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The map label for this gene is merA [H]

Identifier: 110835044

GI number: 110835044

Start: 2491161

End: 2493305

Strand: Direct

Name: merA [H]

Synonym: ABO_2183

Alternate gene names: 110835044

Gene position: 2491161-2493305 (Clockwise)

Preceding gene: 110835043

Following gene: 110835045

Centisome position: 79.84

GC content: 54.36

Gene sequence:

>2145_bases
ATGAGTATCAAAAAAGGCCTCCTCTTCACTGCCCTAGCCGCGCTGATTGCCTGCTACTTTGTTTTTGATCTCGGCCAATA
TTTCAGCCTGGATTATATCAAGCAGCAGCAAAGTGCCTTTGATGCTCTCTATCAGGATAATCCCGCGCTCATTCTCGGCG
GCTTCTTCGGGCTATATGTGCTGGTCACCGCATTGAGCCTACCCGGCGCTGCCATCATGACCCTGGCAGCCGGGGCGCTG
TTCGGTTTCTGGATCGCTCTGGTGATGGTTTCATTTGCCTCCTCTGCCGGCGCGACCTTGGCGTTCTTAGCATCGCGCTT
TTTATTCCATGATGCGGTTCAGAGCCGCTTCGGCGAACGGCTGAAAAAACTCAACGAAGGGGTTAAGAAAGAAGGCGCAT
TTTATCTTTTCACTCTGCGTTTGGTGCCGGTGGTGCCGTTTTTTATCATTAACTTGGTAATGGGGTTAACGCCCATCAAA
GCACGCACCTTCTACTGGGTCAGCCAAGTCGGCATGCTGGCGGGCACGGCCGTCTATGTAAACGCCGGAACCCAGCTCGG
CCAAATTGACAGTCTTAAAGGACTGCTGTCTGTAGAACTCATCGGCGCCTTTGTGTTGCTCGGCATATTCCCCTGGATCG
CCAAGGGCATCATGGCTCGCGTGCAAGCACGCAAAGTCTATAAAGGCTGGAAGAAACCGAAACAATTCGACCGCAACCTG
ATCGTTATCGGGGCAGGGGCCGCAGGCCTAGTAAGCGCCTACATTGCCGCCACCGTGAAAGCGAAAGTGACCCTGATCGA
AAAACACAAAATGGGGGGCGACTGCCTGAACACTGGATGCGTACCCTCTAAGGCATTAATCAAAAGCGCCCGTGTTGCGT
TCAATGACAAGCAGGCCGAAAAGTACGGCTTCGAGGCTATCAATAGCCGCTTCCGCTTCTCCAGCATGATGGAGCGGGTT
CAACAGGTGATCGAGAAAATTGAACCCCATGATTCCGTGGAGCGTTATAGCGAACTAGGGGTGGACTGCCGTCAAGGCGA
AGCGCGCTTCCTCTCGCCCTGGGAAGTGGAAATCCGCAACGGCGATCACGTGGAAACCCTCACCGCCCGCAGCATTATTA
TTGCCTCCGGCGCCCGCCCCTTTGTGCCACCGATTCCGGGCATCGAAGACATCGATATCCTCACCTCCGACAACCTTTGG
CAGATTGAAGAACAACCCAAACGACTACTGGTACTGGGTGGCGGCCCCATCGGTTGTGAGCTAGCCCAGACCTTTGCCCG
CCTGGGCAGCGAAGTCACCCAAATCGAAATGCTACCCCGACTGATGATTCGTGAAGATGCGGAAGCCAGCGAGATTGTCA
CCCGCTCACTAAAGGAAAGCGGCGTACACGTACTTACTAATCACAAAGCCGTTCGGTTCAGCGAAGAGAACAGCGAGAAA
GTATTATTGGTTGAACACGATGGCAAAGAAACTGCCCTGCCTTTTGACCAGGTGCTAGTGGCCGTGGGTCGCAAGGCCAA
CACTGATGGCCTAGGCCTGGATGCCCTGCAATTGCCCACCGAGACCAATGGCACTATCCAGACCAATGATCGCCTACAAA
GCCGCTACCCCAACATCTATGCCTGTGGCGATGTGGCCGGCCCGTACCAGTTCACCCATACCGCCGCCCACCAAGCCTGG
TATGCCAGCGTCAATGCCCTGTTTGGTTTCCTGAAAAGTTTCAAGGTGGATTACCGGGTGATCCCCTGGTGCACCTTTAC
CGACCCGGAAGTGGCGCGCGTGGGCGTCAACGAGCAAGAAGCTGACGAACAAGGCATCGAATACGACATCACTCGTTACG
GGATTGATGATCTGGACCGAGCTATTGCCGACAGTGCGGACCTTGGCTATGTAAAAGTCCTCACTGCCAAAGGCAGCGAC
AAAATCTTGGGTGTCACCATCGTTGGCCAGCATGCGGGTGAATTGATCAGCGAATATGTGCTGGCCATGAAACACGGGCT
AGGCCTGAACAAGATCCTCGGCACCATCCACATTTACCCGACCATGGCCGAGGCTAACAAGTTTGCCGCCGGAGAATGGA
AAAAAGCACGCAAGCCTGAAGGACTGTTACGTTGGGTAGAACGGATTCATAACGTGCGACGATAA

