGCYSWQGIPSIPSSIMLLPEDFPFTIYEMSSWARSSTVPLLIVFDKK
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEHHHHCCCCCCCEEEEECCC
PIFSVNPTINLDELYAEGINNASFELPRKYDLTDLFLGLDKAFKFAENLNLMPLQQEGLK
CCEECCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AAEKWILERQEVTGDWGGIIPAMLNSMLALKCLEYDVADPVVVRGLEAIDRFAIENEDSY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCE
RVQACVSPVWDTAWVIRSLVDSGISPSHPAMVKAGQWLLQQQILDYGDWVFKNKFGKPGG
EEHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
WAFEFMNRFYPDIDDTAVVVMALDVVELPDEDLKGKAIARGMEWIASMQCEAGGWAAFDV
HHHHHHHHHCCCCCCCEEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
DNNQDWLNATPYGDLKAMIDPNTADVTGRVLEMVGCCGLAMDSWRVKRGIDFLVREQEEE
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GCWFGRWGVNYIYGTSGVILALAVMARESHRGYIERGASWLVGCQNSDGGWGESCWSYND
CCEEECCCCCEEECCCHHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCCCCCC
PSLKGKGKSTASQTAWALIGLLAAGEGTGNFARDAIDGGVGFLVSTQNDDGSWLEDEFTG
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCC
TGFPGHFYIKYHFYSQYFPLMALGRYESLLSG
CCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEKNKVKQSILASQKHLLSLQETEGYWWGQLESNVTITAEIILLHKIWQTDKKIPLNKA
CCCHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCEEEEEHHHHHHHHHHCCCCCCHHHH
KNYLISQQREHGGWELFYGDGGDLSTSIEAYMALRLLGVSRTDPIMIEAQNFIIKKGGIS
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECEEEEECCCCH
CSRIFTKLHLALIGCYSWQGIPSIPSSIMLLPEDFPFTIYEMSSWARSSTVPLLIVFDKK
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEHHHHCCCCCCCEEEEECCC
PIFSVNPTINLDELYAEGINNASFELPRKYDLTDLFLGLDKAFKFAENLNLMPLQQEGLK
CCEECCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AAEKWILERQEVTGDWGGIIPAMLNSMLALKCLEYDVADPVVVRGLEAIDRFAIENEDSY
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCE
RVQACVSPVWDTAWVIRSLVDSGISPSHPAMVKAGQWLLQQQILDYGDWVFKNKFGKPGG
EEHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
WAFEFMNRFYPDIDDTAVVVMALDVVELPDEDLKGKAIARGMEWIASMQCEAGGWAAFDV
HHHHHHHHHCCCCCCCEEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEC
DNNQDWLNATPYGDLKAMIDPNTADVTGRVLEMVGCCGLAMDSWRVKRGIDFLVREQEEE
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GCWFGRWGVNYIYGTSGVILALAVMARESHRGYIERGASWLVGCQNSDGGWGESCWSYND
CCEEECCCCCEEECCCHHHHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCCCCCC
PSLKGKGKSTASQTAWALIGLLAAGEGTGNFARDAIDGGVGFLVSTQNDDGSWLEDEFTG
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCCCC
TGFPGHFYIKYHFYSQYFPLMALGRYESLLSG
CCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]