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The map label for this gene is pcoA [H]

Identifier: 110835220

GI number: 110835220

Start: 2682540

End: 2684462

Strand: Direct

Name: pcoA [H]

Synonym: ABO_2359

Alternate gene names: 110835220

Gene position: 2682540-2684462 (Clockwise)

Preceding gene: 110835219

Following gene: 110835221

Centisome position: 85.97

GC content: 58.14

Gene sequence:

>1923_bases
ATGAAAACACCATCGCAGATTTCTCTGCCACGGCGCCGTTTCGTGCAGGGCCTAGCACTGGGTGCCGCTGGCCTCGGCGT
AGGTCTTAACGCCCGTCAGCTACTGGCCAGCCAGGGCCACACCGGTGCACCGGTTCTTACCGGCAACACCTTCCACCTCA
CGCTTGGCGGCGCCGATGTCAATATCACCGGCAAGGCTCGCCCGGCCACCACCATCAATGGCAGCATTCCCGGCCCTACC
CTGCGCTGGAAAGAAGGCGACACCGTCACGATCAAAGTGACCAACCTGTTACCGGAAACCAGCTCCATTCACTGGCATGG
CCTGCTACTTCCCTTCGAAATGGACGGCGTGCCGGGATTGTCTTTCGACGGTATCGCCCCCGGTGAAACCTTCACCTATT
GCTTTCCGGTGAAGCAAAGTGGCACCTACTGGTATCACAGCCATTCCGGCTTTCAGGAGCAAACGGGAATTTATGGTTCC
ATCATTATTGATCCGCGCGAACCGGATCGGCACACGGTTGACCGAGACGAGGTGATTCTACTCTCCGATTGGAGCGATGA
AGATCCTCACCATGTGTATGCCACGCTGAAAAAGCTCAGCCACTACTACAATTTCAATGAACGCACCGTGTTCGACACCC
TGCGCGACTTTCGCAAAAAAGGTGTTATCGACACACTCAAAGACCGCCACATGTGGAACACCATGCGCATGAGCCAAAGC
GACCTGGCGGATGTGACGGGTTATACCTACACCTACTTGATGAATGGCCAAAGCCCTGCCGACAACTGGACCTGCCAGTT
CAAGCCCGGCGAACGTATCCGCCTGCGCTTTATCAACGCCAGTGCCATGACCTTCTTTGATATTCGCATCCCGGGCCTGG
ACATGACCGTGGTCGCCATGGACGGCCAACCGGTAAAACCGGTGGACTTCCATGAAGTCAGGCTAGGGGTAGCGGAAACC
TTAGACGTAATCGTGGCGCCCCGAGCAGACCGGGCGTACACCCTATTCGCACAGAGCATCGACCGGAGTGGCTTCAGCCG
CGGCACTTTGACCCCGGACCCCGCCATGACTGCCGCGGTCCCGAACATGGATGCACCGCCACCGTTAGGCCATACCGAAA
TGGGCATGGGCGCCATGGGTTCGCCGTCAATGAATGCAAAGGGAAGAGCCCACGGTGATATGCACCATGGCGATATGACC
CACGCCGACATGAAGATGGACAGCATGGATCACCACACCATGGGCCACAGCGACACCAAGCCCGTGCCCTTTGCCGTTAA
CGACAACAACCCGGATTTACCGCCGCGCAACAGCGCCATCGAACATGCAGCCAGCGAATTCGGCCCCGGTGTCGACATGC
GCGCCATGGCGCCGGGGGCGATGCTTAACGACCCAGGCATTGGCTTGCGCAACCGGGACTGGAAAGTGCTCACCTATGCA
GATCTAGAAACCCTGAGCGACACGCCCAACAACACCCCTATCGACAGTCTTCATCCGGACCGGGAAATTGTATTGCACCT
GACCGGTAACATGGACCGTTACATGTGGAGCTTTAACGGCATTAAATTTGCCGACTCCGTGCCCTTGACGCTGTTCCACC
ACGAGCGGGTGCGCATCACCCTGGTGAACGACACCATGATGACCCACCCCATCCACCTACACGGACTATGGAGTGACCTG
GAACTGGGGGAAGGCAAACTGCTGCGCAAGCACACCATTACCGTCAAACCGGGCGAAAAACTCAGCTACCTAGTACGCGC
TGATGCGCTCGGGCGTTGGGCCTATCATTGCCACCTTCTCTACCACATGGAGGCCGGCATGTTCCGCGAGGTTCGTGTGG
TTGAAAACGCCCACCCGCCAGCGCCCAACGGCGACCACGCAATGCATGGGGCCCACCGCATGAACGGAGTGAAGCAACCA
TGA

Upstream 100 bases:

>100_bases
TGATCAGTGCGATTCACGCGGGCATCCACCGGTTGCCGTTACGCCCACCCTCCCTGTTCATTTGAGCTGACCTCTTTCTC
AAACGAACAGGATTACGGAA

Downstream 100 bases:

