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The map label for this gene is hmrR [H]

Identifier: 110636216

GI number: 110636216

Start: 4195450

End: 4195899

Strand: Reverse

Name: hmrR [H]

Synonym: Meso_3892

Alternate gene names: 110636216

Gene position: 4195899-4195450 (Counterclockwise)

Preceding gene: 110636217

Following gene: 110636215

Centisome position: 95.09

GC content: 64.89

Gene sequence:

>450_bases
ATGAATATCGGCGAAGCGGCGCGCGCCTCGGGCGTGAGCGCGAAAATGATCCGCTACTACGAGCAGACCGGCCTGATTCC
GCCGGCCGATCGCACGGCGTCAGGCTATCGGGACTATTCGGGGACCGACGTGCATATGCTGCGCTTCATCCGGCGCGCGC
GCGATCTGGGCTTCTCGGTCGCGGAGATCGACGAACTTCTCGGACTCTGGCGCGATCGCAGCCGACAGAGCGCCGACGTC
AAGCGCATCGCTCTCGCGCATATCGAGGACCTGCGGCGCAAGATCGGCGAGATGGAGCAGATGGCCGACACGCTTCAGAC
GCTGGCCTCCTGCTGCTCGGGCGACAACCGGCCAGACTGCCCCATCCTCGCCGACCTCGAAAGCGCGAACGACGATGCCG
ATCAGGAACCGAAGCGGCGGCGTGGTGCGATCGACAATTGCCTTCAGTAA

Upstream 100 bases:

>100_bases
CGCCGATGGAAGCCGTGGCCGGCGCGGCGATCCCCGCCGCGCGGTCGGCGGGTCCGGATGCGACCGGAGATGACCCTTCG
AGGATTGAAAGGAGCGCGGC

Downstream 100 bases:

>100_bases
GCGACCGGCCGCCCGGACACGAAGGGACCATTCTCAATGACGGAACTGTCGCGCCGAAGGATGCTCGGTCTCGCCGCGCT
CGGCGTCGTCGCACCGCTGA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MNIGEAARASGVSAKMIRYYEQTGLIPPADRTASGYRDYSGTDVHMLRFIRRARDLGFSVAEIDELLGLWRDRSRQSADV
KRIALAHIEDLRRKIGEMEQMADTLQTLASCCSGDNRPDCPILADLESANDDADQEPKRRRGAIDNCLQ

Sequences:

>Translated_149_residues
MNIGEAARASGVSAKMIRYYEQTGLIPPADRTASGYRDYSGTDVHMLRFIRRARDLGFSVAEIDELLGLWRDRSRQSADV
KRIALAHIEDLRRKIGEMEQMADTLQTLASCCSGDNRPDCPILADLESANDDADQEPKRRRGAIDNCLQ
>Mature_149_residues
MNIGEAARASGVSAKMIRYYEQTGLIPPADRTASGYRDYSGTDVHMLRFIRRARDLGFSVAEIDELLGLWRDRSRQSADV
KRIALAHIEDLRRKIGEMEQMADTLQTLASCCSGDNRPDCPILADLESANDDADQEPKRRRGAIDNCLQ

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=126, Percent_Identity=42.0634920634921, Blast_Score=117, Evalue=3e-28,
Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=35.9375, Blast_Score=79, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16687; Mature: 16687

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGEAARASGVSAKMIRYYEQTGLIPPADRTASGYRDYSGTDVHMLRFIRRARDLGFSV
CCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
AEIDELLGLWRDRSRQSADVKRIALAHIEDLRRKIGEMEQMADTLQTLASCCSGDNRPDC
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILADLESANDDADQEPKRRRGAIDNCLQ
CEEECCCCCCCCCCCCHHHHHCHHHHHCC
>Mature Secondary Structure
MNIGEAARASGVSAKMIRYYEQTGLIPPADRTASGYRDYSGTDVHMLRFIRRARDLGFSV
CCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
AEIDELLGLWRDRSRQSADVKRIALAHIEDLRRKIGEMEQMADTLQTLASCCSGDNRPDC
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILADLESANDDADQEPKRRRGAIDNCLQ
CEEECCCCCCCCCCCCHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]