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The map label for this gene is lytC [H]

Identifier: 113474224

GI number: 113474224

Start: 520009

End: 522129

Strand: Direct

Name: lytC [H]

Synonym: Tery_0339

Alternate gene names: 113474224

Gene position: 520009-522129 (Clockwise)

Preceding gene: 113474222

Following gene: 113474227

Centisome position: 6.71

GC content: 40.41

Gene sequence:

>2121_bases
ATGAAAAATATATATTCTGGAAATCGTTTGATATTTATCAAAAATACCCAAATGCGAACAACCCTTATGCTACAATGGCT
GCTGCCAAGTATACTCAGCATTTTTGTCTTAGGCAGTCCCTCAGAAGCTGCAACTCTAGAATCTTGGCAATTTAAAGTTA
ATCAGAACGAACTGTCCTTTACTACAGAAGGTGGGGTTCAACCAAAGGCCCAATTAGCAACTAATCCAACTCGGTTAATA
ATAGACCTGCCAGGAACAACTTTAGGTAGTGTAAGACCTTCTCAAGCTATAGGTCGAGCTATCAAAGCAATAAGAGTAGA
ACAATTTGATTCTCAAACAGCTCGGATAGTGGTGGAATTAAACAATGGCTATACCATTGACCCAAAGCAAGTACAATTTC
GGGGTATTTCTCCTAGTGAGTGGACTGTACAAATACCAAGTCCTCAACAAATTACCTCTACTACAAATACAGATATTAAT
TTTGCGCCTCAGTCTTCACCCCCACCTCCTCAAACTCTACAACAGCCTTCACCCCCACTACTCCTAAGTCCTCCTCTGCC
TTTTCTGAAGAAAGAAAGATCAAGTAATCAAAATAGAACAAGACCTACTAACTCTCCTCTGGTAAATCAAGTTACAACTA
CTGGTACACCAACTCTTGTAGAAGATGTCCAAATCAAAAAAGAGGGAGTAGTTCTCAAAACAAGTGGTAGATTACCAGAA
ATTGAACTAAAGAAGAGTGTTGATCGTACCTGGATGACCATTGATGTCCTCAATTCTACTCTGACTGCCAAGGGTCTCAA
GCCCAGTCAAAGATTTAATGAATCAGGATTAACAATTACTCAACTAACTCAACTTTCGACTTCACCAGCAGTAGTTCGTC
TTACACTAAGTTTGCCAGATAAAAGGACTCAATGGCAAGCTCGTGCTTATGCAGGTGGAATAGCAGTATGGCCTGAAGGA
GAAGTACAACCTACAATTAATGAAGCTACTGGTTTTGTTTTCCTTAAGTCAGTGGAATTAAAAAATGGTACTGAGTTAGT
GGTTACTGCAGATAAGCCTATTAACTATACTAGTGGTTGGGATTCTGAAACAGGTGCCTATGGAATTACTATATATAATG
CTAAGATAGATGACCGATTTAGGTTACCAAAAAGAGAAGTTGGTAGCCCTTTAATTTGGGCAAAAATACGTCAAGAAGAT
CCAGAAACAGTTACAATTCTGGTCAAGCCTGCTACTAATGTTAAAATTGCAGAAGTCACTCAGGTTACGACTCAACAGTT
ATCTTTACTTATGGGTTGGGGTAATATTGGAACTGCGCCTCCAGGTTGGAGACCCAACTCTATAGAGCCATCTTCTAGTT
CAAAACCTTCACTATTCCCAAGGAGATATAATTCGTCATCTCCAAATTCATTGGGGGAAAATTCACTACCTCAGAATAGA
TTACCTCGGAATTCTCCTGAAAATTTGCGTCCGAGACGCTGGCCTTTTACTTGGCCTCGTCGCAATAATCAACGCTCATT
AAATAATGATCGTCGTTTTCCTTTGCAAAATCAATTACCTCAAAGTGATGGACGAGTAATGATAGTGATAGACCCTGGAC
ATGGGGGACCAATGGATTTTGGTGGAGTAGGTTTTGGTGGTATGCGGGAGAAGGATATTGTATTACCGATGTCATTGGAA
GTAGCTCAAATCCTGGAGCAGAATAATATACAGGTGGTTATGACTCGTAAGACAGACCGGGATTTGGATTTACCACCACG
CTCAGAGTTGGCTAATAGGGTTGGAGCAGATTTATTTGTGAGTATTCATGCTAATGCTATTAGTATGAGTCGTCCTGATG
TGAATGGTTTAGAAACTTTTTATTATCAAAGTGGGCAGGTTCTAGCACAGTATATTCAGAATAGTATGTTGGAAGCTTTT
CCGACGATGAATAATCGTGGTGTGAAGCGAGCTCGTTTTCATGTGCTAAGACATACTAAGATGCCTGCTGCCTTGGTAGA
GGTAGGTTTTGTCACTGGTAATTATGATTCTCGGATACTTGCTGATCCTGGCCAACGGAGTCGTATGGCACAGGCGATCG
CTCGTGGCATATTGAAATATGTCCAAGTTTATTATCGGTAA