>100_bases
AAAAATCGCTCACTTTTCTTGCCAGTATCGTCATCCTTGCCACCGCCTCACCGGCCACGGCTATGAATAAAAAGGAACCA
CGCTTCACCCGCATAATCGT

Product: copper resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MKTPSQISLPRRRFVQGLALGAAGLGVGLNARQLLASQGHTGAPVLTGNTFHLTLGGADVNITGKARPATTINGSIPGPT
LRWKEGDTVTIKVTNLLPETSSIHWHGLLLPFEMDGVPGLSFDGIAPGETFTYCFPVKQSGTYWYHSHSGFQEQTGIYGS
IIIDPREPDRHTVDRDEVILLSDWSDEDPHHVYATLKKLSHYYNFNERTVFDTLRDFRKKGVIDTLKDRHMWNTMRMSQS
DLADVTGYTYTYLMNGQSPADNWTCQFKPGERIRLRFINASAMTFFDIRIPGLDMTVVAMDGQPVKPVDFHEVRLGVAET
LDVIVAPRADRAYTLFAQSIDRSGFSRGTLTPDPAMTAAVPNMDAPPPLGHTEMGMGAMGSPSMNAKGRAHGDMHHGDMT
HADMKMDSMDHHTMGHSDTKPVPFAVNDNNPDLPPRNSAIEHAASEFGPGVDMRAMAPGAMLNDPGIGLRNRDWKVLTYA
DLETLSDTPNNTPIDSLHPDREIVLHLTGNMDRYMWSFNGIKFADSVPLTLFHHERVRITLVNDTMMTHPIHLHGLWSDL
ELGEGKLLRKHTITVKPGEKLSYLVRADALGRWAYHCHLLYHMEAGMFREVRVVENAHPPAPNGDHAMHGAHRMNGVKQP

Sequences:

>Translated_640_residues
MKTPSQISLPRRRFVQGLALGAAGLGVGLNARQLLASQGHTGAPVLTGNTFHLTLGGADVNITGKARPATTINGSIPGPT
LRWKEGDTVTIKVTNLLPETSSIHWHGLLLPFEMDGVPGLSFDGIAPGETFTYCFPVKQSGTYWYHSHSGFQEQTGIYGS
IIIDPREPDRHTVDRDEVILLSDWSDEDPHHVYATLKKLSHYYNFNERTVFDTLRDFRKKGVIDTLKDRHMWNTMRMSQS
DLADVTGYTYTYLMNGQSPADNWTCQFKPGERIRLRFINASAMTFFDIRIPGLDMTVVAMDGQPVKPVDFHEVRLGVAET
LDVIVAPRADRAYTLFAQSIDRSGFSRGTLTPDPAMTAAVPNMDAPPPLGHTEMGMGAMGSPSMNAKGRAHGDMHHGDMT
HADMKMDSMDHHTMGHSDTKPVPFAVNDNNPDLPPRNSAIEHAASEFGPGVDMRAMAPGAMLNDPGIGLRNRDWKVLTYA
DLETLSDTPNNTPIDSLHPDREIVLHLTGNMDRYMWSFNGIKFADSVPLTLFHHERVRITLVNDTMMTHPIHLHGLWSDL
ELGEGKLLRKHTITVKPGEKLSYLVRADALGRWAYHCHLLYHMEAGMFREVRVVENAHPPAPNGDHAMHGAHRMNGVKQP
>Mature_640_residues
MKTPSQISLPRRRFVQGLALGAAGLGVGLNARQLLASQGHTGAPVLTGNTFHLTLGGADVNITGKARPATTINGSIPGPT
LRWKEGDTVTIKVTNLLPETSSIHWHGLLLPFEMDGVPGLSFDGIAPGETFTYCFPVKQSGTYWYHSHSGFQEQTGIYGS
IIIDPREPDRHTVDRDEVILLSDWSDEDPHHVYATLKKLSHYYNFNERTVFDTLRDFRKKGVIDTLKDRHMWNTMRMSQS
DLADVTGYTYTYLMNGQSPADNWTCQFKPGERIRLRFINASAMTFFDIRIPGLDMTVVAMDGQPVKPVDFHEVRLGVAET
LDVIVAPRADRAYTLFAQSIDRSGFSRGTLTPDPAMTAAVPNMDAPPPLGHTEMGMGAMGSPSMNAKGRAHGDMHHGDMT
HADMKMDSMDHHTMGHSDTKPVPFAVNDNNPDLPPRNSAIEHAASEFGPGVDMRAMAPGAMLNDPGIGLRNRDWKVLTYA
DLETLSDTPNNTPIDSLHPDREIVLHLTGNMDRYMWSFNGIKFADSVPLTLFHHERVRITLVNDTMMTHPIHLHGLWSDL
ELGEGKLLRKHTITVKPGEKLSYLVRADALGRWAYHCHLLYHMEAGMFREVRVVENAHPPAPNGDHAMHGAHRMNGVKQP