Upstream 100 bases:

>100_bases
TGTTGCTAAGTCACAGGTCTCTTCATGGTTGTAACATCCGGCCAGAAAAACCATCAAACCGTCATGCTTACTCTTATACG
CACCACTAACAGGACCTGAC

Downstream 100 bases:

>100_bases
GCGGTCTCTGAAGAACACCTTTCATGCTTTGGCAGACCGCACTTGCATGGCAAAAACCAGTAGGAGTAACTATGTTTATG
CGCTTGCTAATATCCTTGTT

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 714; Mature: 713

Protein sequence:

>714_residues
MSIKKGLLFTALAALIACYFVFDLGQYFSLDYIKQQQSAFDALYQDNPALILGGFFGLYVLVTALSLPGAAIMTLAAGAL
FGFWIALVMVSFASSAGATLAFLASRFLFHDAVQSRFGERLKKLNEGVKKEGAFYLFTLRLVPVVPFFIINLVMGLTPIK
ARTFYWVSQVGMLAGTAVYVNAGTQLGQIDSLKGLLSVELIGAFVLLGIFPWIAKGIMARVQARKVYKGWKKPKQFDRNL
IVIGAGAAGLVSAYIAATVKAKVTLIEKHKMGGDCLNTGCVPSKALIKSARVAFNDKQAEKYGFEAINSRFRFSSMMERV
QQVIEKIEPHDSVERYSELGVDCRQGEARFLSPWEVEIRNGDHVETLTARSIIIASGARPFVPPIPGIEDIDILTSDNLW
QIEEQPKRLLVLGGGPIGCELAQTFARLGSEVTQIEMLPRLMIREDAEASEIVTRSLKESGVHVLTNHKAVRFSEENSEK
VLLVEHDGKETALPFDQVLVAVGRKANTDGLGLDALQLPTETNGTIQTNDRLQSRYPNIYACGDVAGPYQFTHTAAHQAW
YASVNALFGFLKSFKVDYRVIPWCTFTDPEVARVGVNEQEADEQGIEYDITRYGIDDLDRAIADSADLGYVKVLTAKGSD
KILGVTIVGQHAGELISEYVLAMKHGLGLNKILGTIHIYPTMAEANKFAAGEWKKARKPEGLLRWVERIHNVRR

Sequences:

>Translated_714_residues
MSIKKGLLFTALAALIACYFVFDLGQYFSLDYIKQQQSAFDALYQDNPALILGGFFGLYVLVTALSLPGAAIMTLAAGAL
FGFWIALVMVSFASSAGATLAFLASRFLFHDAVQSRFGERLKKLNEGVKKEGAFYLFTLRLVPVVPFFIINLVMGLTPIK
ARTFYWVSQVGMLAGTAVYVNAGTQLGQIDSLKGLLSVELIGAFVLLGIFPWIAKGIMARVQARKVYKGWKKPKQFDRNL
IVIGAGAAGLVSAYIAATVKAKVTLIEKHKMGGDCLNTGCVPSKALIKSARVAFNDKQAEKYGFEAINSRFRFSSMMERV
QQVIEKIEPHDSVERYSELGVDCRQGEARFLSPWEVEIRNGDHVETLTARSIIIASGARPFVPPIPGIEDIDILTSDNLW
QIEEQPKRLLVLGGGPIGCELAQTFARLGSEVTQIEMLPRLMIREDAEASEIVTRSLKESGVHVLTNHKAVRFSEENSEK
VLLVEHDGKETALPFDQVLVAVGRKANTDGLGLDALQLPTETNGTIQTNDRLQSRYPNIYACGDVAGPYQFTHTAAHQAW
YASVNALFGFLKSFKVDYRVIPWCTFTDPEVARVGVNEQEADEQGIEYDITRYGIDDLDRAIADSADLGYVKVLTAKGSD
KILGVTIVGQHAGELISEYVLAMKHGLGLNKILGTIHIYPTMAEANKFAAGEWKKARKPEGLLRWVERIHNVRR
>Mature_713_residues
SIKKGLLFTALAALIACYFVFDLGQYFSLDYIKQQQSAFDALYQDNPALILGGFFGLYVLVTALSLPGAAIMTLAAGALF
GFWIALVMVSFASSAGATLAFLASRFLFHDAVQSRFGERLKKLNEGVKKEGAFYLFTLRLVPVVPFFIINLVMGLTPIKA
RTFYWVSQVGMLAGTAVYVNAGTQLGQIDSLKGLLSVELIGAFVLLGIFPWIAKGIMARVQARKVYKGWKKPKQFDRNLI
VIGAGAAGLVSAYIAATVKAKVTLIEKHKMGGDCLNTGCVPSKALIKSARVAFNDKQAEKYGFEAINSRFRFSSMMERVQ
QVIEKIEPHDSVERYSELGVDCRQGEARFLSPWEVEIRNGDHVETLTARSIIIASGARPFVPPIPGIEDIDILTSDNLWQ
IEEQPKRLLVLGGGPIGCELAQTFARLGSEVTQIEMLPRLMIREDAEASEIVTRSLKESGVHVLTNHKAVRFSEENSEKV
LLVEHDGKETALPFDQVLVAVGRKANTDGLGLDALQLPTETNGTIQTNDRLQSRYPNIYACGDVAGPYQFTHTAAHQAWY
ASVNALFGFLKSFKVDYRVIPWCTFTDPEVARVGVNEQEADEQGIEYDITRYGIDDLDRAIADSADLGYVKVLTAKGSDK
ILGVTIVGQHAGELISEYVLAMKHGLGLNKILGTIHIYPTMAEANKFAAGEWKKARKPEGLLRWVERIHNVRR

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=31.3852813852814, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=28.2327586206897, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=25.4004576659039, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=25.4004576659039, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=25.4004576659039, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI148277065, Length=437, Percent_Identity=25.4004576659039, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI291045266, Length=428, Percent_Identity=28.7383177570093, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=25.4004576659039, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI22035672, Length=433, Percent_Identity=27.4826789838337, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI291045268, Length=425, Percent_Identity=26.5882352941176, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=31.1688311688312, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=30.2375809935205, Blast_Score=182, Evalue=9e-47,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=27.0089285714286, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI1789915, Length=442, Percent_Identity=29.6380090497738, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081964, Length=195, Percent_Identity=24.6153846153846, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1789065, Length=183, Percent_Identity=30.6010928961749, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=35.4838709677419, Blast_Score=243, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=28.8461538461538, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=431, Percent_Identity=25.754060324826, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=431, Percent_Identity=25.754060324826, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=449, Percent_Identity=25.3897550111359, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17532687, Length=160, Percent_Identity=26.875, Blast_Score=83, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=31.3025210084034, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=27.8969957081545, Blast_Score=158, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=24.9466950959488, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=32.244008714597, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24640551, Length=502, Percent_Identity=28.8844621513944, Blast_Score=154, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24640553, Length=504, Percent_Identity=28.5714285714286, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=28.6008230452675, Blast_Score=153, Evalue=5e-37,
Organism=Drosophila melanogaster, GI17737741, Length=498, Percent_Identity=29.1164658634538, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 78646; Mature: 78515