Upstream 100 bases:

>100_bases
CTCACCGCACTAATTATAATATTATGTTATACCCGTTTAAGTAACTAATAAATTATATCATGTCCGGTAGCATAATTTGT
GTATAAAATTAAGTCATAAG

Downstream 100 bases:

>100_bases
GGGGAGTTGTCTGAGATATCAGTTCTTAGTTAATCTAGCTTGAAATAATATGGGGAATTCTATAAACAGAGTCATCTTTG
ATATGGTTGAAGCCATAAAC

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MKNIYSGNRLIFIKNTQMRTTLMLQWLLPSILSIFVLGSPSEAATLESWQFKVNQNELSFTTEGGVQPKAQLATNPTRLI
IDLPGTTLGSVRPSQAIGRAIKAIRVEQFDSQTARIVVELNNGYTIDPKQVQFRGISPSEWTVQIPSPQQITSTTNTDIN
FAPQSSPPPPQTLQQPSPPLLLSPPLPFLKKERSSNQNRTRPTNSPLVNQVTTTGTPTLVEDVQIKKEGVVLKTSGRLPE
IELKKSVDRTWMTIDVLNSTLTAKGLKPSQRFNESGLTITQLTQLSTSPAVVRLTLSLPDKRTQWQARAYAGGIAVWPEG
EVQPTINEATGFVFLKSVELKNGTELVVTADKPINYTSGWDSETGAYGITIYNAKIDDRFRLPKREVGSPLIWAKIRQED
PETVTILVKPATNVKIAEVTQVTTQQLSLLMGWGNIGTAPPGWRPNSIEPSSSSKPSLFPRRYNSSSPNSLGENSLPQNR
LPRNSPENLRPRRWPFTWPRRNNQRSLNNDRRFPLQNQLPQSDGRVMIVIDPGHGGPMDFGGVGFGGMREKDIVLPMSLE
VAQILEQNNIQVVMTRKTDRDLDLPPRSELANRVGADLFVSIHANAISMSRPDVNGLETFYYQSGQVLAQYIQNSMLEAF
PTMNNRGVKRARFHVLRHTKMPAALVEVGFVTGNYDSRILADPGQRSRMAQAIARGILKYVQVYYR

Sequences:

>Translated_706_residues
MKNIYSGNRLIFIKNTQMRTTLMLQWLLPSILSIFVLGSPSEAATLESWQFKVNQNELSFTTEGGVQPKAQLATNPTRLI
IDLPGTTLGSVRPSQAIGRAIKAIRVEQFDSQTARIVVELNNGYTIDPKQVQFRGISPSEWTVQIPSPQQITSTTNTDIN
FAPQSSPPPPQTLQQPSPPLLLSPPLPFLKKERSSNQNRTRPTNSPLVNQVTTTGTPTLVEDVQIKKEGVVLKTSGRLPE
IELKKSVDRTWMTIDVLNSTLTAKGLKPSQRFNESGLTITQLTQLSTSPAVVRLTLSLPDKRTQWQARAYAGGIAVWPEG
EVQPTINEATGFVFLKSVELKNGTELVVTADKPINYTSGWDSETGAYGITIYNAKIDDRFRLPKREVGSPLIWAKIRQED
PETVTILVKPATNVKIAEVTQVTTQQLSLLMGWGNIGTAPPGWRPNSIEPSSSSKPSLFPRRYNSSSPNSLGENSLPQNR
LPRNSPENLRPRRWPFTWPRRNNQRSLNNDRRFPLQNQLPQSDGRVMIVIDPGHGGPMDFGGVGFGGMREKDIVLPMSLE
VAQILEQNNIQVVMTRKTDRDLDLPPRSELANRVGADLFVSIHANAISMSRPDVNGLETFYYQSGQVLAQYIQNSMLEAF
PTMNNRGVKRARFHVLRHTKMPAALVEVGFVTGNYDSRILADPGQRSRMAQAIARGILKYVQVYYR
>Mature_706_residues
MKNIYSGNRLIFIKNTQMRTTLMLQWLLPSILSIFVLGSPSEAATLESWQFKVNQNELSFTTEGGVQPKAQLATNPTRLI
IDLPGTTLGSVRPSQAIGRAIKAIRVEQFDSQTARIVVELNNGYTIDPKQVQFRGISPSEWTVQIPSPQQITSTTNTDIN
FAPQSSPPPPQTLQQPSPPLLLSPPLPFLKKERSSNQNRTRPTNSPLVNQVTTTGTPTLVEDVQIKKEGVVLKTSGRLPE
IELKKSVDRTWMTIDVLNSTLTAKGLKPSQRFNESGLTITQLTQLSTSPAVVRLTLSLPDKRTQWQARAYAGGIAVWPEG
EVQPTINEATGFVFLKSVELKNGTELVVTADKPINYTSGWDSETGAYGITIYNAKIDDRFRLPKREVGSPLIWAKIRQED
PETVTILVKPATNVKIAEVTQVTTQQLSLLMGWGNIGTAPPGWRPNSIEPSSSSKPSLFPRRYNSSSPNSLGENSLPQNR
LPRNSPENLRPRRWPFTWPRRNNQRSLNNDRRFPLQNQLPQSDGRVMIVIDPGHGGPMDFGGVGFGGMREKDIVLPMSLE
VAQILEQNNIQVVMTRKTDRDLDLPPRSELANRVGADLFVSIHANAISMSRPDVNGLETFYYQSGQVLAQYIQNSMLEAF
PTMNNRGVKRARFHVLRHTKMPAALVEVGFVTGNYDSRILADPGQRSRMAQAIARGILKYVQVYYR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=229, Percent_Identity=28.3842794759825, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI87082163, Length=231, Percent_Identity=29.004329004329, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 78618; Mature: 78618