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=443, Percent_Identity=24.8306997742664, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539950, Length=302, Percent_Identity=24.1721854304636, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320714, Length=341, Percent_Identity=26.3929618768328, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323703, Length=138, Percent_Identity=42.7536231884058, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321067, Length=267, Percent_Identity=28.0898876404494, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585842, Length=296, Percent_Identity=30.0675675675676, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221330000, Length=296, Percent_Identity=30.0675675675676, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281360167, Length=296, Percent_Identity=30.0675675675676, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28574104, Length=632, Percent_Identity=24.5253164556962, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI221329998, Length=296, Percent_Identity=30.0675675675676, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650186, Length=312, Percent_Identity=25.9615384615385, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859919, Length=272, Percent_Identity=27.9411764705882, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 71056; Mature: 71056

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPSQISLPRRRFVQGLALGAAGLGVGLNARQLLASQGHTGAPVLTGNTFHLTLGGADV
CCCCCCCCCCHHHHHHHHHHCCHHCCCCCCHHHHHHCCCCCCCCEEECCEEEEEECCCEE
NITGKARPATTINGSIPGPTLRWKEGDTVTIKVTNLLPETSSIHWHGLLLPFEMDGVPGL
EEECCCCCCEEECCCCCCCEEEECCCCEEEEEEEEECCCCCCEEEEEEEEEEECCCCCCC
SFDGIAPGETFTYCFPVKQSGTYWYHSHSGFQEQTGIYGSIIIDPREPDRHTVDRDEVIL
CCCCCCCCCEEEEEEEECCCCEEEEECCCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEE
LSDWSDEDPHHVYATLKKLSHYYNFNERTVFDTLRDFRKKGVIDTLKDRHMWNTMRMSQS
EECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHH
DLADVTGYTYTYLMNGQSPADNWTCQFKPGERIRLRFINASAMTFFDIRIPGLDMTVVAM
HHHHCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEECCEEEEEEEEECCCCEEEEEE
DGQPVKPVDFHEVRLGVAETLDVIVAPRADRAYTLFAQSIDRSGFSRGTLTPDPAMTAAV
CCCCCCCCCHHHHHHCHHHEEEEEEECCCCCEEEEEEHHHCCCCCCCCCCCCCCCCEEEC
PNMDAPPPLGHTEMGMGAMGSPSMNAKGRAHGDMHHGDMTHADMKMDSMDHHTMGHSDTK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCC
PVPFAVNDNNPDLPPRNSAIEHAASEFGPGVDMRAMAPGAMLNDPGIGLRNRDWKVLTYA
CCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCEECCCCCCCCCCCEEEEEEE
DLETLSDTPNNTPIDSLHPDREIVLHLTGNMDRYMWSFNGIKFADSVPLTLFHHERVRIT
CHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCEEEEECCEEEEE
LVNDTMMTHPIHLHGLWSDLELGEGKLLRKHTITVKPGEKLSYLVRADALGRWAYHCHLL
EECCCEEECCEEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEEEEHHHHCCEEEEEEEE
YHMEAGMFREVRVVENAHPPAPNGDHAMHGAHRMNGVKQP
EEECCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKTPSQISLPRRRFVQGLALGAAGLGVGLNARQLLASQGHTGAPVLTGNTFHLTLGGADV
CCCCCCCCCCHHHHHHHHHHCCHHCCCCCCHHHHHHCCCCCCCCEEECCEEEEEECCCEE
NITGKARPATTINGSIPGPTLRWKEGDTVTIKVTNLLPETSSIHWHGLLLPFEMDGVPGL
EEECCCCCCEEECCCCCCCEEEECCCCEEEEEEEEECCCCCCEEEEEEEEEEECCCCCCC
SFDGIAPGETFTYCFPVKQSGTYWYHSHSGFQEQTGIYGSIIIDPREPDRHTVDRDEVIL
CCCCCCCCCEEEEEEEECCCCEEEEECCCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEE
LSDWSDEDPHHVYATLKKLSHYYNFNERTVFDTLRDFRKKGVIDTLKDRHMWNTMRMSQS
EECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHH
DLADVTGYTYTYLMNGQSPADNWTCQFKPGERIRLRFINASAMTFFDIRIPGLDMTVVAM
HHHHCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEECCEEEEEEEEECCCCEEEEEE
DGQPVKPVDFHEVRLGVAETLDVIVAPRADRAYTLFAQSIDRSGFSRGTLTPDPAMTAAV
CCCCCCCCCHHHHHHCHHHEEEEEEECCCCCEEEEEEHHHCCCCCCCCCCCCCCCCEEEC
PNMDAPPPLGHTEMGMGAMGSPSMNAKGRAHGDMHHGDMTHADMKMDSMDHHTMGHSDTK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCC
PVPFAVNDNNPDLPPRNSAIEHAASEFGPGVDMRAMAPGAMLNDPGIGLRNRDWKVLTYA
CCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCEECCCCCCCCCCCEEEEEEE
DLETLSDTPNNTPIDSLHPDREIVLHLTGNMDRYMWSFNGIKFADSVPLTLFHHERVRIT
CHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCEEEEECCEEEEE
LVNDTMMTHPIHLHGLWSDLELGEGKLLRKHTITVKPGEKLSYLVRADALGRWAYHCHLL
EECCCEEECCEEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEEEEHHHHCCEEEEEEEE
YHMEAGMFREVRVVENAHPPAPNGDHAMHGAHRMNGVKQP
EEECCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]