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The map label for this gene is lon2 [H]

Identifier: 113474346

GI number: 113474346

Start: 757621

End: 758259

Strand: Direct

Name: lon2 [H]

Synonym: Tery_0478

Alternate gene names: 113474346

Gene position: 757621-758259 (Clockwise)

Preceding gene: 113474345

Following gene: 113474348

Centisome position: 9.78

GC content: 38.03

Gene sequence:

>639_bases
ATGGCATCCTCTTCTGTAGCTGTTCGAGAACTTCCCCTATTTCCCTTACCAGAAGTAGTATTATTTCCGGGTAGGCCATT
ACCACTATATATCTTTGAATTTCGCTATAGAATTATGATGAATACAATTCTAGAGAGTGATAGTAGATTTGGAGTTATGA
TGTGGGACTCAACCCAAGATCGAGTTGTGGCAACTGGATGCTGCGCTAGAATTGAGGATTATCAGCGTTTACCTGATGAT
CGAATGAAGATTTTAACTATAGGTGAGAAGAGATTTAGAGTTTTAGATACGGTTAGAGAAAAACCGTATTTAGTTGGTTT
AGTTGAATGGATAGAAGATGCTCCTTCTGAAAAGGAGCTTAGAGAGTTAACAACAAAAGTTGATCTCTTACTGAAAGATG
TAGTTCATCTTTCGGGAAAATTGATGGATCAGAGGATAGAGCTACCAGAAGATATTCCTAATTTACCTAAAGAATTATCC
TACTGGGTAGCTAGTAATCTTTATGGTGTGGCGACAGAACAGCAAGCTCTTTTGGAGATGCAAGATACTGGTGCTAGACT
AGAAAGAGAAGTAGAAATTCTCACTTCTACCCGCAATCATCTTGCAGCTAGAACTGTTCTTAAGGATACTTTAAATTGA

Upstream 100 bases:

>100_bases
AATCTCAAAATTATCAAAAATATTAAGTATATATATATCCAAGGATAGAAAAATCCGCTTATAATAAGTCTAATTACTAA
GACTCTATTAAAACTGGAAA

Downstream 100 bases:

>100_bases
CATTCTCTCAAAGTTACTTACTCTCAAAGTTGCTTAACTGCAAAACCTAATGTTTTTTTTGATTGGACATCATCTCAATG
CTGCTCTATGAGACAGCATT

Product: peptidase S16, lon-like

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MASSSVAVRELPLFPLPEVVLFPGRPLPLYIFEFRYRIMMNTILESDSRFGVMMWDSTQDRVVATGCCARIEDYQRLPDD
RMKILTIGEKRFRVLDTVREKPYLVGLVEWIEDAPSEKELRELTTKVDLLLKDVVHLSGKLMDQRIELPEDIPNLPKELS
YWVASNLYGVATEQQALLEMQDTGARLEREVEILTSTRNHLAARTVLKDTLN

Sequences:

>Translated_212_residues
MASSSVAVRELPLFPLPEVVLFPGRPLPLYIFEFRYRIMMNTILESDSRFGVMMWDSTQDRVVATGCCARIEDYQRLPDD
RMKILTIGEKRFRVLDTVREKPYLVGLVEWIEDAPSEKELRELTTKVDLLLKDVVHLSGKLMDQRIELPEDIPNLPKELS
YWVASNLYGVATEQQALLEMQDTGARLEREVEILTSTRNHLAARTVLKDTLN
>Mature_211_residues
ASSSVAVRELPLFPLPEVVLFPGRPLPLYIFEFRYRIMMNTILESDSRFGVMMWDSTQDRVVATGCCARIEDYQRLPDDR
MKILTIGEKRFRVLDTVREKPYLVGLVEWIEDAPSEKELRELTTKVDLLLKDVVHLSGKLMDQRIELPEDIPNLPKELSY
WVASNLYGVATEQQALLEMQDTGARLEREVEILTSTRNHLAARTVLKDTLN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI87080813, Length=212, Percent_Identity=29.7169811320755, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI148528975, Length=204, Percent_Identity=28.921568627451, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24454; Mature: 24323

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSSVAVRELPLFPLPEVVLFPGRPLPLYIFEFRYRIMMNTILESDSRFGVMMWDSTQD
CCCCCCHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
RVVATGCCARIEDYQRLPDDRMKILTIGEKRFRVLDTVREKPYLVGLVEWIEDAPSEKEL
CEEHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHH
RELTTKVDLLLKDVVHLSGKLMDQRIELPEDIPNLPKELSYWVASNLYGVATEQQALLEM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QDTGARLEREVEILTSTRNHLAARTVLKDTLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASSSVAVRELPLFPLPEVVLFPGRPLPLYIFEFRYRIMMNTILESDSRFGVMMWDSTQD
CCCCCHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
RVVATGCCARIEDYQRLPDDRMKILTIGEKRFRVLDTVREKPYLVGLVEWIEDAPSEKEL
CEEHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHH
RELTTKVDLLLKDVVHLSGKLMDQRIELPEDIPNLPKELSYWVASNLYGVATEQQALLEM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QDTGARLEREVEILTSTRNHLAARTVLKDTLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082 [H]