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The map label for this gene is xorIIM [H]

Identifier: 113474395

GI number: 113474395

Start: 840599

End: 841864

Strand: Direct

Name: xorIIM [H]

Synonym: Tery_0531

Alternate gene names: 113474395

Gene position: 840599-841864 (Clockwise)

Preceding gene: 113474394

Following gene: 113474400

Centisome position: 10.85

GC content: 32.62

Gene sequence:

>1266_bases
ATGCAACGACCAATTGGTATTGATTTATTTGCAGGCGCAGGAGGTATGACTCTTGGATTTGAACAAGCAGGATTTGATAT
ACCTATTTCCGTAGAATTAGACCCTATTCACTGTGCTATTCATAAGTTTAATTTTCCCTTTTGGTCCATATTATGTCGTA
ATGTTGTCGAACTCACAGGGAATGAAATTAGAGAGAAATTAAATATTCCAAATAGAGAAATTGATGTAATTTTTGGAGGT
CCTCCATGTCAAGGATTTTCTCAGATTGGAAAACGTGCTTTAGACGATCCTCGAAATGCGCTTATATCTCATTTTTTACG
AATAGTTTTGGAATTAAAACCCAAATATTTTGTCATAGAAAATGTTAAAGGTTTAACTGTAGGAAAACATCAAATTTTTC
TTGAGGAAGTTATTAATAAATTATCTAAAAATAGTTATCAACTACAACTGCCTTACCAAGTTTTAAATGCTGCTAATTAT
GGTGTACCACAACACCGAGAAAGATTATTTATACTAGGATGTAAAAAAGGTTTAAAATTACCAAATTATCCACAAATTCA
AATACATAAAAAATCAGAAGCCTATATAAATGTCTGGGATGCAATAGGAGATTTACCAGAAGTAGAAAATTATCCAGAAT
TATTAGAAATAGACTGGGTAAAAGCAGAAAATGACTATGATAAACCAAGTGAATATGCTAAAAAACTCCGTGGAATTGAA
TATTTTAACAATGATTATTCTTATGAACGTGAATACGACCAGACAATATTAACCTCTAGTTTACGCACAAAACATACACA
ACAATCAATAGCAAGATTTGATGCTACAGCACAAGGAAAAACTGAGCCAGTAAGTCGCTTTTATAAACTGAATCCTCACG
GTATTTGTAACACACTCAGAGCAGGGACTCCAAGTAGTAGAGGTTCATATACTTCTCCTAGACCAATACATCCATTGACA
CCCAGATGTATCACAGTTAGAGAAGCAGCAAGACTACATTCATATCCTGATTGGTTTAGATTTCATGTGACAAAATGGCA
TGGTTTTAGACAAGTAGGTAATTCAGTTCCACCACTATTAGCAAAAGCAGTTGCTCAAGAAATTATTCATGCTTTAAATA
TTCAACCATTTAAACCTACAAAGACAGAATATGAGTTAGAAAATCTCAAAAATTTAGAGCTTAATATGTCTAGAGCCGCC
GATTTATATGGTATTGATAGATATACTATTGCACCCAGACTAAGAAAGTTAAAATTAAATAATTAA

Upstream 100 bases:

>100_bases
GGTTTAACTTTTATCTTTAAGGGCCTATATTTGAAATGGAGTTGATATAATAACAAAAGTTAAATTTAATTAAGATTAAT
AGTAAATCTGAAGATTTTCT

Downstream 100 bases:

>100_bases
TTAATAATTAGTCAGTTAATTTAGGAGTATATTATATCACAATAAAAATTATAAAAAATGGAGATTATAACAAAATAAGA
TAATTTTTATTTATAGATAA

Product: DNA-cytosine methyltransferase

Products: NA

Alternate protein names: M.XorII; Cytosine-specific methyltransferase XorII [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MQRPIGIDLFAGAGGMTLGFEQAGFDIPISVELDPIHCAIHKFNFPFWSILCRNVVELTGNEIREKLNIPNREIDVIFGG
PPCQGFSQIGKRALDDPRNALISHFLRIVLELKPKYFVIENVKGLTVGKHQIFLEEVINKLSKNSYQLQLPYQVLNAANY
GVPQHRERLFILGCKKGLKLPNYPQIQIHKKSEAYINVWDAIGDLPEVENYPELLEIDWVKAENDYDKPSEYAKKLRGIE
YFNNDYSYEREYDQTILTSSLRTKHTQQSIARFDATAQGKTEPVSRFYKLNPHGICNTLRAGTPSSRGSYTSPRPIHPLT
PRCITVREAARLHSYPDWFRFHVTKWHGFRQVGNSVPPLLAKAVAQEIIHALNIQPFKPTKTEYELENLKNLELNMSRAA
DLYGIDRYTIAPRLRKLKLNN

Sequences:

>Translated_421_residues
MQRPIGIDLFAGAGGMTLGFEQAGFDIPISVELDPIHCAIHKFNFPFWSILCRNVVELTGNEIREKLNIPNREIDVIFGG
PPCQGFSQIGKRALDDPRNALISHFLRIVLELKPKYFVIENVKGLTVGKHQIFLEEVINKLSKNSYQLQLPYQVLNAANY
GVPQHRERLFILGCKKGLKLPNYPQIQIHKKSEAYINVWDAIGDLPEVENYPELLEIDWVKAENDYDKPSEYAKKLRGIE
YFNNDYSYEREYDQTILTSSLRTKHTQQSIARFDATAQGKTEPVSRFYKLNPHGICNTLRAGTPSSRGSYTSPRPIHPLT
PRCITVREAARLHSYPDWFRFHVTKWHGFRQVGNSVPPLLAKAVAQEIIHALNIQPFKPTKTEYELENLKNLELNMSRAA
DLYGIDRYTIAPRLRKLKLNN
>Mature_421_residues
MQRPIGIDLFAGAGGMTLGFEQAGFDIPISVELDPIHCAIHKFNFPFWSILCRNVVELTGNEIREKLNIPNREIDVIFGG
PPCQGFSQIGKRALDDPRNALISHFLRIVLELKPKYFVIENVKGLTVGKHQIFLEEVINKLSKNSYQLQLPYQVLNAANY
GVPQHRERLFILGCKKGLKLPNYPQIQIHKKSEAYINVWDAIGDLPEVENYPELLEIDWVKAENDYDKPSEYAKKLRGIE
YFNNDYSYEREYDQTILTSSLRTKHTQQSIARFDATAQGKTEPVSRFYKLNPHGICNTLRAGTPSSRGSYTSPRPIHPLT
PRCITVREAARLHSYPDWFRFHVTKWHGFRQVGNSVPPLLAKAVAQEIIHALNIQPFKPTKTEYELENLKNLELNMSRAA
DLYGIDRYTIAPRLRKLKLNN

Specific function: This methylase recognizes the double-stranded sequence CGATCG, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the XorII endonuclease [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI195927037, Length=274, Percent_Identity=29.5620437956204, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4503351, Length=274, Percent_Identity=29.5620437956204, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4758184, Length=180, Percent_Identity=27.2222222222222, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 48300; Mature: 48300

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00094 C5_MTASE_1 ; PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPIGIDLFAGAGGMTLGFEQAGFDIPISVELDPIHCAIHKFNFPFWSILCRNVVELTG
CCCCCCEEEEECCCCCEECHHHCCCCCEEEEEECHHEEEEEECCCCHHHHHHHHHHHHCC
NEIREKLNIPNREIDVIFGGPPCQGFSQIGKRALDDPRNALISHFLRIVLELKPKYFVIE
HHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEE
NVKGLTVGKHQIFLEEVINKLSKNSYQLQLPYQVLNAANYGVPQHRERLFILGCKKGLKL
CCCCCEECHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCCEEEEEECCCCCCC
PNYPQIQIHKKSEAYINVWDAIGDLPEVENYPELLEIDWVKAENDYDKPSEYAKKLRGIE
CCCCEEEEEECCCCEEEEHHHHCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCH
YFNNDYSYEREYDQTILTSSLRTKHTQQSIARFDATAQGKTEPVSRFYKLNPHGICNTLR
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEECCCCHHHHHHC
AGTPSSRGSYTSPRPIHPLTPRCITVREAARLHSYPDWFRFHVTKWHGFRQVGNSVPPLL
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCHHH
AKAVAQEIIHALNIQPFKPTKTEYELENLKNLELNMSRAADLYGIDRYTIAPRLRKLKLN
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEHHHHHHHHCCCCEECCCHHHHEECC
N
C
>Mature Secondary Structure
MQRPIGIDLFAGAGGMTLGFEQAGFDIPISVELDPIHCAIHKFNFPFWSILCRNVVELTG
CCCCCCEEEEECCCCCEECHHHCCCCCEEEEEECHHEEEEEECCCCHHHHHHHHHHHHCC
NEIREKLNIPNREIDVIFGGPPCQGFSQIGKRALDDPRNALISHFLRIVLELKPKYFVIE
HHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEE
NVKGLTVGKHQIFLEEVINKLSKNSYQLQLPYQVLNAANYGVPQHRERLFILGCKKGLKL
CCCCCEECHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCCCEEEEEECCCCCCC
PNYPQIQIHKKSEAYINVWDAIGDLPEVENYPELLEIDWVKAENDYDKPSEYAKKLRGIE
CCCCEEEEEECCCCEEEEHHHHCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCH
YFNNDYSYEREYDQTILTSSLRTKHTQQSIARFDATAQGKTEPVSRFYKLNPHGICNTLR
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEECCCCHHHHHHC
AGTPSSRGSYTSPRPIHPLTPRCITVREAARLHSYPDWFRFHVTKWHGFRQVGNSVPPLL
CCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCHHH
AKAVAQEIIHALNIQPFKPTKTEYELENLKNLELNMSRAADLYGIDRYTIAPRLRKLKLN
HHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEHHHHHHHHCCCCEECCCHHHHEECC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8078464 [H]