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIYSGNRLIFIKNTQMRTTLMLQWLLPSILSIFVLGSPSEAATLESWQFKVNQNELSF
CCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEEECCCEEEE
TTEGGVQPKAQLATNPTRLIIDLPGTTLGSVRPSQAIGRAIKAIRVEQFDSQTARIVVEL
EECCCCCCCHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEE
NNGYTIDPKQVQFRGISPSEWTVQIPSPQQITSTTNTDINFAPQSSPPPPQTLQQPSPPL
CCCEEECCCCEEEECCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHCCCCCCE
LLSPPLPFLKKERSSNQNRTRPTNSPLVNQVTTTGTPTLVEDVQIKKEGVVLKTSGRLPE
EECCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHCEEEECCCEEEEECCCCCC
IELKKSVDRTWMTIDVLNSTLTAKGLKPSQRFNESGLTITQLTQLSTSPAVVRLTLSLPD
CHHHHCCCCEEEEEEHHCCHHHHCCCCHHHHHCCCCCEEEEEECCCCCCEEEEEEEECCC
KRTQWQARAYAGGIAVWPEGEVQPTINEATGFVFLKSVELKNGTELVVTADKPINYTSGW
CCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCC
DSETGAYGITIYNAKIDDRFRLPKREVGSPLIWAKIRQEDPETVTILVKPATNVKIAEVT
CCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEEECCCCCCEEEEEEECCCCEEEEHHH
QVTTQQLSLLMGWGNIGTAPPGWRPNSIEPSSSSKPSLFPRRYNSSSPNSLGENSLPQNR
HHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LPRNSPENLRPRRWPFTWPRRNNQRSLNNDRRFPLQNQLPQSDGRVMIVIDPGHGGPMDF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCC
GGVGFGGMREKDIVLPMSLEVAQILEQNNIQVVMTRKTDRDLDLPPRSELANRVGADLFV
CCCCCCCCCCCCEEEECCHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCEEEE
SIHANAISMSRPDVNGLETFYYQSGQVLAQYIQNSMLEAFPTMNNRGVKRARFHVLRHTK
EEECCEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
MPAALVEVGFVTGNYDSRILADPGQRSRMAQAIARGILKYVQVYYR
CCHHHEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNIYSGNRLIFIKNTQMRTTLMLQWLLPSILSIFVLGSPSEAATLESWQFKVNQNELSF
CCCEECCCEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEEEECCCEEEE
TTEGGVQPKAQLATNPTRLIIDLPGTTLGSVRPSQAIGRAIKAIRVEQFDSQTARIVVEL
EECCCCCCCHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEE
NNGYTIDPKQVQFRGISPSEWTVQIPSPQQITSTTNTDINFAPQSSPPPPQTLQQPSPPL
CCCEEECCCCEEEECCCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHCCCCCCE
LLSPPLPFLKKERSSNQNRTRPTNSPLVNQVTTTGTPTLVEDVQIKKEGVVLKTSGRLPE
EECCCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHCEEEECCCEEEEECCCCCC
IELKKSVDRTWMTIDVLNSTLTAKGLKPSQRFNESGLTITQLTQLSTSPAVVRLTLSLPD
CHHHHCCCCEEEEEEHHCCHHHHCCCCHHHHHCCCCCEEEEEECCCCCCEEEEEEEECCC
KRTQWQARAYAGGIAVWPEGEVQPTINEATGFVFLKSVELKNGTELVVTADKPINYTSGW
CCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCC
DSETGAYGITIYNAKIDDRFRLPKREVGSPLIWAKIRQEDPETVTILVKPATNVKIAEVT
CCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEEECCCCCCEEEEEEECCCCEEEEHHH
QVTTQQLSLLMGWGNIGTAPPGWRPNSIEPSSSSKPSLFPRRYNSSSPNSLGENSLPQNR
HHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
LPRNSPENLRPRRWPFTWPRRNNQRSLNNDRRFPLQNQLPQSDGRVMIVIDPGHGGPMDF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCCC
GGVGFGGMREKDIVLPMSLEVAQILEQNNIQVVMTRKTDRDLDLPPRSELANRVGADLFV
CCCCCCCCCCCCEEEECCHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHCCCEEEE
SIHANAISMSRPDVNGLETFYYQSGQVLAQYIQNSMLEAFPTMNNRGVKRARFHVLRHTK
EEECCEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
MPAALVEVGFVTGNYDSRILADPGQRSRMAQAIARGILKYVQVYYR
CCHHHEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]