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKKGLLFTALAALIACYFVFDLGQYFSLDYIKQQQSAFDALYQDNPALILGGFFGLYV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
LVTALSLPGAAIMTLAAGALFGFWIALVMVSFASSAGATLAFLASRFLFHDAVQSRFGER
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKKLNEGVKKEGAFYLFTLRLVPVVPFFIINLVMGLTPIKARTFYWVSQVGMLAGTAVYV
HHHHHHCHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEE
NAGTQLGQIDSLKGLLSVELIGAFVLLGIFPWIAKGIMARVQARKVYKGWKKPKQFDRNL
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCE
IVIGAGAAGLVSAYIAATVKAKVTLIEKHKMGGDCLNTGCVPSKALIKSARVAFNDKQAE
EEEECCHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHH
KYGFEAINSRFRFSSMMERVQQVIEKIEPHDSVERYSELGVDCRQGEARFLSPWEVEIRN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECC
GDHVETLTARSIIIASGARPFVPPIPGIEDIDILTSDNLWQIEEQPKRLLVLGGGPIGCE
CCCEEHHHHCEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCEEEEECCCCCCHH
LAQTFARLGSEVTQIEMLPRLMIREDAEASEIVTRSLKESGVHVLTNHKAVRFSEENSEK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCEEEECCCCCCE
VLLVEHDGKETALPFDQVLVAVGRKANTDGLGLDALQLPTETNGTIQTNDRLQSRYPNIY
EEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCEEEECCHHHHHCCCEE
ACGDVAGPYQFTHTAAHQAWYASVNALFGFLKSFKVDYRVIPWCTFTDPEVARVGVNEQE
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCCCCCHHH
ADEQGIEYDITRYGIDDLDRAIADSADLGYVKVLTAKGSDKILGVTIVGQHAGELISEYV
HHHCCCCEEEHHCCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECHHHHHHHHHHH
LAMKHGLGLNKILGTIHIYPTMAEANKFAAGEWKKARKPEGLLRWVERIHNVRR
HHHHHCCCHHHHHHHEEEEEEHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIKKGLLFTALAALIACYFVFDLGQYFSLDYIKQQQSAFDALYQDNPALILGGFFGLYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
LVTALSLPGAAIMTLAAGALFGFWIALVMVSFASSAGATLAFLASRFLFHDAVQSRFGER
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKKLNEGVKKEGAFYLFTLRLVPVVPFFIINLVMGLTPIKARTFYWVSQVGMLAGTAVYV
HHHHHHCHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEE
NAGTQLGQIDSLKGLLSVELIGAFVLLGIFPWIAKGIMARVQARKVYKGWKKPKQFDRNL
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCE
IVIGAGAAGLVSAYIAATVKAKVTLIEKHKMGGDCLNTGCVPSKALIKSARVAFNDKQAE
EEEECCHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHH
KYGFEAINSRFRFSSMMERVQQVIEKIEPHDSVERYSELGVDCRQGEARFLSPWEVEIRN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECC
GDHVETLTARSIIIASGARPFVPPIPGIEDIDILTSDNLWQIEEQPKRLLVLGGGPIGCE
CCCEEHHHHCEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCEEEEECCCCCCHH
LAQTFARLGSEVTQIEMLPRLMIREDAEASEIVTRSLKESGVHVLTNHKAVRFSEENSEK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCEEEECCCCCCE
VLLVEHDGKETALPFDQVLVAVGRKANTDGLGLDALQLPTETNGTIQTNDRLQSRYPNIY
EEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCEECCCCCCCEEEECCHHHHHCCCEE
ACGDVAGPYQFTHTAAHQAWYASVNALFGFLKSFKVDYRVIPWCTFTDPEVARVGVNEQE
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHCCCCCHHH
ADEQGIEYDITRYGIDDLDRAIADSADLGYVKVLTAKGSDKILGVTIVGQHAGELISEYV
HHHCCCCEEEHHCCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECHHHHHHHHHHH
LAMKHGLGLNKILGTIHIYPTMAEANKFAAGEWKKARKPEGLLRWVERIHNVRR
HHHHHCCCHHHHHHHEEEEEEHHHCCCCCCCCCHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]